Detailed information for compound 375009

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 473.688 | Formula: C29H47NO4
  • H donors: 3 H acceptors: 4 LogP: 5.72 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1CC[C@]2(C(=CCC3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](C(=O)NCCCCCCC(=O)O)C)C)C1)C
  • InChi: 1S/C29H47NO4/c1-19(27(34)30-17-7-5-4-6-8-26(32)33)23-11-12-24-22-10-9-20-18-21(31)13-15-28(20,2)25(22)14-16-29(23,24)3/h9,19,21-25,31H,4-8,10-18H2,1-3H3,(H,30,34)(H,32,33)/t19-,21-,22?,23+,24-,25-,28-,29+/m0/s1
  • InChiKey: GAXGWRBRFSCRTB-UPBNICJYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dnaJ subfamily B 0.0369 0.4985 0.5868
Schistosoma mansoni intermediate filament proteins 0.0024 0.0218 0.0256
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0007 0.0005
Trypanosoma cruzi heat shock protein 90, putative 0.0017 0.012 0.0109
Echinococcus granulosus lamin 0.0024 0.0218 0.0251
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0035 0.037 0.0431
Loa Loa (eye worm) fli-1 protein 0.0198 0.2625 0.4848
Leishmania major heat shock protein 83-1 0.0041 0.0453 0.0564
Mycobacterium ulcerans heat shock protein 90 0.0039 0.0418 0.5255
Leishmania major heat shock protein 83-1 0.0041 0.0453 0.0564
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0086 0.1073 0.1258
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0366 0.0425
Plasmodium falciparum heat shock protein 90, putative 0.0024 0.0213 0.1021
Trichomonas vaginalis heat shock protein, putative 0.0035 0.037 0.0451
Leishmania major heat shock protein 83-1 0.0041 0.0453 0.0564
Plasmodium falciparum flap endonuclease 1 0.0024 0.0206 0.0985
Schistosoma mansoni inositol monophosphatase 0.0033 0.0342 0.0403
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0007 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0007 0.0013
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0275 0.0271
Schistosoma mansoni heat shock protein 0.0041 0.0453 0.0533
Schistosoma mansoni bromodomain containing protein 0.0059 0.0691 0.0814
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.054 0.7347 1
Schistosoma mansoni coup transcription factor 0.0009 0.0007 0.0008
Echinococcus granulosus ETS transcription factor Elf 2 0.0009 0.0012 0.0009
Entamoeba histolytica hypothetical protein, conserved 0.054 0.7347 1
Echinococcus granulosus peregrin 0.0037 0.0393 0.0458
Echinococcus multilocularis cpg binding protein 0.0029 0.0284 0.0279
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0021 0.0173 0.1688
Giardia lamblia Flap structure-specific endonuclease 0.0024 0.0206 0.0274
Schistosoma mansoni survival motor neuron protein 0.0044 0.0483 0.0569
Leishmania major GTP-binding protein, putative 0.0019 0.0146 0.0143
Loa Loa (eye worm) hypothetical protein 0.0044 0.0488 0.0894
Echinococcus granulosus jumonji domain containing protein 0.0037 0.0387 0.0451
Schistosoma mansoni hypothetical protein 0.0019 0.0139 0.0163
Trypanosoma cruzi heat shock protein 85, putative 0.0041 0.0453 0.0564
Loa Loa (eye worm) heat shock protein 75 0.0027 0.0261 0.0474
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.037 0.0451
Echinococcus multilocularis Protein lozenge 0.005 0.0574 0.057
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0055 0.0639 0.0634
Trichomonas vaginalis ran, putative 0.0019 0.0146 0.0143
Plasmodium vivax endoplasmin, putative 0.0041 0.0453 0.2127
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0639 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0073
Loa Loa (eye worm) hypothetical protein 0.004 0.0434 0.0794
Leishmania major heat shock protein 83-1 0.0041 0.0453 0.0564
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0007 0.0002
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0055 0.0639 0.0747
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0019 0.0146 0.027
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0672 0.0791
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0146 0.0143
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0019 0.0146 0.0691
Echinococcus granulosus PHD finger protein rhinoceros 0.0026 0.0245 0.0283
Onchocerca volvulus 0.0026 0.0239 0.043
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0639 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0173 0.018
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0078 0.0074
Brugia malayi Isocitrate dehydrogenase 0.0014 0.0078 0.0145
Schistosoma mansoni ran 0.0019 0.0146 0.0172
Echinococcus multilocularis musashi 0.0024 0.0218 0.0213
Brugia malayi CXXC zinc finger family protein 0.0026 0.0239 0.0443
Loa Loa (eye worm) hypothetical protein 0.04 0.5408 1
Echinococcus granulosus heat shock protein 0.0041 0.0453 0.0528
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0005
Schistosoma mansoni hypothetical protein 0.0037 0.0389 0.0458
