Detailed information for compound 37398

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 408.475 | Formula: C17H24N6O4S
  • H donors: 4 H acceptors: 5 LogP: -1.06 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CS[C@H](C(=O)N1)C)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N)Cc1c[nH]cn1
  • InChi: 1S/C17H24N6O4S/c1-9-15(25)22-12(7-28-9)16(26)21-11(5-10-6-19-8-20-10)17(27)23-4-2-3-13(23)14(18)24/h6,8-9,11-13H,2-5,7H2,1H3,(H2,18,24)(H,19,20)(H,21,26)(H,22,25)/t9-,11-,12?,13+/m0/s1
  • InChiKey: RSHMQGIMHQPMEB-HGEKXBLGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0063 0.0063
Trichomonas vaginalis ran, putative 0.0021 0.0039 0.0226
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.011 0.0386
Echinococcus multilocularis beta LACTamase domain containing family member 0.0216 0.1395 0.1485
Leishmania major GTP-binding protein, putative 0.0021 0.0039 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Mycobacterium ulcerans esterase/lipase LipP 0.0216 0.1395 0.5059
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0017 0.0056
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0232 0.1505 0.9709
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.1966 0.7603
Onchocerca volvulus 0.0115 0.0692 0.3821
Schistosoma mansoni ap endonuclease 0.002 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.0039 0.0163 0.0982
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0184 0.0925
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0625 0.0656
Echinococcus granulosus fmrfamide receptor 0.0115 0.0692 0.0737
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Brugia malayi hypothetical protein 0.0052 0.025 0.0507
Echinococcus granulosus neuropeptide Y receptor 0.0115 0.0692 0.0737
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0272 0.029
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0202
Schistosoma mansoni microtubule-associated protein tau 0.1369 0.9395 0.9395
Schistosoma mansoni hypothetical protein 0.0115 0.0692 0.0692
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0235 0.0476
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0115 0.0692 0.1404
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0165 0.083
Trichomonas vaginalis D-aminoacylase, putative 0.0216 0.1395 0.8997
Plasmodium vivax glutathione reductase, putative 0.0046 0.0214 0.1517
Schistosoma mansoni opsin-like receptor 0.0115 0.0692 0.0692
Echinococcus multilocularis neuropeptide FF receptor 2 0.0115 0.0692 0.0737
Brugia malayi hypothetical protein 0.0115 0.0692 0.1404
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0004 0.0008
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0017 0.0073
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.01 0.01
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.01 0.01
Schistosoma mansoni neuropeptide receptor 0.0115 0.0692 0.0692
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.01 0.0106
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0232 0.1505 0.5819
Brugia malayi hypothetical protein 0.0726 0.4931 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.032 0.2112 0.2112
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.01 0.0106
Loa Loa (eye worm) TAR-binding protein 0.0643 0.4359 0.8839
Echinococcus granulosus neuropeptide Y receptor 0.0115 0.0692 0.0737
Entamoeba histolytica presenilin 1 peptidase, putative 0.0232 0.1505 1
Echinococcus granulosus g-protein coupled receptor 0.0115 0.0692 0.0737
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0202
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0017 0.0017
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0031 0.011 0.2423
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.0446 0.172
Schistosoma mansoni hypothetical protein 0.0684 0.4641 0.4641
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.01 0.0202
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.008 0.0399
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0235 0.1493
Echinococcus multilocularis tar DNA binding protein 0.0643 0.4359 0.4639
Echinococcus granulosus allatostatin A receptor 0.0115 0.0692 0.0737
Loa Loa (eye worm) hypothetical protein 0.0055 0.0272 0.0552
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0101 0.0108
Schistosoma mansoni amine GPCR 0.0115 0.0692 0.0692
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.0446 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0123 0.0127
Loa Loa (eye worm) presenilin spe-4 0.0081 0.0457 0.0927
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0031 0.011 0.0113
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.01 0.0202
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0216 0.1395 0.283
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0017 0.0033
Schistosoma mansoni thyroid hormone receptor 0.003 0.01 0.01
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0133 0.0142
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0053 0.0322
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Echinococcus multilocularis Smad4 0.0035 0.0133 0.0142
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0101 0.0101
Brugia malayi MH1 domain containing protein 0.0019 0.0026 0.0052
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0115 0.0692 0.0737
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0017 0.0057
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Brugia malayi MH2 domain containing protein 0.0035 0.0133 0.027
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0133 0.027
Trichomonas vaginalis D-aminoacylase, putative 0.0216 0.1395 0.8997
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0202
Trypanosoma brucei hypothetical protein, conserved 0.0216 0.1395 0.7093
Brugia malayi hypothetical protein 0.0081 0.0457 0.0927
Onchocerca volvulus 0.0065 0.034 0.1878
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.01 0.0202
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0412 0.2754 0.5586
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0165 0.083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Echinococcus multilocularis neuropeptides capa receptor 0.0115 0.0692 0.0737
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0101 0.0108
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Mycobacterium tuberculosis Conserved protein 0.0216 0.1395 0.1468
Echinococcus granulosus 7TM GPCR rhodopsin 0.0115 0.0692 0.0737
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1383 0.9494 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0115 0.0692 0.0737
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0347
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0115 0.0692 0.0692
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0148 0.092 0.1866
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.011 0.0386
Echinococcus multilocularis rhodopsin orphan GPCR 0.0115 0.0692 0.0737
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.0692 0.0692
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.01 0.0106
Schistosoma mansoni biogenic amine receptor 0.0115 0.0692 0.0692
Echinococcus multilocularis neuropeptide receptor A26 0.0115 0.0692 0.0737
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0031 0.011 0.0488
Schistosoma mansoni hypothetical protein 0.0115 0.0692 0.0692
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0388 0.2585 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0065 0.034 0.1334
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0114 0.0122
Mycobacterium tuberculosis Probable lipase LipD 0.0216 0.1395 0.1468
