Detailed information for compound 375595

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1203.48 | Formula: C64H74N12O8S2
  • H donors: 11 H acceptors: 9 LogP: 5.42 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 3
  • SMILES: NCCCC[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](CSSC[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)C(=O)N[C@H](C(=O)N)Cc1cccc(c1)c1ccccc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)N)Cc1c[nH]c2c1cccc2
  • InChi: 1S/C64H74N12O8S2/c1-38(2)56-64(84)75-55(62(82)71-51(57(67)77)31-39-14-12-20-45(28-39)42-16-4-3-5-17-42)37-86-85-36-54(74-58(78)48(66)30-40-24-25-43-18-6-7-19-44(43)29-40)63(83)72-52(32-41-15-13-27-68-34-41)60(80)73-53(33-46-35-69-49-22-9-8-21-47(46)49)61(81)70-50(59(79)76-56)23-10-11-26-65/h3-9,12-22,24-25,27-29,34-35,38,48,50-56,69H,10-11,23,26,30-33,36-37,65-66H2,1-2H3,(H2,67,77)(H,70,81)(H,71,82)(H,72,83)(H,73,80)(H,74,78)(H,75,84)(H,76,79)/t48-,50+,51-,52+,53-,54+,55-,56-/m0/s1
  • InChiKey: KPCJEVXRLXFFET-KMJDICQLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0044 0.0218 0.059
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.0794 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0044 0.0218 0.059
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0079 0.0559
Trypanosoma cruzi cytochrome P450, putative 0.0071 0.047 0.0768
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.1671 0.1733
Schistosoma mansoni acetyl-CoA carboxylase 0.1103 1 1
Entamoeba histolytica Ran family GTPase 0.0022 0.0019 0.0125
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.015 0.1194 0.1194
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.042 0.3694 0.3694
Echinococcus granulosus thyroid hormone receptor alpha 0.0124 0.096 0.096
Echinococcus multilocularis cpg binding protein 0.003 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0263 0.2242 0.2325
Brugia malayi Dopamine receptor 0.0241 0.2039 0.2114
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0079 0.0559
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0044 0.0218 0.059
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0039 0.0171 0.0171
Leishmania major carbamoyl-phosphate synthase, putative 0.0095 0.0691 0.0691
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0794 0.5631
Entamoeba histolytica hypothetical protein 0.0025 0.004 0.026
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0039 0.0171 0.0279
Schistosoma mansoni neuropeptide receptor 0.0241 0.2039 0.2039
Echinococcus multilocularis allatostatin A receptor 0.0241 0.2039 0.2039
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0039 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0124 0.096 0.0995
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0039 0.0171 0.0279
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0241 0.2039 0.2039
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.015 0.1194 0.1952
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0124 0.096 0.0995
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0124 0.096 0.096
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0079 0.0993
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Schistosoma mansoni neuropeptide receptor 0.0241 0.2039 0.2039
Schistosoma mansoni hypothetical protein 0.0323 0.2792 0.2792
Schistosoma mansoni hypothetical protein 0.0241 0.2039 0.2039
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0241 0.2039 0.2114
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.042 0.3694 1
Onchocerca volvulus 0.0241 0.2039 0.9059
Wolbachia endosymbiont of Brugia malayi branched-chain alpha-keto acid dehydrogenase subunit E2 0.0039 0.0171 0.0463
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0794 0.5631
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0263 0.2242 0.2242
Loa Loa (eye worm) hypothetical protein 0.0139 0.1097 0.1138
Brugia malayi MH2 domain containing protein 0.012 0.0919 0.0952
Loa Loa (eye worm) DR-78 0.0124 0.096 0.0995
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0241 0.2039 0.2114
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0375 0.0375
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0263 0.2242 0.2242
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0919 0.0952
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0794 0.0823
Brugia malayi hypothetical protein 0.0124 0.096 0.0995
Leishmania major propionyl-coa carboxylase beta chain, putative 0.015 0.1194 0.1194
Leishmania major cytochrome p450-like protein 0.0071 0.047 0.047
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.042 0.3694 0.3694
