Detailed information for compound 375371

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 469.245 | Formula: C19H17FINO4
  • H donors: 1 H acceptors: 2 LogP: 2 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@H]1OCC(=C2C1=NC1=C([C@H]2c2ccc(c(c2)I)F)C(=O)COC1)O
  • InChi: 1S/C19H17FINO4/c1-2-15-19-18(14(24)8-26-15)16(9-3-4-10(20)11(21)5-9)17-12(22-19)6-25-7-13(17)23/h3-5,15-16,24H,2,6-8H2,1H3/t15-,16-/m1/s1
  • InChiKey: YGSHVUGVSPRNFI-HZPDHXFCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 11 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0012 0.0041 0.0041
Trypanosoma brucei polyadenylate-binding protein 1 0.0012 0.0043 0.014
Toxoplasma gondii HEAT repeat-containing protein 0.002 0.0091 0.0353
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0007 0.001 0.001
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0013 0.0045 0.0349
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0013 0.0044 0.0144
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0006 0.0004 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0013 0.0047 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0046
Schistosoma mansoni transcription factor LCR-F1 0.0103 0.0603 0.0894
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0006 0 0.0001
Brugia malayi Patched family protein 0.0012 0.004 0.0059
Leishmania major phosphatidylinositol 3-kinase, putative 0.0013 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0006
Loa Loa (eye worm) calpain 0.0013 0.0047 0.0069
Brugia malayi nuclear receptor NHR-88 0.0006 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0064
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0013 0.0044 0.0065
Schistosoma mansoni RAR-like nuclear receptor 0.0013 0.0047 0.007
Loa Loa (eye worm) hypothetical protein 0.0103 0.0606 0.09
Brugia malayi Dihydrofolate reductase 0.109 0.674 1
Trichomonas vaginalis replication factor C large subunit, putative 0.0007 0.0007 0.0152
Entamoeba histolytica hypothetical protein 0.0103 0.0603 0.5073
Brugia malayi hypothetical protein 0.0012 0.004 0.0059
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Loa Loa (eye worm) patched family protein 0.0012 0.004 0.0059
Brugia malayi Patched related family protein 10 0.0012 0.004 0.0059
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Toxoplasma gondii target of rapamycin (TOR), putative 0.0013 0.0044 0.0171
Echinococcus multilocularis Niemann Pick C1 protein 0.028 0.1707 0.1707
Trypanosoma cruzi polyadenylate-binding protein 1, putative 0.0012 0.0043 0.014
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0013 0.0044 0.0144
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0013 0.0044 0.0013
Echinococcus granulosus GTP binding nuclear protein Ran 0.0015 0.0058 0.0086
Echinococcus multilocularis lamin 0.0023 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0016
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0007 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0007 0.0152
Trichomonas vaginalis ribonucleoprotein, chloroplast, putative 0.0006 0.0004 0.0083
Plasmodium vivax ataxin-2 like protein, putative 0.0017 0.0072 0.0254
Loa Loa (eye worm) hypothetical protein 0.0008 0.0015 0.0022
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0013 0.0047 0.007
Trypanosoma brucei importin beta-1 subunit, putative 0.002 0.0091 0.0326
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0041 0.0131
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Brugia malayi Patched family protein 0.0012 0.004 0.0059
Loa Loa (eye worm) CXXC zinc finger family protein 0.0018 0.0077 0.0115
Schistosoma mansoni dishevelled 0.0006 0 0.0001
Echinococcus granulosus replication factor c subunit 1 0.0007 0.0007 0.0011
Brugia malayi ImpB/MucB/SamB family protein 0.0012 0.0041 0.0061
Echinococcus multilocularis musashi 0.0023 0.0106 0.0106
Trypanosoma brucei calpain-like protein, putative 0.0013 0.0047 0.0154
Brugia malayi protein C24B5.3 0.0012 0.004 0.0059
Schistosoma mansoni importin beta-1 0.002 0.0091 0.0134
Loa Loa (eye worm) hypothetical protein 0.0007 0.001 0.0015
Loa Loa (eye worm) phosphatidylinositol 3 0.0013 0.0044 0.0065
Brugia malayi hypothetical protein 0.0007 0.0009 0.0013
Brugia malayi hypothetical protein 0.0012 0.004 0.0059
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Echinococcus granulosus segment polarity protein dishevelled 0.0006 0 0.0001
Schistosoma mansoni cpg binding protein 0.0019 0.0084 0.0124
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0047 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Brugia malayi Niemann-Pick C1 protein precursor 0.0196 0.1184 0.1757
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0024 0.0118 0.0174
Brugia malayi hypothetical protein 0.0203 0.1225 0.1818
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0013 0.0045 0.0148
Loa Loa (eye worm) calpain family protein 1 0.0044 0.0238 0.0353
Toxoplasma gondii polyadenylate binding protein, putative 0.0012 0.0043 0.0168
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0007 0.0009 0.0013
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0013 0.0047 0.007
Onchocerca volvulus 0.0012 0.004 0.0322
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0013 0.0047 0.007
Brugia malayi nuclear receptor RXR 0.0006 0.0004 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Brugia malayi MH1 domain containing protein 0.0009 0.0021 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0041 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0007 0.0152
Onchocerca volvulus 0.0006 0.0004 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0041 0.0131
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0013 0.0044 0.0144
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.109 0.674 1
Schistosoma mansoni calpain C (C02 family) 0.0013 0.0047 0.0069
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0006 0.0004 0.0004
Echinococcus granulosus snurportin 1 0.0214 0.1297 0.1925
Plasmodium falciparum polyadenylate-binding protein, putative 0.0012 0.0043 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.001 0.0205
Echinococcus granulosus geminin 0.0106 0.0624 0.0925
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Brugia malayi hypothetical protein 0.0006 0.0004 0.0006
