TDR Targets

Basic information

Technical information

TDR Targets ID: 373683
Name: 13-cyclohexyl-6,7-dihydroindolo[1,2-d][1,4]be nzothiazepine-10-carboxylic acid
MW: 377.499 | Formula: C23H23NO2S
H donors: 1 H acceptors: 2 LogP: 5.94 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)c1ccc2c(c1)n1CCSc3c(c1c2C1CCCCC1)cccc3
InChi: 1S/C23H23NO2S/c25-23(26)16-10-11-17-19(14-16)24-12-13-27-20-9-5-4-8-18(20)22(24)21(17)15-6-2-1-3-7-15/h4-5,8-11,14-15H,1-3,6-7,12-13H2,(H,25,26)
InChiKey: PEZZNCRAAZMOJE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

Indolo[1,2-d][1,4]benzothiazepine-10-carboxylic acid, 13-cyclohexyl-6,7-dihydro-
AIDS-418275
AIDS418275

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Hepatitis C virus	Hepatitis C virus NS5B RNA-dependent RNA polymerase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania braziliensis	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Candida albicans	DNA helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania braziliensis	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma congolense	DNA repair and recombination helicase protein PIF6	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma congolense	DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Schistosoma japonicum	ko:K01529 PIF1 5'-to-3' DNA helicase [EC:3.6.1.-], putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania donovani	PIF1 helicase-like protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Candida albicans	similar to putative DNA helicase involved in repair and recombination of mitochondrial DNA that also plays a role in (nuclear) c	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	Get druggable targets OG5_128192	All targets in OG5_128192
Echinococcus granulosus	ATP dependent DNA helicase PIF1	Get druggable targets OG5_128192	All targets in OG5_128192
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania infantum	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei gambiense	DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	Get druggable targets OG5_128192	All targets in OG5_128192
Giardia lamblia	Rrm3p helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Entamoeba histolytica	hypothetical protein, conserved	Get druggable targets OG5_128192	All targets in OG5_128192
Candida albicans	similar to PIF1 DNA helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania mexicana	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei gambiense	DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania mexicana	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania infantum	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania donovani	PIF1 helicase-like protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Entamoeba histolytica	DNA repair and recombination protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0035	0.008	0.0247
Loa Loa (eye worm)	PAN domain-containing protein	0.0035	0.008	0.0247
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0036	0.0086	0.0201
Leishmania major	hypothetical protein, conserved	0.0079	0.0432	0.4077
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0118	0.0287
Loa Loa (eye worm)	TK/ROR protein kinase	0.0079	0.0432	0.1331
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0086	0.0649
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0031	0.0055
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0118	0.0559
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0145	0.0959	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0035	0.008	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0035	0.008	0.0247
Trypanosoma cruzi	cysteine peptidase, putative	0.0036	0.0086	0.0188
Brugia malayi	PAN domain containing protein	0.0035	0.008	0.0169
Leishmania major	cathepsin L-like protease	0.0036	0.0086	0.0201
Leishmania major	cathepsin L-like protease	0.0036	0.0086	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0086	0.0266
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0086	0.5199
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.0086	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0057	0.0176
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0031	0.0055
Loa Loa (eye worm)	endoprotease bli-4	0.0149	0.099	0.3053
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0086	0.0649
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0128	0.109
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0043	0.0142	0.0362
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0034	0.0069	0.0133
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0036	0.0086	0.0201
Onchocerca volvulus		0.0032	0.0057	0.0439
Echinococcus multilocularis	cysteine protease	0.0036	0.0086	0.0044
