Detailed information for compound 37264

Basic information

Technical information
  • TDR Targets ID: 37264
  • Name: N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[(3-met hyl-2-oxoimidazolidin-1-yl)methyl]-4-(1,3-oxa zol-2-yl)phenyl]benzenesulfonamide
  • MW: 507.562 | Formula: C25H25N5O5S
  • H donors: 1 H acceptors: 5 LogP: 2.78 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN1CCN(C1=O)Cc1cc(ccc1c1ccccc1S(=O)(=O)Nc1onc(c1C)C)c1ncco1
  • InChi: 1S/C25H25N5O5S/c1-16-17(2)27-35-23(16)28-36(32,33)22-7-5-4-6-21(22)20-9-8-18(24-26-10-13-34-24)14-19(20)15-30-12-11-29(3)25(30)31/h4-10,13-14,28H,11-12,15H2,1-3H3
  • InChiKey: CTSLPVTWRWISJE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3,4-dimethylisoxazol-5-yl)-2-[2-[(3-methyl-2-oxo-imidazolidin-1-yl)methyl]-4-oxazol-2-yl-phenyl]benzenesulfonamide
  • N-(3,4-dimethyl-5-isoxazolyl)-2-[2-[(3-methyl-2-oxo-1-imidazolidinyl)methyl]-4-(2-oxazolyl)phenyl]benzenesulfonamide
  • N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[(3-methyl-2-oxo-imidazolidin-1-yl)methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide
  • N-(3,4-dimethylisoxazol-5-yl)-2-[2-[(2-keto-3-methyl-imidazolidin-1-yl)methyl]-4-oxazol-2-yl-phenyl]benzenesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens endothelin receptor type B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni z-protein (S1r protein) 0.0078 0.0123 0.0138
Trypanosoma cruzi extracellular receptor, putative 0.0527 0.1082 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0057 0.0068
Treponema pallidum glutamate transporter 0.06 0.1236 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0054 0.0053
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0078 0.0123 0.0122
Brugia malayi hypothetical protein 0.0527 0.1082 0.132
Brugia malayi hypothetical protein 0.0026 0.0012 0.0014
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1632 0.3436 0.3435
Loa Loa (eye worm) hypothetical protein 0.0076 0.0119 0.0118
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0118 0.0209 0.0208
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0026 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0039 0.004 0.0039
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0083 0.0573
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.004 0.0274
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.006 0.0085 0.0519
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.006 0.0361
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0002 0.0002
Onchocerca volvulus 0.0112 0.0196 0.0686
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.006 0.0462
Brugia malayi Cytochrome P450 family protein 0.0121 0.0216 0.0263
Echinococcus granulosus regulator of G protein signaling 3 0.0078 0.0123 0.0122
Schistosoma mansoni hypothetical protein 0.0182 0.0345 0.0388
Loa Loa (eye worm) 6-phosphofructokinase 0.0222 0.043 0.0429
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0181 0.0343 0.1176
Entamoeba histolytica hypothetical protein 0.0527 0.1082 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.006 0.0072
Brugia malayi von Willebrand factor type A domain containing protein 0.003 0.0022 0.0026
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0527 0.1082 0.3804
Schistosoma mansoni tyrosine kinase 0.0527 0.1082 0.1218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0034 0.0136
Schistosoma mansoni tyrosine kinase 0.0527 0.1082 0.1218
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0054 0.0065
Schistosoma mansoni hypothetical protein 0.0383 0.0774 0.0872
Toxoplasma gondii microneme protein MIC2 0.003 0.0022 0.0339
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1773 0.3737 0.3736
Plasmodium vivax thrombospondin-related anonymous protein 0.003 0.0022 0.0901
Schistosoma mansoni ap endonuclease 0.0059 0.0083 0.0092
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0078 0.0123 0.0122
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.3334 0.7063 0.8627
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0113 0.0197 0.0196
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0138 0.0137
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0011 0.001
Brugia malayi Regulator of G protein signaling domain containing protein 0.0078 0.0123 0.015
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0407 0.0825 0.6614
Loa Loa (eye worm) hypothetical protein 0.0657 0.1357 0.1356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0013 0.0033
Schistosoma mansoni survival motor neuron protein 0.0047 0.0057 0.0063
Loa Loa (eye worm) hypothetical protein 0.0527 0.1082 0.1081
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0085 0.0389
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0527 0.1082 0.1081
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0044 0.0044
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0085 0.3815
Schistosoma mansoni intermediate filament proteins 0.0085 0.0138 0.0155
Echinococcus multilocularis neutral amino acid transporter A 0.1353 0.2842 0.2841
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0026 0.0012 0.0011
Schistosoma mansoni lipoxygenase 0.0059 0.0084 0.0093
Schistosoma mansoni 6-phosphofructokinase 0.0222 0.043 0.0483