Toxoplasma gondii thioredoxin reductase 0.0046 0.0214 0.0958
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0101 0.0449
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.0692 0.0692
Loa Loa (eye worm) MH2 domain-containing protein 0.0509 0.3428 0.6952
Echinococcus multilocularis neuropeptide Y receptor 0.0115 0.0692 0.0737
Schistosoma mansoni neuropeptide F-like receptor 0.0115 0.0692 0.0692
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.034 0.0356
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0272 0.0552
Onchocerca volvulus 0.0115 0.0692 0.3821
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Echinococcus granulosus tachykinin peptides receptor 99D 0.0115 0.0692 0.0737
Brugia malayi follicle stimulating hormone receptor 0.0115 0.0692 0.1404
Leishmania major presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative 0.0232 0.1505 0.593
Brugia malayi neuropeptide F receptor 0.0115 0.0692 0.1404
Loa Loa (eye worm) hypothetical protein 0.0183 0.1163 0.2359
Echinococcus multilocularis GPCR, family 2 0.0032 0.0114 0.0122
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.0446 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0006
Mycobacterium tuberculosis Probable hydrolase 0.0216 0.1395 0.1468
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0165 0.1044
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.032 0.2112 0.4283
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0216 0.1395 0.1395
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0101 0.0101
Echinococcus multilocularis neuropeptides capa receptor 0.0115 0.0692 0.0737
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0017 0.0018
Leishmania major 4-coumarate:coa ligase-like protein 0.0065 0.034 0.1334
Echinococcus granulosus g protein coupled receptor 0.0115 0.0692 0.0737
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0115 0.0692 0.0737
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0165 0.083
Plasmodium falciparum glutathione reductase 0.0016 0.0004 0.0033
Loa Loa (eye worm) transcription factor SMAD2 0.0509 0.3428 0.6952
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0114 0.0122
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0031 0.011 0.0386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.01 0.0202
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0115 0.0692 0.1404
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0002 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0031 0.011 0.0223
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0184 0.0704
Echinococcus granulosus neuropeptide receptor A26 0.0115 0.0692 0.0737
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0232 0.1505 0.9709
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0214 0.1517
Giardia lamblia DINP protein human, muc B family 0.0039 0.0165 0.6994
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0091 0.0403
Brugia malayi Dopamine receptor protein 2 0.0115 0.0692 0.1404
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0115 0.0692 0.0737
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0004 0.0006
Echinococcus granulosus neuropeptides capa receptor 0.0115 0.0692 0.0737
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0032 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0165 0.083
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0133 0.0133
Mycobacterium ulcerans lipase LipD 0.0216 0.1395 0.5059
Schistosoma mansoni ran 0.0021 0.0039 0.0039
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0115 0.0692 0.1404
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0707 0.0742
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.032 0.2112 0.4283
Echinococcus multilocularis neuropeptide Y receptor 0.0115 0.0692 0.0737
Schistosoma mansoni biogenic amine receptor 0.0115 0.0692 0.0692
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0123 0.0127
Schistosoma mansoni amine GPCR 0.0115 0.0692 0.0692
Brugia malayi RNA, U transporter 1 0.0081 0.0457 0.0927
Loa Loa (eye worm) hypothetical protein 0.0726 0.4931 1
Onchocerca volvulus 0.0115 0.0692 0.3821
Schistosoma mansoni smad1 5 8 and 0.0035 0.0133 0.0133
Schistosoma mansoni smad1 5 8 and 0.0035 0.0133 0.0133
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.01 0.0202
Leishmania major hypothetical protein, conserved 0.008 0.0446 0.1753
Onchocerca volvulus 0.0115 0.0692 0.3821
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0006
Mycobacterium leprae Probable lipase LipE 0.0216 0.1395 0.5296
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0114 0.0685 0.0729
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0017 0.0073
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0004 0.0006
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0053 0.0198
Echinococcus granulosus peptide allatostatin:somatostatin 0.0115 0.0692 0.0737
Mycobacterium ulcerans hypothetical protein 0.0065 0.034 0.1224
Loa Loa (eye worm) hypothetical protein 0.0216 0.1395 0.283
Brugia malayi RNA binding protein 0.0643 0.4359 0.8839
Mycobacterium ulcerans hypothetical protein 0.0157 0.0985 0.3566
Echinococcus multilocularis smad 0.0035 0.0133 0.0142
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0133 0.027
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0272 0.029
Brugia malayi Melatonin receptor type 1A 0.0115 0.0692 0.1404
Schistosoma mansoni hypothetical protein 0.0296 0.195 0.195
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0235 0.09
Brugia malayi MH1 domain containing protein 0.0019 0.0026 0.0052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0115 0.0692 0.0737
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Toxoplasma gondii propionate-CoA ligase 0.0031 0.011 0.0488
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0184 0.0704
Brugia malayi Serotonin receptor 0.0115 0.0692 0.1404
Brugia malayi isocitrate dehydrogenase 0.0016 0.0002 0.0004
Brugia malayi hypothetical protein 0.0019 0.0027 0.0055
Echinococcus multilocularis presenilin 0.0232 0.1505 0.1602
Echinococcus granulosus g protein coupled receptor 0.0115 0.0692 0.0737
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0115 0.0692 0.0737
Mycobacterium ulcerans beta-lactamase 0.0216 0.1395 0.5059
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0235 0.025
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Echinococcus granulosus beta LACTamase domain containing family member 0.0216 0.1395 0.1485
Loa Loa (eye worm) steroid hormone receptor 0.003 0.01 0.0202
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0114 0.0685 0.0729
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0115 0.0692 0.0737
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0235 0.09
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0004
Schistosoma mansoni smad1 5 8 and 0.0035 0.0133 0.0133
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0032 0.0682
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0017 0.0033
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.01 0.01
Echinococcus granulosus biogenic amine 5HT receptor 0.0115 0.0692 0.0737
Mycobacterium ulcerans hypothetical protein 0.0216 0.1395 0.5059
Echinococcus granulosus G protein coupled receptor 139 0.0115 0.0692 0.0737
Echinococcus multilocularis rhodopsin orphan GPCR 0.0115 0.0692 0.0737
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0141 0.015
Mycobacterium tuberculosis Probable reductase 0.0106 0.0625 0.0656
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0114 0.0685 0.0685
Onchocerca volvulus 0.0115 0.0692 0.3821
Trichomonas vaginalis penicillin-binding protein, putative 0.0216 0.1395 0.8997