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0005
Echinococcus multilocularis Niemann Pick C1 protein 0.0089 0.111 0.1105
Leishmania major hypothetical protein, conserved 0.0014 0.0072 0.0042
Brugia malayi transcription factor E74 isoform 0.0009 0.0012 0.0022
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0032 0.0329 0.0383
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0672 0.0791
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0639 1
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0245 0.1101
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0055 0.0639 0.0818
Trypanosoma brucei heat shock protein, putative 0.0041 0.0453 0.0616
Trichomonas vaginalis importin beta-1, putative 0.0021 0.0173 0.018
Trichomonas vaginalis endoplasmin, putative 0.003 0.0296 0.0349
Loa Loa (eye worm) hypothetical protein 0.0075 0.0919 0.1691
Echinococcus granulosus microtubule associated protein 2 0.0623 0.8492 1
Trypanosoma cruzi ISWI complex protein 0.0014 0.0072 0.0042
Loa Loa (eye worm) hypothetical protein 0.0064 0.0764 0.1404
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0057 0.0669 0.0787
Onchocerca volvulus Huntingtin homolog 0.0111 0.141 0.2597
Brugia malayi RNA, U transporter 1 0.0074 0.0904 0.1672
Echinococcus multilocularis survival motor neuron protein 1 0.0213 0.2832 0.2828
Loa Loa (eye worm) hypothetical protein 0.0026 0.0241 0.0437
Trichomonas vaginalis inositol monophosphatase, putative 0.0033 0.0342 0.0412
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0007 0.0013
Leishmania major heat shock protein 83-1 0.0041 0.0453 0.0564
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0081 0.0397
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0005
Schistosoma mansoni patched 1 0.0038 0.0408 0.0481
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0033 0.0342 0.363
Brugia malayi Probable ATP-dependent helicase DHX35 0.0037 0.039 0.0721
Trypanosoma cruzi importin beta-1 subunit, putative 0.0021 0.0173 0.018
Onchocerca volvulus 0.0024 0.0218 0.039
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0078 0.0051
Trypanosoma brucei heat shock protein 84, putative 0.0027 0.0261 0.0355
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0116 0.0137
Loa Loa (eye worm) flap endonuclease-1 0.0024 0.0206 0.0373
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0007 0.0008
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0342 0.0412
Plasmodium falciparum phd finger protein, putative 0.0026 0.0245 0.1175
Echinococcus multilocularis protein patched 0.0038 0.0408 0.0404
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0014 0.0078 0.0092
Onchocerca volvulus Alhambra homolog 0.0026 0.0245 0.044
Brugia malayi Bromodomain containing protein 0.0035 0.0359 0.0664
Echinococcus multilocularis snurportin 1 0.0278 0.3722 0.3719
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.0043 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0672 0.0791
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0035 0.036 0.0657
Trypanosoma brucei heat shock protein 90, putative 0.0041 0.0453 0.0616
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0027 0.0261 0.0301
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0019 0.0146 0.0199
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0007 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0007 0.0005
Loa Loa (eye worm) isocitrate dehydrogenase 0.0014 0.0078 0.0136
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0007 0.0008
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0632 0.1161
Echinococcus multilocularis lamin dm0 0.0024 0.0218 0.0213
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.003 0.0294 0.3844
Echinococcus multilocularis lysine specific demethylase 5A 0.0032 0.0321 0.0317
Schistosoma mansoni zinc finger protein 0.0014 0.0072 0.0085
Schistosoma mansoni hypothetical protein 0.0278 0.3722 0.4383
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0007 0.0013
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0418 0.0516
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0009 0.0012 0.0014
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0027 0.0261 0.0256
Trypanosoma cruzi heat shock protein 90, putative 0.0035 0.037 0.0451
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0007 0.0002
Trichomonas vaginalis heat shock protein, putative 0.0041 0.0453 0.0564
Echinococcus granulosus Niemann Pick C1 protein 0.0089 0.111 0.1302
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0024 0.0218 0.0394
Brugia malayi hypothetical protein 0.0136 0.1767 0.3267
Echinococcus multilocularis Niemann Pick C1 protein 0.0127 0.1637 0.1633
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0075 0.0919 0.1082
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0183 0.0178
