Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 2, subfamily D, polypeptide 6 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 2, subfamily D, polypeptide 6 | 497 aa | 425 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | neurogenic locus notch protein | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Schistosoma mansoni | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Schistosoma mansoni | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Schistosoma mansoni | notch | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0833 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Giardia lamblia | High cysteine protein | 0.0269 | 0.0073 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0833 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | Notch2 | 0.0269 | 0.0073 | 0.0073 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0269 | 0.0073 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Onchocerca volvulus | Dual oxidase homolog | 0.0833 | 1 | 1 |
Schistosoma mansoni | notch | 0.0269 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0833 | 1 | 1 | |
Schistosoma mansoni | notch | 0.0269 | 0.0073 | 0.0073 |
Onchocerca volvulus | Peroxidasin homolog | 0.0833 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Echinococcus granulosus | slit 2 protein | 0.0269 | 0.0073 | 0.0073 |
Echinococcus granulosus | protein jagged 2 | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0833 | 1 | 1 |
Schistosoma mansoni | slit | 0.0269 | 0.0073 | 0.0073 |
Echinococcus multilocularis | protein jagged 1 | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Brugia malayi | Blistered cuticle protein 3 | 0.0833 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0269 | 0.0073 | 0.0073 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0269 | 0.0073 | 0.0073 |
Echinococcus multilocularis | slit 2 protein | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0833 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0269 | 0.0073 | 0.0073 |
Schistosoma mansoni | notch | 0.0269 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0833 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0833 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Schistosoma mansoni | peroxidasin | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Schistosoma mansoni | notch | 0.0269 | 0.0073 | 0.0073 |
Brugia malayi | Animal haem peroxidase family protein | 0.0833 | 1 | 1 |
Echinococcus granulosus | protein jagged 1 | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Schistosoma mansoni | peroxidasin | 0.0833 | 1 | 1 |
Echinococcus multilocularis | protein jagged 2 | 0.0269 | 0.0073 | 0.0073 |
Echinococcus granulosus | neural cadherin | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | notch protein | 0.0269 | 0.0073 | 0.0073 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0269 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0833 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0833 | 1 | 1 |
Schistosoma mansoni | cell polarity protein | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Echinococcus multilocularis | protein jagged 1 | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0833 | 1 | 1 |
Echinococcus granulosus | protein jagged 1 | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Echinococcus granulosus | peroxidasin | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0833 | 1 | 1 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0269 | 0.0073 | 0.0073 |
Brugia malayi | Peroxidasin | 0.0833 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0269 | 0.0073 | 0.0073 |
Echinococcus multilocularis | neural cadherin | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Brugia malayi | Animal haem peroxidase family protein | 0.0833 | 1 | 1 |
Echinococcus granulosus | fibropellin Ia | 0.0269 | 0.0073 | 0.0073 |
Schistosoma mansoni | notch | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Schistosoma mansoni | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0833 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0833 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Echinococcus granulosus | notch | 0.0269 | 0.0073 | 0.0073 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0269 | 0.0073 | 0.0073 |
Brugia malayi | Animal haem peroxidase family protein | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Echinococcus granulosus | protein jagged 2 | 0.0269 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0833 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0833 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0833 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0833 | 1 | 1 |
Echinococcus multilocularis | notch | 0.0269 | 0.0073 | 0.0073 |
Echinococcus granulosus | delta-like protein 1 | 0.0269 | 0.0073 | 0.0073 |
Onchocerca volvulus | Peroxidasin homolog | 0.0833 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0269 | 0.0073 | 0.0073 |
Echinococcus multilocularis | fibropellin Ia | 0.0269 | 0.0073 | 0.0073 |
Schistosoma mansoni | septate junction protein | 0.0269 | 0.0073 | 0.0073 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = -5.4 | Inhibition of CYP2D6 | ChEMBL. | 16824755 |
IC50 (ADMET) | = 4.5 uM | Inhibition of CYP2D6 | ChEMBL. | 16824755 |
IC50 (ADMET) | = 4.5 uM | Inhibition of CYP2D6 | ChEMBL. | 16824755 |
Ki (binding) | = -8.6 | Binding affinity to MCHR1 by competitive binding assay | ChEMBL. | 16824755 |
Ki (binding) | = 2.4 nM | Binding affinity to MCHR1 by competitive binding assay | ChEMBL. | 16824755 |
Ki (binding) | = 2.4 nM | Binding affinity to MCHR1 by competitive binding assay | ChEMBL. | 16824755 |
Log IC50 (ADMET) | = 5.4 | Inhibition of CYP2D6 | ChEMBL. | 16824755 |
Log Ki (binding) | = 8.6 | Binding affinity to MCHR1 by competitive binding assay | ChEMBL. | 16824755 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.