Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0172 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0071 | 0.2813 | 0.0378 |
Brugia malayi | hypothetical protein | 0.009 | 0.4142 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.4142 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0071 | 0.2813 | 0.0378 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.0821 | 0.0969 |
Echinococcus granulosus | chromobox protein 1 | 0.0071 | 0.2813 | 0.0378 |
Schistosoma mansoni | eyes absent homolog | 0.009 | 0.4142 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2531 | 0.611 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.2531 | 0.5441 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0608 | 0.1467 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0067 | 0.2531 | 0.611 |
Trichomonas vaginalis | chromobox protein, putative | 0.0071 | 0.2813 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.0821 | 0.0969 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.004 | 0.0608 | 0.7399 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.4142 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.0821 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.2531 | 0.5441 |
Echinococcus multilocularis | chromobox protein 1 | 0.0071 | 0.2813 | 0.0378 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0071 | 0.2813 | 1 |
Echinococcus multilocularis | geminin | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0067 | 0.2531 | 0.611 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0071 | 0.2813 | 0.6792 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2531 | 0.611 |
Echinococcus granulosus | chromobox protein 1 | 0.0071 | 0.2813 | 0.0378 |
Brugia malayi | Heterochromatin protein 1 | 0.0071 | 0.2813 | 0.624 |
Schistosoma mansoni | chromobox protein | 0.0071 | 0.2813 | 0.0378 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 | Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cells | ChEMBL. | 16870431 |
Inhibition (binding) | = 38 % | Inhibition of [125I]MCP-1 binding to human CCR2b expressed in CHO cells at 1 uM | ChEMBL. | 16870431 |
Inhibition (binding) | = 38 % | Inhibition of [125I]MCP-1 binding to human CCR2b expressed in CHO cells at 1 uM | ChEMBL. | 16870431 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.