TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 285.361 | Formula: C16H15NO2S
H donors: 1 H acceptors: 3 LogP: 4.48 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1csc(c1c1ccc(cc1)C(C)(C)C)C(=O)O
InChi: 1S/C16H15NO2S/c1-16(2,3)12-6-4-10(5-7-12)13-11(8-17)9-20-14(13)15(18)19/h4-7,9H,1-3H3,(H,18,19)
InChiKey: LXGOZTHYUCARGI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutamate receptor, ionotropic, AMPA 2	Starlite/ChEMBL	References
Homo sapiens	glutamate receptor, ionotropic, AMPA 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 1	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	glutamate receptor 1	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 4	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor subunit protein glur	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor subunit protein glur	Get druggable targets OG5_128645	All targets in OG5_128645
Brugia malayi	Glutamate receptor 2 precursor	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Brugia malayi	Glutamate receptor 1 precursor	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 4	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	glutamate receptor, ionotropic, AMPA 2	883 aa	810 aa	34.0 %
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	glutamate receptor, ionotropic, AMPA 4	902 aa	818 aa	33.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0049	0.0722	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0049	0.0722	0.0458
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Leishmania major	cysteine peptidase A (CPA)	0.0049	0.0722	0.0845
Onchocerca volvulus		0.0049	0.0722	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Echinococcus granulosus	glutamate receptor 2	0.0152	0.5784	0.5784
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Plasmodium vivax	vivapain-2	0.0049	0.0722	0.0845
Echinococcus multilocularis	cathepsin b	0.0146	0.5512	0.5385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0049	0.0722	0.1301
Entamoeba histolytica	cysteine proteinase, putative	0.0049	0.0722	0.1301
Schistosoma mansoni	glutamate receptor kainate	0.0061	0.131	0.236
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.004	0.0277	0.0277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0049	0.0722	0.0722
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Echinococcus granulosus	glutamate receptor 1	0.0102	0.3345	0.3345
Leishmania major	cathepsin L-like protease	0.0049	0.0722	0.0845
Onchocerca volvulus		0.0049	0.0722	1
Echinococcus multilocularis	cathepsin b	0.0146	0.5512	0.5385
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0054	0.0973	0.1754
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0147	0.555	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0146	0.5512	0.5512
Schistosoma mansoni	glutamate receptor NMDA	0.0061	0.131	0.236
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0722	0.0722
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Plasmodium falciparum	proteasome subunit beta type-5	0.0147	0.555	1
Leishmania major	cathepsin L-like protease	0.0049	0.0722	0.0845
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0072	0.1874	0.1643
Echinococcus multilocularis	glutamate receptor 4	0.0102	0.3345	0.3156
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Toxoplasma gondii	proteasome subunit beta type, putative	0.0147	0.555	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0049	0.0722	0.0458
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Trypanosoma cruzi	cruzipain precursor, putative	0.0049	0.0722	0.1301
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0147	0.555	1
Onchocerca volvulus	Cathepsin L homolog	0.0049	0.0722	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Giardia lamblia	Cathepsin B precursor	0.0054	0.0973	0.1321
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Onchocerca volvulus	Cathepsin F homolog	0.0049	0.0722	1
Onchocerca volvulus		0.0048	0.0714	0.9885
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0147	0.555	0.555
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0147	0.555	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0061	0.131	0.131
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.004	0.0277	0.0499
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0146	0.5512	0.9933
Leishmania major	cathepsin L-like protease	0.0049	0.0722	0.0845
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0722	0.0722
Loa Loa (eye worm)	glutamate receptor 2	0.0061	0.131	0.131
Leishmania major	proteasome beta 5 subunit, putative	0.0147	0.555	1
Schistosoma mansoni	glutamate receptor kainate	0.0061	0.131	0.236
Echinococcus multilocularis	cathepsin L cysteine protease	0.0049	0.0722	0.0458
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0072	0.1874	0.1874
Brugia malayi	proteasome subunit beta type 2	0.004	0.0277	0.0277
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0049	0.0722	0.0722
Brugia malayi	Papain family cysteine protease containing protein	0.0049	0.0722	0.0722
Schistosoma mansoni	glutamate receptor AMPA	0.0061	0.131	0.236
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0147	0.555	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.0722	0.1301
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Echinococcus granulosus	glutamate receptor 4	0.0102	0.3345	0.3345
Schistosoma mansoni	hypothetical protein	0.0048	0.0714	0.1286
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0722	0.0722
Entamoeba histolytica	cysteine proteinase, putative	0.0049	0.0722	0.1301
Leishmania major	cathepsin L-like protease	0.0049	0.0722	0.0845
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.004	0.0277	0.0499
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0049	0.0722	0.0845
Loa Loa (eye worm)	proteasome subunit beta type 2	0.004	0.0277	0.0277
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.0722	0.1301
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0146	0.5512	0.9933
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0147	0.555	1
Echinococcus granulosus	cathepsin b	0.0146	0.5512	0.5512
Schistosoma mansoni	ATP-binding cassette transporter	0.0061	0.131	0.236
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0054	0.0973	0.1754
Loa Loa (eye worm)	glutamate receptor 1	0.0163	0.632	0.632
Giardia lamblia	Cathepsin B precursor	0.0054	0.0973	0.1321
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0049	0.0722	0.1301
Trypanosoma cruzi	20S proteasome subunit	0.004	0.0277	0.0499
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Loa Loa (eye worm)	cysteine protease	0.0049	0.0722	0.0722
