TDR Targets

Basic information

Technical information

TDR Targets ID: 375034
Name: N-[4-[(3S)-3,4-dimethylpiperazin-1-yl]phenyl] -2,3,7,8-tetramethylquinolin-4-amine
MW: 388.548 | Formula: C25H32N4
H donors: 1 H acceptors: 1 LogP: 5.59 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(C[C@@H]1C)c1ccc(cc1)Nc1c(C)c(C)nc2c1ccc(c2C)C
InChi: 1S/C25H32N4/c1-16-7-12-23-24(18(16)3)26-20(5)19(4)25(23)27-21-8-10-22(11-9-21)29-14-13-28(6)17(2)15-29/h7-12,17H,13-15H2,1-6H3,(H,26,27)/t17-/m0/s1
InChiKey: OFZVRVWUVPCFQQ-KRWDZBQOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[4-[(3S)-3,4-dimethylpiperazin-1-yl]phenyl]-2,3,7,8-tetramethyl-quinolin-4-amine
N-[4-[(3S)-3,4-dimethyl-1-piperazinyl]phenyl]-2,3,7,8-tetramethyl-4-quinolinamine
[4-[(3S)-3,4-dimethylpiperazino]phenyl]-(2,3,7,8-tetramethyl-4-quinolyl)amine
[4-[(3S)-3,4-dimethylpiperazin-1-yl]phenyl]-(2,3,7,8-tetramethyl-4-quinolyl)amine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	adrenoceptor alpha 2B	Starlite/ChEMBL	References
Homo sapiens	adrenoceptor alpha 2C	Starlite/ChEMBL	References
Homo sapiens	adrenoceptor alpha 2A	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.2845	0.9472
Schistosoma mansoni	amine GPCR	0.0039	0.2845	0.9472
Schistosoma mansoni	adenoreceptor	0.0039	0.2845	0.9472
Echinococcus granulosus	g protein coupled receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Echinococcus granulosus	cathepsin L	0.0014	0.0337	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0107	1	1
Schistosoma mansoni	hypothetical protein	0.0039	0.2845	0.9472
Echinococcus multilocularis	cysteine protease	0.0028	0.1759	0.5858
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0039	0.2845	0.9472
Echinococcus granulosus	cysteine protease	0.0014	0.0337	0.1124
Brugia malayi	G-protein coupled receptor	0.0039	0.2845	0.9472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.079	0.3182
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.1759	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Onchocerca volvulus		0.0039	0.2845	1
Onchocerca volvulus		0.0013	0.0233	0.0817
Echinococcus multilocularis	glycine receptor subunit beta	0.0013	0.0233	0.0774
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.1759	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Schistosoma mansoni	hypothetical protein	0.0039	0.2845	0.9472
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0013	0.0233	0.0817
Echinococcus multilocularis	serotonin receptor	0.0039	0.2845	0.9472
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.2845	0.9472
Echinococcus multilocularis	nAChR subunit	0.0013	0.0233	0.0774
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.2845	0.9472
Echinococcus multilocularis	allatostatin A receptor	0.0039	0.2845	0.9472
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.2845	0.9472
Brugia malayi	Cation transporter family protein	0.0013	0.0233	0.0774
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0013	0.0233	0.0774
Brugia malayi	hypothetical protein	0.0039	0.2845	0.9472
Loa Loa (eye worm)	G-protein coupled receptor	0.0039	0.2845	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0028	0.1759	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.2845	0.9472
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0013	0.0233	0.0774
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0013	0.0233	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Brugia malayi	Dopamine receptor	0.0039	0.2845	0.9472
Onchocerca volvulus		0.0039	0.2845	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0014	0.0337	0.1124
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.2845	0.9472
Loa Loa (eye worm)	cysteine protease	0.0028	0.1759	0.6185
Brugia malayi	putative neuropeptide receptor NPR1	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.2845	0.9472
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0013	0.0233	0.0774
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0039	0.2845	0.9472
Echinococcus granulosus	somatostatin receptor	0.0039	0.2845	0.9472
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0028	0.1759	1
Brugia malayi	neuropeptide F receptor	0.0039	0.2845	0.9472
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2845	0.9472
Schistosoma mansoni	nAChR subunit	0.0013	0.0233	0.0774
Echinococcus granulosus	neuropeptide receptor	0.0039	0.2845	0.9472
Schistosoma mansoni	nAChR subunit	0.0013	0.0233	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0107	1	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0013	0.0233	0.0774
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.3003	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0013	0.0233	0.0774
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0028	0.1759	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0028	0.1759	0.5858
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0014	0.0337	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0039	0.2845	0.9472
