Detailed information for compound 373677

Basic information

Technical information
  • TDR Targets ID: 373677
  • Name: 2-benzyl-3-phenyl-3-(2-piperazin-1-ylethoxy)i soindol-1-one
  • MW: 427.538 | Formula: C27H29N3O2
  • H donors: 1 H acceptors: 1 LogP: 3.3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1c2ccccc2C(N1Cc1ccccc1)(OCCN1CCNCC1)c1ccccc1
  • InChi: 1S/C27H29N3O2/c31-26-24-13-7-8-14-25(24)27(23-11-5-2-6-12-23,30(26)21-22-9-3-1-4-10-22)32-20-19-29-17-15-28-16-18-29/h1-14,28H,15-21H2
  • InChiKey: XKJRGWIKSJTTGT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-benzyl-3-phenyl-3-(2-piperazin-1-ylethoxy)isoindolin-1-one
  • 2-benzyl-3-phenyl-3-[2-(1-piperazinyl)ethoxy]-1-isoindolinone
  • 3-phenyl-2-(phenylmethyl)-3-(2-piperazin-1-ylethoxy)isoindol-1-one
  • 2-benzyl-3-phenyl-3-(2-piperazinoethoxy)isoindolin-1-one
  • 3-phenyl-2-(phenylmethyl)-3-(2-piperazin-1-ylethoxy)isoindolin-1-one
  • 3-phenyl-2-(phenylmethyl)-3-[2-(1-piperazinyl)ethoxy]-1-isoindolinone
  • 2-(benzyl)-3-phenyl-3-(2-piperazin-1-ylethoxy)isoindolin-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus survival motor neuron protein 1 0.0215 0.3268 0.326
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.138 0.137
Schistosoma mansoni hypothetical protein 0.0044 0.0525 0.0483
Brugia malayi beta-lactamase family protein 0.0033 0.0347 0.0813
Onchocerca volvulus Phospholipase A2 homolog 0.0398 0.6191 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0015 0.0061 0.0049
Schistosoma mansoni cellular tumor antigen P53 0.0046 0.0552 0.0509
Echinococcus multilocularis cysteine protease atg4b 0.0054 0.0682 0.0671
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2494 0.2819
Giardia lamblia Rrm3p helicase 0.0564 0.8848 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0218 0.0247
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0564 0.8848 0.8846
Schistosoma mansoni smad 0.0015 0.0061 0.0016
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0189 0.0165
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0564 0.8848 1
Schistosoma mansoni hypothetical protein 0.0078 0.1071 0.1031
Schistosoma mansoni smad1 5 8 and 0.0015 0.0061 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0485 0.0548
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.1344 0.1334
Toxoplasma gondii ABC1 family protein 0.0033 0.0347 0.3625
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.138 0.3489
Schistosoma mansoni intermediate filament proteins 0.0025 0.0215 0.0171
Mycobacterium ulcerans lipase LipD 0.0033 0.0347 0.5
Echinococcus multilocularis lamin 0.0025 0.0215 0.0204
Brugia malayi MH2 domain containing protein 0.0219 0.3323 0.8519
Schistosoma mansoni lamin 0.0025 0.0215 0.0171
Loa Loa (eye worm) beta-lactamase 0.0033 0.0347 0.0553
Echinococcus multilocularis geminin 0.0154 0.2291 0.2282
Mycobacterium ulcerans hypothetical protein 0.0033 0.0347 0.5
Onchocerca volvulus 0.0033 0.0347 0.022
Loa Loa (eye worm) hypothetical protein 0.0024 0.0208 0.0329
Echinococcus multilocularis musashi 0.0025 0.0215 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0218 0.0247
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0078 0.1071 0.106
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3895 0.4402
Schistosoma mansoni smad1 5 8 and 0.0015 0.0061 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0315 0.0356
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0021 0.0157 0.0128
Schistosoma mansoni hypothetical protein 0.0403 0.6272 0.6256
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0041 0.0485 0.0377
Loa Loa (eye worm) phosphatidylinositol 3 0.0041 0.0485 0.0776
Leishmania major hypothetical protein, conserved 0.0023 0.0189 0.0165
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0275 0.0437
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.138 0.137
Schistosoma mansoni cpg binding protein 0.003 0.0301 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0315 0.0356
Echinococcus granulosus cpg binding protein 0.003 0.0301 0.0289
Echinococcus granulosus dnaJ subfamily B 0.0403 0.6272 0.6268
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0054 0.0682 0.0724
Echinococcus granulosus tumor protein p63 0.0312 0.4806 0.48
Schistosoma mansoni transient receptor potential channel 0.0095 0.1344 0.1305
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0829 0.0818
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3895 0.4402
Brugia malayi Smad1 0.0015 0.0061 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0349 0.0395
Onchocerca volvulus 0.0028 0.0275 0.01
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0347 0.0392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0315 0.0356
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0564 0.8848 1
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0054 0.0682 0.0724
Schistosoma mansoni hypothetical protein 0.0078 0.1071 0.1031
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0054 0.0682 0.064
Brugia malayi Probable ATP-dependent helicase DHX35 0.0037 0.0417 0.0995