Loa Loa (eye worm) hypothetical protein 0.0124 0.096 0.0995
Echinococcus multilocularis orexin receptor type 2 0.0241 0.2039 0.2039
Loa Loa (eye worm) hypothetical protein 0.0201 0.1671 0.1733
Echinococcus multilocularis fmrfamide receptor 0.0241 0.2039 0.2039
Schistosoma mansoni biogenic amine (5HT) receptor 0.0241 0.2039 0.2039
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0039 0.0171 0.0283
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0039 0.0171 0.0279
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0044 0.0218 0.059
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0044 0.0218 0.0356
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.015 0.1194 0.1194
Schistosoma mansoni adenoreceptor 0.0241 0.2039 0.2039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0235 0.0235
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0402 0.0417
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0095 0.0691 0.0691
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0095 0.0691 0.0691
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0095 0.0691 0.1871
Echinococcus multilocularis dro:myosuppressin receptor 0.0241 0.2039 0.2039
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0039 0.0171 0.0171
Brugia malayi neuropeptide F receptor 0.0241 0.2039 0.2114
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0241 0.2039 0.2039
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.004 0.0286
Schistosoma mansoni neuropeptide f receptor 76f 0.0241 0.2039 0.2039
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0044 0.0218 0.059
Echinococcus multilocularis thyroid hormone receptor alpha 0.0263 0.2242 0.2242
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0079 0.0559
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0044 0.0218 0.059
Onchocerca volvulus 0.0241 0.2039 0.9059
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0019 0.0125
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Brugia malayi Importin beta-1 subunit 0.003 0.0093 0.0097
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0794 0.0823
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.015 0.1194 0.2905
Loa Loa (eye worm) hypothetical protein 0.0139 0.1097 0.1138
Loa Loa (eye worm) hypothetical protein 0.0263 0.2242 0.2325
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0799 0.7185 1
Echinococcus granulosus cpg binding protein 0.003 0.0094 0.0094
Brugia malayi 6-phosphofructokinase 0.0106 0.0794 0.0823
Echinococcus multilocularis sex peptide receptor 0.0241 0.2039 0.2039
Loa Loa (eye worm) melatonin receptor type 1A 0.0241 0.2039 0.2114
Echinococcus multilocularis nuclear receptor nhr 48 0.0124 0.096 0.096
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Brugia malayi hypothetical protein 0.0124 0.096 0.0995
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0095 0.0691 0.1129
Brugia malayi ORL1-like opioid receptor 0.0241 0.2039 0.2114
Loa Loa (eye worm) hypothetical protein 0.0124 0.096 0.0995
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0794 0.1297
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0097
Trypanosoma brucei cytochrome P450, putative 0.0071 0.047 0.047
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0039 0.0171 0.0463
Brugia malayi G protein-coupled receptor 0.0241 0.2039 0.2114
Brugia malayi Nuclear hormone receptor-like 1 0.0263 0.2242 0.2325
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0376 0.1017
Echinococcus granulosus fmrfamide receptor 0.0241 0.2039 0.2039
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0019 0.0027
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0402 0.0402
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.0794 0.0794
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0079 0.0559
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0044 0.0218 0.059
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0039 0.0171 0.0283
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.042 0.3694 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.015 0.1194 0.1952
Brugia malayi nuclear hormone receptor family member odr-7 0.0124 0.096 0.0995
Mycobacterium leprae Conserved hypothetical protein 0.0044 0.0218 0.0134
Schistosoma mansoni zinc finger protein 0.0124 0.096 0.096
Brugia malayi Nuclear hormone receptor-like 1 0.0139 0.1097 0.1138
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.004 0.0286
Echinococcus multilocularis g protein coupled receptor 0.0241 0.2039 0.2039
Echinococcus granulosus neuropeptides capa receptor 0.0241 0.2039 0.2039
