TDR Targets

Basic information

Technical information

TDR Targets ID: 372274
Name: 2-[4-[ethyl(pyridin-3-ylmethyl)amino]phenyl]- 1,1,1,3,3,3-hexafluoropropan-2-ol
MW: 378.312 | Formula: C17H16F6N2O
H donors: 1 H acceptors: 2 LogP: 4.03 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCN(c1ccc(cc1)C(C(F)(F)F)(C(F)(F)F)O)Cc1cccnc1
InChi: 1S/C17H16F6N2O/c1-2-25(11-12-4-3-9-24-10-12)14-7-5-13(6-8-14)15(26,16(18,19)20)17(21,22)23/h3-10,26H,2,11H2,1H3
InChiKey: FWZYPDLJUKHKNM-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-[4-[ethyl(3-pyridylmethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol
2-[4-[ethyl(3-pyridylmethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoro-2-propanol
2-[4-[ethyl(pyridin-3-ylmethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol
2-[4-(ethyl-(pyridin-3-ylmethyl)amino)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
2-[4-(ethyl-(3-pyridylmethyl)amino)phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol
2-[4-(ethyl-(3-pyridylmethyl)amino)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
2-[4-(ethyl-(pyridin-3-ylmethyl)amino)phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	nuclear receptor subfamily 1, group H, member 3	Starlite/ChEMBL	References
Homo sapiens	nuclear receptor subfamily 1, group H, member 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_134445	All targets in OG5_134445
Brugia malayi	ecdysteroid receptor	Get druggable targets OG5_134445	All targets in OG5_134445
Onchocerca volvulus	Bile acid receptor homolog	Get druggable targets OG5_134445	All targets in OG5_134445

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	photoreceptor-specific nuclear receptor	nuclear receptor subfamily 1, group H, member 3	387 aa	321 aa	28.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0142	0.0529
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0173	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0273	0.1042
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.0273	0.1669
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0008	0.0067
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0668	0.5936
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0356
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0032	0.0273	0.2424
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0032	0.0273	0.1042
Onchocerca volvulus		0.0024	0.0173	0.065
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0032	0.0273	0.1042
Schistosoma mansoni	nuclear hormone receptor	0.0032	0.0273	0.2424
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0173	0.0486
Loa Loa (eye worm)	steroid hormone receptor	0.0032	0.0273	0.1042
Echinococcus multilocularis	protein patched	0.0043	0.0405	0.0405
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0173	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0273	0.1042
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0032	0.0273	0.1042
Loa Loa (eye worm)	hypothetical protein	0.01	0.1106	0.4315
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0668	0.4088
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0032	0.0273	0.1042
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0162	0.1874	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0011	0.0008	0.0008
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0173	0.0421
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0011	0.0008	0.0046
Brugia malayi	Niemann-Pick C1 protein precursor	0.01	0.1106	0.4315
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0032	0.0273	0.1669
Schistosoma mansoni	RAR-like nuclear receptor	0.0032	0.0273	0.2424
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.0273	0.1042
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0173	0.0486
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0173	0.0421
Toxoplasma gondii	ATPase, AAA family protein	0.001	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0356
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0173	0.065
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0011	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0273	0.1042
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0405	0.0405
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0032	0.0273	0.1669
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0011	0.0008	0.0008
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0405	0.2476
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0032	0.0273	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0356
Onchocerca volvulus		0.0032	0.0273	0.1042
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0173	0.065
Onchocerca volvulus	Bile acid receptor homolog	0.0217	0.2554	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0011	0.0008	0.0046
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0173	0.0421
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0022	0.0142	0.1265
Loa Loa (eye worm)	hypothetical protein	0.0217	0.2554	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0173	0.065
Echinococcus granulosus	ecdysone induced protein 78C	0.0032	0.0273	0.1669
Brugia malayi	Steroid receptor seven-up type 2	0.0032	0.0273	0.1042
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0405	0.1559
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0032	0.0273	0.0273
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.01	0.1106	1
Echinococcus multilocularis	expressed conserved protein	0.0094	0.1032	0.1032
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0173	0.1565
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0032	0.0273	0.1042
Schistosoma mansoni	nuclear receptor	0.0011	0.0008	0.0067
Brugia malayi	nuclear hormone receptor	0.0032	0.0273	0.1042
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0173	0.5
Echinococcus granulosus	FTZ F1 alpha	0.0032	0.0273	0.1669
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0022	0.0142	0.0142
Schistosoma mansoni	retinoic acid receptor RXR	0.0032	0.0273	0.2424
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0668	0.2594
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0142	0.0529
Schistosoma mansoni	nuclear receptor	0.0011	0.0008	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0273	0.1042
Schistosoma mansoni	hypothetical protein	0.0041	0.0386	0.3426
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0142	0.0529
Echinococcus granulosus	Niemann Pick C1 protein	0.01	0.1106	0.6771
Brugia malayi	steroid hormone receptor	0.0032	0.0273	0.1042
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0668	0.5936
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0523	0.2025
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.0273	0.1042
Brugia malayi	ecdysteroid receptor	0.0217	0.2554	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.0273	0.0273
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0032	0.0273	0.0273
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0022	0.0142	0.0529
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0032	0.0273	0.1042
Brugia malayi	RNA binding protein	0.0064	0.0668	0.2594
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0011	0.0008	0.0008
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0668	0.2594
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0173	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0142	0.0529
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0032	0.0273	0.2424
Onchocerca volvulus	Protein ultraspiracle homolog	0.0032	0.0273	0.1042
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0011	0.0008	0.0067
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0011	0.0008	0.0008
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0032	0.0273	0.1042
Brugia malayi	nuclear receptor NHR-88	0.0032	0.0273	0.1042
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0098	0.5
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0162	0.1874	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0098	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0098	0.0068
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0101	0.1125	1
Giardia lamblia	Replication factor C, subunit 1	0.001	0	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.0032	0.0273	0.1042
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0405	1
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0668	0.2594
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0173	0.065
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0273	0.1042
Echinococcus granulosus	nuclear receptor nhr 48	0.0011	0.0008	0.0046
Schistosoma mansoni	patched 1	0.0043	0.0405	0.3595
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0405	0.1559
Echinococcus multilocularis	Niemann Pick C1 protein	0.01	0.1106	0.1106
Brugia malayi	hypothetical protein	0.0022	0.0142	0.0529
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0173	0.065
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.0273	0.0273
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0008	0.0067
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0032	0.0273	0.1669
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0032	0.0273	0.1042
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0142	0.0529
Echinococcus multilocularis	ecdysone induced protein 78C	0.0032	0.0273	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0273	0.1042
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0032	0.0273	0.1042
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0008	0.0046
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0173	0.065
Schistosoma mansoni	hypothetical protein	0.0041	0.0386	0.3426
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0173	0.0421
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.0273	0.1669
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0032	0.0273	0.1042
Schistosoma mansoni	thyroid hormone receptor	0.0032	0.0273	0.2424
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0173	0.0421
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0668	0.2594
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0098	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0032	0.0273	0.1042
Schistosoma mansoni	coup transcription factor	0.0032	0.0273	0.2424
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0032	0.0273	0.2424
Brugia malayi	TAR-binding protein	0.0064	0.0668	0.2594
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.0273	0.1042
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0032	0.0273	0.1042
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0008	0.0008
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0032	0.0273	0.1042
Schistosoma mansoni	thyroid hormone receptor	0.0032	0.0273	0.2424
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0142	0.0529
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0173	0.0421
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0032	0.0273	0.1669
Brugia malayi	hypothetical protein	0.0022	0.0142	0.0529
Echinococcus granulosus	expressed conserved protein	0.0094	0.1032	0.6315
Echinococcus granulosus	Niemann Pick C1 protein	0.0143	0.1634	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0142	0.1265
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0032	0.0273	0.1042
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0356
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0032	0.0273	0.0273
Schistosoma mansoni	hypothetical protein	0.0041	0.0386	0.3426
Echinococcus multilocularis	FTZ F1 alpha	0.0032	0.0273	0.0273
Brugia malayi	nuclear receptor RXR	0.0022	0.0142	0.0529
Brugia malayi	Nuclear hormone receptor-like 1	0.0032	0.0273	0.1042
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0173	0.1565
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0405	0.2476
Echinococcus granulosus	thyroid hormone receptor alpha	0.0011	0.0008	0.0046
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0173	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0032	0.0273	0.1042
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0032	0.0273	0.2424
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0668	0.5936
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0032	0.0273	0.0273
Schistosoma mansoni	zinc finger protein	0.0011	0.0008	0.0067
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.0273	0.1042
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0032	0.0273	0.1669
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0011	0.0008	0.0046
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0032	0.0273	0.2424
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0022	0.0142	0.0871
Schistosoma mansoni	nuclear receptor nhr-48	0.0011	0.0008	0.0067
Brugia malayi	CHE-14 protein	0.0043	0.0405	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0142	0.0529
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0173	0.0421
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0668	0.5936
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0173	0.5
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0011	0.0008	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0273	0.1042
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0668	0.5936
Echinococcus multilocularis	protein dispatched 1	0.0049	0.0479	0.0479
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.0273	0.1042
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0173	0.1565
Echinococcus multilocularis	Niemann Pick C1 protein	0.0143	0.1634	0.1634
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0032	0.0273	0.2424
Schistosoma mansoni	hypothetical protein	0.0041	0.0386	0.3426
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0668	0.0668
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.0273	0.1042
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0032	0.0273	0.2424