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0054 0.0682 0.077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0044 0.005
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0054 0.0682 0.0724
Loa Loa (eye worm) hypothetical protein 0.0025 0.0215 0.034
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0054 0.0682 0.077
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0033 0.0347 0.0553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0044 0.005
Schistosoma mansoni cpg binding protein 0.003 0.0301 0.0258
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0829 0.0818
Brugia malayi hypothetical protein 0.0023 0.0189 0.0406
Brugia malayi hypothetical protein 0.0215 0.3268 0.8377
Trichomonas vaginalis conserved hypothetical protein 0.0564 0.8848 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0315 0.0356
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0388 0.092
Brugia malayi Calcitonin receptor-like protein seb-1 0.0247 0.3768 0.9672
Echinococcus multilocularis Smad4 0.0015 0.0061 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.018 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0252 0.0285
Echinococcus multilocularis tumor protein p63 0.0312 0.4806 0.48
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0214 0.0242
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0564 0.8848 1
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2494 0.2819
Brugia malayi Phospholipase A2 family protein 0.0084 0.1163 0.2927
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.3895 0.6288
Onchocerca volvulus 0.0033 0.0347 0.022
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.1071 0.106
Loa Loa (eye worm) hypothetical protein 0.0095 0.1344 0.2165
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.1293 0.1283
Echinococcus multilocularis microtubule associated protein 2 0.0636 1 1
Schistosoma mansoni hypothetical protein 0.0078 0.1071 0.1031
Schistosoma mansoni hypothetical protein 0.0078 0.1071 0.1031
Entamoeba histolytica peptidase, C54 family 0.0054 0.0682 0.0603
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0033 0.035 0.0347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0388 0.0439
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0014 0.0044 0.0033
Echinococcus multilocularis mothers against decapentaplegic 5 0.0015 0.0061 0.0049
Leishmania major hypothetical protein, conserved 0.0033 0.0347 0.0343
Echinococcus granulosus Peptidase C54 0.0054 0.0682 0.0671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.018 0.0204
Brugia malayi Latrophilin receptor protein 2 0.0078 0.1071 0.2688
Entamoeba histolytica DNA repair and recombination protein, putative 0.0564 0.8848 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0347 0.0553
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0041 0.0485 0.05
Loa Loa (eye worm) hypothetical protein 0.0054 0.0682 0.1094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0485 0.0548
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0021 0.0157 0.0128
Schistosoma mansoni hypothetical protein 0.0564 0.8848 0.8843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.138 0.1342
Trypanosoma cruzi target of rapamycin kinase 3 0.0033 0.035 0.0347
Schistosoma mansoni hypothetical protein 0.0169 0.252 0.2486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0315 0.0356
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.138 0.137
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0347 0.0343
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2494 0.2819
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0054 0.0682 0.064
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.1344 0.1334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0315 0.0356
Brugia malayi MH2 domain containing protein 0.0015 0.0061 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0218 0.0247
Mycobacterium leprae Probable lipase LipE 0.0033 0.0347 0.5
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0041 0.0485 0.05
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0564 0.8848 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.1071 0.1723
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.018 0.0203
Loa Loa (eye worm) hypothetical protein 0.0169 0.252 0.4065
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3895 0.4402
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0044 0.003
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0033 0.0347 0.5
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.068 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0061 0.0091
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0021 0.0157 0.0128
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3895 0.4402
Echinococcus granulosus geminin 0.0154 0.2291 0.2282
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2494 0.2819
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.3895 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0829 0.0818
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0061 0.0091
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0347 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0044 0.005
