Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Bos taurus | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of human erythrocyte AChE | ChEMBL. | 17154513 | |
IC50 (binding) | 0 | Inhibition of human erythrocyte AChE | ChEMBL. | 17154513 |
IC50 (binding) | = 225 nM | Inhibition of human erythrocyte AChE | ChEMBL. | 17154513 |
IC50 (binding) | = 225 nM | Inhibition of human erythrocyte AChE | ChEMBL. | 17154513 |
IC50 (binding) | = 389 nM | Inhibition of bovine erythrocyte AChE | ChEMBL. | 17154513 |
IC50 (binding) | = 389 nM | Inhibition of bovine erythrocyte AChE | ChEMBL. | 17154513 |
IC50 (binding) | = 447 nM | Inhibition of bovine erythrocyte AChE after 45 mins | ChEMBL. | 17154513 |
IC50 (binding) | = 447 nM | Inhibition of bovine erythrocyte AChE after 45 mins | ChEMBL. | 17154513 |
IC50 (binding) | = 478 nM | Inhibition of bovine erythrocyte AChE after 45 mins | ChEMBL. | 17154513 |
IC50 (binding) | = 478 nM | Inhibition of bovine erythrocyte AChE after 45 mins | ChEMBL. | 17154513 |
IC50 (binding) | = 482 nM | Inhibition of bovine erythrocyte AChE | ChEMBL. | 17154513 |
IC50 (binding) | = 482 nM | Inhibition of bovine erythrocyte AChE | ChEMBL. | 17154513 |
IC50 (binding) | = 601 nM | Inhibition of human serum BChE | ChEMBL. | 17154513 |
IC50 (binding) | = 601 nM | Inhibition of human serum BChE | ChEMBL. | 17154513 |
IC50 (binding) | = 6480 nM | Inhibition of human serum BChE | ChEMBL. | 17154513 |
IC50 (binding) | = 6480 nM | Inhibition of human serum BChE | ChEMBL. | 17154513 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.