Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0223 | 0.7102 | 1 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 0.7102 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.8692 | 1 |
Leishmania major | acyl-CoA oxidase, putative | 0.0037 | 0.0744 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 0.7102 | 1 |
Trypanosoma cruzi | acyl-CoA oxidase, putative | 0.0037 | 0.0744 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0744 | 0.0856 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0015 | 0 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0744 | 0.1048 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 0.7102 | 1 |
Toxoplasma gondii | acyl-CoA dehydrogenase, middle domain-containing protein | 0.0308 | 1 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0223 | 0.7102 | 0.7102 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 0.7102 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 0.7102 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 0.7102 | 0.5 |
Trypanosoma brucei | acyl-CoA oxidase, putative | 0.0037 | 0.0744 | 1 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0744 | 0.0744 |
Schistosoma mansoni | dihydropteridine reductase | 0.0015 | 0 | 0.5 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0015 | 0 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0223 | 0.7102 | 1 |
Trypanosoma cruzi | acyl-CoA oxidase, putative | 0.0037 | 0.0744 | 1 |
Mycobacterium ulcerans | acyl-CoA dehydrogenase | 0.0038 | 0.0792 | 0.1115 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | acyl-CoA oxidase | 0.019 | 0.597 | 0.6868 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.14 uM | Inhibition of Mycobacterium tuberculosis InhA | ChEMBL. | 17034137 |
IC50 (binding) | = 0.14 uM | Inhibition of Mycobacterium tuberculosis InhA | ChEMBL. | 17034137 |
Inhibition (binding) | = 70 % | Inhibition of Mycobacterium tuberculosis InhA at 15 uM | ChEMBL. | 17034137 |
Inhibition (binding) | = 70 % | Inhibition of Mycobacterium tuberculosis InhA at 15 uM | ChEMBL. | 17034137 |
Inhibition (binding) | = 72.7 % | Inhibition of Mycobacterium tuberculosis InhA at 2.4 uM | ChEMBL. | 17034137 |
Inhibition (binding) | = 72.7 % | Inhibition of Mycobacterium tuberculosis InhA at 2.4 uM | ChEMBL. | 17034137 |
Inhibition (binding) | = 90 % | Inhibition of Mycobacterium tuberculosis InhA at 1.5 uM | ChEMBL. | 17034137 |
Inhibition (binding) | > 90 % | Inhibition of Mycobacterium tuberculosis InhA at 15 uM | ChEMBL. | 17034137 |
Inhibition (binding) | = 90 % | Inhibition of Mycobacterium tuberculosis InhA at 1.5 uM | ChEMBL. | 17034137 |
Inhibition (binding) | > 90 % | Inhibition of Mycobacterium tuberculosis InhA at 15 uM | ChEMBL. | 17034137 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.