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0099 0.0169 0.0189
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.006 0.0085 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0222 0.043 0.3361
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.0084 0.0083
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0099 0.0169 0.0168
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0877 0.1827 0.1826
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0002 0.0002
Echinococcus granulosus excitatory amino acid transporter 3 0.1353 0.2842 0.2841
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0002 0.0002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.0343 0.4088
Trichomonas vaginalis phosphofructokinase, putative 0.0222 0.043 0.2091
Schistosoma mansoni hypothetical protein 0.003 0.0022 0.0024
Onchocerca volvulus 0.0026 0.0012 0.004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.0343 0.4088
Echinococcus granulosus axis inhibition protein axin 0.0078 0.0123 0.0122
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0527 0.1082 0.1081
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.004 0.0274
Brugia malayi von Willebrand factor type A domain containing protein 0.003 0.0022 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0039 0.0163
Echinococcus multilocularis neutral amino acid transporter A 0.1353 0.2842 0.2841
Toxoplasma gondii phosphofructokinase domain-containing protein 0.006 0.0085 0.2234
Echinococcus multilocularis regulator of G protein signaling 0.0078 0.0123 0.0122
Schistosoma mansoni regulator of G protein signaling 0.0078 0.0123 0.0138
Onchocerca volvulus 0.0973 0.2032 0.7151
Echinococcus granulosus Excitatory amino acid transporter 0.1353 0.2842 0.2841
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0108 0.0121
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0083 0.0082
Brugia malayi Glutamate receptor 2 precursor 0.0768 0.1594 0.1946
Echinococcus granulosus glutamate receptor 2 0.1295 0.2718 0.2718
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0407 0.0825 1
Echinococcus granulosus lamin dm0 0.0085 0.0138 0.0137
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0021
Echinococcus multilocularis excitatory amino acid transporter 2 0.1353 0.2842 0.2841
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0026 0.0099
Echinococcus multilocularis musashi 0.0085 0.0138 0.0137
Echinococcus granulosus regulator of G protein signaling 7 0.0078 0.0123 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0219 0.0246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0034 0.0136
Onchocerca volvulus 0.0047 0.0057 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0013 0.0033
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0.0012 0.0011
Brugia malayi Cytochrome P450 family protein 0.0025 0.0011 0.0012
Onchocerca volvulus 0.0026 0.0012 0.004
Onchocerca volvulus Poor gastrulation protein homolog 0.0597 0.123 0.4328
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0099 0.0169 0.0189
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0222 0.043 0.3914
Brugia malayi Regulator of G protein signaling domain containing protein 0.0078 0.0123 0.015
Onchocerca volvulus 0.0026 0.0012 0.004
Plasmodium vivax SET domain protein, putative 0.0123 0.0219 1
Schistosoma mansoni regulator of G protein signaling 0.0078 0.0123 0.0138
Loa Loa (eye worm) hypothetical protein 0.0113 0.0197 0.0196
Schistosoma mansoni ap endonuclease 0.0059 0.0083 0.0092
Onchocerca volvulus 0.003 0.0022 0.0074
Loa Loa (eye worm) solute carrier family 6 member 4 0.0076 0.0119 0.0118
Echinococcus multilocularis excitatory amino acid transporter 2 0.1353 0.2842 0.2841
Echinococcus granulosus voltage dependent calcium channel subunit 0.0742 0.1539 0.1539
Schistosoma mansoni glutamate receptor kainate 0.1246 0.2612 0.2942
Echinococcus granulosus intermediate filament protein 0.0085 0.0138 0.0137
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0222 0.043 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0041 0.004
Plasmodium falciparum von Willebrand factor A domain-related protein 0.003 0.0022 0.2561
Onchocerca volvulus 0.0085 0.0138 0.0483
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0045 0.0044
Schistosoma mansoni sodium-dependent amino acid transporter 0.0026 0.0012 0.0013
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0085 1
Echinococcus granulosus regulator of G protein signaling 3 0.0078 0.0123 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0039 0.0163
Brugia malayi PXA domain containing protein 0.0078 0.0123 0.015
Echinococcus granulosus cytochrome P450 2K1 0.0025 0.0011 0.001
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0108 0.0107
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0078 0.0123 0.0138
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0012 0.0049
Echinococcus granulosus atrial natriuretic peptide receptor 0.0527 0.1082 0.1081
Treponema pallidum sodium- and chloride- dependent transporter 0.0076 0.0119 0.0803
Chlamydia trachomatis neutral amino acid transporter 0.06 0.1236 0.4324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0013 0.0033
