TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 285.361 | Formula: C16H15NO2S
H donors: 1 H acceptors: 3 LogP: 4.48 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1csc(c1c1ccc(cc1)C(C)(C)C)C(=O)O
InChi: 1S/C16H15NO2S/c1-16(2,3)12-6-4-10(5-7-12)13-11(8-17)9-20-14(13)15(18)19/h4-7,9H,1-3H3,(H,18,19)
InChiKey: LXGOZTHYUCARGI-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutamate receptor, ionotropic, AMPA 4	Starlite/ChEMBL	References
Homo sapiens	glutamate receptor, ionotropic, AMPA 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Glutamate receptor 2 precursor	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor subunit protein glur	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 4	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor subunit protein glur	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645
Brugia malayi	Glutamate receptor 1 precursor	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 4	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 1	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	glutamate receptor 1	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	Get druggable targets OG5_128645	All targets in OG5_128645

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	glutamate receptor, ionotropic, AMPA 4	902 aa	818 aa	33.4 %
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	glutamate receptor, ionotropic, AMPA 2	883 aa	810 aa	34.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.004	0.0277	0.0499
Leishmania major	cathepsin L-like protease	0.0049	0.0722	0.0845
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0072	0.1874	0.1643
Onchocerca volvulus		0.0049	0.0722	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0072	0.1874	0.1874
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0072	0.1874	0.1874
Onchocerca volvulus		0.0049	0.0722	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0049	0.0722	0.0722
Onchocerca volvulus		0.0049	0.0722	1
Entamoeba histolytica	cysteine proteinase, putative	0.0049	0.0722	0.1301
Echinococcus multilocularis	glutamate receptor 2	0.0163	0.632	0.6216
Toxoplasma gondii	cathepsin CPL	0.0049	0.0722	0.0845
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0061	0.131	0.1062
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Leishmania major	cathepsin L-like protease	0.0049	0.0722	0.0845
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0054	0.0973	0.1754
Echinococcus multilocularis	cathepsin b	0.0146	0.5512	0.5385
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0049	0.0722	0.0722
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0124	0.4446	0.4446
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0147	0.555	0.555
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0049	0.0722	0.0458
Leishmania major	proteasome beta 5 subunit, putative	0.0147	0.555	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Brugia malayi	Glutamate receptor 2 precursor	0.0163	0.632	0.632
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0049	0.0722	0.0722
Giardia lamblia	Cathepsin B precursor	0.0054	0.0973	0.1321
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0147	0.555	1
Echinococcus multilocularis	glutamate receptor 2	0.0174	0.6885	0.6796
Schistosoma mansoni	glutamate receptor AMPA	0.0061	0.131	0.236
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Leishmania major	cathepsin L-like protease	0.0049	0.0722	0.0845
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0049	0.0722	0.0845
Onchocerca volvulus	Cathepsin L homolog	0.0049	0.0722	1
Schistosoma mansoni	glutamate receptor kainate	0.0061	0.131	0.236
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.0722	0.1301
Trypanosoma cruzi	20S proteasome subunit	0.004	0.0277	0.0499
Trypanosoma cruzi	cruzipain precursor, putative	0.0049	0.0722	0.1301
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0722	0.0722
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0238	1	1
Toxoplasma gondii	proteasome subunit beta type, putative	0.0147	0.555	1
Leishmania major	cysteine peptidase A (CPA)	0.0049	0.0722	0.0845
Loa Loa (eye worm)	glutamate receptor 1	0.0163	0.632	0.632
Loa Loa (eye worm)	proteasome subunit beta type 2	0.004	0.0277	0.0277
Brugia malayi	Glutamate receptor 1 precursor	0.0163	0.632	0.632
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0174	0.6885	0.6885
Echinococcus multilocularis	cysteine protease	0.0049	0.0722	0.0458
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0072	0.1874	0.1643
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0146	0.5512	0.9933
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3345	0.3345
Mycobacterium ulcerans	proteasome PrcB	0.0147	0.555	0.5
Brugia malayi	proteasome subunit beta type 2	0.004	0.0277	0.0277
Echinococcus multilocularis	cysteine protease	0.0049	0.0722	0.0458
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.0722	0.1301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0147	0.555	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0049	0.0722	0.0845
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0147	0.555	1
Onchocerca volvulus		0.0048	0.0714	0.9885
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0146	0.5512	0.9933
Loa Loa (eye worm)	glutamate receptor 2	0.0061	0.131	0.131
Plasmodium vivax	vivapain-2	0.0049	0.0722	0.0845
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.004	0.0277	0.0499
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0054	0.0973	0.1321
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0147	0.555	1
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.004	0.0277	0.0277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Loa Loa (eye worm)	fibroinase	0.0049	0.0722	0.0722
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0124	0.4446	0.4288
Brugia malayi	Papain family cysteine protease containing protein	0.0049	0.0722	0.0722
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0061	0.131	0.131
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0054	0.0973	0.1754
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Plasmodium vivax	vivapain-2	0.0049	0.0722	0.0845
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.004	0.0277	0.0499
Schistosoma mansoni	glutamate receptor kainate	0.0061	0.131	0.236
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0146	0.5512	0.5512
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0174	0.6885	0.6796
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0714	0.0714
Brugia malayi	Proteasome A-type and B-type family protein	0.0147	0.555	0.555
