Detailed information for compound 37208

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 349.378 | Formula: C18H23NO6
  • H donors: 4 H acceptors: 5 LogP: 0.36 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(=O)O.CCNC(C(COc1cccc2c1cccc2)O)C
  • InChi: 1S/C16H21NO2.C2H2O4/c1-3-17-12(2)15(18)11-19-16-10-6-8-13-7-4-5-9-14(13)16;3-1(4)2(5)6/h4-10,12,15,17-18H,3,11H2,1-2H3;(H,3,4)(H,5,6)
  • InChiKey: KEEVBMWBNYWMMR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0105 0.1051 0.3438
Brugia malayi Protein kinase domain containing protein 0.0017 0.0128 0.028
Loa Loa (eye worm) hypothetical protein 0.0029 0.0251 0.0522
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0075 0.0021
Schistosoma mansoni DNA helicase recq5 0.001 0.0054 0.0201
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0017 0.012 0.0078
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0054 0.0011
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0075 0.0021
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0017 0.012 0.0078
Schistosoma mansoni hypothetical protein 0.0012 0.0075 0.0279
Schistosoma mansoni hypothetical protein 0.0199 0.2046 0.766
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0017 0.012 0.0078
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0054 0.1703
Brugia malayi topoisomerase 0.001 0.0054 0.0012
Mycobacterium tuberculosis Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltra 0.0847 0.891 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0017 0.012 0.0078
Schistosoma mansoni DNA helicase recq1 0.001 0.0054 0.0201
Schistosoma mansoni lamin 0.006 0.0579 0.2168
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0054 0.0004
Loa Loa (eye worm) hypothetical protein 0.006 0.0579 0.138
Echinococcus multilocularis protein C ets 2 0.0012 0.0075 0.0021
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0251 0.0198
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0017 0.012 0.0078
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0209 0.0556
Schistosoma mansoni hypothetical protein 0.0199 0.2046 0.766
Brugia malayi DKFZp564C0469 protein 0.001 0.0054 0.0012
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0121 0.3851
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0017 0.012 0.0078
Schistosoma mansoni netrin receptor unc5 0.0017 0.0123 0.0459
Brugia malayi DNA-binding protein D-ETS-3 0.0012 0.0075 0.0086
Echinococcus multilocularis musashi 0.006 0.0579 0.0528
Schistosoma mansoni DNA ligase IV 0.001 0.0054 0.0202
Schistosoma mansoni ets 0.0012 0.0075 0.0279
Loa Loa (eye worm) hypothetical protein 0.002 0.0155 0.0273
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0086 0.0858 0.0808
Echinococcus multilocularis Ankyrin 0.0017 0.0124 0.0071
Schistosoma mansoni cytochrome P450 0.0017 0.012 0.0449
Entamoeba histolytica protein kinase, putative 0.0105 0.1051 1
Echinococcus granulosus dual specificity 0.0105 0.1051 0.5007
Brugia malayi Cytochrome P450 family protein 0.0027 0.0229 0.0643
Brugia malayi Cytochrome P450 family protein 0.0039 0.0356 0.1105
Loa Loa (eye worm) hypothetical protein 0.0059 0.0567 0.135
Echinococcus multilocularis GA binding protein alpha chain 0.0085 0.0842 0.0793
Loa Loa (eye worm) hypothetical protein 0.001 0.0053 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0315 0.1178
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0017 0.012 0.0078
Brugia malayi Pre-SET motif family protein 0.0244 0.2525 0.8947
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0017 0.012 0.0078
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0012 0.0075 0.0021
Brugia malayi Pre-SET motif family protein 0.0035 0.0315 0.0954
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0054 0.0007
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0315 0.0262
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0105 0.1051 0.3511
Loa Loa (eye worm) intermediate filament protein 0.006 0.0579 0.138
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0017 0.012 0.0078
Loa Loa (eye worm) hypothetical protein 0.0035 0.0315 0.0689
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0123 0.2659
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0123 0.0347
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0054 0.1715
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0054 0.0012
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0054 0.1703
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0054 0.0011
Brugia malayi follicle stimulating hormone receptor 0.0271 0.2816 1
Schistosoma mansoni lamin 0.006 0.0579 0.2168
Onchocerca volvulus 0.001 0.0054 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0188
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.012 0.0232
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0017 0.012 0.0078
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0229 0.0464
Echinococcus granulosus nuclear factor of activated T cells 5 0.0086 0.0858 0.4036
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0017 0.012 0.0078
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0105 0.1051 0.9149
Schistosoma mansoni ets-related 0.0012 0.0075 0.0279
Leishmania major hypothetical protein, conserved 0.0279 0.2894 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0017 0.012 0.0078
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0075 0.0106
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0054 0.0011
Brugia malayi hypothetical protein 0.001 0.0054 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0008
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0054 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0054 0.0011
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0123 0.0254
Brugia malayi Protein kinase domain containing protein 0.0105 0.1051 0.3617
Echinococcus granulosus ewsr:fli fusion protein type 0.0012 0.0075 0.0106
Loa Loa (eye worm) hypothetical protein 0.0028 0.0239 0.0492
Chlamydia trachomatis methylated-DNA protein-cysteine methyltransferase 0.0279 0.2894 1
Schistosoma mansoni topbp1 0.001 0.0054 0.0202
Echinococcus granulosus lamin 0.006 0.0579 0.2638
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0209 0.0556
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0054 0.001