Echinococcus multilocularis NMDA receptor 0.0877 0.1827 0.1826
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.004 0.0167
Echinococcus multilocularis nmda type glutamate receptor 0.0761 0.158 0.1579
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0712 0.1475 0.1661
Schistosoma mansoni rab6-interacting 0.0021 0.0002 0.0002
Echinococcus multilocularis sodium:dicarboxylate symporter 0.06 0.1236 0.1235
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.004 0.0039
Echinococcus multilocularis metabotropic glutamate receptor 5 0.4711 1 1
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0354 0.0712 0.0711
Echinococcus granulosus tyrosine kinase 0.0527 0.1082 0.1081
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0123 0.0578
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0083 0.01
Brugia malayi Pre-SET motif family protein 0.0123 0.0219 0.0266
Brugia malayi phosphofructokinase 0.0222 0.043 0.0524
Schistosoma mansoni glutamate receptor kainate 0.0722 0.1497 0.1686
Brugia malayi Cytochrome P450 family protein 0.0025 0.0011 0.0012
Treponema pallidum glutamate/aspartate transporter 0.06 0.1236 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.06 0.1236 0.1392
Loa Loa (eye worm) hypothetical protein 0.0045 0.0054 0.0053
Brugia malayi Guanylyl cyclase protein 23 0.0527 0.1082 0.132
Loa Loa (eye worm) hypothetical protein 0.0597 0.123 0.123
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0002 0.0002
Echinococcus granulosus serotonin transporter 0.0076 0.0119 0.0118
Loa Loa (eye worm) PXA domain-containing protein 0.0078 0.0123 0.0122
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.003 0.0022 0.0901
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0078 0.0123 0.0122
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.004 0.0039
Plasmodium falciparum transporter, putative 0.0026 0.0012 0.1419
Brugia malayi hypothetical protein 0.0112 0.0196 0.0238
Onchocerca volvulus 0.0527 0.1082 0.3804
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0045 0.0044
Chlamydia trachomatis glutamine binding protein 0.0407 0.0825 0.2872
Echinococcus granulosus Regulator of G protein signaling 20 0.0078 0.0123 0.0122
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0108 0.0107
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Brugia malayi von Willebrand Factor 0.003 0.0022 0.0026
Schistosoma mansoni serine-rich repeat protein 0.0383 0.0774 0.0872
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.004 0.0044
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.006 0.0067
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0407 0.0825 0.2872
Schistosoma mansoni hypothetical protein 0.0597 0.123 0.1385
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0123 0.0578
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0138 0.0168
Onchocerca volvulus 0.0085 0.0138 0.0483
Brugia malayi hypothetical protein 0.0078 0.0123 0.015
Entamoeba histolytica hypothetical protein 0.0078 0.0123 0.0956
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0012 0.0453
Loa Loa (eye worm) hypothetical protein 0.0527 0.1082 0.1081
Entamoeba histolytica hypothetical protein 0.0078 0.0123 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0123 0.0578
Loa Loa (eye worm) RGC/RGC protein kinase 0.0527 0.1082 0.1081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0034 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0034 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0123 0.0578
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1353 0.2842 0.3201
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.003 0.0022 0.0901
Brugia malayi A-kinase anchor protein 10, precursor 0.0078 0.0123 0.015
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0026 0.0012 0.0013
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.0451 0.045
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0012 0.0049
Loa Loa (eye worm) RGC/RGC protein kinase 0.0527 0.1082 0.1081
Echinococcus granulosus regulator of G protein signaling 7 0.0078 0.0123 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0045 0.0192
Echinococcus granulosus neutral amino acid transporter A 0.1353 0.2842 0.2841
Echinococcus granulosus sodium and chloride dependent glycine 0.0026 0.0012 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0018 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0013 0.0033
Schistosoma mansoni cytochrome P450 0.0025 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0018 0.0059
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0083 0.0254
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.004 0.0048
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0113 0.0197 0.0221
Trichomonas vaginalis set domain proteins, putative 0.0973 0.2032 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.004 0.0929
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0021
Echinococcus granulosus voltage dependent calcium channel subunit 0.1632 0.3436 0.3435
Echinococcus granulosus glutamate receptor 2 0.0941 0.1964 0.1963
Schistosoma mansoni aldehyde dehydrogenase 0.0181 0.0343 0.0386
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.004 0.0039
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.006 0.0462