Echinococcus multilocularis ETS transcription factor Elf 2 0.0009 0.0012 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0007 0.0013
Loa Loa (eye worm) ets-domain-containing protein 0.0009 0.0012 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0007 0.0005
Schistosoma mansoni hypothetical protein 0.0014 0.0072 0.0085
Loa Loa (eye worm) RecQ helicase 0.0022 0.0181 0.0326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0007 0.0005
Leishmania major heat shock protein, putative 0.0027 0.0261 0.0301
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0044 0.0488 0.0575
Schistosoma mansoni ets-related 0.0009 0.0012 0.0014
Schistosoma mansoni hypothetical protein 0.0153 0.1996 0.235
Schistosoma mansoni methyl-cpg binding protein mbd 0.0015 0.0094 0.0111
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0039 0.0418 0.6057
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0015 0.0094 0.0089
Onchocerca volvulus 0.04 0.5408 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0089 0.111 0.1463
Echinococcus granulosus methyl CpG binding domain protein 2 0.0015 0.0094 0.0105
Schistosoma mansoni niemann-pick C1 (NPC1) 0.009 0.1129 0.1329
Loa Loa (eye worm) DEAH box polypeptide 35 0.0037 0.039 0.0713
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0056 0.0654 0.1201
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0072
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0275 0.1343
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0032 0.0329 0.0325
Trypanosoma brucei heat shock protein, putative 0.0041 0.0453 0.0616
Loa Loa (eye worm) D-ets-2 protein 0.0009 0.0012 0.0014
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0007 0.0002
Plasmodium vivax SET domain protein, putative 0.0029 0.0275 0.125
Trypanosoma brucei heat shock protein 90, putative 0.0041 0.0453 0.0616
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0078 0.0074
Plasmodium vivax heat shock protein, putative 0.0157 0.2048 1
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0031 0.0312 0.0361
Brugia malayi Hsp90 protein 0.0027 0.0261 0.0483
Trichomonas vaginalis flap endonuclease-1, putative 0.0024 0.0206 0.0226
Loa Loa (eye worm) hypothetical protein 0.0045 0.0505 0.0925
Loa Loa (eye worm) bromodomain containing protein 0.0016 0.0102 0.0179
Toxoplasma gondii heat shock protein 90, putative 0.0041 0.0453 0.2211
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0275 0.0324
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.0241 0.0328
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0014
Schistosoma mansoni zinc finger protein 0.0019 0.0146 0.0172
Trypanosoma brucei heat shock protein, putative 0.0041 0.0453 0.0616
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0007 0.0008
Schistosoma mansoni endoplasmin 0.0041 0.0453 0.0533
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0078 0.0074
Schistosoma mansoni inositol monophosphatase 0.0033 0.0342 0.0403
Toxoplasma gondii PHD-finger domain-containing protein 0.0026 0.0245 0.1196
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0342 0.0412
Loa Loa (eye worm) RNA binding protein 0.0057 0.0672 0.1234
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0672 0.0791
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0672 0.0791
Brugia malayi RNA binding protein 0.0057 0.0672 0.1242
Echinococcus granulosus zinc finger protein 0.0019 0.0146 0.0166
Schistosoma mansoni hypothetical protein 0.0044 0.0483 0.0569
Brugia malayi heat shock protein 90 0.0041 0.0453 0.0837
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0038 0.0408 0.0747
Schistosoma mansoni gabp alpha 0.0065 0.0785 0.0924
Brugia malayi hypothetical protein 0.0032 0.033 0.061
Brugia malayi jmjC domain containing protein 0.0035 0.0366 0.0676
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0005 0.0023
Schistosoma mansoni methyl-cpg binding protein mbd 0.0015 0.0094 0.0111
Echinococcus granulosus importin subunit beta 1 0.0026 0.0241 0.0278
Schistosoma mansoni cpg binding protein 0.0029 0.0284 0.0334
Schistosoma mansoni DNA helicase recq5 0.0009 0.0005 0.0006
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0007 0.0002
Echinococcus multilocularis microtubule associated protein 2 0.0623 0.8492 0.8492
Trypanosoma cruzi Heat shock protein 83, putative 0.0041 0.0453 0.0564
Brugia malayi hypothetical protein 0.0111 0.141 0.2607
Giardia lamblia Heat shock protein HSP 90-alpha 0.0035 0.037 0.0498
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0055 0.0639 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0173 0.018
Schistosoma mansoni hypothetical protein 0.054 0.7347 0.8651
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0366 0.0431
Plasmodium vivax heat shock protein 86, putative 0.0041 0.0453 0.2127
Echinococcus granulosus bloom syndrome protein 0.0022 0.0181 0.0207
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0005 0.0009