Brugia malayi Uncoordinated protein 44 0.0017 0.0123 0.026
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0301 0.1242
Onchocerca volvulus 0.006 0.0579 0.1865
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0123 0.0069
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0008
Loa Loa (eye worm) fli-1 protein 0.0258 0.2671 0.6845
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0105 0.1051 0.3511
Echinococcus granulosus bloom syndrome protein 0.0025 0.0209 0.078
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0017 0.012 0.0078
Echinococcus granulosus intermediate filament protein 0.006 0.0579 0.2638
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0054 0.0011
Echinococcus granulosus GA binding protein alpha chain 0.0085 0.0842 0.396
Echinococcus granulosus nibrin 0.001 0.0054 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0315 0.1178
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0086 0.0123
Trypanosoma cruzi O-6 methyl-guanine alkyl transferase, putative 0.0279 0.2894 1
Brugia malayi Death domain containing protein 0.0017 0.0123 0.026
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0315 0.0262
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0017 0.012 0.0078
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0315 1
Entamoeba histolytica protein kinase, putative 0.0105 0.1051 1
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.012 0.0333
Echinococcus multilocularis geminin 0.0199 0.2046 0.2003
Entamoeba histolytica hypothetical protein 0.001 0.0054 0.0513
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.012 0.0232
Loa Loa (eye worm) hypothetical protein 0.0073 0.0712 0.1728
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0123 0.0188
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0054 0.0011
Echinococcus granulosus ETS domain containing protein Elk 1 0.0012 0.0075 0.0106
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0271 0.2816 0.7226
Echinococcus granulosus replication factor c subunit 1 0.001 0.0054 0.0002
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0017 0.012 0.0078
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0229 0.0201
Entamoeba histolytica hypothetical protein 0.0105 0.1051 1
Brugia malayi intermediate filament protein 0.006 0.0579 0.191
Giardia lamblia Replication factor C, subunit 1 0.001 0.0054 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0315 0.1178
Schistosoma mansoni hypothetical protein 0.0017 0.0123 0.0459
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0209 0.0572
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0054 0.5
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0017 0.012 0.0078
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0017 0.012 0.0078
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0229 0.0615
Echinococcus multilocularis lamin 0.006 0.0579 0.0528
Schistosoma mansoni ets-related 0.0258 0.2671 1
Trichomonas vaginalis methylated-DNA--protein-cysteine methyltransferase, putative 0.0279 0.2894 1
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0054 0.8744
Loa Loa (eye worm) hypothetical protein 0.0028 0.0239 0.0492
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.006 0.0579 0.138
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0017 0.012 0.0078
Echinococcus granulosus lamin dm0 0.006 0.0579 0.2638
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0153 0.0574
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0229 0.1602
Echinococcus granulosus death domain containing protein 0.0017 0.0123 0.0347
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0017 0.012 0.0078
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0229 0.0464
Echinococcus granulosus protein C ets 2 0.0012 0.0075 0.0106
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0017 0.012 0.0078
Mycobacterium ulcerans methylated-DNA--protein-cysteine methyltransferase Ogt 0.0847 0.891 1
Mycobacterium leprae PROBABLE METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE OGT (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA 0.0847 0.891 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0177 1
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0229 0.0464
Echinococcus granulosus geminin 0.0199 0.2046 1
Echinococcus granulosus Ankyrin 0.0017 0.0124 0.0354
Brugia malayi hypothetical protein 0.001 0.0054 0.0012
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0012 0.0075 0.0062
Brugia malayi Cytochrome P450 family protein 0.0017 0.012 0.025
Loa Loa (eye worm) D-ets-2 protein 0.0012 0.0075 0.0062
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0017 0.012 0.0078
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0229 0.0615
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0123 0.0069
Schistosoma mansoni hypothetical protein 0.0012 0.0075 0.0279
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0062
Echinococcus granulosus ETS transcription factor Elf 5 0.0012 0.0075 0.0106
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0062
Onchocerca volvulus 0.0278 0.2883 1
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.1144 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0017 0.012 0.0078
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0086 0.0112
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0017 0.012 0.0078
Mycobacterium leprae putative cytochrome p450 0.0017 0.012 0.0074
Trypanosoma cruzi O-6 methyl-guanine alkyl transferase, putative 0.0279 0.2894 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0054 0.0011
Brugia malayi Ets-domain containing protein 0.0012 0.0075 0.0086
Schistosoma mansoni elf1 0.0012 0.0075 0.0279
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0315 0.1178
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0086 0.0291
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0012 0.0075 0.0279
Brugia malayi Fli-1 protein 0.0258 0.2671 0.9473
Echinococcus multilocularis lamin dm0 0.006 0.0579 0.0528
Mycobacterium leprae Conserved hypothetical protein 0.0017 0.012 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0017 0.012 0.0078
Schistosoma mansoni topbp1 0.001 0.0054 0.0202
Loa Loa (eye worm) cytochrome P450 0.0017 0.012 0.0181
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0017 0.012 0.0078