Schistosoma mansoni glutamate receptor AMPA 0.0722 0.1497 0.1686
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.0012 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0039 0.0163
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.006 0.0361
Plasmodium vivax amine transporter, putative 0.0026 0.0012 0.0453
Echinococcus granulosus beta-adrenergic receptor kinase 0.0078 0.0123 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0034 0.0136
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0123 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0034 0.0136
Echinococcus granulosus axis inhibition protein axin 0.0078 0.0123 0.0122
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1353 0.2842 1
Brugia malayi regulator of G-protein signaling egl-10 0.0078 0.0123 0.015
Brugia malayi Pre-SET motif family protein 0.0855 0.178 0.2174
Schistosoma mansoni ATP-binding cassette transporter 0.0722 0.1497 0.1686
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0597 0.123 0.4328
Trichomonas vaginalis phosphofructokinase, putative 0.0222 0.043 0.2091
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.004 0.0274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.006 0.0267
Echinococcus granulosus lamin 0.0085 0.0138 0.0137
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0078 0.0123 0.0122
Schistosoma mansoni metabotropic glutamate receptor 0.1975 0.4167 0.4695
Loa Loa (eye worm) hypothetical protein 0.0078 0.0123 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0013 0.0033
Echinococcus granulosus geminin 0.0182 0.0345 0.0344
Brugia malayi Cache domain containing protein 0.0329 0.0658 0.0802
Loa Loa (eye worm) hypothetical protein 0.0527 0.1082 0.1081
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.0444 0.0443
Onchocerca volvulus 0.0527 0.1082 0.3804
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0407 0.0825 0.6614
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0222 0.043 0.1481
Echinococcus multilocularis beta adrenergic receptor kinase 0.0078 0.0123 0.0122
Echinococcus multilocularis 0.0025 0.0011 0.001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0135 0.0246 0.0276
Toxoplasma gondii hypothetical protein 0.0026 0.0012 0.0049
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0039 0.0267
Loa Loa (eye worm) 6-phosphofructokinase 0.0222 0.043 0.0429
Plasmodium vivax hypothetical protein, conserved 0.003 0.0022 0.0901
Brugia malayi von Willebrand factor type A domain containing protein 0.003 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0078 0.0123 0.0122
Loa Loa (eye worm) hypothetical protein 0.0078 0.0123 0.0122
Echinococcus multilocularis GPCR, family 3, C terminal 0.0597 0.123 0.123
Echinococcus granulosus excitatory amino acid transporter 2 0.1353 0.2842 0.2841
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0123 0.0578
Brugia malayi Zona pellucida-like domain containing protein 0.003 0.0022 0.0026
Onchocerca volvulus 0.0112 0.0196 0.0686
Schistosoma mansoni hypothetical protein 0.0354 0.0712 0.0801
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.1284 0.2694 0.2694
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0099 0.0169 0.0168
Loa Loa (eye worm) hypothetical protein 0.0527 0.1082 0.1081
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.4184 0.8876 1
Brugia malayi 6-phosphofructokinase 0.0222 0.043 0.0524
Loa Loa (eye worm) glutamate receptor 0.3861 0.8188 0.8187
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0083 0.0378
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0526 0.1078 0.8698
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.003 0.0022 0.0901
Echinococcus granulosus neutral amino acid transporter A 0.1353 0.2842 0.2841
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0025 0.0011 0.0247
Schistosoma mansoni polycystin 1-related 0.0021 0.0002 0.0002
Toxoplasma gondii hypothetical protein 0.0026 0.0012 0.0049
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.006 0.1399
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0855 0.178 0.178
Brugia malayi Cytochrome P450 family protein 0.0025 0.0011 0.0012
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0083 0.05
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.0084 0.0083
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0329 0.0658 0.0657
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1773 0.3737 0.3736
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0219 0.0246
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0123 0.0219 0.6255
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.004 0.017
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0022 0.0026
Onchocerca volvulus 0.003 0.0022 0.0074
Schistosoma mansoni hypothetical protein 0.003 0.0022 0.0024
Loa Loa (eye worm) glutamate receptor 1 0.0768 0.1594 0.1593
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1353 0.2842 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0078 0.0123 0.0122
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0108 0.0107
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1353 0.2842 0.2841
Echinococcus multilocularis Regulator of G protein signaling 20 0.0078 0.0123 0.0122