Plasmodium falciparum	proteasome subunit beta type-5	0.0147	0.555	1
Loa Loa (eye worm)	ctsf protein	0.0049	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3345	0.3345
Giardia lamblia	Cathepsin B precursor	0.0054	0.0973	0.1321
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0072	0.1874	0.1874
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0147	0.555	1
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0722	0.0722
Loa Loa (eye worm)	cathepsin B	0.0054	0.0973	0.0973
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0147	0.555	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0054	0.0973	0.1321
Echinococcus multilocularis	glutamate receptor 2	0.0152	0.5784	0.5664
Toxoplasma gondii	cathepsin B	0.0054	0.0973	0.1321
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0147	0.555	1
Onchocerca volvulus		0.0049	0.0722	1
Leishmania major	cathepsin L-like protease	0.0049	0.0722	0.0845
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Echinococcus multilocularis	survival motor neuron protein 1	0.0238	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0146	0.5512	0.9933
Echinococcus granulosus	proteasome prosome macropain	0.0147	0.555	0.555
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0147	0.555	0.5423
Echinococcus multilocularis	cathepsin b	0.0146	0.5512	0.5385
Echinococcus multilocularis	cathepsin L cysteine protease	0.0049	0.0722	0.0458
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0722	0.0722
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0714	0.1286
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0147	0.555	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0054	0.0973	0.1754
Entamoeba histolytica	cysteine protease, putative	0.0049	0.0722	0.1301
Schistosoma mansoni	cathepsin F (C01 family)	0.0049	0.0722	0.1301
Echinococcus granulosus	glutamate receptor 1	0.0102	0.3345	0.3345
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Onchocerca volvulus		0.0049	0.0722	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0072	0.1874	0.1643
Echinococcus granulosus	glutamate receptor 4	0.0102	0.3345	0.3345
Schistosoma mansoni	ATP-binding cassette transporter	0.0061	0.131	0.236
Echinococcus granulosus	cathepsin b	0.0146	0.5512	0.5512
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.004	0.0277	0.0499
Onchocerca volvulus	Cathepsin F homolog	0.0049	0.0722	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Entamoeba histolytica	cysteine proteinase, putative	0.0049	0.0722	0.1301
Leishmania major	cathepsin L-like protease	0.0049	0.0722	0.0845
Echinococcus multilocularis	cathepsin L cysteine protease	0.0049	0.0722	0.0458
Schistosoma mansoni	glutamate receptor AMPA	0.0061	0.131	0.236
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0146	0.5512	0.9933
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0049	0.0722	0.0722
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.004	0.0277	0.0499
Leishmania major	cathepsin L-like protease	0.0049	0.0722	0.0845
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0147	0.555	0.5
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3345	0.3345
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0722	0.1301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0049	0.0722	0.1301
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0049	0.0722	0.0845
Schistosoma mansoni	glutamate receptor NMDA	0.0072	0.1874	0.3377
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0049	0.0722	0.0458
Schistosoma mansoni	cathepsin F (C01 family)	0.0049	0.0722	0.1301
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0722	0.0722
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.0722	0.1301
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0146	0.5512	0.9933
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0722	0.0722
Echinococcus granulosus	cathepsin l1	0.0049	0.0722	0.0722
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.004	0.0277	0.0499
Schistosoma mansoni	glutamate receptor kainate	0.0061	0.131	0.236
Leishmania major	cathepsin L-like protease	0.0049	0.0722	0.0845
Echinococcus granulosus	cathepsin b	0.0146	0.5512	0.5512
Echinococcus granulosus	glutamate receptor 2	0.0152	0.5784	0.5784
Echinococcus granulosus	survival motor neuron protein 1	0.0238	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0049	0.0722	1
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0147	0.555	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0146	0.5512	0.5512
Schistosoma mansoni	hypothetical protein	0.0048	0.0714	0.1286
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0722	0.0722
Leishmania major	cathepsin L-like protease	0.0049	0.0722	0.0845
Giardia lamblia	Cathepsin B precursor	0.0054	0.0973	0.1321
Onchocerca volvulus		0.0049	0.0722	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Echinococcus multilocularis	glutamate receptor 4	0.0102	0.3345	0.3156
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.0722	0.0845
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0722	0.1301
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.0722	0.1301
Schistosoma mansoni	glutamate receptor NMDA	0.0061	0.131	0.236
Loa Loa (eye worm)	cysteine protease	0.0049	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0722	0.0722
Echinococcus granulosus	glutamate receptor 2	0.0174	0.6885	0.6885
Onchocerca volvulus		0.0049	0.0722	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0049	0.0722	0.1301

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	> 3000 nM	Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay	ChEMBL.	16879964
EC50 (functional)	> 3000 nM	Activity against human GLUR4 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay	ChEMBL.	16879964
EC50 (functional)	> 3000 nM	Activity against human GLUR2 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay	ChEMBL.	16879964
EC50 (functional)	> 3000 nM	Activity against human GLUR2 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay	ChEMBL.	16879964
EC50 (functional)	> 3000 nM	Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay	ChEMBL.	16879964
EC50 (functional)	> 3000 nM	Activity against human GLUR4 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay	ChEMBL.	16879964
EC50 (functional)	> 3000 nM	Activity against human GLUR2 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay	ChEMBL.	16879964
EC50 (functional)	> 3000 nM	Activity against human GLUR2 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay	ChEMBL.	16879964

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL385502

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 374858