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0432	0.3242	0.3225
Onchocerca volvulus		0.0035	0.008	0.0764
Onchocerca volvulus		0.0035	0.008	0.0764
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0036	0.0086	0.0201
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0029	0.0031	0.0055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0086	0.0649
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0117	0.0736	0.0712
Echinococcus multilocularis	cathepsin L cysteine protease	0.0036	0.0086	0.0044
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.004	0.0118	0.0165
Schistosoma mansoni	hypothetical protein	0.0079	0.0432	0.0407
Loa Loa (eye worm)	cysteine protease	0.0036	0.0086	0.0266
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0118	0.0991
Loa Loa (eye worm)	inositol-1	0.004	0.0118	0.0365
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0086	0.0649
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0086	0.0649
Echinococcus granulosus	Furin 1	0.0035	0.0082	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0128	0.0393
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0086	0.0649
Giardia lamblia	Rrm3p helicase	0.0034	0.0069	0.0405
Echinococcus multilocularis	cathepsin L cysteine protease	0.0036	0.0086	0.0044
Echinococcus granulosus	tm gpcr rhodopsin	0.0541	0.4109	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0035	0.0082	0.0599
Giardia lamblia	Cathepsin B precursor	0.0145	0.0959	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0086	0.0649
Brugia malayi	cathepsin B-like cysteine proteinase	0.0432	0.3242	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0035	0.0082	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0736	0.2269
Trypanosoma cruzi	cyclin, putative	0.0043	0.0142	0.0362
Brugia malayi	Trypsin family protein	0.0117	0.0736	0.2207
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0031	0.0055
Onchocerca volvulus		0.0043	0.0142	0.1642
Toxoplasma gondii	PAN domain-containing protein	0.0326	0.2399	1
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.0034	0.0069	0.0133
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0432	0.3242	1
Onchocerca volvulus	Cathepsin L homolog	0.0036	0.0086	0.0853
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0086	0.0649
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0091	0.0524	0.1126
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0086	0.0649
Plasmodium falciparum	cysteine repeat modular protein 1	0.0079	0.0432	1
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.004	0.0118	0.5
Loa Loa (eye worm)	fibroinase	0.0036	0.0086	0.0266
Schistosoma mansoni	inositol monophosphatase	0.004	0.0118	0.0093
Leishmania major	cathepsin L-like protease	0.0036	0.0086	0.0201
Onchocerca volvulus	Cathepsin F homolog	0.0036	0.0086	0.0853
Schistosoma mansoni	cyclin B	0.0043	0.0142	0.0117
Loa Loa (eye worm)	proprotein convertase 2	0.0035	0.0082	0.0252
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0152	0.1356
Echinococcus multilocularis	calpain family protein 1, d	0.0042	0.0138	0.0172
Leishmania major	cyclin	0.0043	0.0142	0.0828
Trypanosoma brucei	mitotic cyclin 6	0.0043	0.0142	0.0828
Echinococcus granulosus	neuropeptide s receptor	0.051	0.3865	0.9401
Trichomonas vaginalis	cyclin B, putative	0.0043	0.0142	0.1248
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.006	0.0279	0.0522
Echinococcus multilocularis	tissue type plasminogen activator	0.0079	0.0432	0.0899
Trichomonas vaginalis	cyclin B, putative	0.0043	0.0142	0.1248
Echinococcus multilocularis	neuropeptide s receptor	0.051	0.3865	0.9395
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0117	0.0736	0.0712
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0035	0.0082	0.0599
Leishmania major	cathepsin L-like protease	0.0036	0.0086	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0138	0.0425
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0086	0.0649
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.006	0.0279	0.0621
Echinococcus multilocularis	neuroendocrine convertase 2	0.0094	0.0548	0.1187
Onchocerca volvulus		0.0035	0.008	0.0764
Onchocerca volvulus		0.0035	0.008	0.0764
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0036	0.0086	0.0201
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.004	0.0118	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0086	0.0649
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.004	0.0118	0.7937
Onchocerca volvulus		0.0036	0.0086	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0432	0.1331
Loa Loa (eye worm)	cathepsin B	0.0145	0.0959	0.2958
Onchocerca volvulus	Cathepsin L homolog	0.0036	0.0086	0.0853
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0036	0.0086	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0035	0.008	0.0247