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0108 0.0912
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0407 0.0825 0.2876
Echinococcus multilocularis lamin 0.0085 0.0138 0.0137
Echinococcus multilocularis glutamate receptor 2 0.0941 0.1964 0.1963
Onchocerca volvulus 0.003 0.0022 0.0074
Loa Loa (eye worm) cytochrome P450 family protein 0.0121 0.0216 0.0215
Echinococcus multilocularis receptor type guanylyl cyclase 0.0527 0.1082 0.1081
Echinococcus multilocularis collagen alpha 1(VII) chain 0.003 0.0022 0.0021
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.0012 0.0013
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0011 0.001
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.06 0.1236 0.1235
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0078 0.0123 0.0138
Brugia malayi von Willebrand factor type A domain containing protein 0.003 0.0022 0.0026
Echinococcus multilocularis RUN 0.0021 0.0002 0.0002
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0108 0.0912
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.004 0.0167
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0083 0.0885
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0083 0.0672
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0113 0.0197 0.0221
Giardia lamblia GTOR 0.0048 0.006 0.4481
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1773 0.3737 0.3736
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0123 0.0219 0.0218
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0002 0.0002
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.06 0.1236 0.1392
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0078 0.0123 0.0122
Onchocerca volvulus 0.003 0.0022 0.0074
Schistosoma mansoni glutamate receptor kainate 0.1246 0.2612 0.2942
Schistosoma mansoni rab6-interacting 0.0021 0.0002 0.0002
Echinococcus multilocularis glutamate receptor 2 0.0768 0.1594 0.1593
Brugia malayi metabotropic glutamate receptor type 2 0.1975 0.4167 0.5089
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.006 0.0462
Schistosoma mansoni loxhd1 0.0021 0.0002 0.0002
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1353 0.2842 0.2841
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0877 0.1827 0.1826
Entamoeba histolytica hypothetical protein 0.0078 0.0123 0.0956
Echinococcus granulosus expressed protein 0.1516 0.3189 0.3188
Entamoeba histolytica phosphofructokinase, putative 0.0222 0.043 0.3849
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0527 0.1082 0.1081
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0011 0.0247
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0011 0.001
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.006 0.0059
Schistosoma mansoni lamin 0.0085 0.0138 0.0155
Onchocerca volvulus 0.0076 0.0119 0.0417
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0112 0.0196 0.0195
Brugia malayi regulator of G-protein signaling rgs-7 0.0078 0.0123 0.015
Schistosoma mansoni glutamate receptor AMPA 0.0722 0.1497 0.1686
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0021
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0123 0.0219 0.0218
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.003 0.0022 0.0339
Loa Loa (eye worm) hypothetical protein 0.0076 0.0119 0.0118
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0108 0.0912
Brugia malayi intermediate filament protein 0.0085 0.0138 0.0168
Brugia malayi von Willebrand factor type A domain containing protein 0.003 0.0022 0.0026
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.1125 0.2355 0.2354
Echinococcus multilocularis 6 phosphofructokinase 0.0222 0.043 0.0429
Loa Loa (eye worm) RGS-3 protein 0.0078 0.0123 0.0122
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0021
Loa Loa (eye worm) glutamate receptor 2 0.0722 0.1497 0.1497
Toxoplasma gondii exonuclease III APE 0.0059 0.0083 0.2164
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.006 0.0462
Echinococcus granulosus excitatory amino acid transporter 2 0.1353 0.2842 0.2841
Echinococcus multilocularis excitatory amino acid transporter 3 0.1353 0.2842 0.2841
Brugia malayi Doublecortin family protein 0.0021 0.0002 0.0002
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0085 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0013 0.0033
Brugia malayi hypothetical protein 0.003 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0228 0.0444 0.0443
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0123 0.0219 0.0218
Leishmania major extracellular receptor, putative 0.0527 0.1082 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.0011
Toxoplasma gondii aldehyde dehydrogenase 0.0181 0.0343 1
Schistosoma mansoni aldehyde dehydrogenase 0.0181 0.0343 0.0386
Loa Loa (eye worm) hypothetical protein 0.0078 0.0123 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0219 0.0246
Schistosoma mansoni metabotropic glutamate receptor 0.3264 0.6915 0.779
Schistosoma mansoni hypothetical protein 0.0021 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0039 0.0163
Echinococcus granulosus RUN 0.0021 0.0002 0.0002
Echinococcus multilocularis sodium and chloride dependent glycine 0.0026 0.0012 0.0011
