Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1381 | 0.4481 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0198 | 0.0295 | 0.039 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.0473 | 0.0441 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.294 | 1 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.015 | 0.0125 | 0.0092 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.294 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0125 | 0.0092 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Onchocerca volvulus | 0.1116 | 0.3544 | 0.3522 | |
Onchocerca volvulus | 0.0992 | 0.3103 | 0.308 | |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.015 | 0.0125 | 0.0125 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1381 | 0.4481 | 1 |
Brugia malayi | Trypsin family protein | 0.1116 | 0.3544 | 0.3522 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0125 | 0.0092 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.015 | 0.0125 | 0.0092 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1381 | 0.4481 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0442 | 0.1157 | 0.1127 |
Loa Loa (eye worm) | hypothetical protein | 0.1116 | 0.3544 | 0.3522 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1116 | 0.3544 | 0.3544 |
Echinococcus multilocularis | dihydrofolate reductase | 0.205 | 0.6848 | 0.6838 |
Trichomonas vaginalis | conserved hypothetical protein | 0.021 | 0.0337 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.205 | 0.6848 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.015 | 0.0125 | 0.0125 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0442 | 0.1157 | 0.1157 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Brugia malayi | hypothetical protein | 0.021 | 0.0337 | 0.0305 |
Echinococcus granulosus | dihydrofolate reductase | 0.205 | 0.6848 | 0.6838 |
Brugia malayi | dihydrofolate reductase family protein | 0.205 | 0.6848 | 0.6838 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1381 | 0.4481 | 1 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0315 | 0.0709 | 0.0678 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0198 | 0.0295 | 0.0262 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0125 | 0.0092 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.294 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.294 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.294 | 1 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.015 | 0.0125 | 0.0092 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Onchocerca volvulus | 0.0442 | 0.1157 | 0.1127 | |
Echinococcus granulosus | Tolloid protein 1 | 0.015 | 0.0125 | 0.0092 |
Brugia malayi | Protein kinase domain containing protein | 0.0198 | 0.0295 | 0.0262 |
Echinococcus granulosus | thymidylate synthase | 0.0442 | 0.1157 | 0.1127 |
Chlamydia trachomatis | dihydrofolate reductase | 0.205 | 0.6848 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1116 | 0.3544 | 0.3544 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Onchocerca volvulus | Arrow homolog | 0.015 | 0.0125 | 0.0092 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.0033 | 0.0033 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.294 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.021 | 0.0337 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.0295 | 0.0262 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0124 | 0.0033 | 0.0033 |
Brugia malayi | Fibulin-1 precursor | 0.015 | 0.0125 | 0.0092 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0198 | 0.0295 | 0.0262 |
Onchocerca volvulus | 0.0198 | 0.0295 | 0.0262 | |
Loa Loa (eye worm) | hypothetical protein | 0.1116 | 0.3544 | 0.3522 |
Schistosoma mansoni | dihydrofolate reductase | 0.205 | 0.6848 | 0.6848 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0198 | 0.0295 | 0.0262 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0125 | 0.0092 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.015 | 0.0125 | 0.0092 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.015 | 0.0125 | 0.0092 |
Brugia malayi | Kringle domain containing protein | 0.0198 | 0.0295 | 0.0262 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0442 | 0.1157 | 0.1259 |
Brugia malayi | Dihydrofolate reductase | 0.205 | 0.6848 | 0.6838 |
Echinococcus granulosus | laminin | 0.015 | 0.0125 | 0.0092 |
Echinococcus multilocularis | thymidylate synthase | 0.0442 | 0.1157 | 0.1127 |
Leishmania major | hypothetical protein, conserved | 0.0198 | 0.0295 | 0.0032 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.205 | 0.6848 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.015 | 0.0125 | 0.0092 |
Echinococcus multilocularis | laminin | 0.015 | 0.0125 | 0.0092 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.0295 | 0.0295 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.205 | 0.6848 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.205 | 0.6848 | 0.6838 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.015 | 0.0125 | 0.0092 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.294 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1381 | 0.4481 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1381 | 0.4481 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0066 | 0.0032 |
Mycobacterium ulcerans | thymidylate synthase | 0.0442 | 0.1157 | 0.1649 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0125 | 0.0092 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Brugia malayi | thymidylate synthase | 0.0442 | 0.1157 | 0.1127 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.