Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidasin homolog | 0.0047 | 1 | 1 |
Plasmodium falciparum | apical sushi protein | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0047 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.015 | 0.015 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.015 | 0.015 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.015 | 0.015 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.015 | 0.015 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.015 | 0.015 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.015 | 0.015 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.015 | 0.015 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.015 | 0.015 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.015 | 0.015 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.015 | 0.015 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.015 | 0.015 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.015 | 0.015 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.015 | 0.015 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.015 | 0.015 |
Brugia malayi | Blistered cuticle protein 3 | 0.0047 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.015 | 0.015 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.015 | 0.015 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.015 | 0.015 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.015 | 0.015 |
Echinococcus granulosus | peroxidasin | 0.0047 | 1 | 1 |
Onchocerca volvulus | 0.0047 | 1 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.015 | 0.015 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.015 | 0.015 |
Plasmodium vivax | apical sushi protein, putative | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.015 | 0.015 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.015 | 0.015 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.015 | 0.015 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.015 | 0.015 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.015 | 0.015 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.015 | 0.015 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0047 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0047 | 1 | 1 |
Onchocerca volvulus | 0.0047 | 1 | 1 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.015 | 0.015 |
Schistosoma mansoni | peroxidasin | 0.0047 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.015 | 0.015 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.015 | 0.015 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.015 | 0.015 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0.015 | 0.015 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.015 | 0.015 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0018 | 0.1739 | 0.1739 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.015 | 0.015 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.015 | 0.015 |
Onchocerca volvulus | Peroxidase homolog | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.015 | 0.015 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0.015 | 0.015 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.015 | 0.015 |
Onchocerca volvulus | Peroxidase homolog | 0.0047 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.015 | 0.015 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0047 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.015 | 0.015 |
Toxoplasma gondii | rhoptry neck protein RON9 | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0047 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0047 | 1 | 1 |
Onchocerca volvulus | 0.0012 | 0.015 | 0.015 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.015 | 0.015 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1739 | 0.1739 |
Brugia malayi | Animal haem peroxidase family protein | 0.0047 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.015 | 0.015 |
Brugia malayi | Animal haem peroxidase family protein | 0.0047 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.015 | 0.015 |
Onchocerca volvulus | Dual oxidase homolog | 0.0047 | 1 | 1 |
Toxoplasma gondii | rhoptry neck protein RON1 | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.015 | 0.015 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.015 | 0.015 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.015 | 0.015 |
Onchocerca volvulus | 0.0047 | 1 | 1 | |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.015 | 0.015 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.015 | 0.015 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.015 | 0.015 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0.015 | 0.015 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.036 | 0.036 |
Echinococcus multilocularis | peroxidasin | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0047 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0047 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Viability of BAEC by Roche-XTT assay relative to control | ChEMBL. | 17004713 |
Activity (functional) | = 68 % | Viability in ATP-lite assay relative to control | ChEMBL. | 17004713 |
Activity (functional) | = 80 % | Viability of MM6 cells at 100 uM by Roche-XTT assay relative to control | ChEMBL. | 17004713 |
Activity (functional) | = 80 % | Viability of MM6 cells at 100 uM by Roche-XTT assay relative to control | ChEMBL. | 17004713 |
Inhibition (functional) | 0 | Inhibition of MM6 cell adhesion to recombinant E-selectin at 100 uM relative to control by flow chamber assay | ChEMBL. | 17004713 |
Inhibition (functional) | = 26 % | Inhibition of MM6 cell adhesion to BAEC at 100 uM relative to control by static assay | ChEMBL. | 17004713 |
Inhibition (binding) | = 65 % | Inhibition of sLex binding to E-selectin at 100 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 |
Inhibition (binding) | = 65 % | Inhibition of sLex binding to E-selectin at 100 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 |
Inhibition (binding) | = 75 % | Inhibition of sLex binding to L-selectin at 500 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 |
Inhibition (binding) | = 75 % | Inhibition of sLex binding to L-selectin at 500 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 |
Inhibition (binding) | = 78 % | Inhibition of sLex binding to P-selectin at 500 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 |
Inhibition (binding) | = 78 % | Inhibition of sLex binding to P-selectin at 500 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.