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0032 0.012
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0257 0.1677 0.3401
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.01 0.0202
Brugia malayi putative neuropeptide receptor 0.0115 0.0692 0.1404
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0334 0.2209 0.2351
Trichomonas vaginalis penicillin-binding protein, putative 0.0216 0.1395 0.8997
Brugia malayi Steroid receptor seven-up type 2 0.003 0.01 0.0202
Echinococcus multilocularis rhodopsin orphan GPCR 0.0115 0.0692 0.0737
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0039 0.0078
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0017 0.0073
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0031 0.011 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.01 0.0202
Onchocerca volvulus 0.0048 0.0226 0.1248
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0165 0.0631
Echinococcus multilocularis dro:myosuppressin receptor 0.0115 0.0692 0.0737
Brugia malayi hypothetical protein 0.0081 0.0457 0.0927
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.0692 0.0692
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Brugia malayi G-protein coupled receptor 0.0115 0.0692 0.1404
Schistosoma mansoni smad 0.0035 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.0039 0.0163 0.0163
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0216 0.1395 0.1395
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0004 0.0033
Trypanosoma brucei PAB1-binding protein , putative 0.008 0.0446 0.2262
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0874 0.4438
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0133 0.0142
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0006
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.01 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0004
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0039 0.0261
Brugia malayi Presenilin-like protein At2g29900 0.0081 0.0457 0.0927
Echinococcus granulosus geminin 0.0684 0.4641 0.494
Schistosoma mansoni tar DNA-binding protein 0.0643 0.4359 0.4359
Plasmodium falciparum thioredoxin reductase 0.0046 0.0214 0.4758
Echinococcus granulosus rhodopsin orphan GPCR 0.0115 0.0692 0.0737
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0017 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Echinococcus multilocularis g protein coupled receptor 0.0115 0.0692 0.0737
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0141 0.015
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0115 0.0692 0.0692
Trichomonas vaginalis set domain proteins, putative 0.0239 0.155 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0031 0.011 0.0425
Loa Loa (eye worm) hypothetical protein 0.0029 0.0091 0.0185
Trypanosoma brucei protein kinase, putative 0.0049 0.0235 0.1184
Entamoeba histolytica hypothetical protein 0.0039 0.0163 0.0982
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0625 0.0656
Brugia malayi hypothetical protein 0.0019 0.0027 0.0055
Loa Loa (eye worm) beta-lactamase 0.0216 0.1395 0.283
Brugia malayi MH1 domain containing protein 0.0035 0.0133 0.027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Schistosoma mansoni neuropeptide f receptor 76f 0.0115 0.0692 0.0692
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.01 0.0106
Loa Loa (eye worm) RNA binding protein 0.0643 0.4359 0.8839
Brugia malayi hypothetical protein 0.0115 0.0692 0.1404
Echinococcus multilocularis dna polymerase eta 0.0039 0.0165 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Echinococcus multilocularis tumor protein p63 0.0335 0.222 0.2363
Entamoeba histolytica Ran family GTPase 0.0021 0.0039 0.0148
Echinococcus granulosus Smad4 0.0035 0.0133 0.0142
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0114 0.0122
Brugia malayi G protein-coupled receptor F59B2.13 0.0115 0.0692 0.1404
Loa Loa (eye worm) hypothetical protein 0.0216 0.1395 0.283
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0115 0.0692 0.0737
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.01 0.0202
Loa Loa (eye worm) oxidoreductase 0.0031 0.011 0.0223
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Echinococcus multilocularis FTZ F1 alpha 0.003 0.01 0.0106
Onchocerca volvulus 0.0115 0.0692 0.3821
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Echinococcus multilocularis neuropeptide s receptor 0.0115 0.0692 0.0737
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0031 0.011 0.0117
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0091 0.0452
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0032 1
Brugia malayi hypothetical protein 0.0115 0.0692 0.1404
Echinococcus granulosus dna polymerase kappa 0.0039 0.0165 0.0176
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0226 0.0226
Mycobacterium ulcerans fatty-acid-CoA ligase 0.004 0.0171 0.0609
Onchocerca volvulus 0.0115 0.0692 0.3821
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0017 0.0056
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0115 0.0692 0.0737
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0031 0.011 0.0386
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.01 0.0202
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0165 0.0631
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0235 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0065 0.034 0.1224
Schistosoma mansoni nuclear hormone receptor 0.003 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0165 0.083
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0055
Echinococcus granulosus serotonin receptor 0.0115 0.0692 0.0737
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0115 0.0692 0.0692
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0381 0.2537 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0027 0.0027
Brugia malayi RE15519p 0.0115 0.0692 0.1404
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0235 0.0917
Loa Loa (eye worm) neuropeptide F receptor 0.0115 0.0692 0.1404
Leishmania major fatty acid transporter protein-like protein 0.0381 0.2537 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0115 0.0692 0.1404
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0006
Brugia malayi ORL1-like opioid receptor 0.0115 0.0692 0.1404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.01 0.0202
Plasmodium falciparum acyl-CoA synthetase 0.004 0.0171 0.3801
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0031 0.011 0.0386
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0032 0.0107
Trichomonas vaginalis D-aminoacylase, putative 0.0216 0.1395 0.8997
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0017 0.0057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Onchocerca volvulus Neuropeptide F receptor homolog 0.0115 0.0692 0.3821
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.011 0.0386
Entamoeba histolytica acyl-CoA synthetase, putative 0.0065 0.034 0.2174
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0235 0.025
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Trypanosoma cruzi hypothetical protein, conserved 0.0216 0.1395 0.5393
Brugia malayi mbt repeat family protein 0.0048 0.0226 0.0459
Schistosoma mansoni subfamily A22A unassigned peptidase (A22 family) 0.0232 0.1505 0.1505
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0062 0.0063
Onchocerca volvulus 0.0031 0.011 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0165 0.0165
Echinococcus granulosus 7tm_1 domain containing protein 0.0115 0.0692 0.0737
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.1966 0.7603