Brugia malayi	Papain family cysteine protease containing protein	0.0014	0.0337	0.1124
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0107	1	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0013	0.0233	0.0774
Echinococcus granulosus	neuropeptides capa receptor	0.0039	0.2845	0.9472
Echinococcus multilocularis	somatostatin receptor	0.0039	0.2845	0.9472
Onchocerca volvulus		0.0039	0.2845	1
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.2845	0.9472
Schistosoma mansoni	biogenic amine receptor	0.0039	0.2845	0.9472
Echinococcus granulosus	glycine receptor subunit beta	0.0013	0.0233	0.0774
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0013	0.0233	0.0774
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2845	0.9472
Echinococcus granulosus	neuropeptide Y receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.1759	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0039	0.2845	0.9472
Onchocerca volvulus	Cathepsin L homolog	0.0028	0.1759	0.6185
Entamoeba histolytica	hypothetical protein	0.004	0.3003	1
Echinococcus granulosus	g protein coupled receptor	0.0039	0.2845	0.9472
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Brugia malayi	cathepsin L-like precursor	0.0019	0.079	0.263
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Onchocerca volvulus		0.0028	0.1759	0.6185
Schistosoma mansoni	opsin-like receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0039	0.2845	0.9472
Echinococcus granulosus	allatostatin A receptor	0.0039	0.2845	0.9472
Brugia malayi	GnHR receptor homolog	0.0039	0.2845	0.9472
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0028	0.1759	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0013	0.0233	0.0774
Loa Loa (eye worm)	TYRA-2 protein	0.0039	0.2845	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0013	0.0233	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Schistosoma mansoni	neuropeptide receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0107	1	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0039	0.2845	0.9472
Plasmodium vivax	vivapain-2	0.0028	0.1759	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0039	0.2845	0.9472
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0039	0.2845	0.9472
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.2845	0.9472
Echinococcus granulosus	nAChR subunit	0.0013	0.0233	0.0774
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0013	0.0233	0.0774
Schistosoma mansoni	hypothetical protein	0.004	0.3003	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.2845	0.9472
Brugia malayi	hypothetical protein	0.0039	0.2845	0.9472
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0039	0.2845	0.9472
Echinococcus multilocularis	dro:myosuppressin receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.2845	0.9472
Brugia malayi	larval opioid receptor	0.0039	0.2845	0.9472
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0013	0.0233	0.0774
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0013	0.0233	0.0774
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0013	0.0233	0.0774
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0028	0.1759	0.5858
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.2845	0.9472
Onchocerca volvulus		0.0039	0.2845	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Echinococcus multilocularis	cathepsin L	0.0014	0.0337	0.1124
Onchocerca volvulus		0.0028	0.1759	0.6185
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.2845	0.9472
Brugia malayi	excitatory GABA receptor EXP-1A	0.0013	0.0233	0.0774
Echinococcus multilocularis	orexin receptor type 2	0.0039	0.2845	0.9472
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.2845	0.9472
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0013	0.0233	0.0774
Schistosoma mansoni	nAChR subunit	0.0013	0.0233	0.0774
Onchocerca volvulus		0.0039	0.2845	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0028	0.1759	0.5858
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0013	0.0233	0.0774
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0013	0.0233	0.0774
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0013	0.0233	0.0774
Loa Loa (eye worm)	ACC-1 protein	0.0013	0.0233	0.0817
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.2845	0.9472
Brugia malayi	hypothetical protein	0.004	0.3003	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0039	0.2845	0.9472
Brugia malayi	sulfakinin receptor protein	0.0039	0.2845	0.9472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.1759	1
Echinococcus granulosus	neuropeptides capa receptor	0.0039	0.2845	0.9472
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2845	0.9472
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0039	0.2845	0.9472
Echinococcus granulosus	cathepsin l1	0.0028	0.1759	0.5858