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0021 0.0173 0.5
Trypanosoma brucei heat shock protein, putative 0.0041 0.0453 0.0616
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0019 0.0146 0.0192
Trypanosoma brucei heat shock protein, putative 0.0041 0.0453 0.0616
Echinococcus granulosus ETS transcription factor Elf 5 0.0009 0.0012 0.0009
Echinococcus multilocularis geminin 0.0153 0.1996 0.1992
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0007 0.0002
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0007 0.0008
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0019 0.0146 0.0712
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0086 0.1073 0.1068
Echinococcus granulosus endoplasmin 0.0039 0.0418 0.0487
Giardia lamblia Heat shock protein HSP 90-alpha 0.0041 0.0453 0.061
Leishmania major heat shock protein 83-1 0.0041 0.0453 0.0564
Toxoplasma gondii HEAT repeat-containing protein 0.0026 0.0241 0.1176
Entamoeba histolytica hypothetical protein 0.0032 0.033 0.0395
Schistosoma mansoni DNA helicase recq1 0.0009 0.0005 0.0006
Entamoeba histolytica hypothetical protein 0.0032 0.033 0.0395
Schistosoma mansoni hypothetical protein 0.0032 0.033 0.0389
Schistosoma mansoni hypothetical protein 0.0153 0.1996 0.235
Loa Loa (eye worm) TAR-binding protein 0.0057 0.0672 0.1234
Echinococcus multilocularis isocitrate dehydrogenase 0.0014 0.0078 0.0074
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0007 0.0013
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0007 0.0008
Echinococcus multilocularis heat shock protein 90 0.0041 0.0453 0.0448
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0078 0.0107
Schistosoma mansoni ran 0.0019 0.0146 0.0172
Brugia malayi PHD-finger family protein 0.0026 0.0245 0.0453
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0342 0.0412
Leishmania major heat shock protein 83-1 0.0041 0.0453 0.0564
Onchocerca volvulus 0.0044 0.0483 0.0881
Entamoeba histolytica heat shock protein 90, putative 0.0041 0.0453 0.0564
Brugia malayi Endoplasmin precursor 0.0041 0.0453 0.0837
Loa Loa (eye worm) runx1 0.005 0.0574 0.1054
Entamoeba histolytica DNA repair and recombination protein, putative 0.054 0.7347 1
Brugia malayi Pre-SET motif family protein 0.0029 0.0275 0.0509
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0005
Leishmania major heat shock protein 83-1 0.0041 0.0453 0.0564
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0021 0.0173 0.0745
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0041 0.0056
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0009 0.0012 0.0014
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.0241 0.0328
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0161 0.0297
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0007 0.0008
Schistosoma mansoni SET domain protein 0.0014 0.0079 0.0093
Brugia malayi Bromodomain containing protein 0.0069 0.0837 0.1548
Brugia malayi RNA recognition motif domain containing protein 0.0057 0.0672 0.1242
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0032 0.033 0.0383
Schistosoma mansoni ets-related 0.0198 0.2625 0.3091
Schistosoma mansoni heat shock protein 0.0027 0.0261 0.0307
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0012 0.0043 0.0039
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0065 0.0785 0.1444
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0239 0.0434
Echinococcus multilocularis expressed conserved protein 0.0083 0.1035 0.1031
Brugia malayi Ets-domain containing protein 0.0065 0.0785 0.1451
Onchocerca volvulus 0.0029 0.0275 0.0496
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0007 0.0002
Echinococcus granulosus sterol regulatory element binding protein 0.0038 0.0408 0.0475
Plasmodium vivax importin-beta 2, putative 0.0026 0.0241 0.1081
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0007 0.0003
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0342 0.0466
Entamoeba histolytica hypothetical protein 0.0021 0.0173 0.018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0366 0.0431
Loa Loa (eye worm) hypothetical protein 0.0024 0.0211 0.0383
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0019 0.0015
Echinococcus granulosus heat shock protein 90 0.0035 0.037 0.0431
Leishmania major heat shock protein 83-1 0.0041 0.0453 0.0564
Loa Loa (eye worm) MH2 domain-containing protein 0.0108 0.1371 0.2528
Echinococcus multilocularis PHD finger protein rhinoceros 0.0026 0.0245 0.024
Echinococcus granulosus ETS transcription factor Elf 2 0.0009 0.0012 0.0009
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.054 0.7347 0.7345
Echinococcus multilocularis L aminoadipate semialdehyde 0.0075 0.0919 0.0914
Loa Loa (eye worm) hypothetical protein 0.0111 0.141 0.26
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0007 0.0008