Brugia malayi Nuclear hormone receptor-like 1 0.0007 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0041 0.0131
Echinococcus granulosus short transient receptor potential channel 6 0.0043 0.0233 0.0346
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0015 0.0058 0.0086
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0199 0.1203 0.1785
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0024 0.0118 0.0432
Onchocerca volvulus 0.0203 0.1225 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0047 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0013 0.0047 0.007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0013 0.0045 0.0045
Onchocerca volvulus Huntingtin homolog 0.0077 0.0441 0.3601
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0013 0.0044 0.0065
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0024 0.0118 0.0118
Brugia malayi Patched family protein 0.0012 0.004 0.0059
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0007 0.001 0.001
Toxoplasma gondii isocitrate dehydrogenase 0.0024 0.0118 0.0458
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0047 0.0024
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0214 0.1297 0.1925
Schistosoma mansoni z-protein (S1r protein) 0.0006 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Toxoplasma gondii FATC domain-containing protein 0.0017 0.0073 0.0285
Onchocerca volvulus 0.0018 0.0077 0.0629
Plasmodium vivax importin-beta 2, putative 0.002 0.0091 0.0326
Brugia malayi exodeoxyribonuclease III family protein 0.0013 0.0045 0.0067
Echinococcus granulosus segment polarity protein dishevelled 0.0006 0 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0012 0.0041 0.0131
Loa Loa (eye worm) hypothetical protein 0.0024 0.0116 0.0173
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0006 0.0004 0.0006
Brugia malayi CXXC zinc finger family protein 0.0018 0.0077 0.0115
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0489 0.0725
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.007
Schistosoma mansoni ap endonuclease 0.0013 0.0045 0.0067
Loa Loa (eye worm) nuclear receptor NHR-67 0.0006 0.0004 0.0006
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0066 0.0097
Echinococcus granulosus regulator of G protein signaling 7 0.0006 0 0.0001
Brugia malayi nuclear hormone receptor 0.0013 0.0047 0.007
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.1431 0.2123
Brugia malayi MH1 domain containing protein 0.0009 0.0021 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.001 0.0205
Trypanosoma brucei PAB1-binding protein , putative 0.0017 0.0072 0.0254
Leishmania major kinesin, putative 0.0013 0.0047 0.0024
Brugia malayi photoreceptor-specific nuclear receptor 0.0013 0.0047 0.007
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0013 0.0044 0.0013
Brugia malayi hypothetical protein 0.0011 0.0035 0.0051
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0006
Echinococcus multilocularis smad 0.0016 0.0066 0.0066
Echinococcus granulosus smad 0.0016 0.0066 0.0097
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0024 0.0118 0.0432
Trichomonas vaginalis poly(A) binding protein, putative 0.0006 0.0004 0.0083
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0047 0.0024
Loa Loa (eye worm) hypothetical protein 0.0041 0.022 0.0326
Brugia malayi RNA, U transporter 1 0.0057 0.0321 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0047 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0015 0.0308
Onchocerca volvulus 0.0012 0.004 0.0322
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0006
Brugia malayi intermediate filament protein 0.0023 0.0106 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Loa Loa (eye worm) patched family protein 0.0012 0.004 0.0059
Loa Loa (eye worm) isocitrate dehydrogenase 0.0024 0.0118 0.0174
Brugia malayi ecdysone receptor 0.0006 0.0004 0.0006
Trypanosoma brucei DNA polymerase IV, putative 0.0012 0.0041 0.0131
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0006 0.0004 0.0004
Brugia malayi Patched family protein 0.0012 0.004 0.0059
Schistosoma mansoni Smad4 0.0007 0.0011 0.0016
Brugia malayi nuclear receptor RXR 0.0007 0.0009 0.0013
Leishmania major hypothetical protein, conserved 0.0017 0.0072 0.0125
Echinococcus granulosus neuropeptide receptor A26 0.0291 0.1771 0.2628
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Plasmodium vivax calpain, putative 0.0013 0.0047 0.0154
Loa Loa (eye worm) patched family protein 0.0012 0.004 0.0059
Loa Loa (eye worm) nuclear factor I 0.0009 0.0021 0.0031
Schistosoma mansoni calpain-7 (C02 family) 0.0013 0.0047 0.0069
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0006
Leishmania major importin beta-1 subunit, putative 0.0016 0.0067 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Echinococcus multilocularis isocitrate dehydrogenase 0.0024 0.0118 0.0118
Echinococcus multilocularis short transient receptor potential channel 6 0.0043 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Leishmania major phosphatidylinositol kinase related protein, putative 0.0013 0.0044 0.0014
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0006 0.0004 0.0006
Trichomonas vaginalis DNA polymerase eta, putative 0.0012 0.0041 0.0835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.001 0.0205
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0007 0.0007 0.0152
Echinococcus granulosus neuropeptide s receptor 0.0291 0.1771 0.2628
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0047 0.0047
Toxoplasma gondii patched family protein 0.0012 0.004 0.0154
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0107
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.004 0.0127
Trichomonas vaginalis nuclear acid binding protein, putative 0.0006 0.0004 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0013 0.0047 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Echinococcus granulosus nuclear receptor nhr 48 0.0006 0.0004 0.0006
Plasmodium falciparum importin beta, putative 0.002 0.0091 0.0326
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0041 0.0131
Echinococcus granulosus calpain 5 0.0013 0.0047 0.0069
Onchocerca volvulus 0.0012 0.004 0.0322