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0214 0.0227
Brugia malayi neuropeptide F receptor 0.0115 0.0692 0.1404
Echinococcus multilocularis serotonin receptor 0.0115 0.0692 0.0737
Brugia malayi AMP-binding enzyme family protein 0.0065 0.034 0.069
Brugia malayi nuclear receptor NHR-88 0.003 0.01 0.0202
Schistosoma mansoni hypothetical protein 0.0115 0.0692 0.0692
Onchocerca volvulus 0.003 0.0101 0.0559
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0707 0.246
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0216 0.1395 0.1468
Brugia malayi mbt repeat family protein 0.0048 0.0226 0.0459
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0165 0.083
Trypanosoma brucei unspecified product 0.0027 0.008 0.0399
Brugia malayi Importin beta-1 subunit 0.0029 0.0091 0.0185
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Echinococcus granulosus importin subunit beta 1 0.0029 0.0091 0.0097
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0115 0.0692 0.0692
Schistosoma mansoni growth hormone secretagogue receptor 0.0115 0.0692 0.0692
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.01 0.01
Brugia malayi Tachykinin-like peptides receptor 99D 0.0115 0.0692 0.1404
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0031 0.011 0.0417
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0031 0.011 0.0386
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0226 0.0241
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0039 0.0078
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.011 0.0223
Toxoplasma gondii hypothetical protein 0.0048 0.0227 0.1018
Brugia malayi larval opioid receptor 0.0115 0.0692 0.1404
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.01 0.0106
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0032 0.0035
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0163 0.0173
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0004 0.0007
Schistosoma mansoni thyroid hormone receptor 0.003 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0347
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0114 0.0685 0.139
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Plasmodium falciparum thioredoxin reductase 0.0016 0.0004 0.0033
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0232 0.1505 0.5819
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.01 0.0106
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.01 0.01
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0115 0.0692 0.0692
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0216 0.1395 0.283
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0031 0.011 0.0113
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0643 0.4359 0.8839
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.011 0.0113
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0004 0.0033
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0226 0.1248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0065 0.034 0.1224
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.0692 0.0692
Loa Loa (eye worm) hypothetical protein 0.0216 0.1395 0.283
Echinococcus granulosus microtubule associated protein 2 0.1369 0.9395 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0031 0.011 0.0386
Loa Loa (eye worm) hypothetical protein 0.0101 0.0594 0.1204
Loa Loa (eye worm) hypothetical protein 0.0101 0.0594 0.1204
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0226 0.0241
Brugia malayi Dopamine receptor 0.0115 0.0692 0.1404
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.034 0.1224
Entamoeba histolytica hypothetical protein 0.0039 0.0163 0.0982
Brugia malayi glutathione reductase 0.0046 0.0214 0.0433
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0115 0.0692 0.0692
Echinococcus granulosus presenilin 0.0232 0.1505 0.1602
Schistosoma mansoni hypothetical protein 0.0032 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0063 0.0309
Schistosoma mansoni tar DNA-binding protein 0.0643 0.4359 0.4359
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.0692 0.0692
Schistosoma mansoni hypothetical protein 0.0032 0.0114 0.0114
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0165 0.0335
Brugia malayi nuclear hormone receptor 0.0257 0.1677 0.3401
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0115 0.0692 0.1404
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.032 0.2112 0.2248
Trypanosoma brucei unspecified product 0.0027 0.008 0.0399
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0063 0.0067
Brugia malayi hypothetical protein 0.0101 0.0594 0.1204
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0031 0.011 0.0417
Echinococcus multilocularis g-protein coupled receptor 0.0115 0.0692 0.0737
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.01 0.0106
Brugia malayi beta-lactamase 0.0216 0.1395 0.283
Leishmania major hypothetical protein, conserved 0.0216 0.1395 0.5496
Loa Loa (eye worm) nuclear factor I 0.0019 0.0026 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.011 0.0386
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0165 0.1044
Echinococcus granulosus rhodopsin orphan GPCR 0.0115 0.0692 0.0737
Brugia malayi nuclear receptor RXR 0.0019 0.0027 0.0055
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0017 0.0033
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0163 0.0163
Onchocerca volvulus 0.0216 0.1395 0.7699
Mycobacterium leprae conserved hypothetical protein 0.0216 0.1395 0.5296
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0165 0.083
Echinococcus granulosus orexin receptor type 2 0.0115 0.0692 0.0737
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.032 0.2112 0.2112
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0114 0.0122
Schistosoma mansoni alpha-1 adrenergic receptor 0.0115 0.0692 0.0692
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0002 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0004 0.0006
Brugia malayi steroid hormone receptor 0.003 0.01 0.0202
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0226 0.0241
Mycobacterium tuberculosis Probable lipase LipE 0.0216 0.1395 0.1468
Brugia malayi hypothetical protein 0.0081 0.0457 0.0927
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0235 0.09
Trypanosoma brucei presenilin-like aspartic peptidase, putative 0.0232 0.1505 0.7654
Echinococcus multilocularis rhodopsin orphan GPCR 0.0115 0.0692 0.0737
Echinococcus multilocularis geminin 0.0684 0.4641 0.494
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0002 0.0002
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0184 0.0704
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0114 0.0685 0.0729
Brugia malayi nuclear hormone receptor 0.003 0.01 0.0202
Brugia malayi putative neuropeptide receptor NPR1 0.0115 0.0692 0.1404
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.01 0.01
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.01 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0165 0.0176
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0006
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0063 0.0235
Brugia malayi GnHR receptor homolog 0.0115 0.0692 0.1404
Loa Loa (eye worm) hypothetical protein 0.0247 0.1605 0.3254
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0039 0.0143
Echinococcus multilocularis sex peptide receptor 0.0115 0.0692 0.0737
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0115 0.0692 0.0737
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0202
Brugia malayi Presenilin spe-4 0.0081 0.0457 0.0927