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0007 0.0008
Schistosoma mansoni lozenge 0.005 0.0574 0.0676
Loa Loa (eye worm) hypothetical protein 0.0089 0.111 0.2045
Plasmodium falciparum heat shock protein 90, putative 0.0157 0.2048 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0146 0.0143
Trypanosoma cruzi heat shock protein 90, putative 0.0041 0.0453 0.0564
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0275 0.0324
Loa Loa (eye worm) hypothetical protein 0.04 0.5408 1
Echinococcus granulosus ETS transcription factor Elf 1 0.0009 0.0012 0.0009
Loa Loa (eye worm) PHD-finger family protein 0.0026 0.0245 0.0444
Brugia malayi TAR-binding protein 0.0057 0.0672 0.1242
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0014 0.0078 0.0278
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0213 0.0236
Echinococcus granulosus intermediate filament protein 0.0024 0.0218 0.0251
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0007 0.0008
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0007 0.0008
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0055 0.0647 0.0642
Echinococcus granulosus tar DNA binding protein 0.0057 0.0672 0.0786
Brugia malayi PHD-finger family protein 0.0012 0.0044 0.0082
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0027 0.0261 0.047
Leishmania major importin beta-1 subunit, putative 0.0021 0.0173 0.018
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0181 0.0191
Schistosoma mansoni hypothetical protein 0.0037 0.0389 0.0458
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0007 0.0013
Echinococcus granulosus Protein patched homolog 1 0.0038 0.0408 0.0475
Giardia lamblia Rrm3p helicase 0.054 0.7347 1
Echinococcus multilocularis dnaJ subfamily B 0.0369 0.4985 0.4983
Echinococcus granulosus expressed conserved protein 0.0083 0.1035 0.1214
Loa Loa (eye worm) hypothetical protein 0.0024 0.0218 0.0394
Onchocerca volvulus 0.0215 0.2858 0.5279
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.003 0.0294 0.4934
Loa Loa (eye worm) hypothetical protein 0.0038 0.0408 0.0747
Trypanosoma brucei ISWI complex protein 0.0014 0.0072 0.0098
Echinococcus multilocularis sterol regulatory element binding protein 0.0038 0.0408 0.0404
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.054 0.7347 0.865
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0007 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0007 0.0013
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0011 0.0035 0.0036
Brugia malayi Niemann-Pick C1 protein precursor 0.0089 0.111 0.2052
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0007 0.0005
Echinococcus multilocularis jumonji domain containing protein 0.0037 0.0387 0.0383
Schistosoma mansoni transcription factor LCR-F1 0.0032 0.033 0.0389
Schistosoma mansoni endoplasmin 0.0041 0.0453 0.0533
Echinococcus granulosus inositol monophosphatase 1 0.0033 0.0342 0.0397
Echinococcus multilocularis lamin 0.0024 0.0218 0.0213
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0009 0.0012 0.0014
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0005 0.0023
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0183 0.0215
Toxoplasma gondii heat shock protein HSP90 0.0041 0.0453 0.2211
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0014 0.0078 0.0051
Giardia lamblia PHD finger protein 15 0.0026 0.0245 0.0327
Entamoeba histolytica hypothetical protein 0.0032 0.033 0.0395
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.0078 0.0382
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.054 0.7347 1
Echinococcus multilocularis ETS transcription factor Elf 1 0.0009 0.0012 0.0007
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0055 0.0647 0.0756
Leishmania major heat shock protein 83-1 0.0041 0.0453 0.0564
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0007 0.0002
Entamoeba histolytica Ran family GTPase 0.0019 0.0146 0.0143
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0044 0.0483 0.0893
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.054 0.7347 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0039 0.0418 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0007 0.0013
Plasmodium vivax heat shock protein 90, putative 0.0027 0.0261 0.118
Leishmania major heat shock protein 83-1 0.0041 0.0453 0.0564
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0007 0.0003
Echinococcus multilocularis importin subunit beta 1 0.0026 0.0241 0.0236
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0075 0.0919 0.1698
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0007 0.0013
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0009 0.0012 0.0007
Brugia malayi intermediate filament protein 0.0024 0.0218 0.0402
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0024 0.0206 0.1006
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0019 0.0146 0.0612
