Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0401 | 0.2464 | 0.2464 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.1215 | 0.1215 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.0976 | 0.0976 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0928 | 0.6622 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0928 | 0.6622 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0928 | 0.6622 | 0.5 |
Giardia lamblia | Kinase, STE STE20 | 0.009 | 0 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1355 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0156 | 0.0521 | 0.0787 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0928 | 0.6622 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0327 | 0.1876 | 0.1876 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0928 | 0.6622 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0327 | 0.1876 | 0.1876 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0327 | 0.1876 | 0.1876 |
Loa Loa (eye worm) | thymidylate synthase | 0.0327 | 0.1876 | 0.1876 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1355 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0156 | 0.0521 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0327 | 0.1876 | 0.143 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0243 | 0.1215 | 0.1215 |
Onchocerca volvulus | 0.0327 | 0.1876 | 0.5 | |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1355 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1355 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.1355 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1355 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0928 | 0.6622 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1355 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1355 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0156 | 0.0521 | 0.0521 |
Brugia malayi | thymidylate synthase | 0.0327 | 0.1876 | 0.1876 |
Echinococcus granulosus | dihydrofolate reductase | 0.1355 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 28654 ng h/ml | AUC following oral dose | ChEMBL. | 16934458 |
EC50 (functional) | = 140 nM | Inhibitory activity against MEK-1 | ChEMBL. | 16934458 |
EC50 (functional) | = 140 nM | Inhibitory activity against MEK-1 | ChEMBL. | 16934458 |
IC50 (binding) | = 44 nM | Inhibition of MEK-1 activity | ChEMBL. | 16934458 |
IC50 (binding) | = 44 nM | Inhibition of MEK-1 activity | ChEMBL. | 16934458 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.