Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | hypothetical protein | Get druggable targets OG5_144688 | All targets in OG5_144688 |
Echinococcus multilocularis | conserved hypothetical protein | Get druggable targets OG5_144688 | All targets in OG5_144688 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.07 | 0.1872 | 0.0476 |
Echinococcus granulosus | carbonic anhydrase | 0.07 | 0.1872 | 0.0745 |
Schistosoma mansoni | carbonic anhydrase-related | 0.07 | 0.1872 | 0.0476 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0569 | 0.1465 | 0.0283 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.149 | 0.4322 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0569 | 0.1465 | 0.0283 |
Echinococcus multilocularis | carbonic anhydrase | 0.07 | 0.1872 | 0.0745 |
Echinococcus granulosus | dihydrofolate reductase | 0.3321 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.149 | 0.4322 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.07 | 0.1872 | 0.0745 |
Echinococcus multilocularis | carbonic anhydrase | 0.07 | 0.1872 | 0.0745 |
Trypanosoma cruzi | hexose transporter, putative | 0.0176 | 0.0248 | 0.0574 |
Plasmodium falciparum | carbonic anhydrase | 0.07 | 0.1872 | 0.187 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3321 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.07 | 0.1872 | 0.187 |
Trypanosoma cruzi | hexose transporter | 0.0176 | 0.0248 | 0.0574 |
Trypanosoma cruzi | hexose transporter, putative | 0.0176 | 0.0248 | 0.0574 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.07 | 0.1872 | 0.0476 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.127 | 0.3639 | 0.8322 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.07 | 0.1872 | 0.0476 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.149 | 0.4322 | 0.3348 |
Brugia malayi | Dihydrofolate reductase | 0.3321 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.07 | 0.1872 | 0.0476 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 0.1872 | 0.0476 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.149 | 0.4322 | 0.3348 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.149 | 0.4322 | 0.3348 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.127 | 0.3639 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.07 | 0.1872 | 0.0476 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3321 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3321 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.07 | 0.1872 | 0.0745 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0569 | 0.1465 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0569 | 0.1465 | 0.0283 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.127 | 0.3639 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.127 | 0.3639 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3321 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.149 | 0.4322 | 0.3535 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.07 | 0.1872 | 0.0476 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.07 | 0.1872 | 0.0476 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.07 | 0.1872 | 0.0476 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.149 | 0.4322 | 0.3348 |
Schistosoma mansoni | carbonic anhydrase-related | 0.07 | 0.1872 | 0.0476 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0833 | 0.2285 | 0.1216 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0569 | 0.1465 | 0.0283 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0569 | 0.1465 | 0.0283 |
Trypanosoma cruzi | hexose transporter, putative | 0.0176 | 0.0248 | 0.0574 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.149 | 0.4322 | 0.3348 |
Schistosoma mansoni | carbonic anhydrase-related | 0.07 | 0.1872 | 0.0476 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 0.1872 | 0.0476 |
Leishmania major | carbonic anhydrase-like protein | 0.149 | 0.4322 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.149 | 0.4322 | 0.3535 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3321 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0836 | 0.2294 | 0.1226 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.149 | 0.4322 | 0.3348 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.127 | 0.3639 | 0.8418 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0569 | 0.1465 | 0.0283 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.127 | 0.3639 | 0.8322 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3321 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.07 | 0.1872 | 0.0476 |
Echinococcus granulosus | carbonic anhydrase | 0.07 | 0.1872 | 0.0745 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0569 | 0.1465 | 0.0283 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.149 | 0.4322 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.3321 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0569 | 0.1465 | 0.0283 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 42 nM | Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release | ChEMBL. | 16844377 |
IC50 (functional) | = 42 nM | Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release | ChEMBL. | 16844377 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.