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0036	0.0086	0.0201
Echinococcus granulosus	neuroendocrine convertase 2	0.0094	0.0548	0.1279
Trichomonas vaginalis	cyclins, putative	0.0043	0.0142	0.1248
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0026	0.008
Brugia malayi	PAN domain containing protein	0.0035	0.008	0.0169
Onchocerca volvulus		0.0036	0.0086	0.0853
Trichomonas vaginalis	cyclin B, putative	0.0043	0.0142	0.1248
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0736	0.2269
Trypanosoma cruzi	cyclin 6, putative	0.0043	0.0142	0.0362
Echinococcus multilocularis		0.012	0.076	0.1711
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0036	0.0085	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0031	0.0055
Echinococcus granulosus	calpain A	0.006	0.0279	0.0621
Loa Loa (eye worm)	calpain family protein 1	0.0057	0.0259	0.0798
Onchocerca volvulus		0.0035	0.008	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0142	0.0439
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0086	0.0649
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0262	0.1888	0.5824
Entamoeba histolytica	cyclin, putative	0.0043	0.0142	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0036	0.0086	0.0188
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0145	0.0959	0.2902
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0031	0.0055
Echinococcus granulosus	chromobox protein 1	0.0073	0.0384	0.0876
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0086	0.0188
Echinococcus granulosus	chromobox protein 1	0.0073	0.0384	0.0876
Toxoplasma gondii	cathepsin B	0.0145	0.0959	0.3792
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0432	0.3242	0.3225
Brugia malayi	endoprotease bli-4 precursor	0.0149	0.099	0.2997
Trichomonas vaginalis	cyclins, putative	0.0043	0.0142	0.1248
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0118	0.0991
Leishmania major	cathepsin L-like protease	0.0036	0.0086	0.0201
Onchocerca volvulus		0.0036	0.0086	0.0853
Onchocerca volvulus		0.0035	0.008	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0149	0.099	0.3053
Onchocerca volvulus		0.0035	0.008	0.0764
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0032	0.0068
Echinococcus granulosus	cathepsin b	0.0432	0.3242	0.7877
Trichomonas vaginalis	cyclin B, putative	0.0043	0.0142	0.1248
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.0384	0.3833
Entamoeba histolytica	DNA repair and recombination protein, putative	0.0034	0.0069	0.3666
Leishmania major	cathepsin L-like protease	0.0036	0.0086	0.0201
Echinococcus granulosus	inositol monophosphatase 1	0.004	0.0118	0.0226
Brugia malayi	Protein kinase domain containing protein	0.0079	0.0432	0.1262
Giardia lamblia	High cysteine membrane protein Group 2	0.0055	0.0243	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0035	0.008	0.0247
Schistosoma mansoni	chromobox protein	0.0073	0.0384	0.0359
Loa Loa (eye worm)	ctsf protein	0.0036	0.0086	0.0266
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0035	0.0082	0.0599
Echinococcus multilocularis	neuropeptide receptor A26	0.051	0.3865	0.9395
Leishmania major	cathepsin L-like protease	0.0036	0.0086	0.0201
Onchocerca volvulus		0.0036	0.0086	0.0848
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0036	0.0086	0.0148
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0086	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0207	0.0638
Echinococcus multilocularis	cyclin B	0.0043	0.0142	0.0183
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0086	0.0649
Onchocerca volvulus		0.0117	0.0736	1
Leishmania major	cathepsin L-like protease	0.0036	0.0086	0.0201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0086	0.0649
Brugia malayi	celfurPC protein	0.012	0.076	0.2282
Brugia malayi	PAN domain containing protein	0.0035	0.008	0.0169
Trypanosoma cruzi	hypothetical protein, conserved	0.0079	0.0432	0.1262
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.0086	0.0266
Schistosoma mansoni	hypothetical protein	0.0034	0.0069	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0086	0.0265
Brugia malayi	PAN domain containing protein	0.0035	0.008	0.0169
Schistosoma mansoni	inositol monophosphatase	0.004	0.0118	0.0093
Brugia malayi	Heterochromatin protein 1	0.0073	0.0384	0.1112
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0029	0.0031	0.0055
Trypanosoma cruzi	cruzipain precursor, putative	0.0036	0.0086	0.0188
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0043	0.0142	0.0828
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0086	0.0188
Brugia malayi	calpain family protein 1	0.0057	0.0259	0.0724
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0149	0.099	0.0967
Loa Loa (eye worm)	PAN domain-containing protein	0.0035	0.008	0.0247
