Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0901 | 0.233 | 0.2191 |
Loa Loa (eye worm) | sugar transporter | 0.0498 | 0.1056 | 0.0894 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1271 | 0.3501 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0498 | 0.1056 | 0.0249 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1271 | 0.3501 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1271 | 0.3501 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0498 | 0.1056 | 0.0249 |
Brugia malayi | Dihydrofolate reductase | 0.3324 | 1 | 1 |
Brugia malayi | Sugar transporter family protein | 0.0498 | 0.1056 | 0.0894 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1271 | 0.3501 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0498 | 0.1056 | 0.0249 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1271 | 0.3501 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.075 | 0.1852 | 0.1117 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0498 | 0.1056 | 0.0249 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.075 | 0.1852 | 0.1117 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3324 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0498 | 0.1056 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0901 | 0.233 | 0.2191 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0498 | 0.1056 | 0.0249 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0498 | 0.1056 | 0.0249 |
Schistosoma mansoni | dihydrofolate reductase | 0.3324 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.3324 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3324 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1271 | 0.3501 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3324 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3324 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3324 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0498 | 0.1056 | 0.0249 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0498 | 0.1056 | 0.0249 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3324 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 53.32 % | Inhibition of oleate production in Mycobacterium bovis BCG | ChEMBL. | 16875817 |
Inhibition (functional) | = 53.32 % | Inhibition of oleate production in Mycobacterium bovis BCG | ChEMBL. | 16875817 |
MIC99 (functional) | Antibacterial activity against Mycobacterium tuberculosis H37Rv | ChEMBL. | 16875817 | |
MIC99 (functional) | 0 | Antibacterial activity against Mycobacterium tuberculosis H37Rv | ChEMBL. | 16875817 |
MIC99 (functional) | = 0.5 ug ml-1 | Antibacterial activity against Mycobacterium bovis BCG | ChEMBL. | 16875817 |
MIC99 (functional) | = 0.5 ug ml-1 | Antibacterial activity against Mycobacterium bovis BCG | ChEMBL. | 16875817 |
Selectivity index (functional) | 0 | Selectivity index, IC50 against Vero cells/MIC against Mycobacterium | ChEMBL. | 16875817 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.