Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Brugia malayi | ecdysteroid receptor | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | nuclear receptor subfamily 1, group H, member 3 | 387 aa | 321 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0285 | 1 | 1 |
Echinococcus multilocularis | cyclin B | 0.0285 | 1 | 1 |
Echinococcus granulosus | cyclin B3 1 | 0.0285 | 1 | 1 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0285 | 1 | 1 |
Entamoeba histolytica | cyclin family protein | 0.0285 | 1 | 1 |
Echinococcus multilocularis | cyclins | 0.0285 | 1 | 1 |
Echinococcus multilocularis | cyclin B3 1 | 0.0285 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0285 | 1 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0285 | 1 | 1 |
Echinococcus multilocularis | cyclins | 0.0285 | 1 | 1 |
Echinococcus granulosus | cyclins | 0.0285 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0285 | 1 | 1 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0285 | 1 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0285 | 1 | 1 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0223 | 0.7147 | 0.7147 |
Trichomonas vaginalis | cyclin B, putative | 0.0285 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0069 | 0 | 0.5 |
Echinococcus multilocularis | cyclins | 0.0285 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0223 | 0.7147 | 0.7147 |
Echinococcus multilocularis | cyclin b3 | 0.0285 | 1 | 1 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0285 | 1 | 1 |
Onchocerca volvulus | 0.0285 | 1 | 1 | |
Trichomonas vaginalis | cyclin A, putative | 0.0285 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0285 | 1 | 1 |
Echinococcus granulosus | cyclins | 0.0285 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0223 | 0.7147 | 0.7147 |
Giardia lamblia | Cyclin A | 0.0285 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0285 | 1 | 1 |
Plasmodium falciparum | cyclin | 0.0285 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0285 | 1 | 1 |
Echinococcus multilocularis | cyclins | 0.0285 | 1 | 1 |
Echinococcus granulosus | cyclins | 0.0285 | 1 | 1 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0285 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0285 | 1 | 1 |
Echinococcus multilocularis | cyclins | 0.0285 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0207 | 0.6389 | 0.6389 |
Echinococcus granulosus | cyclin b3 | 0.0285 | 1 | 1 |
Leishmania major | cyclin | 0.0285 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0285 | 1 | 1 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0285 | 1 | 1 |
Trypanosoma cruzi | cyclin 6, putative | 0.0285 | 1 | 1 |
Brugia malayi | Stress-activated protein kinase jnk-1 | 0.0223 | 0.7147 | 0.7147 |
Trichomonas vaginalis | cyclin B3, putative | 0.0285 | 1 | 1 |
Echinococcus multilocularis | cyclins | 0.0285 | 1 | 1 |
Echinococcus granulosus | cyclin B | 0.0285 | 1 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0285 | 1 | 1 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0223 | 0.7147 | 0.7147 |
Entamoeba histolytica | cyclin, putative | 0.0285 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0285 | 1 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0285 | 1 | 1 |
Echinococcus granulosus | cyclins | 0.0285 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0285 | 1 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0285 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 1 | 1 |
Echinococcus multilocularis | cyclins | 0.0285 | 1 | 1 |
Schistosoma mansoni | cyclin B | 0.0285 | 1 | 1 |
Plasmodium vivax | cyclin 4, putative | 0.0069 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.6389 | 0.6389 |
Schistosoma mansoni | cyclin B3 | 0.0285 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0216 | 0.6819 | 1 |
Echinococcus granulosus | cyclins | 0.0285 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0285 | 1 | 1 |
Schistosoma mansoni | cyclins | 0.0285 | 1 | 1 |
Plasmodium vivax | cyclin homologue, putative | 0.0069 | 0 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0285 | 1 | 1 |
Plasmodium vivax | cyclin dependent kinase binding protein, putative | 0.0069 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0207 | 0.6389 | 0.6389 |
Trypanosoma cruzi | cyclin, putative | 0.0285 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0285 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0285 | 1 | 1 |
Entamoeba histolytica | cyclin family protein | 0.0285 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 83 % | Transactivation of LXRbeta relative to T0901317 by luciferase reporter gene assay | ChEMBL. | 16876993 |
Activity (functional) | = 83 % | Transactivation of LXRbeta relative to T0901317 by luciferase reporter gene assay | ChEMBL. | 16876993 |
Activity (functional) | = 130 % | Transactivation of LXRalpha relative to T0901317 by luciferase reporter gene assay | ChEMBL. | 16876993 |
Activity (functional) | = 130 % | Transactivation of LXRalpha relative to T0901317 by luciferase reporter gene assay | ChEMBL. | 16876993 |
EC50 (functional) | = 0.1 uM | Transactivation of LXRbeta by luciferase reporter gene assay | ChEMBL. | 16876993 |
EC50 (functional) | = 0.1 uM | Transactivation of LXRbeta by luciferase reporter gene assay | ChEMBL. | 16876993 |
EC50 (functional) | = 0.7 uM | Transactivation of LXRalpha by luciferase reporter gene assay | ChEMBL. | 16876993 |
EC50 (functional) | = 0.7 uM | Transactivation of LXRalpha by luciferase reporter gene assay | ChEMBL. | 16876993 |
IC50 (binding) | = 0.013 uM | Binding affinity to LXRalpha by radioligand displacement assay | ChEMBL. | 16876993 |
IC50 (binding) | = 0.013 uM | Binding affinity to LXRalpha by radioligand displacement assay | ChEMBL. | 16876993 |
IC50 (binding) | = 0.02 uM | Binding affinity to LXRbeta by radioligand displacement assay | ChEMBL. | 16876993 |
IC50 (binding) | = 0.02 uM | Binding affinity to LXRbeta by radioligand displacement assay | ChEMBL. | 16876993 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.