Ki (binding)
|
= 1.1 uM
|
Inhibition of Escherichia coli thymidylate synthase
|
ChEMBL.
|
17004711
|
Ki (binding)
|
= 1.1 uM
|
Inhibition of Escherichia coli thymidylate synthase
|
ChEMBL.
|
17004711
|
Ki (binding)
|
= 1.8 uM
|
Inhibition of Lactobacillus casei thymidylate synthase
|
ChEMBL.
|
17004711
|
Ki (binding)
|
= 1.8 uM
|
Inhibition of Lactobacillus casei thymidylate synthase
|
ChEMBL.
|
17004711
|
Ki (binding)
|
= 6.5 uM
|
Inhibition of Cryptococcus neoformans thymidylate synthase
|
ChEMBL.
|
17004711
|
Ki (binding)
|
= 6.5 uM
|
Inhibition of Cryptococcus neoformans thymidylate synthase
|
ChEMBL.
|
17004711
|
Ki (binding)
|
= 12 uM
|
Inhibition of human dihydrofolate reductase
|
ChEMBL.
|
17004711
|
Ki (binding)
|
= 12 uM
|
Inhibition of human dihydrofolate reductase
|
ChEMBL.
|
17004711
|
Ki (binding)
|
> 245 uM
|
Inhibition of human thymidylate synthase
|
ChEMBL.
|
17004711
|
Ki (binding)
|
> 245 uM
|
Inhibition of human thymidylate synthase
|
ChEMBL.
|
17004711
|
MIC (functional)
|
= 10 ug ml-1
|
Antibacterial activity against Listeria monocytogenes 3
|
ChEMBL.
|
17004711
|
MIC (functional)
|
= 10 ug ml-1
|
Antibacterial activity against Listeria monocytogenes 4
|
ChEMBL.
|
17004711
|
MIC (functional)
|
= 10 ug ml-1
|
Antibacterial activity against Listeria monocytogenes 5
|
ChEMBL.
|
17004711
|
MIC (functional)
|
= 10 ug ml-1
|
Antibacterial activity against Listeria monocytogenes 6
|
ChEMBL.
|
17004711
|
MIC (functional)
|
= 10 ug ml-1
|
Antibacterial activity against Listeria monocytogenes 7
|
ChEMBL.
|
17004711
|
MIC (functional)
|
= 10 ug ml-1
|
Antibacterial activity against Listeria monocytogenes ATCC4428
|
ChEMBL.
|
17004711
|
MIC (functional)
|
= 10 ug ml-1
|
Antibacterial activity against Staphylococcus aureus 341
|
ChEMBL.
|
17004711
|
MIC (functional)
|
= 10 ug ml-1
|
Antibacterial activity against Staphylococcus aureus 343
|
ChEMBL.
|
17004711
|
MIC (functional)
|
= 10 ug ml-1
|
Antibacterial activity against Staphylococcus aureus K28
|
ChEMBL.
|
17004711
|
MIC (functional)
|
= 10 ug ml-1
|
Antibacterial activity against Staphylococcus aureus ATCC29213
|
ChEMBL.
|
17004711
|
MIC (functional)
|
= 10 ug ml-1
|
Antibacterial activity against Staphylococcus haemolyticus ATCC2997
|
ChEMBL.
|
17004711
|
MIC (functional)
|
= 10 ug ml-1
|
Antibacterial activity against Staphylococcus saprophyticus ATCC15305
|
ChEMBL.
|
17004711
|
MIC (functional)
|
= 10 ug ml-1
|
Antibacterial activity against Streptococcus 42
|
ChEMBL.
|
17004711
|
MIC (functional)
|
= 25 ug ml-1
|
Antibacterial activity against Enterococcus faecalis ATCCC29212
|
ChEMBL.
|
17004711
|
MIC (functional)
|
= 25 ug ml-1
|
Antibacterial activity against Listeria monocytogenes 8
|
ChEMBL.
|
17004711
|
MIC (functional)
|
> 50 ug ml-1
|
Antibacterial activity against Escherichia coli 256
|
ChEMBL.
|
17004711
|
MIC (functional)
|
> 50 ug ml-1
|
Antibacterial activity against Escherichia coli 292
|
ChEMBL.
|
17004711
|
MIC (functional)
|
> 50 ug ml-1
|
Antibacterial activity against Citrobacter 224
|
ChEMBL.
|
17004711
|
MIC (functional)
|
> 50 ug ml-1
|
Antibacterial activity against Escherichia coli 256
|
ChEMBL.
|
17004711
|
MIC (functional)
|
> 50 ug ml-1
|
Antibacterial activity against Escherichia coli 292
|
ChEMBL.
|
17004711
|
Ratio Ki (binding)
|
> 38
|
Specificity Index, Ki for human thymidylate synthase/Ki for Cryptococcus neoformans thymidylate synthase
|
ChEMBL.
|
17004711
|
Ratio Ki (binding)
|
> 136
|
Specificity Index, Ki for human thymidylate synthase/Ki for Lactobacillus casei thymidylate synthase
|
ChEMBL.
|
17004711
|
Ratio Ki (binding)
|
> 223
|
Specificity Index, Ki for human thymidylate synthase/Ki for Escherichia coli thymidylate synthase
|
ChEMBL.
|
17004711
|
Selectivity index (binding)
|
< 0.05
|
Selectivity Index, Ki for human dihydrofolate reductase/Ki for human thymidylate synthase
|
ChEMBL.
|
17004711
|