Trichomonas vaginalis conserved hypothetical protein 0.054 0.7347 1
Brugia malayi steroid hormone receptor 0.0009 0.0007 0.0013
Schistosoma mansoni hypothetical protein 0.0369 0.4985 0.587
Echinococcus granulosus GA binding protein alpha chain 0.0065 0.0785 0.0919
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0007 0.0008
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.054 0.7347 1
Echinococcus granulosus flap endonuclease 1 0.0024 0.0206 0.0237
Brugia malayi hypothetical protein 0.0213 0.2832 0.5236
Loa Loa (eye worm) heat shock protein 90 0.0041 0.0453 0.0829
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0007 0.0013
Echinococcus granulosus cpg binding protein 0.0029 0.0284 0.0329
Brugia malayi Pre-SET motif family protein 0.0189 0.25 0.4622
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.006
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.001 0.0022 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0007 0.0013
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0007 0.0003
Echinococcus multilocularis flap endonuclease 1 0.0024 0.0206 0.0201
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0024 0.0206 0.0226
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0026 0.0245 0.0288
Echinococcus multilocularis ETS transcription factor Elf 5 0.0009 0.0012 0.0007
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0019 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0007 0.0013
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0639 0.0752
Plasmodium falciparum heat shock protein 90 0.0041 0.0453 0.2193
Brugia malayi hypothetical protein 0.04 0.5408 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0019 0.0146 0.0261
Schistosoma mansoni elf1 0.0009 0.0012 0.0014
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.054 0.7347 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0007 0.0013
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0278 0.3722 0.688
Echinococcus granulosus protein C ets 2 0.0009 0.0012 0.0009
Plasmodium falciparum endoplasmin, putative 0.003 0.0296 0.1426
Trypanosoma brucei heat shock protein, putative 0.0041 0.0453 0.0616
Schistosoma mansoni jumonji domain containing protein 0.0068 0.0828 0.0975
Schistosoma mansoni lamin 0.0024 0.0218 0.0256
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0181 0.0191
Loa Loa (eye worm) transcription factor SMAD2 0.0108 0.1371 0.2528
Loa Loa (eye worm) intermediate filament protein 0.0024 0.0218 0.0394
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0111 0.141 0.26
Brugia malayi PHD-finger family protein 0.0024 0.0212 0.0393
Brugia malayi Ets-domain containing protein 0.0009 0.0012 0.0022
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0007 0.0005
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0021 0.0173 0.0844
Echinococcus granulosus ETS domain containing protein Elk 1 0.0009 0.0012 0.0009
Brugia malayi Ets-domain containing protein 0.0065 0.0785 0.1451
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0021 0.0173 0.0823
Echinococcus multilocularis inositol monophosphatase 1 0.0033 0.0342 0.0337
Echinococcus granulosus geminin 0.0153 0.1996 0.2346
Trichomonas vaginalis set domain proteins, putative 0.0215 0.2858 0.3857
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0032 0.033 0.0325
Brugia malayi CHE-14 protein 0.0038 0.0408 0.0755
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0039 0.0418 1
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.054 0.7347 1
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.0078 0.0382
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0408 0.0503
Trypanosoma brucei heat shock protein, putative 0.0041 0.0453 0.0616
Schistosoma mansoni ets 0.0009 0.0012 0.0014
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0617 0.3013
Treponema pallidum heat shock protein 90 0.0039 0.0418 1
Echinococcus multilocularis ETS transcription factor Elf 2 0.0009 0.0012 0.0007
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0181 0.0176
Echinococcus multilocularis peregrin 0.0037 0.0393 0.0389
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0024 0.0206 0.0226
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0139 0.0248
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0007 0.0003
Brugia malayi Importin beta-1 subunit 0.0026 0.0241 0.0445
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0044 0.0488 0.0483
Leishmania major heat shock protein 83-1 0.0041 0.0453 0.0564
Leishmania major heat shock protein 83-1 0.0041 0.0453 0.0564
Echinococcus granulosus lamin dm0 0.0024 0.0218 0.0251
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0183 0.021
Echinococcus multilocularis protein dispatched 1 0.0044 0.0483 0.0478
Loa Loa (eye worm) hypothetical protein 0.0047 0.0527 0.0966
Trypanosoma cruzi heat shock protein, putative 0.0027 0.0261 0.0301