Echinococcus multilocularis dna polymerase eta 0.0012 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Brugia malayi tailless protein 0.0006 0.0004 0.0006
Schistosoma mansoni ubiquitin--protein ligase edd 0.0006 0.0005 0.0007
Schistosoma mansoni topbp1 0.0007 0.0007 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Loa Loa (eye worm) hypothetical protein 0.0102 0.06 0.089
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0013 0.0044 0.0144
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.007
Schistosoma mansoni hypothetical protein 0.0256 0.1554 0.2305
Toxoplasma gondii hypothetical protein 0.0012 0.004 0.0154
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0015 0.0058 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Brugia malayi Intermediate filament tail domain containing protein 0.0023 0.0106 0.0157
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0013 0.0045 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0013 0.0047 0.0383
Loa Loa (eye worm) Smad1 0.0016 0.0066 0.0097
Schistosoma mansoni transient receptor potential channel 0.0043 0.0233 0.0346
Onchocerca volvulus Protein patched homolog 0.0012 0.004 0.0322
Onchocerca volvulus 0.0012 0.004 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0012 0.0041 0.0061
Trypanosoma brucei unspecified product 0.0008 0.0018 0.004
Loa Loa (eye worm) hypothetical protein 0.0007 0.0009 0.0013
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0417 0.2556 1
Schistosoma mansoni Mername-AA248 (C02 family) 0.0013 0.0047 0.0069
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0024 0.0118 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0007 0.0152
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0013 0.0044 0.0144
Trypanosoma cruzi polyadenylate-binding protein, putative 0.0012 0.0043 0.014
Echinococcus multilocularis Niemann Pick C1 protein 0.0196 0.1184 0.1184
Schistosoma mansoni smad 0.0007 0.0011 0.0016
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0011 0.0033 0.005
Brugia malayi nuclear hormone receptor family member nhr-6 0.0006 0.0004 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0013 0.0044 0.0144
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Entamoeba histolytica hypothetical protein 0.0016 0.0067 0.0534
Schistosoma mansoni hypothetical protein 0.0103 0.0603 0.0894
Brugia malayi Patched family protein 0.0012 0.004 0.0059
Brugia malayi Patched family protein 0.0012 0.004 0.0059
Toxoplasma gondii LsmAD domain-containing protein 0.0017 0.0072 0.0281
Schistosoma mansoni DNA ligase IV 0.0007 0.0007 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0024 0.0118 0.0118
Brugia malayi Patched family protein 0.0012 0.004 0.0059
Echinococcus multilocularis Smad4 0.0016 0.0066 0.0066
Schistosoma mansoni ap endonuclease 0.0013 0.0045 0.0067
Brugia malayi hypothetical protein 0.0006 0 0.0001
Brugia malayi nuclear hormone receptor 0.0006 0.0004 0.0006
Entamoeba histolytica Ran family GTPase 0.0015 0.0058 0.0454
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0013 0.0044 0.0044
Trypanosoma brucei unspecified product 0.0012 0.0041 0.0131
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0013 0.0047 0.0154
Schistosoma mansoni dishevelled 0.0006 0 0.0001
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0013 0.0047 0.0154
Loa Loa (eye worm) hypothetical protein 0.0044 0.0238 0.0353
Echinococcus granulosus mothers against decapentaplegic 6 0.0007 0.0011 0.0016
Echinococcus granulosus TRP transient receptor potential channel 0.0024 0.0116 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0013 0.0047 0.007
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0008 0.0015 0.0057
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.007
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0013 0.0044 0.0065
Loa Loa (eye worm) hypothetical protein 0.0007 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Brugia malayi Patched related family protein 12 0.0012 0.004 0.0059
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0103 0.0603 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0013 0.0047 0.007
Echinococcus granulosus Smad4 0.0016 0.0066 0.0097
Brugia malayi N-terminal motif family protein 0.0113 0.0667 0.0989
Loa Loa (eye worm) phosphatidylinositol 3 0.0013 0.0044 0.0065
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0046 0.0252 0.0373
Schistosoma mansoni hypothetical protein 0.0081 0.047 0.0697
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0015 0.0058 0.0197
Trypanosoma cruzi kinesin, putative 0.0013 0.0047 0.0154
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0013 0.0044 0.0339
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0013 0.0045 0.0148
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0007 0.001 0.005
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0113 0.0667 0.544
Echinococcus granulosus lamin 0.0023 0.0106 0.0157
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0023 0.0106 0.0157
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0013 0.0047 0.0383
Echinococcus multilocularis mothers against decapentaplegic 6 0.0007 0.0011 0.0011
Echinococcus multilocularis calpain A 0.0046 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.007
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Echinococcus granulosus dihydrofolate reductase 0.109 0.674 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0013 0.0045 0.0056
Loa Loa (eye worm) hypothetical protein 0.0006 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Toxoplasma gondii patched family protein 0.0012 0.004 0.0154
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0004 0.0006
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0017 0.0073 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0047 0.0154
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0047 0.007
Loa Loa (eye worm) intermediate filament protein 0.0023 0.0106 0.0157
Echinococcus multilocularis dna polymerase kappa 0.0012 0.0041 0.0041
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.109 0.674 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0153
Echinococcus multilocularis expressed conserved protein 0.0184 0.111 0.111