Schistosoma mansoni	nAChR subunit	0.0013	0.0233	0.0774
Brugia malayi	Cathepsin L-like precursor	0.0028	0.1759	0.5858
Onchocerca volvulus		0.0039	0.2845	1
Onchocerca volvulus		0.0039	0.2845	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0013	0.0233	0.0774
Brugia malayi	Dopamine receptor protein 1	0.0039	0.2845	0.9472
Brugia malayi	Cathepsin L-like precursor	0.0028	0.1759	0.5858
Brugia malayi	Serotonin receptor	0.0039	0.2845	0.9472
Brugia malayi	Dopamine receptor protein 2	0.0039	0.2845	0.9472
Trypanosoma cruzi	cysteine peptidase, putative	0.0107	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.2845	0.9472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.1759	1
Brugia malayi	hypothetical protein	0.0039	0.2845	0.9472
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0013	0.0233	0.0774
Brugia malayi	Papain family cysteine protease containing protein	0.0014	0.0337	0.1124
Trypanosoma cruzi	major cysteine proteinase, putative	0.0084	0.7609	0.7525
Brugia malayi	hypothetical protein	0.0039	0.2845	0.9472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0028	0.1759	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0013	0.0233	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Brugia malayi	hypothetical protein	0.0039	0.2845	0.9472
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.3003	1
Onchocerca volvulus		0.0013	0.0233	0.0817
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2845	0.9472
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0013	0.0233	0.0774
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0107	1	1
Entamoeba histolytica	hypothetical protein	0.004	0.3003	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0107	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0028	0.1759	1
Toxoplasma gondii	cathepsin CPL	0.0028	0.1759	0.5
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0013	0.0233	0.0774
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0039	0.2845	0.9472
Onchocerca volvulus		0.0039	0.2845	1
Schistosoma mansoni	neuropeptide receptor	0.0039	0.2845	0.9472
Leishmania major	cathepsin L-like protease	0.0107	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0039	0.2845	0.9472
Brugia malayi	G protein-coupled receptor F59B2.13	0.0039	0.2845	0.9472
Schistosoma mansoni	amine GPCR	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Echinococcus granulosus	neuropeptide receptor A26	0.0039	0.2845	0.9472
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0039	0.2845	0.9472
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0039	0.2845	0.9472
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0028	0.1759	1
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0013	0.0233	0.0774
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0013	0.0233	0.0774
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0028	0.1759	0.6185
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Schistosoma mansoni	histamine h1 receptor	0.0039	0.2845	0.9472
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0013	0.0233	0.0774
Loa Loa (eye worm)	G-protein coupled receptor	0.0039	0.2845	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0039	0.2845	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Onchocerca volvulus		0.0039	0.2845	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0039	0.2845	0.9472
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2845	0.9472
Echinococcus multilocularis	neuropeptide Y receptor	0.0039	0.2845	0.9472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.1759	1
Echinococcus granulosus	fmrfamide receptor	0.0039	0.2845	0.9472
Onchocerca volvulus	Cathepsin L homolog	0.0028	0.1759	0.6185
Schistosoma mansoni	neuropeptide receptor	0.0039	0.2845	0.9472
Echinococcus granulosus	sex peptide receptor	0.0039	0.2845	0.9472
Onchocerca volvulus		0.0039	0.2845	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.2845	0.9472
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0039	0.2845	1
Echinococcus granulosus	g protein coupled receptor	0.0039	0.2845	0.9472
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0039	0.2845	0.9472
Echinococcus multilocularis	cysteine protease	0.0028	0.1759	0.5858
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.1759	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0039	0.2845	0.9472
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0039	0.2845	1
Schistosoma mansoni	amine GPCR	0.0039	0.2845	0.9472
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0028	0.1759	0.5858
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0039	0.2845	0.9472
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0039	0.2845	0.9472
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0013	0.0233	0.0774
Echinococcus multilocularis	fmrfamide receptor	0.0039	0.2845	0.9472
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0013	0.0233	0.0774