Mycobacterium leprae conserved hypothetical protein 0.0033 0.0347 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.1071 0.106
Schistosoma mansoni lamin 0.0025 0.0215 0.0171
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0025 0.0215 0.034
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3895 0.4402
Entamoeba histolytica hypothetical protein, conserved 0.0564 0.8848 1
Echinococcus granulosus cysteine protease atg4b 0.0054 0.0682 0.0671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0315 0.0356
Loa Loa (eye worm) hypothetical protein 0.0033 0.0347 0.0553
Loa Loa (eye worm) hypothetical protein 0.0398 0.6191 1
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.1293 0.1283
Echinococcus multilocularis survival motor neuron protein 1 0.0215 0.3268 0.326
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0347 0.0392
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0189 0.0165
Brugia malayi MH2 domain containing protein 0.0015 0.0061 0.0072
Echinococcus granulosus Smad4 0.0015 0.0061 0.0049
Loa Loa (eye worm) hypothetical protein 0.0033 0.0347 0.0553
Brugia malayi beta-lactamase family protein 0.0033 0.0347 0.0813
Loa Loa (eye worm) DEAH box polypeptide 35 0.0037 0.0417 0.0666
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0021 0.0157 0.0128
Echinococcus granulosus mothers against decapentaplegic 5 0.0015 0.0061 0.0049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0041 0.0485 0.1171
Brugia malayi Peptidase family C54 containing protein 0.0054 0.0682 0.168
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.0347 0.0304
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0347 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0267 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.018 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0349 0.0395
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.138 0.137
Echinococcus granulosus lamin dm0 0.0025 0.0215 0.0204
Schistosoma mansoni hypothetical protein 0.0154 0.2291 0.2257
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0054 0.0682 0.077
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.0347 0.0392
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.138 0.2224
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0041 0.0485 0.05
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.6272 0.6268
Loa Loa (eye worm) hypothetical protein 0.0046 0.0552 0.0884
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3895 0.4402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0044 0.005
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0044 0.0064
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0041 0.0485 0.0377
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.0347 0.0392
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2638 0.2982
Onchocerca volvulus 0.0044 0.0525 0.0519
Echinococcus multilocularis beta LACTamase domain containing family member 0.0033 0.0347 0.0335
Echinococcus multilocularis cpg binding protein 0.003 0.0301 0.0289
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2494 0.2819
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.2494 0.3814
Schistosoma mansoni smad1 5 8 and 0.0015 0.0061 0.0016
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0041 0.0485 0.05
Schistosoma mansoni Smad4 0.0015 0.0061 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.018 0.0204
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0247 0.3768 0.6084
Brugia malayi MH1 domain containing protein 0.0015 0.0061 0.0072
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0564 0.8848 0.8846
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0214 0.0242
Loa Loa (eye worm) intermediate filament protein 0.0025 0.0215 0.034
Loa Loa (eye worm) hypothetical protein 0.0215 0.3268 0.5275
Loa Loa (eye worm) hypothetical protein 0.0084 0.1163 0.1872
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0347 0.0343
Toxoplasma gondii target of rapamycin (TOR), putative 0.0031 0.0315 0.3018
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0078 0.1071 0.106
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.1071 0.2688
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0829 0.0818
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0041 0.0485 0.05
Schistosoma mansoni survival motor neuron protein 0.0044 0.0525 0.0483
Echinococcus multilocularis GPCR, family 2 0.0078 0.1071 0.106
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0041 0.0485 0.05
Loa Loa (eye worm) hypothetical protein 0.0037 0.0417 0.0666
Toxoplasma gondii LsmAD domain-containing protein 0.0023 0.0189 0.0615
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0189 1
Schistosoma mansoni transient receptor potential channel 0.0063 0.0829 0.0788
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.018 0.0204
Echinococcus granulosus smad 0.0015 0.0061 0.0049
Onchocerca volvulus 0.0046 0.0552 0.0563
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0041 0.0485 0.0474
