Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Onchocerca volvulus | 0.1116 | 0.3544 | 0.3522 | |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.294 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0125 | 0.0092 |
Brugia malayi | hypothetical protein | 0.021 | 0.0337 | 0.0305 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.015 | 0.0125 | 0.0092 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.015 | 0.0125 | 0.0092 |
Onchocerca volvulus | 0.0992 | 0.3103 | 0.308 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.205 | 0.6848 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0125 | 0.0092 |
Echinococcus granulosus | thymidylate synthase | 0.0442 | 0.1157 | 0.1127 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1381 | 0.4481 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.0295 | 0.0262 |
Onchocerca volvulus | 0.0198 | 0.0295 | 0.0262 | |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0198 | 0.0295 | 0.0262 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.205 | 0.6848 | 1 |
Brugia malayi | thymidylate synthase | 0.0442 | 0.1157 | 0.1127 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.294 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.1116 | 0.3544 | 0.3522 |
Echinococcus granulosus | laminin | 0.015 | 0.0125 | 0.0092 |
Mycobacterium ulcerans | thymidylate synthase | 0.0442 | 0.1157 | 0.1649 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0315 | 0.0709 | 0.0678 |
Echinococcus granulosus | Tolloid protein 1 | 0.015 | 0.0125 | 0.0092 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.294 | 1 | 1 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.294 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.205 | 0.6848 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1116 | 0.3544 | 0.3544 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Onchocerca volvulus | 0.0442 | 0.1157 | 0.1127 | |
Echinococcus granulosus | tissue type plasminogen activator | 0.0198 | 0.0295 | 0.0262 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Trichomonas vaginalis | conserved hypothetical protein | 0.021 | 0.0337 | 0.5 |
Echinococcus multilocularis | fibrillin 1 | 0.015 | 0.0125 | 0.0092 |
Schistosoma mansoni | dihydrofolate reductase | 0.205 | 0.6848 | 0.6848 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1116 | 0.3544 | 0.3544 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0442 | 0.1157 | 0.1259 |
Loa Loa (eye worm) | thymidylate synthase | 0.0442 | 0.1157 | 0.1127 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0198 | 0.0295 | 0.0262 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.015 | 0.0125 | 0.0125 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1381 | 0.4481 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0124 | 0.0033 | 0.0033 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0442 | 0.1157 | 0.1157 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.015 | 0.0125 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0125 | 0.0092 |
Schistosoma mansoni | serine/threonine protein kinase | 0.294 | 1 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.015 | 0.0125 | 0.0125 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.294 | 1 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.015 | 0.0125 | 0.0092 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.0033 | 0.0033 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Onchocerca volvulus | Arrow homolog | 0.015 | 0.0125 | 0.0092 |
Chlamydia trachomatis | dihydrofolate reductase | 0.205 | 0.6848 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.015 | 0.0125 | 0.0092 |
Toxoplasma gondii | kringle domain-containing protein | 0.0198 | 0.0295 | 0.039 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Echinococcus multilocularis | thymidylate synthase | 0.0442 | 0.1157 | 0.1127 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1381 | 0.4481 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1381 | 0.4481 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.015 | 0.0125 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.1116 | 0.3544 | 0.3522 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0125 | 0.0092 |
Brugia malayi | dihydrofolate reductase family protein | 0.205 | 0.6848 | 0.6838 |
Echinococcus multilocularis | laminin | 0.015 | 0.0125 | 0.0092 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.0473 | 0.0441 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0125 | 0.0092 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.205 | 0.6848 | 0.6838 |
Brugia malayi | Fibulin-1 precursor | 0.015 | 0.0125 | 0.0092 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.0295 | 0.0295 |
Brugia malayi | Dihydrofolate reductase | 0.205 | 0.6848 | 0.6838 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1381 | 0.4481 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1116 | 0.3544 | 0.3522 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1381 | 0.4481 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.294 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0066 | 0.0032 |
Leishmania major | hypothetical protein, conserved | 0.0198 | 0.0295 | 0.0032 |
Echinococcus granulosus | dihydrofolate reductase | 0.205 | 0.6848 | 0.6838 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.021 | 0.0337 | 0.0101 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.0033 | 0.0033 |
Brugia malayi | Protein kinase domain containing protein | 0.0198 | 0.0295 | 0.0262 |
Echinococcus multilocularis | dihydrofolate reductase | 0.205 | 0.6848 | 0.6838 |
Brugia malayi | Kringle domain containing protein | 0.0198 | 0.0295 | 0.0262 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.