Brugia malayi hypothetical protein 0.0017 0.0072 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.001 0.0205
Echinococcus granulosus FTZ F1 alpha 0.0013 0.0047 0.007
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0066 0.0097
Onchocerca volvulus Bile acid receptor homolog 0.0013 0.0047 0.0383
Brugia malayi Patched family protein 0.0012 0.004 0.0059
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0103 0.0603 0.0603
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0024 0.0118 0.0432
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0007 0.0009 0.0013
Entamoeba histolytica deoxycytidyl transferase, putative 0.0012 0.0041 0.0311
Giardia lamblia DINP protein human, muc B family 0.0012 0.0041 0.6852
Brugia malayi ecdysteroid receptor 0.0013 0.0047 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0015 0.0308
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Leishmania major poly(A)-binding protein 3 0.0012 0.0043 0.001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0013 0.0047 0.007
Brugia malayi hypothetical protein 0.0103 0.0603 0.0894
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.007
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0007
Echinococcus granulosus mothers against decapentaplegic 2 0.0007 0.0011 0.0016
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0004 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Echinococcus multilocularis dnaJ subfamily B 0.0256 0.1554 0.1554
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0017 0.0073 0.0259
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0013 0.0047 0.007
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0013 0.0044 0.0144
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Schistosoma mansoni transient receptor potential channel 0.0043 0.0233 0.0346
Echinococcus multilocularis mothers against decapentaplegic 2 0.0007 0.0011 0.0011
Echinococcus multilocularis lamin dm0 0.0023 0.0106 0.0106
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0016 0.0067 0.1372
Trypanosoma cruzi DNA polymerase kappa, putative 0.0012 0.0041 0.0131
Brugia malayi Patched family protein 0.0012 0.004 0.0059
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0007 0.0009 0.0013
Entamoeba histolytica hypothetical protein 0.0103 0.0603 0.5073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0013 0.0047 0.007
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0013 0.0045 0.0148
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0013 0.0044 0.0339
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Echinococcus granulosus importin subunit beta 1 0.002 0.0091 0.0134
Schistosoma mansoni nuclear receptor 0.0006 0.0004 0.0006
Trypanosoma cruzi PAB1-binding protein , putative 0.0017 0.0072 0.0254
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0007 0.0009 0.0013
Trypanosoma cruzi PAB1-binding protein , putative 0.0017 0.0072 0.0254
Schistosoma mansoni hypothetical protein 0.0214 0.1297 0.1925
Schistosoma mansoni hypothetical protein 0.0008 0.0014 0.002
Echinococcus granulosus lamin dm0 0.0023 0.0106 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0018 0.004
Echinococcus granulosus Nuclear hormone receptor HR96 0.0006 0.0004 0.0006
Brugia malayi nuclear hormone receptor family member odr-7 0.0006 0.0004 0.0006
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0013 0.0047 0.0047
Echinococcus granulosus Pleckstrin G protein interacting region 0.0006 0 0.0001
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0012 0.0041 0.0835
Schistosoma mansoni polyadenylate binding protein 0.0012 0.0043 0.0064
Brugia malayi Patched family protein 0.0012 0.004 0.0059
Entamoeba histolytica calpain large subunit domain III containing protein 0.0013 0.0047 0.0362
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0008 0.0015 0.003
Echinococcus multilocularis geminin 0.0106 0.0624 0.0624
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0015 0.0058 0.0086
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0202 0.03
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0013 0.0047 0.007
Toxoplasma gondii isocitrate dehydrogenase 0.0024 0.0118 0.0458
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0006
Brugia malayi hypothetical protein 0.0006 0.0004 0.0006
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0015 0.0058 0.0197
Trypanosoma brucei kinesin, putative 0.0013 0.0047 0.0154
Loa Loa (eye worm) histone methyltransferase 0.0006 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Brugia malayi hypothetical protein 0.0007 0.0009 0.0013
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0044 0.0238 0.0353
Leishmania major GTP-binding protein, putative 0.0015 0.0058 0.0067
Echinococcus multilocularis FTZ F1 alpha 0.0013 0.0047 0.0047
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0013 0.0045 0.0148
Trypanosoma cruzi kinesin, putative 0.0013 0.0047 0.0154
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0015 0.0058 0.0197
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0013 0.0044 0.0013
Brugia malayi Patched family protein 0.0012 0.004 0.0059
Loa Loa (eye worm) DIX domain-containing protein 0.0006 0 0.0001
Giardia lamblia Replication factor C, subunit 1 0.0007 0.0007 0.0632
Schistosoma mansoni chromosome transmission fidelity factor 0.0007 0.0007 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0024 0.0118 0.0118
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0024 0.0116 0.0116
Echinococcus granulosus ecdysone induced protein 78C 0.0013 0.0047 0.007
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0007 0.0007 0.0152
Echinococcus multilocularis calpain 7 (C02 family) 0.0013 0.0047 0.0047
Brugia malayi DKFZp564C0469 protein 0.0007 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0007 0.0009 0.0013
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.1431 0.2123
Schistosoma mansoni polyadenylate binding protein 0.0012 0.0043 0.0064
Brugia malayi MH2 domain containing protein 0.0016 0.0066 0.0097
Schistosoma mansoni smad1 5 8 and 0.0016 0.0066 0.0097
Schistosoma mansoni terminal deoxycytidyl transferase 0.0012 0.0041 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Loa Loa (eye worm) hypothetical protein 0.0031 0.0157 0.0233
Loa Loa (eye worm) hypothetical protein 0.0113 0.0667 0.0989