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 88 %	Transactivation of LXRalpha relative to T0901317 by luciferase reporter gene assay	ChEMBL.	16876993
Activity (functional)	= 88 %	Transactivation of LXRalpha relative to T0901317 by luciferase reporter gene assay	ChEMBL.	16876993
Activity (functional)	= 106 %	Transactivation of LXRbeta relative to T0901317 by luciferase reporter gene assay	ChEMBL.	16876993
Activity (functional)	= 106 %	Transactivation of LXRbeta relative to T0901317 by luciferase reporter gene assay	ChEMBL.	16876993
EC50 (functional)	= 2.3 uM	Transactivation of LXRbeta by luciferase reporter gene assay	ChEMBL.	16876993
EC50 (functional)	= 2.3 uM	Transactivation of LXRbeta by luciferase reporter gene assay	ChEMBL.	16876993
EC50 (functional)	= 4.3 uM	Transactivation of LXRalpha by luciferase reporter gene assay	ChEMBL.	16876993
EC50 (functional)	= 4.3 uM	Transactivation of LXRalpha by luciferase reporter gene assay	ChEMBL.	16876993
IC50 (binding)	= 2.32 uM	Binding affinity to LXRbeta by radioligand displacement assay	ChEMBL.	16876993
IC50 (binding)	= 2.32 uM	Binding affinity to LXRbeta by radioligand displacement assay	ChEMBL.	16876993
IC50 (binding)	= 2.7 uM	Binding affinity to LXRalpha by radioligand displacement assay	ChEMBL.	16876993
IC50 (binding)	= 2.7 uM	Binding affinity to LXRalpha by radioligand displacement assay	ChEMBL.	16876993

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL216055
PubChem: 11559891

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 372274