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0013	0.0233	0.0774
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0013	0.0233	0.0817
Echinococcus granulosus	hypothetical protein	0.0039	0.2845	0.9472
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0014	0.0337	0.1124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.2845	0.9472
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0039	0.2845	0.9472
Echinococcus granulosus	neuropeptide Y receptor	0.0039	0.2845	0.9472
Onchocerca volvulus		0.0039	0.2845	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0039	0.2845	0.9472
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0107	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.1759	1
Echinococcus granulosus	serotonin receptor	0.0039	0.2845	0.9472
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.2845	0.9472
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.079	0.263
Loa Loa (eye worm)	hypothetical protein	0.0019	0.079	0.2777
Brugia malayi	follicle stimulating hormone receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0039	0.2845	0.9472
Brugia malayi	G protein-coupled receptor	0.0039	0.2845	0.9472
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0013	0.0233	0.0774
Brugia malayi	neuropeptide F receptor	0.0039	0.2845	0.9472
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0107	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0107	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0028	0.1759	0.1472
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0039	0.2845	0.9472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.1759	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.2845	0.9472
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0039	0.2845	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0039	0.2845	0.9472
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0013	0.0233	0.0774
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0013	0.0233	0.0774
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0028	0.1759	0.5858
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0013	0.0233	0.0774
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0013	0.0233	0.0817
Echinococcus multilocularis	neuropeptide Y receptor	0.0039	0.2845	0.9472
Brugia malayi	Cathepsin L-like precursor	0.0028	0.1759	0.5858
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0028	0.1759	0.6185
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0039	0.2845	0.9472
Schistosoma mansoni	opsin-like receptor	0.0039	0.2845	0.9472
Echinococcus multilocularis	neuropeptide s receptor	0.0039	0.2845	0.9472
Echinococcus multilocularis	neuropeptide receptor A26	0.0039	0.2845	0.9472
Onchocerca volvulus		0.0039	0.2845	1
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0013	0.0233	0.0774
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0039	0.2845	0.9472
Onchocerca volvulus		0.0039	0.2845	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0039	0.2845	0.9472
Schistosoma mansoni	biogenic amine receptor	0.0039	0.2845	0.9472
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0028	0.1759	1
Echinococcus multilocularis	g-protein coupled receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Brugia malayi	hypothetical protein	0.0039	0.2845	0.9472
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0039	0.2845	0.9472
Loa Loa (eye worm)	ACC-1 protein	0.0013	0.0233	0.0817
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0019	0.079	0.263
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.2845	0.9472
Schistosoma mansoni	nAChR subunit	0.0013	0.0233	0.0774
Onchocerca volvulus		0.0039	0.2845	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0028	0.1759	0.6185
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Echinococcus multilocularis	neuropeptide receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	LGC-31 protein	0.0013	0.0233	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0013	0.0233	0.0774
Onchocerca volvulus		0.0019	0.079	0.2777
Echinococcus granulosus	cathepsin l1	0.0019	0.079	0.263
Onchocerca volvulus	Putative nachr subunit	0.0013	0.0233	0.0817
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0013	0.0233	0.0817
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0013	0.0233	0.0817
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0107	1	1
Brugia malayi	Serotonin receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2845	0.9472
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.2845	0.9472
Echinococcus granulosus	cathepsin L cysteine protease	0.0014	0.0337	0.1124
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0039	0.2845	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0039	0.2845	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0013	0.0233	0.0774
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0039	0.2845	0.9472
Schistosoma mansoni	myosin xvIII	0.0039	0.2845	0.9472