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0013 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0077 0.0441 0.0655
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.001 0.0205
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Onchocerca volvulus 0.0023 0.0106 0.0862
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0066 0.0097
Schistosoma mansoni thyroid hormone receptor 0.0013 0.0047 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0031
Schistosoma mansoni polyadenylate binding protein 0.0012 0.0043 0.0064
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0489 0.0725
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Plasmodium falciparum ataxin-2 like protein, putative 0.0017 0.0072 0.0254
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0007 0.0007 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.001 0.0205
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0013 0.0047 0.0154
Brugia malayi dihydrofolate reductase family protein 0.109 0.674 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0013 0.0047 0.007
Schistosoma mansoni Smad4 0.0016 0.0066 0.0097
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0007 0.0007 0.0029
Echinococcus multilocularis importin subunit beta 1 0.002 0.0091 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Schistosoma mansoni hypothetical protein 0.0106 0.0624 0.0925
Onchocerca volvulus 0.0023 0.0106 0.0862
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0013 0.0045 0.0018
Schistosoma mansoni DNA polymerase eta 0.0012 0.0041 0.0061
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0011
Brugia malayi hypothetical protein 0.0007 0.0007 0.0011
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0024 0.0118 0.0432
Brugia malayi calpain family protein 1 0.0044 0.0238 0.0353
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0417 0.2556 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0012 0.0041 0.0131
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0066 0.0097
Schistosoma mansoni steroid hormone receptor ad4bp 0.0013 0.0047 0.007
Echinococcus granulosus transient receptor potential ion channel A 0.0063 0.0357 0.0529
Treponema pallidum exodeoxyribonuclease (exoA) 0.0013 0.0045 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0013 0.0047 0.007
Schistosoma mansoni hypothetical protein 0.0081 0.047 0.0697
Plasmodium vivax patched family protein, putative 0.0012 0.004 0.0127
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0013 0.0047 0.0154
Schistosoma mansoni fkbp-rapamycin associated protein 0.0007 0.001 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0013 0.0047 0.007
Toxoplasma gondii patched family protein 0.0012 0.004 0.0154
Echinococcus multilocularis thyroid hormone receptor alpha 0.0013 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0102 0.06 0.089
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0007 0.001 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0041 0.0131
Brugia malayi Smad1 0.0016 0.0066 0.0097
Schistosoma mansoni calpain (C02 family) 0.0013 0.0047 0.0069
Schistosoma mansoni regulator of G protein signaling 0.0006 0 0.0001
Brugia malayi protein C24B5.3 0.0012 0.004 0.0059
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0046 0.0252 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Echinococcus granulosus transient receptor potential gamma protein 0.0065 0.037 0.0549
Schistosoma mansoni lamin 0.0023 0.0106 0.0157
Schistosoma mansoni smad1 5 8 and 0.0016 0.0066 0.0097
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0011
Trichomonas vaginalis ap endonuclease, putative 0.0013 0.0045 0.0926
Loa Loa (eye worm) DR-78 0.0006 0.0004 0.0006
Onchocerca volvulus Huntingtin homolog 0.0077 0.0441 0.3601
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0013 0.0047 0.007
Echinococcus granulosus expressed conserved protein 0.0184 0.111 0.1647
Loa Loa (eye worm) hypothetical protein 0.0102 0.06 0.089
Echinococcus granulosus calpain A 0.0046 0.0252 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0013 0.0047 0.007
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0013 0.0047 0.007
Echinococcus multilocularis nibrin 0.0007 0.0007 0.0007
Schistosoma mansoni ran 0.0015 0.0058 0.0086
Loa Loa (eye worm) hypothetical protein 0.0065 0.037 0.0549
Trypanosoma brucei calpain-like protein, putative 0.0013 0.0047 0.0154
Brugia malayi MH1 domain containing protein 0.0016 0.0066 0.0097
Trichomonas vaginalis RNA-binding protein, putative 0.0006 0.0004 0.0083
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0007 0.0007 0.0152
Brugia malayi Isocitrate dehydrogenase 0.0024 0.0118 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0018 0.004
Loa Loa (eye worm) steroid hormone receptor 0.0013 0.0047 0.007
Trypanosoma brucei calpain-like protein, putative 0.0013 0.0047 0.0154
Echinococcus multilocularis hypothetical protein 0.0013 0.0047 0.0047
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0013 0.0045 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0013 0.0047 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0041 0.0131
Brugia malayi MH1 domain containing protein 0.0016 0.0066 0.0097
Schistosoma mansoni thyroid hormone receptor 0.0013 0.0047 0.007
Brugia malayi cytoplasmic intermediate filament protein 0.0012 0.0041 0.0061
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0008 0.0014 0.0014
Brugia malayi hypothetical protein 0.0077 0.0441 0.0655
Entamoeba histolytica protein kinase, putative 0.0013 0.0047 0.0362
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0102 0.06 0.089
Loa Loa (eye worm) hypothetical protein 0.0077 0.0441 0.0655
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0006
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0024 0.0118 0.0115
Schistosoma mansoni coup transcription factor 0.0013 0.0047 0.007
Schistosoma mansoni cpg binding protein 0.0018 0.0077 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Echinococcus multilocularis polyadenylate binding protein 0.0012 0.0043 0.0043
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0046 0.0252 0.0373
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0008 0.0014 0.002
