Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | ecdysteroid receptor | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Onchocerca volvulus | Bile acid receptor homolog | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | nuclear receptor subfamily 1, group H, member 3 | 387 aa | 321 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.0207 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 58 % | Transactivation of LXRbeta relative to T0901317 by luciferase reporter gene assay | ChEMBL. | 16876993 |
Activity (functional) | = 58 % | Transactivation of LXRbeta relative to T0901317 by luciferase reporter gene assay | ChEMBL. | 16876993 |
Activity (functional) | = 92 % | Transactivation of LXRalpha relative to T0901317 by luciferase reporter gene assay | ChEMBL. | 16876993 |
Activity (functional) | = 92 % | Transactivation of LXRalpha relative to T0901317 by luciferase reporter gene assay | ChEMBL. | 16876993 |
EC50 (functional) | = 0.04 uM | Transactivation of LXRbeta by luciferase reporter gene assay | ChEMBL. | 16876993 |
EC50 (functional) | = 0.04 uM | Transactivation of LXRbeta by luciferase reporter gene assay | ChEMBL. | 16876993 |
EC50 (functional) | = 0.2 uM | Transactivation of LXRalpha by luciferase reporter gene assay | ChEMBL. | 16876993 |
EC50 (functional) | = 0.2 uM | Transactivation of LXRalpha by luciferase reporter gene assay | ChEMBL. | 16876993 |
IC50 (binding) | = 0.03 uM | Binding affinity to LXRbeta by radioligand displacement assay | ChEMBL. | 16876993 |
IC50 (binding) | = 0.03 uM | Binding affinity to LXRbeta by radioligand displacement assay | ChEMBL. | 16876993 |
IC50 (binding) | = 0.05 uM | Binding affinity to LXRalpha by radioligand displacement assay | ChEMBL. | 16876993 |
IC50 (binding) | = 0.05 uM | Binding affinity to LXRalpha by radioligand displacement assay | ChEMBL. | 16876993 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.