Onchocerca volvulus		0.0035	0.008	0.0764
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0086	0.0649
Brugia malayi	follicle stimulating hormone receptor	0.0262	0.1888	0.5791
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0267	0.0824
Echinococcus multilocularis	cathepsin b	0.0432	0.3242	0.7854
Giardia lamblia	G2/mitotic-specific cyclin B	0.0043	0.0142	0.12
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0091	0.0524	0.1219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0036	0.0086	0.0649
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0034	0.0069	0.0105
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0152	0.1783
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0086	0.5199
Echinococcus granulosus	cathepsin b	0.0432	0.3242	0.7877
Brugia malayi	proprotein convertase 2	0.0094	0.0548	0.1624
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0031	0.0055
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0233	0.1655	0.1634
Echinococcus granulosus	neuropeptide receptor A26	0.051	0.3865	0.9401
Brugia malayi	PAN domain containing protein	0.0035	0.008	0.0169
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0086	0.0649
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0152	0.1356
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0036	0.0086	0.0649
Onchocerca volvulus		0.0079	0.0432	0.5719
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0035	0.0082	0.0056
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0029	0.0031	0.0055
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0128	0.109
Brugia malayi	Inositol-1	0.004	0.0118	0.0287
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0036	0.0086	0.0201
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0086	0.5199
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0043	0.0142	0.0362
Echinococcus multilocularis	chromobox protein 1	0.0073	0.0384	0.078
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0036	0.0086	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0432	0.3242	1
Schistosoma mansoni	furin-1 (S08 family)	0.0065	0.0318	0.0293
Trichomonas vaginalis	cyclins, putative	0.0029	0.0034	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0035	0.008	0.0247
Schistosoma mansoni	chromobox protein	0.0073	0.0384	0.0359
Onchocerca volvulus		0.0035	0.008	0.0764
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0069	0.0458
Trichomonas vaginalis	cyclins, putative	0.0043	0.0142	0.1248
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0086	0.0649
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0086	0.0649
Trichomonas vaginalis	cyclin A, putative	0.0043	0.0142	0.1248
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0031	0.0055
Trichomonas vaginalis	hypothetical protein	0.0029	0.0031	0.0055
Toxoplasma gondii	kringle domain-containing protein	0.0079	0.0432	0.1517
Trypanosoma cruzi	cyclin, putative	0.0043	0.0142	0.0362
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.006	0.0279	0.0254
Trichomonas vaginalis	cyclins, putative	0.0043	0.0142	0.1248
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0031	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0259	0.0798
Echinococcus granulosus	cathepsin l1	0.0036	0.0086	0.0148
Onchocerca volvulus		0.0035	0.008	0.0764
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0432	0.3242	0.3225
Echinococcus granulosus	tissue type plasminogen activator	0.0079	0.0432	0.0994
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0086	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0026	0.008
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0036	0.0086	0.0201
Echinococcus multilocularis	inositol monophosphatase 1	0.004	0.0118	0.0123
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0079	0.0432	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0035	0.008	0.0247
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0034	0.0069	0.0133
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0036	0.0085	0.5
Trichomonas vaginalis	inositol monophosphatase, putative	0.004	0.0118	0.0991
Brugia malayi	PAN domain containing protein	0.0035	0.008	0.0169
Echinococcus multilocularis	cathepsin b	0.0432	0.3242	0.7854
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0145	0.0959	1
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0086	0.0188
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0032	0.0068
Echinococcus multilocularis	cysteine protease	0.0036	0.0086	0.0044
Giardia lamblia	Cathepsin B precursor	0.0145	0.0959	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0128	0.1434
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0086	0.0649
Loa Loa (eye worm)	heterochromatin protein 1	0.0073	0.0384	0.1183
Brugia malayi	calpain family protein 1	0.0057	0.0259	0.0724
