Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | pteridine reductase 1 | 0.0188 | 0.0718 | 0.0973 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2382 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0106 | 0.0371 | 0.0065 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2382 | 1 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0033 | 0.0063 | 0.0092 |
Brugia malayi | thymidylate synthase | 0.0537 | 0.2196 | 0.1895 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0106 | 0.0371 | 0.0065 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0537 | 0.2196 | 0.1895 |
Leishmania major | pteridine reductase 1 | 0.019 | 0.0729 | 0.0988 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1626 | 0.6803 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0106 | 0.0371 | 0.0065 |
Brugia malayi | Dihydrofolate reductase | 0.2382 | 1 | 1 |
Onchocerca volvulus | 0.0537 | 0.2196 | 0.5 | |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0106 | 0.0371 | 0.0065 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0255 | 0.1005 | 0.1477 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1626 | 0.6803 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1626 | 0.6803 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0255 | 0.1005 | 1 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0106 | 0.0371 | 0.0065 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0106 | 0.0371 | 0.0065 |
Echinococcus granulosus | thymidylate synthase | 0.0537 | 0.2196 | 0.1948 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1626 | 0.6803 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0033 | 0.0063 | 0.0092 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0106 | 0.0371 | 0.0065 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1626 | 0.6803 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0106 | 0.0371 | 0.3273 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2382 | 1 | 0.5 |
Trypanosoma cruzi | hexose transporter | 0.0033 | 0.0063 | 0.0092 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1626 | 0.6803 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0537 | 0.2196 | 0.1948 |
Loa Loa (eye worm) | thymidylate synthase | 0.0537 | 0.2196 | 0.1895 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2382 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0537 | 0.2196 | 0.1324 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2382 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.2382 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2382 | 1 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0033 | 0.0063 | 0.0092 |
Brugia malayi | hypothetical protein | 0.0255 | 0.1005 | 0.0658 |
Echinococcus granulosus | dihydrofolate reductase | 0.2382 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0106 | 0.0371 | 0.0065 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC25 (binding) | = 7.6 uM | Inhibition of binding to hERG | ChEMBL. | 17107791 |
IC25 (binding) | = 7.6 uM | Inhibition of binding to hERG | ChEMBL. | 17107791 |
IC50 (binding) | > 100 uM | Inhibition of binding to serotonin receptor 5HT2C | ChEMBL. | 17107791 |
IC50 (binding) | > 100 uM | Inhibition of binding to serotonin receptor 5HT2C | ChEMBL. | 17107791 |
Ki (functional) | = 145 nM | Functional antagonism of MCH-R1 expressed in HEK293 cells | ChEMBL. | 17107791 |
Ki (functional) | = 145 nM | Functional antagonism of MCH-R1 expressed in HEK293 cells | ChEMBL. | 17107791 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.