Onchocerca volvulus 0.0031 0.011 0.0606
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0031 0.011 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Onchocerca volvulus 0.0115 0.0692 0.3821
Schistosoma mansoni biogenic amine (5HT) receptor 0.0115 0.0692 0.0692
Loa Loa (eye worm) hypothetical protein 0.0069 0.0372 0.0754
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0123 0.0127
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.01 0.0106
Brugia malayi AMP-binding enzyme family protein 0.0412 0.2754 0.5586
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0002 0.0002
Echinococcus granulosus GPCR family 2 0.0032 0.0114 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0165 0.083
Mycobacterium tuberculosis Probable esterase LipL 0.0216 0.1395 0.1468
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0216 0.1395 0.1468
Onchocerca volvulus 0.0115 0.0692 0.3821
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0232 0.1505 0.9709
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Onchocerca volvulus 0.0115 0.0692 0.3821
Onchocerca volvulus 0.0216 0.1395 0.7699
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0388 0.2585 1
Schistosoma mansoni FFA transport protein 0.0388 0.2585 0.2585
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0115 0.0692 0.0737
Mycobacterium tuberculosis Conserved protein 0.0216 0.1395 0.1468
Schistosoma mansoni opsin-like receptor 0.0115 0.0692 0.0692
Onchocerca volvulus 0.0239 0.155 0.8555
Echinococcus granulosus hypothetical protein 0.0115 0.0692 0.0737
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.011 0.0386
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.1349 0.2736
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0065 0.034 0.069
Brugia malayi AMP-binding enzyme family protein 0.0031 0.011 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.0446 0.172
Echinococcus granulosus somatostatin receptor 0.0115 0.0692 0.0737
Schistosoma mansoni myosin xvIII 0.0115 0.0692 0.0692
Echinococcus granulosus biogenic amine 5HT receptor 0.0115 0.0692 0.0737
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0017 0.0057
Schistosoma mansoni survival motor neuron protein 0.0148 0.092 0.092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.0692 0.0692
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.008 0.0399
Echinococcus granulosus neuropeptide s receptor 0.0115 0.0692 0.0737
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0017 0.0058
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.01 0.0106
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0165 0.0631
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0115 0.0692 0.0692
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0032 0.0105
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0115 0.0692 0.0692
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0133 0.0142
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0165 0.083
Brugia malayi MH2 domain containing protein 0.0509 0.3428 0.6952
Loa Loa (eye worm) hypothetical protein 0.0101 0.0594 0.1204
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0017 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.0692 0.0692
Brugia malayi hypothetical protein 0.0115 0.0692 0.1404
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0031 0.011 0.0417
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.01 0.0106
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0055
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0017 0.0018
Onchocerca volvulus 0.0115 0.0692 0.3821
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0707 0.0742
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.01 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Schistosoma mansoni DNA polymerase eta 0.0039 0.0165 0.0165
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0065 0.034 0.1224
Echinococcus multilocularis orexin receptor type 2 0.0115 0.0692 0.0737
Toxoplasma gondii hypothetical protein 0.0081 0.0457 0.2062
Toxoplasma gondii ABC1 family protein 0.0216 0.1395 0.6314
Trypanosoma cruzi hypothetical protein, conserved 0.0216 0.1395 0.5393
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.01 0.0202
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.01 0.01
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0115 0.0692 0.0737
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0032 0.0218
Schistosoma mansoni hypothetical protein 0.0115 0.0692 0.0692
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.01 0.0106
Brugia malayi hypothetical protein 0.008 0.0446 0.0905
Loa Loa (eye worm) hypothetical protein 0.0065 0.034 0.069
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0115 0.0692 0.0692
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0114 0.0685 0.139
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0165 0.0643
Echinococcus granulosus tar DNA binding protein 0.0643 0.4359 0.4639
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0115 0.0692 0.0692
Schistosoma mansoni acetyl-CoA synthetase 0.0031 0.011 0.011
Schistosoma mansoni Smad4 0.0035 0.0133 0.0133
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0004 0.0011
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0031 0.011 0.0113
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0235 0.09
Plasmodium falciparum glutathione reductase 0.0046 0.0214 0.4758
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0202
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0165 0.0172
Brugia malayi Pre-SET motif family protein 0.021 0.1349 0.2736
Mycobacterium ulcerans acetyl-CoA synthetase 0.0031 0.011 0.0386
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0004 0.0006
Brugia malayi RNA recognition motif domain containing protein 0.0643 0.4359 0.8839
Brugia malayi MH1 domain containing protein 0.0035 0.0133 0.027
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0115 0.0692 0.0737
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.01 0.0202
Brugia malayi ecdysteroid receptor 0.003 0.01 0.0202
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0163 0.0173
Brugia malayi AKH receptor 0.0115 0.0692 0.1404
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0039 0.0185
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0272 0.029
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0372 0.0754
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0053 0.0322
Plasmodium vivax hypothetical protein, conserved 0.0216 0.1395 1
Brugia malayi AMP-binding enzyme family protein 0.0065 0.034 0.069
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0194 0.1236 0.1316
Loa Loa (eye worm) hypothetical protein 0.003 0.0101 0.0205
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.034 0.1224
Schistosoma mansoni amine GPCR 0.0115 0.0692 0.0692
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0017 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0235 0.0235
Echinococcus granulosus rhodopsin orphan GPCR 0.0115 0.0692 0.0737
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0277 0.1812 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.011 0.0113
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0004 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.01 0.0202
Loa Loa (eye worm) hypothetical protein 0.0031 0.011 0.0223
Leishmania major trypanothione reductase 0.0046 0.0214 0.0834
Loa Loa (eye worm) hypothetical protein 0.0049 0.0233 0.0473
Schistosoma mansoni ran 0.0021 0.0039 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0101 0.0101
Plasmodium vivax ataxin-2 like protein, putative 0.008 0.0446 0.3189