Loa Loa (eye worm) hypothetical protein 0.0124 0.096 0.0995
Echinococcus multilocularis FTZ F1 alpha 0.0263 0.2242 0.2242
Brugia malayi nuclear hormone receptor 0.0124 0.096 0.0995
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.0794 0.2149
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0241 0.2039 0.2039
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0044 0.0218 0.059
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0093 0.0093
Mycobacterium ulcerans pyruvate carboxylase 0.042 0.3694 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0079 0.011
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.015 0.1194 0.1952
Echinococcus granulosus neuropeptides capa receptor 0.0241 0.2039 0.2039
Loa Loa (eye worm) hypothetical protein 0.0139 0.1097 0.1138
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.042 0.3694 0.6036
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0044 0.0218 0.059
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0044 0.0218 0.059
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Echinococcus multilocularis neuropeptide FF receptor 2 0.0241 0.2039 0.2039
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.015 0.1194 0.3233
Echinococcus multilocularis neuropeptide Y receptor 0.0241 0.2039 0.2039
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0044 0.0218 0.059
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Echinococcus granulosus neuropeptide FF receptor 2 0.0241 0.2039 0.2039
Schistosoma mansoni neuropeptide receptor 0.0241 0.2039 0.2039
Brugia malayi neuropeptide F receptor 0.0241 0.2039 0.2114
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0263 0.2242 0.2242
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0263 0.2242 0.2325
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0124 0.096 0.096
Brugia malayi GnHR receptor homolog 0.0241 0.2039 0.2114
Schistosoma mansoni hypothetical protein 0.0044 0.0218 0.0218
Brugia malayi nuclear hormone receptor family member nhr-6 0.0124 0.096 0.0995
Leishmania major GTP-binding protein, putative 0.0022 0.0019 0.0019
Schistosoma mansoni amine GPCR 0.0241 0.2039 0.2039
Echinococcus granulosus G protein coupled receptor 139 0.0241 0.2039 0.2039
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0263 0.2242 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0241 0.2039 0.2039
Echinococcus granulosus dnaJ subfamily B 0.0408 0.3581 0.3581
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.042 0.3694 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.2039 0.2039
Brugia malayi hypothetical protein 0.0241 0.2039 0.2114
Schistosoma mansoni opsin-like receptor 0.0241 0.2039 0.2039
Loa Loa (eye worm) hypothetical protein 0.0263 0.2242 0.2325
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0241 0.2039 0.2039
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0241 0.2039 0.2039
Echinococcus multilocularis somatostatin receptor 0.0241 0.2039 0.2039
Echinococcus granulosus 7TM GPCR rhodopsin 0.0241 0.2039 0.2039
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0039 0.0171 0.0171
Echinococcus multilocularis 0.0044 0.0218 0.0218
Schistosoma mansoni alpha-1 adrenergic receptor 0.0241 0.2039 0.2039
Brugia malayi RE15519p 0.0241 0.2039 0.2114
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.042 0.3694 0.3694
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0241 0.2039 0.2114
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0241 0.2039 0.2039
Loa Loa (eye worm) hypothetical protein 0.0124 0.096 0.0995
Echinococcus multilocularis importin subunit beta 1 0.003 0.0093 0.0093
Brugia malayi nuclear receptor RXR 0.0124 0.096 0.0995
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0241 0.2039 0.2039
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0263 0.2242 0.2325
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0079 0.011
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Brugia malayi putative neuropeptide receptor NPR1 0.0241 0.2039 0.2114
Echinococcus granulosus neuropeptide receptor 0.0241 0.2039 0.2039
Trypanosoma brucei unspecified product 0.0276 0.2365 0.2365
Schistosoma mansoni biogenic amine receptor 0.0241 0.2039 0.2039
Loa Loa (eye worm) hypothetical protein 0.0263 0.2242 0.2325
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0263 0.2242 0.2242
Echinococcus granulosus g protein coupled receptor 0.0241 0.2039 0.2039
Echinococcus multilocularis fmrfamide receptor 0.0241 0.2039 0.2039
Brugia malayi larval opioid receptor 0.0241 0.2039 0.2114
Onchocerca volvulus 0.0241 0.2039 0.9059