Schistosoma mansoni	hypothetical protein	0.0039	0.2845	0.9472
Brugia malayi	G-protein coupled receptor	0.0039	0.2845	0.9472
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0107	1	1
Brugia malayi	Cathepsin L-like precursor	0.0019	0.079	0.263
Schistosoma mansoni	cathepsin F (C01 family)	0.0028	0.1759	0.5858
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0039	0.2845	0.9472
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.1759	0.5334
Brugia malayi	Cation transporter family protein	0.0013	0.0233	0.0774
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0028	0.1759	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0039	0.2845	0.9472
Onchocerca volvulus		0.0028	0.1759	0.6185
Entamoeba histolytica	hypothetical protein	0.004	0.3003	1
Onchocerca volvulus		0.0013	0.0233	0.0817
Brugia malayi	putative neuropeptide receptor	0.0039	0.2845	0.9472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.1759	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0039	0.2845	0.9472
Onchocerca volvulus		0.0013	0.0233	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Schistosoma mansoni	hypothetical protein	0.0039	0.2845	0.9472
Onchocerca volvulus		0.0013	0.0233	0.0817
Schistosoma mansoni	neuropeptide receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	ctsf protein	0.0028	0.1759	0.6185
Echinococcus multilocularis	neuropeptides capa receptor	0.0039	0.2845	0.9472
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.1759	0.5334
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.3003	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0013	0.0233	0.0774
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0039	0.2845	0.9472
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0013	0.0233	0.0774
Onchocerca volvulus		0.0039	0.2845	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2845	0.9472
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0107	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0013	0.0233	0.0774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.1759	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Brugia malayi	Cathepsin L-like precursor	0.0028	0.1759	0.5858
Brugia malayi	Cathepsin L-like precursor	0.0028	0.1759	0.5858
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0028	0.1759	1
Echinococcus granulosus	G protein coupled receptor 139	0.0039	0.2845	0.9472
Plasmodium vivax	vivapain-2	0.0028	0.1759	1
Echinococcus granulosus	orexin receptor type 2	0.0039	0.2845	0.9472
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0039	0.2845	0.9472
Echinococcus granulosus	neuropeptide receptor	0.0039	0.2845	0.9472
Onchocerca volvulus		0.0028	0.1759	0.6185
Echinococcus multilocularis	cathepsin L cysteine protease	0.0028	0.1759	0.5858
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0028	0.1759	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0028	0.1759	1
Onchocerca volvulus		0.0028	0.1759	0.6185
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0013	0.0233	0.0774
Brugia malayi	hypothetical protein	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0019	0.079	0.2777
Schistosoma mansoni	growth hormone secretagogue receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0039	0.2845	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0039	0.2845	0.9472
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0039	0.2845	1
Brugia malayi	Melatonin receptor type 1A	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0013	0.0233	0.0774
Onchocerca volvulus		0.0039	0.2845	1
Echinococcus granulosus	glycine receptor subunit beta	0.0013	0.0233	0.0774
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0028	0.1759	1
Brugia malayi	RE15519p	0.0039	0.2845	0.9472
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Schistosoma mansoni	amine GPCR	0.0039	0.2845	0.9472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.1759	1
Brugia malayi	hypothetical protein	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Echinococcus multilocularis	serotonin receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.1759	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.2845	0.9472
Onchocerca volvulus		0.0013	0.0233	0.0817
Echinococcus multilocularis	neuropeptide receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	fibroinase	0.0028	0.1759	0.6185
Entamoeba histolytica	cysteine protease, putative	0.0028	0.1759	0.5334
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.079	0.3182
Brugia malayi	hypothetical protein	0.0039	0.2845	0.9472
Loa Loa (eye worm)	melatonin receptor type 1A	0.0039	0.2845	1
Schistosoma mansoni	nAChR subunit	0.0013	0.0233	0.0774
Entamoeba histolytica	hypothetical protein	0.004	0.3003	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0039	0.2845	0.9472
Onchocerca volvulus	Cathepsin F homolog	0.0028	0.1759	0.6185
Echinococcus multilocularis	sex peptide receptor	0.0039	0.2845	0.9472