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0226 0.0241
Schistosoma mansoni histamine h1 receptor 0.0115 0.0692 0.0692
Onchocerca volvulus 0.003 0.01 0.055
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0004 0.0006
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0063 0.0128
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0115 0.0692 0.0737
Loa Loa (eye worm) hypothetical protein 0.008 0.0446 0.0905
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0027 0.0029
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0032 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0165 0.0587
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.011 0.0386
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.032 0.2112 0.2248
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0165 0.0631
Brugia malayi Dopamine receptor protein 1 0.0115 0.0692 0.1404
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.01 0.055
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Onchocerca volvulus 0.0115 0.0692 0.3821
Giardia lamblia GTOR 0.0018 0.0017 0.0557
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0031 0.011 0.0627
Echinococcus granulosus neuropeptide FF receptor 2 0.0115 0.0692 0.0737
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0048 0.0226 0.0459
Trichomonas vaginalis antibiotic synthetase, putative 0.0031 0.011 0.0687
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0027 0.0055
Schistosoma mansoni hypothetical protein 0.0684 0.4641 0.4641
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.1966 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0625 0.0656
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0115 0.0692 0.1404
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0235 0.1493
Trichomonas vaginalis antibiotic synthetase, putative 0.0031 0.011 0.0687
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0115 0.0692 0.0737
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0101 0.0108
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Toxoplasma gondii exonuclease III APE 0.002 0.0032 0.0137
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0272 0.0272
Schistosoma mansoni tar DNA-binding protein 0.0643 0.4359 0.4359
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0017 0.0018
Brugia malayi sulfakinin receptor protein 0.0115 0.0692 0.1404
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0214 0.0433
Brugia malayi MAP kinase sur-1 0.0049 0.0235 0.0476
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0065 0.034 0.1224
Schistosoma mansoni hypothetical protein 0.0305 0.2013 0.2013
Plasmodium vivax acyl-CoA synthetase, putative 0.004 0.0171 0.1212
Loa Loa (eye worm) MBCTL1 0.0055 0.0272 0.0552
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0233 0.0233
Trypanosoma brucei trypanothione reductase 0.0046 0.0214 0.1076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0165 0.083
Schistosoma mansoni adenoreceptor 0.0115 0.0692 0.0692
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.0692 0.0692
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0115 0.0692 0.0737
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0165 0.0335
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.01 0.0202
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0165 0.0999
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.01 0.01
Leishmania major acetyl-CoA synthetase, putative 0.0031 0.011 0.0425
Schistosoma mansoni hypothetical protein 0.0032 0.0114 0.0114
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0707 0.0742
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0052
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0032 0.0117
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0115 0.0692 0.0737
Echinococcus multilocularis g protein coupled receptor 0.0115 0.0692 0.0737
Plasmodium vivax importin-beta 2, putative 0.0029 0.0091 0.0638
Echinococcus granulosus neuropeptides capa receptor 0.0115 0.0692 0.0737
Schistosoma mansoni hypothetical protein 0.0069 0.0372 0.0372
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.011 0.0386
Leishmania major 4-coumarate:coa ligase-like protein 0.0065 0.034 0.1334
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0065 0.034 0.0356
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.011 0.0113
Schistosoma mansoni neuropeptide F-like receptor 0.0115 0.0692 0.0692
Brugia malayi G-protein coupled receptor 0.0115 0.0692 0.1404
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0031 0.011 0.0417
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0115 0.0692 0.0737
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0063 0.0067
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0874 0.3374
Schistosoma mansoni hypothetical protein 0.0032 0.0114 0.0114
Onchocerca volvulus 0.0049 0.0233 0.1286
Onchocerca volvulus Bile acid receptor homolog 0.003 0.01 0.055
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0115 0.0692 0.0737
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.01 0.0202
Echinococcus multilocularis fmrfamide receptor 0.0115 0.0692 0.0737
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0594 0.1204
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0079
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0272 0.029
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0625 0.0656
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0235 0.1493
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0031 0.011 0.0223
Brugia malayi beta-lactamase family protein 0.0216 0.1395 0.283
Loa Loa (eye worm) G-protein coupled receptor 0.0115 0.0692 0.1404
Echinococcus granulosus long chain fatty acid transport protein 4 0.0388 0.2585 0.2752
Onchocerca volvulus 0.0148 0.092 0.5077
Echinococcus granulosus tumor protein p63 0.0335 0.222 0.2363
Echinococcus multilocularis allatostatin A receptor 0.0115 0.0692 0.0737
Brugia malayi hypothetical protein 0.0115 0.0692 0.1404
Echinococcus multilocularis microtubule associated protein 2 0.1369 0.9395 1
Brugia malayi hypothetical protein 0.0115 0.0692 0.1404
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0226 0.0459
Onchocerca volvulus 0.0031 0.011 0.0606
Schistosoma mansoni hypothetical protein 0.0036 0.0141 0.0141
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0006
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0235 0.025
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0165 0.0172
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0226 0.0226
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0027 0.0055
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0031 0.011 0.0117
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0004 0.0002
Loa Loa (eye worm) Smad1 0.0035 0.0133 0.027
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0031 0.011 0.0386
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0115 0.0692 0.0737
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0017 0.0056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.032 0.2112 0.2248
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0031 0.011 0.0548
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.034 0.1224
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0412 0.2754 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.01 0.0106
Schistosoma mansoni neuropeptide receptor 0.0115 0.0692 0.0692
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0235 0.0917
Trypanosoma brucei unspecified product 0.0039 0.0165 0.083
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.01 0.0202