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0013 0.0047 0.007
Mycobacterium ulcerans DNA polymerase IV 0.0012 0.0041 0.005
Onchocerca volvulus 0.0013 0.0047 0.0383
Echinococcus granulosus cpg binding protein 0.0019 0.0084 0.0124
Schistosoma mansoni dihydrofolate reductase 0.109 0.674 1
Onchocerca volvulus 0.0012 0.004 0.0322
Trichomonas vaginalis polyadenylate-binding protein, putative 0.0006 0.0004 0.0083
Onchocerca volvulus Protein patched homolog 0.0012 0.004 0.0322
Brugia malayi Importin beta-1 subunit 0.002 0.0091 0.0134
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Echinococcus granulosus dnaJ subfamily B 0.0256 0.1554 0.2305
Schistosoma mansoni lamin 0.0023 0.0106 0.0157
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0417 0.2556 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Brugia malayi topoisomerase 0.0007 0.0007 0.0011
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0006 0.0004 0.0032
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0153
Schistosoma mansoni patched 1 0.0084 0.0489 0.0725
Echinococcus multilocularis serine protein kinase ATM 0.0017 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0006
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0417 0.2556 1
Entamoeba histolytica hypothetical protein 0.0103 0.0603 0.5073
Loa Loa (eye worm) dihydrofolate reductase 0.109 0.674 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0006
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0017 0.0073 0.0259
Schistosoma mansoni nuclear receptor nhr-48 0.0006 0.0004 0.0006
Brugia malayi Nuclear hormone receptor-like 1 0.0007 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0006
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0046 0.0252 0.0252
Loa Loa (eye worm) nuclear hormone receptor 0.0006 0.0004 0.0006
Brugia malayi hypothetical protein 0.0006 0 0.0001
Echinococcus granulosus calpain 0.0013 0.0047 0.0069
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0007 0.0011 0.0083
Trypanosoma brucei importin beta-1 subunit, putative 0.002 0.0091 0.0326
Brugia malayi Patched protein homolog 1 0.0012 0.004 0.0059
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0006 0 0.0001
Echinococcus multilocularis snurportin 1 0.0214 0.1297 0.1297
Echinococcus granulosus calpain 7 C02 family 0.0013 0.0047 0.0069
Onchocerca volvulus 0.0012 0.004 0.0322
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0024 0.0118 0.0174
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0007 0.0007 0.0011
Echinococcus granulosus short transient receptor potential channel 6 0.0043 0.0233 0.0346
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0006
Brugia malayi Pax transcription activation domain interacting protein 0.0007 0.0007 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0015 0.0058 0.0058
Entamoeba histolytica protein kinase rad3, putative 0.0007 0.001 0.005
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0013 0.0047 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0006 0 0.0001
Echinococcus multilocularis ecdysone induced protein 78C 0.0013 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0073 0.1501
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0013 0.0047 0.0154
Onchocerca volvulus 0.0006 0.0004 0.0032
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0013 0.0047 0.0154
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0024 0.0118 0.0432
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0013 0.0044 0.0065
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0015 0.0058 0.0197
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0013 0.0045 0.0007
Echinococcus multilocularis calpain family protein 1, d 0.0031 0.0157 0.0157
Echinococcus multilocularis dihydrofolate reductase 0.109 0.674 0.674
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0066 0.0066
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0006 0.0004 0.0006
Trichomonas vaginalis ran, putative 0.0015 0.0058 0.118
Echinococcus multilocularis calpain 5 0.0013 0.0047 0.0047
Toxoplasma gondii patched family protein 0.0012 0.004 0.0154
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0066 0.0066
Giardia lamblia GTOR 0.0013 0.0044 0.747
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Brugia malayi MH2 domain containing protein 0.0236 0.1431 0.2123
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0013 0.0047 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Entamoeba histolytica hypothetical protein 0.0017 0.0073 0.0587
Schistosoma mansoni dep domain containing protein 0.0006 0 0.0001
Brugia malayi ImpB/MucB/SamB family protein 0.0012 0.0041 0.0061
Entamoeba histolytica hypothetical protein 0.0007 0.0007 0.0029
Loa Loa (eye worm) calpain family protein 1 0.0031 0.0157 0.0233
Loa Loa (eye worm) hypothetical protein 0.0203 0.1225 0.1818
Brugia malayi Patched related family protein 4 0.0012 0.004 0.0059
Schistosoma mansoni cpg binding protein 0.0019 0.0084 0.0124
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.005
Echinococcus multilocularis short transient receptor potential channel 6 0.0043 0.0233 0.0233
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0013 0.0047 0.007
Brugia malayi hypothetical protein 0.0007 0.0007 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0024 0.0118 0.0118
Toxoplasma gondii exonuclease III APE 0.0013 0.0045 0.0176
Loa Loa (eye worm) hypothetical protein 0.0084 0.0489 0.0725
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0013 0.0044 0.0013
Brugia malayi polyadenylate-binding protein 1 0.0012 0.0043 0.0064
Trichomonas vaginalis RNA-binding protein, putative 0.0006 0.0004 0.0083
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Echinococcus multilocularis nuclear receptor nhr 48 0.0006 0.0004 0.0004
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0013 0.0045 0.0148
Trypanosoma cruzi DNA polymerase kappa, putative 0.0012 0.0041 0.0131
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0013 0.0044 0.0144
Schistosoma mansoni nuclear receptor 0.0006 0.0004 0.0006
Brugia malayi polyadenylate-binding protein 4 0.0006 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0061
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0013 0.0047 0.007
