Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3324 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0498 | 0.1056 | 0.0249 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0498 | 0.1056 | 0.0249 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1271 | 0.3501 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1271 | 0.3501 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0901 | 0.233 | 0.2191 |
Echinococcus granulosus | dihydrofolate reductase | 0.3324 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0901 | 0.233 | 0.2191 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.075 | 0.1852 | 0.1117 |
Brugia malayi | Dihydrofolate reductase | 0.3324 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.3324 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1271 | 0.3501 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3324 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.075 | 0.1852 | 0.1117 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0498 | 0.1056 | 0.0249 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0498 | 0.1056 | 0.0249 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3324 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0498 | 0.1056 | 0.0249 |
Loa Loa (eye worm) | sugar transporter | 0.0498 | 0.1056 | 0.0894 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1271 | 0.3501 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0498 | 0.1056 | 0.0249 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0498 | 0.1056 | 0.0249 |
Brugia malayi | Sugar transporter family protein | 0.0498 | 0.1056 | 0.0894 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0498 | 0.1056 | 0.0249 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3324 | 1 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1271 | 0.3501 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3324 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0498 | 0.1056 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3324 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1271 | 0.3501 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | Inhibition of oleate production in Mycobacterium bovis BCG | ChEMBL. | 16875817 | |
Inhibition (functional) | 0 | Inhibition of oleate production in Mycobacterium bovis BCG | ChEMBL. | 16875817 |
MIC99 (functional) | = 0.06 ug ml-1 | Antibacterial activity against Mycobacterium bovis BCG | ChEMBL. | 16875817 |
MIC99 (functional) | = 0.06 ug ml-1 | Antibacterial activity against Mycobacterium bovis BCG | ChEMBL. | 16875817 |
MIC99 (functional) | = 0.2 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv | ChEMBL. | 16875817 |
MIC99 (functional) | = 0.2 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv | ChEMBL. | 16875817 |
Selectivity index (functional) | = 45.5 | Selectivity index, IC50 against Vero cells/MIC against Mycobacterium | ChEMBL. | 16875817 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.