Loa Loa (eye worm) cytochrome P450 0.0025 0.0011 0.001
Echinococcus multilocularis metabotropic glutamate receptor 2 0.3264 0.6915 0.6914
Onchocerca volvulus 0.003 0.0022 0.0074
Echinococcus granulosus 6 phosphofructokinase 0.0222 0.043 0.0429
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.003 0.0022 0.0026
Echinococcus multilocularis nmda type glutamate receptor 0.0527 0.1082 0.1081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.006 0.0267
Echinococcus multilocularis expressed protein 0.1516 0.3189 0.3188
Onchocerca volvulus 0.0021 0.0002 0.0005
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0002 0.0002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0083 0.0082
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0085 0.0389
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.003 0.0022 0.0021
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.1295 0.2718 0.2718
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.1125 0.2355 0.2354
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.006 0.0085 0.0595
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0021
Echinococcus multilocularis axis inhibition protein axin 0.0078 0.0123 0.0122
Loa Loa (eye worm) excitatory amino acid transporter 0.1353 0.2842 0.2841
Schistosoma mansoni glutamate receptor NMDA 0.0722 0.1497 0.1686
Brugia malayi hypothetical protein 0.0228 0.0444 0.0542
Chlamydia trachomatis glutamate symporter 0.1353 0.2842 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.0085 0.0257
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0354 0.0712 0.0711
Brugia malayi Metabotropic glutamate receptor precursor. 0.3861 0.8188 1
Onchocerca volvulus 0.003 0.0022 0.0074
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0012 0.0014
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0078 0.0123 0.0578
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1773 0.3737 0.3736
Loa Loa (eye worm) glutamate receptor 0.1448 0.3043 0.3042
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0026 0.0012 0.0014
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0722 0.1497 0.1497
Loa Loa (eye worm) norepinephrine transporter 0.0076 0.0119 0.0118
Loa Loa (eye worm) CUTiclin-Like family member 0.003 0.0022 0.0021
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0085 0.3815
Brugia malayi von Willebrand factor type A domain containing protein 0.003 0.0022 0.0026
Plasmodium falciparum thrombospondin-related anonymous protein 0.003 0.0022 0.2561
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1353 0.2842 1
Onchocerca volvulus 0.003 0.0022 0.0074
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0108 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0013 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0019 0.0062
Loa Loa (eye worm) hypothetical protein 0.0527 0.1082 0.1081
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0222 0.043 1
Schistosoma mansoni protein kinase 0.0527 0.1082 0.1218
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1773 0.3737 0.3736
Brugia malayi hypothetical protein 0.0021 0.0002 0.0002
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0181 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.0045 0.0054 0.0053
Brugia malayi Zona pellucida-like domain containing protein 0.003 0.0022 0.0026
Echinococcus granulosus glutamate receptor subunit protein glur 0.0399 0.0809 0.0808
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.004 0.0039
Schistosoma mansoni sodium/chloride dependent transporter 0.0076 0.0119 0.0134
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0012 0.0013
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0026 0.0012 0.0011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0083 0.0082
Echinococcus granulosus metabotropic glutamate receptor 2 0.3264 0.6915 0.6914
Brugia malayi von Willebrand factor type A domain containing protein 0.003 0.0022 0.0026
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0039 0.0267
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0123 0.0138
Echinococcus multilocularis sodium and chloride dependent glycine 0.0026 0.0012 0.0011
Schistosoma mansoni hypothetical protein 0.0025 0.0011 0.0011
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0006 0.0006
Brugia malayi Glutamate receptor 1 precursor 0.0768 0.1594 0.1946
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0085 0.0389
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.006 0.0059
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0085 1
Schistosoma mansoni regulator of G protein signaling 0.0078 0.0123 0.0138
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0012 0.0014
Brugia malayi 6-phosphofructokinase 0.0222 0.043 0.0524
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0006 0.0138
Loa Loa (eye worm) hypothetical protein 0.0076 0.0119 0.0118
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0021
Schistosoma mansoni regulator of G protein signaling 0.0078 0.0123 0.0138
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.004 0.0039
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0076 0.0119 0.0145
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0399 0.0809 0.0808
