Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 10000 nM | Agonist activity at human androgen receptor in CV1 cells measured as stimulation of luciferase reporter gene activity by cotransfection assay | ChEMBL. | 17034117 |
EC50 (functional) | > 10000 nM | Agonist activity at human androgen receptor in CV1 cells measured as stimulation of luciferase reporter gene activity by cotransfection assay | ChEMBL. | 17034117 |
Efficacy (functional) | < 20 % | Agonist activity at human androgen receptor in CV1 cells measured as stimulation of luciferase reporter gene activity with relative to DHT by cotransfection assay | ChEMBL. | 17034117 |
Efficacy (functional) | < 20 % | Agonist activity at human androgen receptor in CV1 cells measured as stimulation of luciferase reporter gene activity with relative to DHT by cotransfection assay | ChEMBL. | 17034117 |
Efficacy (functional) | = 72 % | Antagonist activity against human androgen receptor in CV1 cells measured as percent of maximal inhibition of DHT-stimulated luciferase reporter gene activity by cotransfection assay | ChEMBL. | 17034117 |
Efficacy (functional) | = 72 % | Antagonist activity against human androgen receptor in CV1 cells measured as percent of maximal inhibition of DHT-stimulated luciferase reporter gene activity by cotransfection assay | ChEMBL. | 17034117 |
IC50 (functional) | = 34 nM | Antagonist activity against human androgen receptor in CV1 cells measured as inhibition of DHT-stimulated luciferase reporter gene activity by cotransfection assay | ChEMBL. | 17034117 |
IC50 (functional) | = 34 nM | Antagonist activity against human androgen receptor in CV1 cells measured as inhibition of DHT-stimulated luciferase reporter gene activity by cotransfection assay | ChEMBL. | 17034117 |
Ki (binding) | = 153 nM | Displacement of [3H]DHT from human androgen receptor expressed in MDA-MB-453 cells by whole cell receptor binding assay | ChEMBL. | 17034117 |
Ki (binding) | = 153 nM | Displacement of [3H]DHT from human androgen receptor expressed in MDA-MB-453 cells by whole cell receptor binding assay | ChEMBL. | 17034117 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.