Echinococcus granulosus snurportin 1 0.0278 0.3722 0.438
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0173 0.0235
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0019 0.0146 0.0141
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0342 0.0412
Schistosoma mansoni heat shock protein 0.0041 0.0453 0.0533
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0639 0.0752
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0021 0.0173 0.0844
Loa Loa (eye worm) hypothetical protein 0.0109 0.1389 0.2562
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0005
Trypanosoma cruzi heat shock protein 85, putative 0.0041 0.0453 0.0564
Leishmania major phosphopantetheinyl transferase-like protein 0.0021 0.0173 0.018
Trypanosoma brucei Heat shock protein 83, putative 0.0041 0.0453 0.0616
Schistosoma mansoni hypothetical protein 0.0037 0.0389 0.0458
Loa Loa (eye worm) endoplasmin 0.0041 0.0453 0.0829
Entamoeba histolytica hypothetical protein 0.0021 0.0173 0.018
Schistosoma mansoni cpg binding protein 0.0026 0.0239 0.0282
Echinococcus granulosus GTP binding nuclear protein Ran 0.0019 0.0146 0.0166
Leishmania major heat shock protein 83-1 0.0041 0.0453 0.0564
Onchocerca volvulus 0.0075 0.0919 0.1687
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0033 0.0342 0.0412
Giardia lamblia Grp94/Hsp90 0.0039 0.0418 0.0563
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0366 0.0668
Brugia malayi MH2 domain containing protein 0.0108 0.1371 0.2535
Loa Loa (eye worm) hypothetical protein 0.0213 0.2832 0.5232
Echinococcus multilocularis ewsr:fli fusion protein type 0.0009 0.0012 0.0007
Entamoeba histolytica heat shock protein 90, putative 0.0041 0.0453 0.0564
Echinococcus multilocularis GA binding protein alpha chain 0.0065 0.0785 0.078
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0014 0.0078 0.0087
Echinococcus multilocularis endoplasmin 0.0039 0.0418 0.0413
Echinococcus multilocularis tar DNA binding protein 0.0057 0.0672 0.0667
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0418 0.0516
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0005
Echinococcus granulosus Niemann Pick C1 protein 0.0127 0.1637 0.1923
Brugia malayi Inositol-1 0.0033 0.0342 0.0632
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0014 0.0078 0.036
Echinococcus multilocularis ets variant gene 4 0.0009 0.0012 0.0007
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0014 0.0078 0.0074
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0026 0.024 0.0277
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0078 0.0051
Trypanosoma brucei heat shock protein, putative 0.0041 0.0453 0.0616
Schistosoma mansoni importin beta-1 0.0026 0.0241 0.0284
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.054 0.7347 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0245 0.0444
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0033 0.0342 0.6906
Echinococcus granulosus survival motor neuron protein 1 0.0213 0.2832 0.3331
Entamoeba histolytica Flap nuclease, putative 0.0024 0.0206 0.0226
Loa Loa (eye worm) inositol-1 0.0033 0.0342 0.0624
Toxoplasma gondii Hsp90 domain-containing protein 0.0157 0.2048 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0075 0.0919 0.1077
Brugia malayi Flap endonuclease-1 0.0024 0.0206 0.0381
Onchocerca volvulus Huntingtin homolog 0.0111 0.141 0.2597
Plasmodium falciparum importin beta, putative 0.0026 0.0241 0.1156
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0144 0.0683
Onchocerca volvulus 0.0136 0.1767 0.3258
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0044 0.0488 0.0575
Brugia malayi nuclear hormone receptor 0.0009 0.0007 0.0013
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0031 0.0312 0.0307
Brugia malayi DNA-binding protein D-ETS-3 0.0009 0.0012 0.0022
Schistosoma mansoni flap endonuclease-1 0.0021 0.0175 0.0206
Schistosoma mansoni hypothetical protein 0.0009 0.0012 0.0014
Plasmodium vivax flap endonuclease 1, putative 0.0024 0.0206 0.0909
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0011 0.0035 0.003
Entamoeba histolytica hypothetical protein 0.0032 0.033 0.0395
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0181 0.0334
Brugia malayi jmjC domain containing protein 0.0086 0.1073 0.1983
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0007 0.0013
Schistosoma mansoni phd finger protein 0.0011 0.0029 0.0035
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0014 0.0078 0.0107
Echinococcus granulosus ewsr:fli fusion protein type 0.0009 0.0012 0.0009
Echinococcus multilocularis heat shock protein 0.0041 0.0453 0.0448
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0057 0.0672 0.1234
Leishmania major heat shock protein 83-1 0.0041 0.0453 0.0564
Toxoplasma gondii PHD-finger domain-containing protein 0.0026 0.0245 0.1196
