Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | dihydrofolate reductase family protein | 0.0414 | 0.1841 | 0.2759 |
Brugia malayi | Kringle domain containing protein | 0.0347 | 0.1304 | 0.1954 |
Mycobacterium ulcerans | thymidylate synthase | 0.1014 | 0.6673 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0342 | 0.1264 | 0.1895 |
Echinococcus multilocularis | fibrillin 1 | 0.0342 | 0.1264 | 0.1895 |
Onchocerca volvulus | 0.0682 | 0.4001 | 0.5059 | |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0379 | 0.1561 | 0.2339 |
Echinococcus granulosus | thymidylate synthase | 0.1014 | 0.6673 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1014 | 0.6673 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.1014 | 0.6673 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1428 | 1 | 0.5 |
Onchocerca volvulus | 0.1014 | 0.6673 | 1 | |
Echinococcus granulosus | Tolloid protein 1 | 0.0342 | 0.1264 | 0.1895 |
Echinococcus granulosus | dihydrofolate reductase | 0.0414 | 0.1841 | 0.2759 |
Brugia malayi | hypothetical protein | 0.0483 | 0.2396 | 0.359 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.1264 | 0.1895 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0483 | 0.2396 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0682 | 0.4001 | 0.5912 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0682 | 0.4001 | 0.5912 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.1264 | 0.1895 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1428 | 1 | 1 |
Echinococcus granulosus | Mastin | 0.0379 | 0.1561 | 0.2339 |
Onchocerca volvulus | 0.0534 | 0.2806 | 0.2851 | |
Schistosoma mansoni | hypothetical protein | 0.0347 | 0.1304 | 0.1786 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0379 | 0.1561 | 0.2179 |
Brugia malayi | Trypsin family protein | 0.0682 | 0.4001 | 0.5995 |
Brugia malayi | thymidylate synthase | 0.1014 | 0.6673 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0414 | 0.1841 | 0.2759 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1014 | 0.6673 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1014 | 0.6673 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0414 | 0.1841 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1428 | 1 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0347 | 0.1304 | 0.0046 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0342 | 0.1264 | 0.1895 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0347 | 0.1304 | 0.1954 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0379 | 0.1561 | 0.2339 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1428 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.1264 | 0.1895 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0342 | 0.1264 | 0.1895 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0347 | 0.1304 | 0.1954 |
Echinococcus granulosus | enteropeptidase | 0.0379 | 0.1561 | 0.2339 |
Echinococcus granulosus | laminin | 0.0342 | 0.1264 | 0.1895 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1428 | 1 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.0342 | 0.1264 | 0.1895 |
Schistosoma mansoni | egf-like domain protein | 0.0342 | 0.1264 | 0.1726 |
Onchocerca volvulus | 0.0347 | 0.1304 | 0.0074 | |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0342 | 0.1264 | 0.1895 |
Brugia malayi | Protein kinase domain containing protein | 0.0347 | 0.1304 | 0.1954 |
Brugia malayi | Dihydrofolate reductase | 0.0414 | 0.1841 | 0.2759 |
Echinococcus multilocularis | thymidylate synthase | 0.1014 | 0.6673 | 1 |
Echinococcus multilocularis | Mastin | 0.0379 | 0.1561 | 0.2339 |
Echinococcus multilocularis | laminin | 0.0342 | 0.1264 | 0.1895 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0483 | 0.2396 | 0.1148 |
Schistosoma mansoni | dihydrofolate reductase | 0.0414 | 0.1841 | 0.2608 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.1264 | 0.1895 |
Loa Loa (eye worm) | hypothetical protein | 0.0682 | 0.4001 | 0.5995 |
Echinococcus multilocularis | enteropeptidase | 0.0379 | 0.1561 | 0.2339 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0342 | 0.1264 | 0.1895 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0342 | 0.1264 | 0.1726 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0347 | 0.1304 | 0.1954 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0483 | 0.2396 | 0.1255 |
Loa Loa (eye worm) | hypothetical protein | 0.0682 | 0.4001 | 0.5995 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.1264 | 0.1895 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0342 | 0.1264 | 0.1895 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0414 | 0.1841 | 0.2759 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.1304 | 0.1954 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 62 mM | Inhibition of West Nile virus NS3 protease | ChEMBL. | 17064076 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.