Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, shaker-related subfamily, member 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | voltage gated potassium channel | potassium voltage-gated channel, shaker-related subfamily, member 5 | 613 aa | 521 aa | 34.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0072 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0905 | 0.0905 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0072 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0072 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0072 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0104 | 0.0905 | 0.0905 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0072 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0076 | 0.0128 | 0.0128 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0104 | 0.0905 | 0.0905 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0104 | 0.0905 | 0.0905 |
Onchocerca volvulus | 0.0072 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0072 | 0 | 0.5 |
Onchocerca volvulus | 0.0072 | 0 | 0.5 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0104 | 0.0905 | 0.0905 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0072 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0425 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0425 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0425 | 1 | 1 |
Onchocerca volvulus | 0.0072 | 0 | 0.5 | |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0104 | 0.0905 | 0.0905 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0104 | 0.0905 | 0.0905 |
Onchocerca volvulus | 0.0072 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0425 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0425 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0425 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0425 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0425 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0425 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0425 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0099 | 0.0776 | 0.0776 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
dp/dt(max) (functional) | = -32 % | Reduced contractility in mini-pig model after 15 minute infusion at 30mg/kg | ChEMBL. | 17010606 |
dp/dt(max) (functional) | = -26 % | Reduced contractility in mini-pig model after 15 minute infusion at 10mg/kg | ChEMBL. | 17010606 |
IC50 (functional) | = 0.33 uM | Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assay | ChEMBL. | 17010606 |
IC50 (functional) | = 0.33 uM | Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assay | ChEMBL. | 17010606 |
Inhibition (functional) | = 75 % | Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assay at 1uM | ChEMBL. | 17010606 |
Inhibition (functional) | = 75 % | Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assay at 1uM | ChEMBL. | 17010606 |
Prolonged ARP (functional) | = 3 % | Prolonged ARP in mini-pig after 15 minute infusion with 10mg/kg | ChEMBL. | 17010606 |
Prolonged ARP (functional) | = 23 % | Prolonged ARP in mini-pig after 15 minute infusion with 310mg/kg | ChEMBL. | 17010606 |
Prolonged VRP (functional) | = 0 % | Prolonged VRP in mini-pig after 15 minute infusion with 10mg/kg | ChEMBL. | 17010606 |
Prolonged VRP (functional) | = 0 % | Prolonged VRP in mini-pig after 15 minute infusion with 30mg/kg | ChEMBL. | 17010606 |
Reduced BP (functional) | = -21 % | Reduced blood pressure in mini-pig model after 15 minute infusion at 30mg/kg | ChEMBL. | 17010606 |
Reduced BP (functional) | = -11 % | Reduced blood pressure in mini-pig model after 15 minute infusion at 10mg/kg | ChEMBL. | 17010606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.