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0216 0.1395 0.1468
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0027 0.0027
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.1966 0.7748
Onchocerca volvulus 0.0115 0.0692 0.3821
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0002 0.0004
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0027 0.0029
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0031 0.011 0.0113
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0347
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Echinococcus granulosus dro:myosuppressin receptor 0.0115 0.0692 0.0737
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0039 0.1511
Brugia malayi hypothetical protein 0.0115 0.0692 0.1404
Brugia malayi Smad1 0.0035 0.0133 0.027
Schistosoma mansoni microsomal glutathione s-transferase 0.0334 0.2209 0.2209
Schistosoma mansoni biogenic amine receptor 0.0115 0.0692 0.0692
Echinococcus granulosus rhodopsin orphan GPCR 0.0115 0.0692 0.0737
Echinococcus multilocularis survival motor neuron protein 1 0.0726 0.4931 0.5249
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0235 0.1493
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Schistosoma mansoni coup transcription factor 0.003 0.01 0.01
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0123 0.0127
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0031 0.011 0.0548
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0031 0.011 0.0386
Echinococcus multilocularis snurportin 1 0.0305 0.2013 0.2143
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0115 0.0692 0.1404
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0214 0.0227
Echinococcus multilocularis rhodopsin orphan GPCR 0.0115 0.0692 0.0737
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0165 0.0587
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0115 0.0692 0.0737
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0165 0.0165
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.004 0.0171 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0165 0.0335
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0031 0.011 0.0113
Schistosoma mansoni amine GPCR 0.0115 0.0692 0.0692
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.032 0.2112 0.2248
Plasmodium vivax acetyl-CoA synthetase, putative 0.0031 0.011 0.0773
Loa Loa (eye worm) glutathione reductase 0.0046 0.0214 0.0433
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.004 0.0171 0.0178
Schistosoma mansoni neuropeptide receptor 0.0115 0.0692 0.0692
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0027 0.0055
Echinococcus granulosus g protein coupled receptor 0.0115 0.0692 0.0737
Loa Loa (eye worm) hypothetical protein 0.0032 0.0114 0.0232
Loa Loa (eye worm) hypothetical protein 0.0216 0.1395 0.283
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0347
Loa Loa (eye worm) neuropeptide F receptor 0.0115 0.0692 0.1404
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0032 0.0035
Brugia malayi Presenilin spe-4 0.0081 0.0457 0.0927
Schistosoma mansoni tar DNA-binding protein 0.0643 0.4359 0.4359
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0115 0.0692 0.0692
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0063 0.0275
Entamoeba histolytica hypothetical protein 0.0039 0.0163 0.0982
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0388 0.2585 0.2752
Plasmodium falciparum importin beta, putative 0.0029 0.0091 0.1999
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0133 0.0142
Schistosoma mansoni neuropeptide receptor 0.0115 0.0692 0.0692
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0017 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.0115 0.0692 0.0737
Brugia malayi Pre-SET motif family protein 0.003 0.0101 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.008 0.0399
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0115 0.0692 0.0692
Entamoeba histolytica acyl-CoA synthetase, putative 0.0065 0.034 0.2174
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0115 0.0692 0.3821
Loa Loa (eye worm) G-protein coupled receptor 0.0115 0.0692 0.1404
Onchocerca volvulus 0.0115 0.0692 0.3821
Brugia malayi Thioredoxin reductase 0.0046 0.0214 0.0433
Entamoeba histolytica hypothetical protein 0.0025 0.0063 0.0312
Leishmania major DNA polymerase kappa, putative 0.0039 0.0165 0.0643
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0165 0.0631
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.01 0.01
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0115 0.0692 0.1404
Loa Loa (eye worm) hypothetical protein 0.0031 0.011 0.0223
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.011 0.0386
Leishmania major DNA polymerase eta, putative 0.0039 0.0165 0.0643
Schistosoma mansoni opsin-like receptor 0.0115 0.0692 0.0692
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0053 0.0322
Echinococcus multilocularis rhodopsin orphan GPCR 0.0115 0.0692 0.0737
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0202
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.01 0.0202
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0091 0.0097
Onchocerca volvulus 0.0216 0.1395 0.7699
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0114 0.0685 0.0729
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Mycobacterium tuberculosis Conserved protein 0.0216 0.1395 0.1468
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0115 0.0692 0.0737
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.032 0.2112 0.2112
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0165 0.083
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0032 0.1248
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0039 0.0165
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0039 0.0041
Echinococcus multilocularis G protein coupled receptor 139 0.0115 0.0692 0.0737
Loa Loa (eye worm) hypothetical protein 0.0216 0.1395 0.283
Brugia malayi MH2 domain containing protein 0.0035 0.0133 0.027
Echinococcus multilocularis neuropeptide receptor 0.0115 0.0692 0.0737
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0031 0.011 0.0113
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0115 0.0692 0.1404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Brugia malayi Presenilin spe-4 0.0081 0.0457 0.0927
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0194 0.1236 0.1316
Trichomonas vaginalis conserved hypothetical protein 0.0178 0.1128 0.7271
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0165 0.0335
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0032 0.0186
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0114 0.0232
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0002 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0165 0.083
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.01 0.0106
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0039 0.0041
Brugia malayi hypothetical protein 0.0115 0.0692 0.1404
Echinococcus multilocularis rhodopsin orphan GPCR 0.0115 0.0692 0.0737
Brugia malayi G protein-coupled receptor 0.0115 0.0692 0.1404
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0101 0.0101
Echinococcus granulosus tm gpcr rhodopsin 0.0115 0.0692 0.0737
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0039 0.0819
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Schistosoma mansoni biogenic amine (5HT) receptor 0.0115 0.0692 0.0692
Echinococcus multilocularis somatostatin receptor 0.0115 0.0692 0.0737
Onchocerca volvulus 0.0115 0.0692 0.3821
Echinococcus multilocularis g protein coupled receptor 0.0115 0.0692 0.0737