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0011 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0013 0.0047 0.007
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0015 0.0058 0.0199
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0013 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0046
Trypanosoma brucei DNA polymerase IV, putative 0.0012 0.0041 0.0131
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0007 0.0009 0.0013
Echinococcus granulosus Niemann Pick C1 protein 0.028 0.1707 0.2533
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0011 0.0016
Brugia malayi Transient-receptor-potential like protein 0.0024 0.0116 0.0173
Trypanosoma cruzi importin beta-1 subunit, putative 0.0016 0.0067 0.0234
Echinococcus multilocularis protein patched 0.0084 0.0489 0.0489
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0047 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0018 0.004
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0047 0.007
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0047 0.0154
Onchocerca volvulus 0.0012 0.004 0.0322
Loa Loa (eye worm) patched family protein 0.0012 0.004 0.0059
Brugia malayi nuclear receptor NHR-88 0.0013 0.0047 0.007
Brugia malayi orphan nuclear receptor NR2E1 0.0006 0.0004 0.0006
Schistosoma mansoni calpain-7 (C02 family) 0.0013 0.0047 0.0069
Chlamydia trachomatis dihydrofolate reductase 0.109 0.674 1
Echinococcus multilocularis transient receptor potential ion channel A 0.0063 0.0357 0.0357
Schistosoma mansoni smad1 5 8 and 0.0016 0.0066 0.0097
Brugia malayi Patched family protein 0.0012 0.004 0.0059
Schistosoma mansoni hypothetical protein 0.0106 0.0624 0.0925
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0013 0.0044 0.0044
Echinococcus multilocularis protein dispatched 1 0.0096 0.0563 0.0563
Echinococcus granulosus polyadenylate binding protein 0.0012 0.0043 0.0064
Toxoplasma gondii ATPase, AAA family protein 0.0007 0.0007 0.0028
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0047 0.0154
Echinococcus multilocularis neuropeptide receptor A26 0.0291 0.1771 0.1771
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0047 0.0154
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0007 0.0007 0.0028
Schistosoma mansoni hypothetical protein 0.0081 0.047 0.0697
Trichomonas vaginalis importin beta-1, putative 0.0016 0.0067 0.1372
Brugia malayi Patched family protein 0.0012 0.004 0.0059
Brugia malayi calpain family protein 1 0.0044 0.0238 0.0353
Brugia malayi isocitrate dehydrogenase 0.0024 0.0118 0.0174
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0011
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0066 0.0097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0012 0.0041 0.0131
Toxoplasma gondii histone lysine methyltransferase SET1 0.0034 0.0177 0.0691
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0006 0 0.0001
Schistosoma mansoni transient receptor potential channel 0.0065 0.037 0.0549
Schistosoma mansoni zinc finger protein 0.0006 0.0004 0.0006
Schistosoma mansoni hypothetical protein 0.0013 0.0048 0.0072
Brugia malayi calpain 5 0.0013 0.0047 0.0069
Schistosoma mansoni Smad4 0.0007 0.0011 0.0016
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0012 0.0041 0.0061
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0013 0.0045 0.7686
Schistosoma mansoni hypothetical protein 0.0081 0.047 0.0697
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0013 0.0044 0.0065
Brugia malayi hypothetical protein 0.0012 0.004 0.0059
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0024 0.0118 0.0432
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0006 0.0004 0.0006
Echinococcus multilocularis cpg binding protein 0.0019 0.0084 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.001 0.0205
Entamoeba histolytica hypothetical protein 0.0103 0.0603 0.5073
Brugia malayi CHE-14 protein 0.0084 0.0489 0.0725
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.007
Echinococcus granulosus dna polymerase eta 0.0012 0.0041 0.0061
Trypanosoma cruzi target of rapamycin kinase 3 0.0013 0.0044 0.0144
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0006 0 0.0001
Schistosoma mansoni retinoic acid receptor RXR 0.0013 0.0047 0.007
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.109 0.674 1
Plasmodium vivax polyadenylate-binding protein, putative 0.0012 0.0043 0.014
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0007 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Brugia malayi MH2 domain containing protein 0.0016 0.0066 0.0097
Trichomonas vaginalis ap endonuclease, putative 0.0013 0.0045 0.0926
Loa Loa (eye worm) hypothetical protein 0.0007 0.0009 0.0013
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0006 0.0004 0.0032
Brugia malayi calpain 7 0.0013 0.0047 0.0069
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0006 0.0004 0.0004
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0013 0.0044 0.0065
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0073 0.0109
Schistosoma mansoni smad 0.0016 0.0066 0.0097
Mycobacterium ulcerans DNA polymerase IV 0.0012 0.0041 0.005
Echinococcus multilocularis neuropeptide s receptor 0.0291 0.1771 0.1771
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0417 0.2556 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0013 0.0047 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0013 0.0047 0.007
Brugia malayi DIX domain containing protein 0.0006 0 0.0001
Onchocerca volvulus 0.0007 0.0007 0.0058
Loa Loa (eye worm) hypothetical protein 0.0023 0.0106 0.0157
Brugia malayi Steroid receptor seven-up type 2 0.0013 0.0047 0.007
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0196 0.1184 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0013 0.0047 0.007
Trypanosoma brucei DNA polymerase IV, putative 0.0012 0.0041 0.0131
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0417 0.2556 1
Echinococcus granulosus regulator of G protein signaling 7 0.0006 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0134
Brugia malayi MH2 domain containing protein 0.0007 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0044 0.0238 0.0353
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0013 0.0047 0.007
Trypanosoma brucei unspecified product 0.0008 0.0018 0.004