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0078 0.0123 0.015
Schistosoma mansoni glutamate receptor NMDA 0.125 0.2622 0.2953
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.1295 0.2718 0.2718
Schistosoma mansoni hypothetical protein 0.0047 0.0057 0.0063
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0085 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0123 0.0578
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0012 0.0013
Loa Loa (eye worm) RGC/RGC protein kinase 0.0527 0.1082 0.1081
Brugia malayi von Willebrand factor type A domain containing protein 0.003 0.0022 0.0026
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0108 0.252
Echinococcus multilocularis serotonin transporter 0.0076 0.0119 0.0118
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1773 0.3737 0.3736
Echinococcus multilocularis neutral amino acid transporter A 0.1353 0.2842 0.2841
Echinococcus multilocularis axis inhibition protein axin 0.0078 0.0123 0.0122
Echinococcus granulosus sodium:dicarboxylate symporter 0.1353 0.2842 0.2841
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0742 0.1539 0.1539
Loa Loa (eye worm) hypothetical protein 0.0085 0.0138 0.0137
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0026 0.0012 0.0011
Echinococcus multilocularis glutamate receptor 2 0.1295 0.2718 0.2718
Onchocerca volvulus 0.0135 0.0246 0.0862
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0039 0.0163
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0597 0.123 0.1502
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0181 0.0343 0.0343
Schistosoma mansoni lamin 0.0085 0.0138 0.0155
Loa Loa (eye worm) hypothetical protein 0.1125 0.2355 0.2354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0019 0.0062
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.0444 0.0443
Echinococcus granulosus glutamate NMDA receptor subunit 0.0722 0.1497 0.1497
Echinococcus granulosus Excitatory amino acid transporter 0.1353 0.2842 0.2841
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.004 0.0039
Schistosoma mansoni axis inhibition protein axin 0.0078 0.0123 0.0138
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0039 0.0911
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.0011
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0359 0.0722 0.0813
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.006 0.1399
Loa Loa (eye worm) serotonin transporter b 0.0076 0.0119 0.0118
Schistosoma mansoni hypothetical protein 0.0182 0.0345 0.0388
Plasmodium falciparum amino acid transporter, putative 0.0026 0.0012 0.1419
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0002 0.0262
Echinococcus multilocularis geminin 0.0182 0.0345 0.0344
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0113 0.0197 0.0221
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.006 0.0059
Echinococcus granulosus nmda type glutamate receptor 0.0761 0.158 0.1579
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0138 0.0137
Brugia malayi cytochrome P450 0.0025 0.0011 0.0012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.0343 0.4088
Leishmania major ATP-dependent phosphofructokinase 0.0222 0.043 0.3914
Echinococcus granulosus glutamate receptor 4 0.0045 0.0054 0.0053
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.0085 0.0257
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.003 0.0022 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.006 0.0267
Trichomonas vaginalis phosphofructokinase, putative 0.0222 0.043 0.2091
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0076 0.0119 0.0134
Brugia malayi Receptor family ligand binding region containing protein 0.0527 0.1082 0.132
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Mycobacterium ulcerans 6-phosphofructokinase 0.0222 0.043 0.5149
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0083 0.0672
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0012 0.0049
Echinococcus granulosus histone lysine methyltransferase setb 0.0123 0.0219 0.0218
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0083 0.3707
Brugia malayi hypothetical protein 0.0252 0.0494 0.0603
Echinococcus multilocularis glutamate receptor 4 0.0045 0.0054 0.0053
Schistosoma mansoni regulator of G protein signaling 0.0078 0.0123 0.0138
Echinococcus granulosus receptor type guanylyl cyclase 0.0527 0.1082 0.1081
Brugia malayi Receptor family ligand binding region containing protein 0.1125 0.2355 0.2875
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0083 0.9725
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0083 0.0672
Loa Loa (eye worm) hypothetical protein 0.0527 0.1082 0.1081
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0527 0.1082 0.132
Trichomonas vaginalis 6-phosphofructokinase, putative 0.006 0.0085 0.0389
Brugia malayi hypothetical protein 0.0021 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0078 0.0123 0.0122
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0006 0.0005
Brugia malayi Excitatory amino acid transporter 0.1353 0.2842 0.347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0024 0.0088
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Echinococcus granulosus sodium and chloride dependent glycine 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.0011