Mycobacterium ulcerans esterase/lipase LipP 0.0033 0.0347 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.0778 0.125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0349 0.0395
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2494 0.2819
Schistosoma mansoni hypothetical protein 0.0154 0.2291 0.2257
Brugia malayi Intermediate filament tail domain containing protein 0.0025 0.0215 0.0472
Loa Loa (eye worm) hypothetical protein 0.0247 0.3768 0.6084
Loa Loa (eye worm) hypothetical protein 0.0033 0.0347 0.0553
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.1071 0.1723
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.0347 0.0304
Brugia malayi MH1 domain containing protein 0.0015 0.0061 0.0072
Brugia malayi hypothetical protein 0.0015 0.0059 0.0069
Loa Loa (eye worm) MH2 domain-containing protein 0.0219 0.3323 0.5364
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2638 0.2982
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.002 0.0136 0.0104
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0783 0.0742
Trichomonas vaginalis esterase, putative 0.0033 0.0347 0.0392
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0041 0.0485 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0044 0.005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0337 0.0538
Brugia malayi beta-lactamase 0.0033 0.0347 0.0813
Brugia malayi CXXC zinc finger family protein 0.0028 0.0275 0.0628
Mycobacterium tuberculosis Possible penicillin-binding protein 0.021 0.3174 1
Loa Loa (eye worm) transcription factor SMAD2 0.0219 0.3323 0.5364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0485 0.0548
Echinococcus granulosus beta LACTamase domain containing family member 0.0033 0.0347 0.0335
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.138 0.1342
Echinococcus granulosus lamin 0.0025 0.0215 0.0204
Mycobacterium ulcerans beta-lactamase 0.0033 0.0347 0.5
Echinococcus multilocularis Peptidase C54 0.0054 0.0682 0.0671
Onchocerca volvulus 0.0033 0.0347 0.022
Loa Loa (eye worm) hypothetical protein 0.0035 0.0388 0.062
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0347 0.0392
Brugia malayi intermediate filament protein 0.0025 0.0215 0.0472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.138 0.1342
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0388 0.0377
Loa Loa (eye worm) hypothetical protein 0.0033 0.0347 0.0553
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0564 0.8848 1
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0054 0.0682 0.077
Echinococcus multilocularis lamin dm0 0.0025 0.0215 0.0204
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2494 0.2819
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0017 0.0097 0.006
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0564 0.8848 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0247 0.3768 0.9672
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.018 0.0204
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0033 0.0347 0.0813
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0013 0.0033 0.0045
Echinococcus granulosus GPCR family 2 0.0078 0.1071 0.106
Loa Loa (eye worm) Smad1 0.0015 0.0061 0.0091
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.1344 0.1305
Schistosoma mansoni microtubule-associated protein tau 0.0636 1 1
Trypanosoma brucei PAB1-binding protein , putative 0.0023 0.0189 0.0165
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0033 0.035 0.0347
Schistosoma mansoni transient receptor potential channel 0.0063 0.0829 0.0788
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0014 0.0044 0.0033
Schistosoma mansoni cpg binding protein 0.0028 0.0275 0.0232
Brugia malayi latrophilin 2 splice variant baaae 0.0169 0.252 0.6439
Onchocerca volvulus Phospholipase A2 homolog 0.0084 0.1163 0.1586
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0015 0.0061 0.0049
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0015 0.0061 0.0016
Echinococcus multilocularis smad 0.0015 0.0061 0.0049
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0564 0.8848 1
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0054 0.0682 0.077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0349 0.0395
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0388 0.0377
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0044 0.0525 0.1275
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0041 0.0485 0.0442
Schistosoma mansoni autophagin-1 (C54 family) 0.0054 0.0682 0.064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0349 0.0395
Loa Loa (eye worm) hypothetical protein 0.0023 0.0189 0.0299
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Echinococcus granulosus intermediate filament protein 0.0025 0.0215 0.0204
Loa Loa (eye worm) hypothetical protein 0.0033 0.0347 0.0553
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0189 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 315 uM Inhibition of p53-MDM2 interaction by ELISA ChEMBL. 17034127
IC50 (binding) = 315 uM Inhibition of p53-MDM2 interaction by ELISA ChEMBL. 17034127

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.