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0086	0.0649
Brugia malayi	PAN domain containing protein	0.0035	0.008	0.0169
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0057	0.0259	0.0233
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0091	0.0524	0.5332
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0086	0.0188
Echinococcus granulosus	cyclin B	0.0043	0.0142	0.0285
Onchocerca volvulus		0.0036	0.0086	0.0853
Brugia malayi	chromobox protein homolog 3	0.0041	0.0128	0.0316
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0145	0.0959	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0086	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0026	0.008
Onchocerca volvulus		0.0036	0.0086	0.0853
Trypanosoma cruzi	cysteine peptidase, putative	0.0036	0.0086	0.0188
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0031	0.0055
Brugia malayi	PAN domain containing protein	0.0035	0.008	0.0169
Loa Loa (eye worm)	calpain family protein 1	0.0042	0.0138	0.0425
Toxoplasma gondii	cathepsin CPL	0.0036	0.0086	0.0027
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.006	0.0279	0.0254
Echinococcus multilocularis	Furin 1	0.0035	0.0082	0.0033
Echinococcus granulosus	furin	0.0149	0.099	0.2361
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0118	0.0559
Brugia malayi	PAN domain containing protein	0.0035	0.008	0.0169
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0031	0.0055
Onchocerca volvulus		0.0036	0.0086	0.0853
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0031	0.0055
Schistosoma mansoni	hypothetical protein	0.0029	0.0031	0.0005
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0036	0.0086	0.0201
Onchocerca volvulus		0.0093	0.0541	0.7258
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0118	0.0287
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0091	0.0524	0.5332
Trypanosoma cruzi	cysteine peptidase, putative	0.0036	0.0086	0.0188
Brugia malayi	Kringle domain containing protein	0.0079	0.0432	0.1262
Brugia malayi	PAN domain containing protein	0.0035	0.008	0.0169
Echinococcus multilocularis	calpain A	0.006	0.0279	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0142	0.0439
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0035	0.0082	0.0599
Giardia lamblia	Cathepsin B precursor	0.0145	0.0959	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0036	0.0086	0.0044
Onchocerca volvulus		0.0036	0.0086	0.0853
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0036	0.0086	0.0201
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0086	0.0649
Onchocerca volvulus		0.0035	0.008	0.0764
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0043	0.0142	0.0362
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.0384	0.3833
Echinococcus multilocularis	chromobox protein 1	0.0073	0.0384	0.078
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0541	0.4109	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0036	0.0086	0.0201
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0145	0.0959	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0035	0.008	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0035	0.008	0.0247
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0036	0.0086	0.0044
Loa Loa (eye worm)	PAN domain-containing protein	0.0035	0.008	0.0247
Entamoeba histolytica	hypothetical protein, conserved	0.0034	0.0069	0.3666
Leishmania major	cysteine peptidase A (CPA)	0.0036	0.0086	0.0201
Toxoplasma gondii	PAN domain-containing protein	0.0326	0.2399	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.0086	0.0061
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0036	0.0086	0.0148
Brugia malayi	neuroendocrine convertase 1 precursor	0.0094	0.0548	0.1624
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0035	0.0082	0.0599
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0086	0.0188
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0432	0.3242	0.3225
Toxoplasma gondii	subtilisin SUB12	0.0041	0.0131	0.0219
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0086	0.0188

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 1.4 uM	Inhibition of replication of HCV 1b BK RNA in Huh5-2 cells in presence of 10% fetal calf serum	ChEMBL.	17125247
EC50 (functional)	= 1.4 uM	Inhibition of replication of HCV 1b BK RNA in Huh5-2 cells in presence of 10% fetal calf serum	ChEMBL.	17125247
IC50 (binding)	= 0.038 uM	Inhibition of HCV NS5B RNA polymerase	ChEMBL.	17125247
IC50 (binding)	= 0.038 uM	Inhibition of HCV NS5B RNA polymerase	ChEMBL.	17125247

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	17125247

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL215708
PubChem: 11994885

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 373683