Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidylate synthase | 0.1441 | 0.6387 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0587 | 0.1139 | 0.1784 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0462 | 0.0365 | 0.0365 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0587 | 0.1139 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2028 | 1 | 0.5 |
Onchocerca volvulus | 0.0718 | 0.194 | 0.3038 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0685 | 0.1742 | 0.1742 |
Brugia malayi | hypothetical protein | 0.0685 | 0.1742 | 0.2727 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0462 | 0.0365 | 0.0572 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0462 | 0.0365 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.0365 | 0.0572 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0621 | 0.1345 | 0.2106 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0462 | 0.0365 | 0.0572 |
Onchocerca volvulus | 0.0531 | 0.0794 | 0.1243 | |
Toxoplasma gondii | PAN domain-containing protein | 0.0701 | 0.1836 | 0.1836 |
Loa Loa (eye worm) | hypothetical protein | 0.0718 | 0.194 | 0.3038 |
Echinococcus granulosus | thymidylate synthase | 0.1441 | 0.6387 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0462 | 0.0365 | 0.0572 |
Echinococcus granulosus | laminin | 0.0462 | 0.0365 | 0.0572 |
Schistosoma mansoni | dihydrofolate reductase | 0.0587 | 0.1139 | 0.1784 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1441 | 0.6387 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2028 | 1 | 1 |
Echinococcus granulosus | Mastin | 0.0453 | 0.0315 | 0.0493 |
Echinococcus granulosus | enteropeptidase | 0.0453 | 0.0315 | 0.0493 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0685 | 0.1742 | 0.1148 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.0365 | 0.0572 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0685 | 0.1742 | 1 |
Brugia malayi | thymidylate synthase | 0.1441 | 0.6387 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0678 | 0.1696 | 0.2655 |
Loa Loa (eye worm) | thymidylate synthase | 0.1441 | 0.6387 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.0701 | 0.1836 | 0.1836 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.0365 | 0.0572 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1441 | 0.6387 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0462 | 0.0365 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.0365 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.0365 | 0.0572 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1441 | 0.6387 | 1 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0453 | 0.0315 | 0.0493 |
Echinococcus granulosus | Tolloid protein 1 | 0.0462 | 0.0365 | 0.0572 |
Brugia malayi | Trypsin family protein | 0.0718 | 0.194 | 0.3038 |
Loa Loa (eye worm) | hypothetical protein | 0.0718 | 0.194 | 0.3038 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0621 | 0.1345 | 0.2106 |
Echinococcus granulosus | dihydrofolate reductase | 0.0587 | 0.1139 | 0.1784 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0621 | 0.1345 | 0.2106 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0718 | 0.194 | 0.3038 |
Echinococcus multilocularis | enteropeptidase | 0.0453 | 0.0315 | 0.0493 |
Echinococcus multilocularis | laminin | 0.0462 | 0.0365 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.0539 | 0.0841 | 0.1316 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0587 | 0.1139 | 0.1784 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2028 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0587 | 0.1139 | 0.1784 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0462 | 0.0365 | 0.0365 |
Schistosoma mansoni | egf-like domain protein | 0.0462 | 0.0365 | 0.0572 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0718 | 0.194 | 0.3038 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0453 | 0.0315 | 0.0493 |
Echinococcus multilocularis | fibrillin 1 | 0.0462 | 0.0365 | 0.0572 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0453 | 0.0315 | 0.0493 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0678 | 0.1696 | 0.2655 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0462 | 0.0365 | 0.0572 |
Brugia malayi | Dihydrofolate reductase | 0.0587 | 0.1139 | 0.1784 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2028 | 1 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.0462 | 0.0365 | 0.0572 |
Mycobacterium ulcerans | thymidylate synthase | 0.1441 | 0.6387 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0621 | 0.1345 | 0.2106 |
Onchocerca volvulus | 0.1441 | 0.6387 | 1 | |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0462 | 0.0365 | 0.0572 |
Onchocerca volvulus | Arrow homolog | 0.0462 | 0.0365 | 0.0572 |
Echinococcus multilocularis | Mastin | 0.0453 | 0.0315 | 0.0493 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 25 % | Ability to block calcium channel T type 3.2v expressed in Xenopus oocytes at 100 uM by two-microelectrode voltage-clamp method | ChEMBL. | 16876404 |
Inhibition (functional) | = 25 % | Ability to block calcium channel T type 3.2v expressed in Xenopus oocytes at 100 uM by two-microelectrode voltage-clamp method | ChEMBL. | 16876404 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.