Schistosoma mansoni hypothetical protein 0.0017 0.012 0.0449
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0123 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0054 0.0011
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0054 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0017 0.012 0.0078
Entamoeba histolytica protein kinase domain containing protein 0.0105 0.1051 1
Brugia malayi Cytochrome P450 family protein 0.0027 0.0229 0.0643
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0012 0.0075 0.0062
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0008
Treponema pallidum methylated-DNA-protein-cysteine S-methyltransferase (dat) 0.0279 0.2894 1
Brugia malayi cytochrome P450 0.0017 0.012 0.025
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.012 0.0605
Echinococcus multilocularis 0.0017 0.012 0.0067
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0075 0.0106
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0054 0.0012
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0284 0.0845
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0054 0.1716
Schistosoma mansoni gabp alpha 0.0085 0.0842 0.3154
Leishmania major cytochrome p450-like protein 0.0017 0.012 0.0122
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0017 0.012 0.0078
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0017 0.012 0.0122
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0017 0.012 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0054 0.0011
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.012 0.3811
Brugia malayi Ets-domain containing protein 0.0085 0.0842 0.2862
Leishmania major cytochrome p450-like protein 0.0027 0.0229 0.0509
Loa Loa (eye worm) ets-domain-containing protein 0.0012 0.0075 0.0062
Echinococcus granulosus ETS transcription factor Elf 1 0.0012 0.0075 0.0106
Brugia malayi transcription factor E74 isoform 0.0012 0.0075 0.0086
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0054 0.0202
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0251 0.0989
Plasmodium vivax SET domain protein, putative 0.0035 0.0315 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.012 0.0232
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0.0124 0.0465
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.1051 0.3936
Onchocerca volvulus 0.006 0.0579 0.1865
Loa Loa (eye worm) hypothetical protein 0.0104 0.1045 0.2598
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0017 0.012 0.0078
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0008
Mycobacterium ulcerans DNA-methyltransferase (modification methylase) 0.0113 0.1144 0.1234
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0007
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0209 0.0156
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0244 0.2525 0.6465
Loa Loa (eye worm) hypothetical protein 0.0017 0.0124 0.0192
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0315 0.131
Echinococcus multilocularis ets variant gene 4 0.0012 0.0075 0.0021
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0017 0.012 0.0078
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0017 0.012 0.0078
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0017 0.012 0.0078
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0017 0.012 0.0078
Echinococcus multilocularis dual specificity 0.0105 0.1051 0.1003
Trichomonas vaginalis set domain proteins, putative 0.0278 0.2882 0.9958
Echinococcus multilocularis ETS transcription factor Elf 5 0.0012 0.0075 0.0021
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0017 0.012 0.0078
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0017 0.012 0.0078
Brugia malayi Intermediate filament tail domain containing protein 0.006 0.0579 0.191
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0085 0.0842 0.2068
Echinococcus multilocularis ETS transcription factor Elf 1 0.0012 0.0075 0.0021
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0356 0.0799
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0017 0.012 0.0078
Loa Loa (eye worm) hypothetical protein 0.0372 0.3878 1
Onchocerca volvulus 0.0035 0.0315 0.0931
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0123 0.026
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0123 0.0459
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0054 0.001
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0086 0.0815
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0017 0.012 0.0078
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0105 0.1051 0.2613
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0017 0.012 0.0078
Leishmania major cytochrome p450-like protein 0.0017 0.012 0.0122
Echinococcus multilocularis ewsr:fli fusion protein type 0.0012 0.0075 0.0021
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0054 0.0513
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0008
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0017 0.012 0.0078
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0284 0.061
Loa Loa (eye worm) hypothetical protein 0.0104 0.1045 0.2598
Brugia malayi Ets-domain containing protein 0.0085 0.0842 0.2862
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0017 0.012 0.0078
Loa Loa (eye worm) RecQ helicase 0.0025 0.0209 0.0413
Brugia malayi hypothetical protein 0.0143 0.1454 0.5073
Schistosoma mansoni intermediate filament proteins 0.006 0.0579 0.2168

Activities

Activity type Activity value Assay description Source Reference
Dose (functional) = 750 mg kg-1 Beta adrenoreceptor blocking potency was estimated by inhibition of 50% of the tachycardia produced by a submaximal dose of the isoproterenol (0.2microg/kg, intravenously) ChEMBL. 6118435
Dose (functional) = 750 mg kg-1 Beta adrenoreceptor blocking potency was estimated by inhibition of 50% of the tachycardia produced by a submaximal dose of the isoproterenol (0.2microg/kg, intravenously) ChEMBL. 6118435
Inhibition (functional) = 87 % Percent inhibition of vasorepressor response ChEMBL. 6118435
Inhibition (functional) = 87 % Percent inhibition of vasorepressor response ChEMBL. 6118435

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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