Echinococcus multilocularis regulator of G protein signaling 3 0.0078 0.0123 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0034 0.0136
Loa Loa (eye worm) hypothetical protein 0.0039 0.0041 0.004
Entamoeba histolytica phosphofructokinase, putative 0.0222 0.043 0.3849
Loa Loa (eye worm) hypothetical protein 0.4711 1 1
Loa Loa (eye worm) RecQ helicase 0.0023 0.0006 0.0005
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0044 0.0044
Brugia malayi PXA domain containing protein 0.0078 0.0123 0.015
Loa Loa (eye worm) CUTiclin family member 0.003 0.0022 0.0021
Brugia malayi follicle stimulating hormone receptor 0.0232 0.0451 0.055
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0108 0.0816
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0026 0.0012 0.0011
Echinococcus multilocularis lamin dm0 0.0085 0.0138 0.0137
Onchocerca volvulus 0.0021 0.0002 0.0005
Echinococcus multilocularis Excitatory amino acid transporter 0.1353 0.2842 0.2841
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0113 0.0197 0.0196
Echinococcus granulosus glutamate receptor 1 0.0045 0.0054 0.0053
Brugia malayi hypothetical protein 0.0078 0.0123 0.015
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0021
Echinococcus granulosus collagen alpha 1VII chain 0.003 0.0022 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0123 0.0138
Loa Loa (eye worm) hypothetical protein 0.0083 0.0135 0.0134
Loa Loa (eye worm) hypothetical protein 0.0112 0.0196 0.0195
Schistosoma mansoni lipoxygenase 0.0021 0.0002 0.0002
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0002 0.0002
Echinococcus multilocularis tyrosine kinase 0.0527 0.1082 0.1081
Echinococcus multilocularis regulator of G protein signaling 7 0.0078 0.0123 0.0122
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0012 0.0014
Echinococcus granulosus nmda type glutamate receptor 0.0527 0.1082 0.1081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0019 0.0062
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0085 0.0389
Schistosoma mansoni axis inhibition protein axin 0.0078 0.0123 0.0138
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0021
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0078 0.0123 0.0138
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0083 0.9483
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0034 0.0696
Trichomonas vaginalis phosphofructokinase, putative 0.0222 0.043 0.2091
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.003 0.0022 0.2561
Loa Loa (eye worm) hypothetical protein 0.0113 0.0197 0.0196
Toxoplasma gondii phosphofructokinase PFKII 0.006 0.0085 0.2234
Echinococcus granulosus neutral amino acid transporter 0.1353 0.2842 0.2841
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0021
Echinococcus granulosus bloom syndrome protein 0.0023 0.0006 0.0005
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0877 0.1827 0.1826
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.004 0.0044
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.0011
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0012 0.0013
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0083 0.1922
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0083 0.0378
Toxoplasma gondii 6-phosphofructokinase 0.006 0.0085 0.2234
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0021
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0078 0.0123 0.0122
Schistosoma mansoni 6-phosphofructokinase 0.0222 0.043 0.0483
Echinococcus multilocularis Excitatory amino acid transporter 0.1353 0.2842 0.2841
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.004 0.0167
Brugia malayi M-phase phosphoprotein, mpp8 0.0112 0.0196 0.0238
Echinococcus granulosus GPCR family 3 C terminal 0.0597 0.123 0.123
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.003 0.0022 0.0078
Entamoeba histolytica phosphofructokinase, putative 0.0222 0.043 0.3849
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0181 0.0343 0.3108
Echinococcus multilocularis regulator of G protein signaling 3 0.0078 0.0123 0.0122
Loa Loa (eye worm) phosphofructokinase 0.0222 0.043 0.0429

Activities

Activity type Activity value Assay description Source Reference
cLogP (ADMET) = 2.14 cLogP of the compound ChEMBL. 12502366
Ki (binding) = 0.004 nM Inhibitory activity against human endothelin A receptor expressed in CHO cells ChEMBL. 12502366
Ki (binding) = 0.004 nM Inhibitory activity against human endothelin A receptor expressed in CHO cells ChEMBL. 12502366
Ki (binding) = 1300 nM Inhibitory activity against human endothelin B receptor expressed in CHO cells ChEMBL. 12502366
Ki (binding) = 1300 nM Inhibitory activity against human endothelin B receptor expressed in CHO cells ChEMBL. 12502366
ND (functional) 0 In vitro inhibition of ET-1 induced contractions in rabbit carotid artery rings; ND means not determined. ChEMBL. 12502366
Pc (ADMET) = 20 nm s-1 Permeability (caco-2 cell assay) ChEMBL. 12502366
Pc (ADMET) = 20 nm s-1 Permeability (caco-2 cell assay) ChEMBL. 12502366

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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