Leishmania major poly(A)-binding protein 2 0.0012 0.0043 0.001
Echinococcus granulosus nibrin 0.0007 0.0007 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0489 1
Echinococcus granulosus intermediate filament protein 0.0023 0.0106 0.0157
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0011
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0015 0.0058 0.0224
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0011
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0015 0.0058 1
Trypanosoma brucei calpain-like protein, putative 0.0013 0.0047 0.0154
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0047 0.0047
Brugia malayi nuclear receptor NHR-67 0.0006 0.0004 0.0006
Schistosoma mansoni topbp1 0.0007 0.0007 0.0011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0013 0.0045 0.0067
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0006 0.0004 0.0006
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0047 0.0154
Echinococcus granulosus calpain A 0.0013 0.0047 0.0069
Schistosoma mansoni transient receptor potential channel 4 0.0065 0.037 0.0549
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0007 0.0152
Brugia malayi mothers against decapentaplegic homolog 3 0.0007 0.0011 0.0016
Echinococcus granulosus Nuclear hormone receptor HR96 0.0006 0.0004 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Trypanosoma brucei antigen, putative 0.0013 0.0047 0.0154
Brugia malayi Patched family protein 0.0012 0.004 0.0059
Brugia malayi hypothetical protein 0.0012 0.004 0.0059
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0012 0.0041 0.0061
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.007
Echinococcus granulosus Niemann Pick C1 protein 0.0196 0.1184 0.1757
Echinococcus granulosus serine protein kinase ATM 0.0017 0.0073 0.0109
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.0086
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Brugia malayi steroid hormone receptor 0.0013 0.0047 0.007
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0006 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0041 0.0131
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0059
Echinococcus multilocularis replication factor c subunit 1 0.0007 0.0007 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0006 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0031 0.0157 0.0233
Brugia malayi regulator of G-protein signaling egl-10 0.0006 0 0.0001
Echinococcus granulosus dna polymerase kappa 0.0012 0.0041 0.0061
Loa Loa (eye worm) hypothetical protein 0.0006 0 0.0001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0013 0.0047 0.007
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0013 0.0044 0.0144
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0013 0.0044 0.0144
Loa Loa (eye worm) hypothetical protein 0.0196 0.1184 0.1757
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0041 0.0131
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.007
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0013 0.0047 0.0154
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0489 0.0725
Trypanosoma brucei polyadenylate-binding protein 2 0.0012 0.0043 0.014
Echinococcus multilocularis transient receptor potential gamma protein 0.0065 0.037 0.037
Echinococcus multilocularis calpain 0.0013 0.0047 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0041 0.0131
Echinococcus granulosus thyroid hormone receptor alpha 0.0006 0.0004 0.0006
Loa Loa (eye worm) patched family protein 0.0012 0.004 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0013 0.0047 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0044 0.0903
Trypanosoma brucei DNA polymerase eta, putative 0.0012 0.0041 0.0131
Onchocerca volvulus 0.0031 0.0157 0.1278
Schistosoma mansoni intermediate filament proteins 0.0023 0.0106 0.0157
Brugia malayi conserved hypotetical protein 0.0006 0.0004 0.0006
Plasmodium falciparum ataxin-2 like protein, putative 0.0017 0.0072 0.0254
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0006 0 0.0001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0012 0.0041 0.0061
Schistosoma mansoni ran 0.0015 0.0058 0.0086
Loa Loa (eye worm) calpain 5 0.0013 0.0047 0.0069
Toxoplasma gondii hypothetical protein 0.0102 0.06 0.2346
Brugia malayi Patched family protein 0.0012 0.004 0.0059
Brugia malayi Myosin head containing protein 0.0012 0.004 0.0059
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0016 0.0067 0.1372
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0007 0.0152

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = -5.89 Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay ChEMBL. 17154517
EC50 (functional) = -5.53 Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay ChEMBL. 17154517
EC50 (functional) = -4.92 Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay ChEMBL. 17154517
Efficacy (functional) = 47 % Ability to open human urinary bladder Kir6.2 containing SUR2B in Ltk cells by FLIPR assay relative to P1075 ChEMBL. 17154517
Efficacy (functional) = 47 % Ability to open human urinary bladder Kir6.2 containing SUR2B in Ltk cells by FLIPR assay relative to P1075 ChEMBL. 17154517
Efficacy (functional) = 53 % Ability to open human urinary bladder Kir6.2 containing SUR2B in Ltk cells by FLIPR assay relative to P1075 ChEMBL. 17154517
Efficacy (functional) = 53 % Ability to open human urinary bladder Kir6.2 containing SUR2B in Ltk cells by FLIPR assay relative to P1075 ChEMBL. 17154517
Efficacy (functional) = 69 % Ability to open human urinary bladder Kir6.2 containing SUR2B in Ltk cells by FLIPR assay relative to P1075 ChEMBL. 17154517
Efficacy (functional) = 69 % Ability to open human urinary bladder Kir6.2 containing SUR2B in Ltk cells by FLIPR assay relative to P1075 ChEMBL. 17154517
Log EC50 (functional) = 4.92 Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay ChEMBL. 17154517
Log EC50 (functional) = 5.53 Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay ChEMBL. 17154517
Log EC50 (functional) = 5.89 Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay ChEMBL. 17154517

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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