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0039 0.0418 0.0516
Leishmania major heat shock protein 83-1 0.0041 0.0453 0.0564
Trypanosoma cruzi ISWI complex protein 0.0014 0.0072 0.0042
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0189 0.25 0.4617
Echinococcus multilocularis heat shock protein 90 0.0035 0.037 0.0366
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0024 0.0206 0.028
Brugia malayi cytoplasmic intermediate filament protein 0.0013 0.0061 0.0113
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0037 0.039 0.0713
Leishmania major heat shock protein 83-1 0.0041 0.0453 0.0564
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0007 0.0013
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0027 0.0261 0.0302
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.0043 0.0045
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0007 0.0003
Brugia malayi Fli-1 protein 0.0198 0.2625 0.4853
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0007 0.0003
Schistosoma mansoni lamin 0.0024 0.0218 0.0256
Toxoplasma gondii heat shock protein 75, putative 0.0027 0.0261 0.1274
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0033 0.0342 0.167
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0007 0.0003
Brugia malayi ecdysteroid receptor 0.0009 0.0007 0.0013
Schistosoma mansoni hypothetical protein 0.0037 0.0389 0.0458
Schistosoma mansoni hypothetical protein 0.0009 0.0012 0.0014
Echinococcus granulosus histone lysine methyltransferase setb 0.0044 0.0488 0.0569
Schistosoma mansoni hypothetical protein 0.0026 0.0245 0.0288
Brugia malayi Intermediate filament tail domain containing protein 0.0024 0.0218 0.0402
Schistosoma mansoni cpg binding protein 0.0029 0.0284 0.0334
Toxoplasma gondii aldehyde dehydrogenase 0.0055 0.0639 0.3119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0007 0.0005
Echinococcus multilocularis protein C ets 2 0.0009 0.0012 0.0007
Schistosoma mansoni SET domain protein 0.0031 0.0312 0.0367
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0118 0.0139
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0012 0.0043 0.0046
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0007 0.0008
Brugia malayi nuclear receptor NHR-88 0.0009 0.0007 0.0013
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0342 0.0412
Echinococcus granulosus heat shock protein 90 0.0041 0.0453 0.0528
Onchocerca volvulus 0.0024 0.0218 0.039
Echinococcus multilocularis zinc finger protein 0.0019 0.0146 0.0141
Brugia malayi Bromodomain containing protein 0.0028 0.0274 0.0507
Loa Loa (eye worm) hypothetical protein 0.0136 0.1767 0.3261
Loa Loa (eye worm) hypothetical protein 0.0037 0.0389 0.0712
Trypanosoma cruzi heat shock protein 85, putative 0.0041 0.0453 0.0564
Brugia malayi isocitrate dehydrogenase 0.0014 0.0078 0.0145
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0013 0.0061 0.0105
Trichomonas vaginalis heat shock protein, putative 0.003 0.0296 0.0349
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0084 0.0305
Loa Loa (eye worm) histone methyltransferase 0.001 0.0019 0.0027
Schistosoma mansoni microtubule-associated protein tau 0.0623 0.8492 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) 0 Antimalarial activity against Plasmodium falciparum K1 ChEMBL. 17004723
ED50 (functional) = 2.32 uM Antitrypanosomal activity against Trypanosoma brucei rhodesiense trypomastigotes ChEMBL. 17004723
ED50 (functional) = 2.32 uM Antitrypanosomal activity against Trypanosoma brucei rhodesiense trypomastigotes ChEMBL. 17004723
ED50 (functional) = 34.52 uM Antitrypanosomal activity against Trypanosoma cruzi trypomastigotes in CD1 mouse macrophage ChEMBL. 17004723
ED50 (functional) = 34.52 uM Antitrypanosomal activity against Trypanosoma cruzi trypomastigotes in CD1 mouse macrophage ChEMBL. 17004723
ED50 (functional) > 63 uM Antileishmanial activity against Leishmania donovani amastigotes in CD1 mouse macrophage ChEMBL. 17004723
ED50 (functional) > 63 uM Antimalarial activity against Plasmodium falciparum 3D7 ChEMBL. 17004723
ED50 (functional) > 63 uM Antileishmanial activity against Leishmania donovani amastigotes in CD1 mouse macrophage ChEMBL. 17004723
ED50 (functional) > 63 uM Antimalarial activity against Plasmodium falciparum 3D7 ChEMBL. 17004723
IC50 (binding) 0 Inhibition of Trypanosoma brucei brucei recombinant 24-SMT ChEMBL. 17004723
IC50 (binding) > 100 uM Inhibition of Leishmania major recombinant 24-SMT ChEMBL. 17004723
IC50 (binding) > 100 uM Inhibition of Leishmania major recombinant 24-SMT ChEMBL. 17004723
TD50 (functional) = 252 uM Cytotoxicity against KB cell line ChEMBL. 17004723
TD50 (functional) = 252 uM Cytotoxicity against KB cell line ChEMBL. 17004723

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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