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0174	0.6885	0.6796
Leishmania major	cathepsin L-like protease	0.0049	0.0722	0.0845
Mycobacterium ulcerans	proteasome PrcB	0.0147	0.555	0.5
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0072	0.1874	0.1874
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.004	0.0277	0.0499
Leishmania major	cathepsin L-like protease	0.0049	0.0722	0.0845
Echinococcus multilocularis	cysteine protease	0.0049	0.0722	0.0458
Echinococcus granulosus	proteasome prosome macropain	0.0147	0.555	0.555
Leishmania major	cathepsin L-like protease	0.0049	0.0722	0.0845
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0049	0.0722	0.0722
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.0722	0.1301
Schistosoma mansoni	glutamate receptor kainate	0.0061	0.131	0.236
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0072	0.1874	0.1643
Brugia malayi	Glutamate receptor 1 precursor	0.0163	0.632	0.632
Onchocerca volvulus		0.0049	0.0722	1
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0147	0.555	0.5423
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0722	0.0722
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0714	0.0714
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0147	0.555	1
Echinococcus multilocularis	glutamate receptor 2	0.0163	0.632	0.6216
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0174	0.6885	0.6885
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3345	0.3345
Entamoeba histolytica	cysteine protease, putative	0.0049	0.0722	0.1301
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0049	0.0722	0.0845
Echinococcus multilocularis	cathepsin L cysteine protease	0.0049	0.0722	0.0458
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0072	0.1874	0.1643
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Echinococcus multilocularis	survival motor neuron protein 1	0.0238	1	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0054	0.0973	0.1321
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0054	0.0973	0.1321
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0146	0.5512	0.9933
Schistosoma mansoni	glutamate receptor AMPA	0.0061	0.131	0.236
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.004	0.0277	0.0499
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3345	0.3345
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0147	0.555	0.5
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0049	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3345	0.3345
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0147	0.555	1
Onchocerca volvulus		0.0049	0.0722	1
Onchocerca volvulus		0.0049	0.0722	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0722	0.0722
Onchocerca volvulus	Cathepsin L homolog	0.0049	0.0722	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.004	0.0277	0.0499
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0722	0.0722
Loa Loa (eye worm)	fibroinase	0.0049	0.0722	0.0722
Toxoplasma gondii	cathepsin CPL	0.0049	0.0722	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0238	1	1
Loa Loa (eye worm)	cathepsin B	0.0054	0.0973	0.0973
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0054	0.0973	0.1754
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.004	0.0277	0.0499
Toxoplasma gondii	cathepsin B	0.0054	0.0973	0.1321
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0049	0.0722	0.0845
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0124	0.4446	0.4446
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0146	0.5512	0.9933
Brugia malayi	Glutamate receptor 2 precursor	0.0163	0.632	0.632
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0061	0.131	0.1062
Echinococcus multilocularis	glutamate receptor 2	0.0174	0.6885	0.6796
Echinococcus granulosus	survival motor neuron protein 1	0.0238	1	1
Echinococcus granulosus	cathepsin l1	0.0049	0.0722	0.0722
Schistosoma mansoni	glutamate receptor NMDA	0.0072	0.1874	0.3377
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Echinococcus multilocularis	cysteine protease	0.0049	0.0722	0.0458
Giardia lamblia	Cathepsin B precursor	0.0054	0.0973	0.1321
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Onchocerca volvulus		0.0049	0.0722	1
Brugia malayi	Proteasome A-type and B-type family protein	0.0147	0.555	0.555
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.0722	0.1301
Leishmania major	cathepsin L-like protease	0.0049	0.0722	0.0845
Schistosoma mansoni	cathepsin F (C01 family)	0.0049	0.0722	0.1301
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0124	0.4446	0.4288
Loa Loa (eye worm)	ctsf protein	0.0049	0.0722	0.0722
Echinococcus granulosus	cathepsin b	0.0146	0.5512	0.5512
Loa Loa (eye worm)	hypothetical protein	0.0146	0.5512	0.5512
Schistosoma mansoni	cathepsin F (C01 family)	0.0049	0.0722	0.1301
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0714	0.1286
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0072	0.1874	0.1874
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0147	0.555	1
Echinococcus multilocularis	glutamate receptor 2	0.0152	0.5784	0.5664
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0147	0.555	1
Echinococcus granulosus	glutamate receptor 2	0.0174	0.6885	0.6885
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Plasmodium vivax	vivapain-2	0.0049	0.0722	0.0845
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0146	0.5512	0.9933
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0722	0.0722

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	> 3000 nM	Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay	ChEMBL.	16879964
EC50 (functional)	> 3000 nM	Activity against human GLUR4 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay	ChEMBL.	16879964
EC50 (functional)	> 3000 nM	Activity against human GLUR2 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay	ChEMBL.	16879964
EC50 (functional)	> 3000 nM	Activity against human GLUR2 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay	ChEMBL.	16879964
EC50 (functional)	> 3000 nM	Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay	ChEMBL.	16879964
EC50 (functional)	> 3000 nM	Activity against human GLUR4 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay	ChEMBL.	16879964
EC50 (functional)	> 3000 nM	Activity against human GLUR2 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay	ChEMBL.	16879964
EC50 (functional)	> 3000 nM	Activity against human GLUR2 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay	ChEMBL.	16879964

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL385502

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 374858