Brugia malayi	ORL1-like opioid receptor	0.0039	0.2845	0.9472
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0028	0.1759	1
Echinococcus multilocularis	fmrfamide receptor	0.0039	0.2845	0.9472
Brugia malayi	Cathepsin L-like precursor	0.0028	0.1759	0.5858
Brugia malayi	Papain family cysteine protease containing protein	0.0028	0.1759	0.5858
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0013	0.0233	0.0774
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0039	0.2845	0.9472
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.079	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Schistosoma mansoni	biogenic amine receptor	0.0039	0.2845	0.9472
Brugia malayi	hypothetical protein	0.0039	0.2845	0.9472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.1759	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0233	0.0817
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0039	0.2845	0.9472
Echinococcus granulosus	neuropeptide s receptor	0.0039	0.2845	0.9472
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0039	0.2845	0.9472
Brugia malayi	Cathepsin L-like precursor	0.0019	0.079	0.263
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2845	0.9472
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Schistosoma mansoni	opsin-like receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0039	0.2845	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0107	1	1
Leishmania major	cathepsin L-like protease	0.0107	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0098	0.9031	0.8997
Schistosoma mansoni	amine GPCR	0.0039	0.2845	0.9472
Onchocerca volvulus		0.0028	0.1759	0.6185
Echinococcus multilocularis	cathepsin L cysteine protease	0.0028	0.1759	0.5858
Schistosoma mansoni	nAChR subunit	0.0013	0.0233	0.0774
Schistosoma mansoni	neuropeptide F-like receptor	0.0039	0.2845	0.9472
Brugia malayi	Cation transporter family protein	0.0013	0.0233	0.0774
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0013	0.0233	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Onchocerca volvulus		0.0039	0.2845	1
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0013	0.0233	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Echinococcus granulosus	g-protein coupled receptor	0.0039	0.2845	0.9472
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0039	0.2845	0.9472
Echinococcus granulosus	7tm_1 domain containing protein	0.0039	0.2845	0.9472
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0107	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0013	0.0233	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0019	0.079	0.2777
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.2845	0.9472
Onchocerca volvulus		0.0028	0.1759	0.6185
Brugia malayi	AKH receptor	0.0039	0.2845	0.9472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2845	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0039	0.2845	0.9472

Activities

Activity type	Activity value	Assay description	Source	Reference
KB (functional)	= 74 nM	Antagonist activity at human ADRA2C expressed in CHO cell membrane assessed as inhibition of epinephrine-induced [35S]GTPgammaS binding	ChEMBL.	17034141
Kb (functional)	= 74 nM	Antagonist activity at human ADRA2C expressed in CHO cell membrane assessed as inhibition of epinephrine-induced [35S]GTPgammaS binding	ChEMBL.	17034141
KB (functional)	= 2440 nM	Antagonist activity at human ADRA2A expressed in CHO cell membrane assessed as inhibition of epinephrine-induced [35S]GTPgammaS binding	ChEMBL.	17034141
Kb (functional)	= 2440 nM	Antagonist activity at human ADRA2A expressed in CHO cell membrane assessed as inhibition of epinephrine-induced [35S]GTPgammaS binding	ChEMBL.	17034141
KB (functional)	= 3500 nM	Antagonist activity at human ADRA2B expressed in CHO cell membrane assessed as inhibition of epinephrine-induced [35S]GTPgammaS binding	ChEMBL.	17034141
Kb (functional)	= 3500 nM	Antagonist activity at human ADRA2B expressed in CHO cell membrane assessed as inhibition of epinephrine-induced [35S]GTPgammaS binding	ChEMBL.	17034141
Ki (binding)	= 7.076	Binding affinity to human cloned Alpha-2C adrenergic receptor	ChEMBL.	21277656
Ki (binding)	= 84 nM	Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells	ChEMBL.	17034141
Ki (binding)	= 84 nM	Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells	ChEMBL.	17034141
Ki (binding)	= 850 nM	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL.	17034141
Ki (binding)	= 850 nM	Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cells	ChEMBL.	17034141
Ki (binding)	= 1320 nM	Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells	ChEMBL.	17034141
Ki (binding)	= 1320 nM	Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cells	ChEMBL.	17034141

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL216674
PubChem: 16090594

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 375034