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0235 0.025
Brugia malayi TAR-binding protein 0.0643 0.4359 0.8839
Brugia malayi Serotonin receptor 0.0115 0.0692 0.1404
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0032 0.0117
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Plasmodium vivax SET domain protein, putative 0.003 0.0101 0.0711
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0165 0.083
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0381 0.2537 0.267
Brugia malayi AMP-binding enzyme family protein 0.0065 0.034 0.069
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0031 0.011 0.0223
Loa Loa (eye worm) TYRA-2 protein 0.0115 0.0692 0.1404
Onchocerca volvulus 0.0031 0.011 0.0606
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0625 0.0656
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0183 0.1163 0.2359
Schistosoma mansoni tar DNA-binding protein 0.0643 0.4359 0.4359
Brugia malayi AMP-binding enzyme family protein 0.0031 0.011 0.0223
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0004
Echinococcus granulosus alpha 1A adrenergic receptor 0.0115 0.0692 0.0737
Brugia malayi hypothetical protein 0.0039 0.0163 0.033
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0165 0.083
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0065 0.034 0.0949
Toxoplasma gondii LsmAD domain-containing protein 0.008 0.0446 0.2014
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0216 0.1395 0.5059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0055
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0091 0.0452
Echinococcus granulosus dna polymerase eta 0.0039 0.0165 0.0176
Echinococcus granulosus sex peptide receptor 0.0115 0.0692 0.0737
Echinococcus granulosus snurportin 1 0.0305 0.2013 0.2143
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0004 0.0008
Leishmania major importin beta-1 subunit, putative 0.0023 0.0053 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Entamoeba histolytica acyl-coA synthetase, putative 0.0065 0.034 0.2174
Brugia malayi hypothetical protein 0.0115 0.0692 0.1404
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Echinococcus multilocularis G-protein coupled receptor, putative 0.0115 0.0692 0.0737
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.01 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.01 0.0202
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0039 0.0141
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0008
Schistosoma mansoni ap endonuclease 0.002 0.0032 0.0032
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0017 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0063 0.0383
Brugia malayi hypothetical protein 0.0115 0.0692 0.1404
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0017 0.0057
Echinococcus granulosus neuropeptide receptor 0.0115 0.0692 0.0737
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0248 0.0951
Schistosoma mansoni hypothetical protein 0.0148 0.092 0.092
Echinococcus granulosus neuropeptide receptor 0.0115 0.0692 0.0737
Leishmania major acetyl-CoA synthetase, putative 0.0031 0.011 0.0425
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0347
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0032 0.0032
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0032 0.0066
Schistosoma mansoni amine GPCR 0.0115 0.0692 0.0692
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0165 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0594 0.1204
Echinococcus multilocularis serotonin receptor 0.0115 0.0692 0.0737
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0202
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0985 0.1035
Echinococcus granulosus smad 0.0035 0.0133 0.0142
Loa Loa (eye worm) hypothetical protein 0.0216 0.1395 0.283
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0017 0.0033
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0115 0.0692 0.1404
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.01 0.0202
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0165 0.0176
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0006
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0017 0.0056
Schistosoma mansoni eyes absent homolog 0.0101 0.0594 0.0594
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.2013 0.4083
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0004 0.0007
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0214 0.0818
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0235 0.1053
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0065 0.034 0.0949
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0094 0.01
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0017 0.0073
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.011 0.0113
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0032 0.0154
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0594 0.1204
Toxoplasma gondii MAPEG family protein 0.0334 0.2209 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0114 0.0232
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0017 0.0073
Entamoeba histolytica hypothetical protein 0.0023 0.0053 0.0248
Onchocerca volvulus 0.0115 0.0692 0.3821
Onchocerca volvulus 0.0115 0.0692 0.3821
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0039 0.0141
Echinococcus multilocularis neuropeptide receptor 0.0115 0.0692 0.0737
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0055
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0032 0.0186
Echinococcus multilocularis fmrfamide receptor 0.0115 0.0692 0.0737
Brugia malayi Presenilin family protein 0.0232 0.1505 0.3053
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0008
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0004 0.0007
Trichomonas vaginalis esterase, putative 0.0216 0.1395 0.8997
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.0692 0.0692
Schistosoma mansoni importin beta-1 0.0029 0.0091 0.0091
Echinococcus granulosus tm gpcr rhodopsin 0.0115 0.0692 0.0737
Echinococcus granulosus microsomal glutathione S transferase 3 0.0334 0.2209 0.2351
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.01 0.0202
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0874 0.3439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0017 0.0083
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0625 0.2123
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0115 0.0692 0.0692
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.01 0.0202
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0235 0.1184
Loa Loa (eye worm) hypothetical protein 0.0065 0.034 0.069
Echinococcus granulosus FTZ F1 alpha 0.003 0.01 0.0106
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0115 0.0692 0.1404
Echinococcus granulosus survival motor neuron protein 1 0.0726 0.4931 0.5249
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0214 0.0223
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Brugia malayi beta-lactamase family protein 0.0216 0.1395 0.283
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0114 0.0232
Loa Loa (eye worm) hypothetical protein 0.0115 0.0692 0.1404
Echinococcus granulosus rhodopsin orphan GPCR 0.0115 0.0692 0.0737
Echinococcus granulosus tm gpcr rhodopsin 0.0115 0.0692 0.0737

Activities

Activity type Activity value Assay description Source Reference
Relative activity (functional) = 17 Relative CNS activity against reserpine hypothermia in mice relatived to TRH ChEMBL. 3917509

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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