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0039 0.0171 0.0279
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0263 0.2242 0.2242
Schistosoma mansoni neuropeptide F-like receptor 0.0241 0.2039 0.2039
Echinococcus multilocularis neuropeptide Y receptor 0.0241 0.2039 0.2039
Echinococcus multilocularis serotonin receptor 0.0241 0.2039 0.2039
Echinococcus multilocularis ecdysone induced protein 78C 0.0263 0.2242 0.2242
Echinococcus multilocularis Biotin lipoyl attachment 0.0039 0.0171 0.0171
Echinococcus multilocularis G protein coupled receptor 139 0.0241 0.2039 0.2039
Echinococcus multilocularis GPCR, family 2 0.0064 0.0402 0.0402
Brugia malayi Carboxyl transferase domain containing protein 0.1065 0.9643 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.2039 0.2039
Echinococcus granulosus Nuclear hormone receptor HR96 0.0124 0.096 0.096
Schistosoma mansoni aspartate carbamoyltransferase 0.0095 0.0691 0.0691
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.2039 0.2039
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0139 0.1097 0.1097
Schistosoma mansoni biogenic amine receptor 0.0241 0.2039 0.2039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0235 0.0235
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0188 0.1551 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0241 0.2039 0.2039
Onchocerca volvulus 0.0263 0.2242 1
Schistosoma mansoni opsin-like receptor 0.0241 0.2039 0.2039
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0039 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Brugia malayi Nuclear hormone receptor E75 0.0124 0.096 0.0995
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0044 0.0218 0.059
Schistosoma mansoni amine GPCR 0.0241 0.2039 0.2039
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.1084 0.1124
Treponema pallidum pyruvate carboxylase subunit B 0.0039 0.0171 0.2152
Plasmodium falciparum carbamoyl phosphate synthetase 0.0095 0.0691 0.0962
Loa Loa (eye worm) hypothetical protein 0.0124 0.096 0.0995
Loa Loa (eye worm) CYP4Cod1 0.0071 0.047 0.0487
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0263 0.2242 0.2242
Schistosoma mansoni hypothetical protein 0.0138 0.1084 0.1084
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0241 0.2039 0.2039
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0124 0.096 0.096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0263 0.2242 0.2325
Echinococcus granulosus allatostatin A receptor 0.0241 0.2039 0.2039
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0044 0.0218 0.059
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0039 0.0171 0.0238
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0241 0.2039 0.2114
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.0794 0.2149
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.2039 0.2039
Loa Loa (eye worm) cytochrome P450 family protein 0.0142 0.1122 0.1164
Echinococcus granulosus tm gpcr rhodopsin 0.0241 0.2039 0.2039
Brugia malayi G-protein coupled receptor 0.0241 0.2039 0.2114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.2039 0.2039
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.141 1
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.042 0.3694 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.0794 0.1769
Echinococcus granulosus tm gpcr rhodopsin 0.0241 0.2039 0.2039
Schistosoma mansoni hypothetical protein 0.0241 0.2039 0.2039
Onchocerca volvulus 0.0241 0.2039 0.9059
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0241 0.2039 0.2039
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0241 0.2039 0.2114
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Brugia malayi Steroid receptor seven-up type 2 0.0263 0.2242 0.2325
Brugia malayi orphan nuclear receptor NR2E1 0.0124 0.096 0.0995
Loa Loa (eye worm) hypothetical protein 0.0124 0.096 0.0995
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0235 0.0235
Brugia malayi Cytochrome P450 family protein 0.0044 0.0218 0.0226
Brugia malayi AKH receptor 0.0241 0.2039 0.2114
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0039 0.0171 0.0238
Echinococcus multilocularis geminin 0.0516 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0139 0.1097 0.1138
Echinococcus multilocularis neuropeptide receptor 0.0241 0.2039 0.2039
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0039 0.0171 0.0279
Brugia malayi hypothetical protein 0.0241 0.2039 0.2114
Schistosoma mansoni hypothetical protein 0.0408 0.3581 0.3581
Schistosoma mansoni nuclear hormone receptor 0.0124 0.096 0.096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0171 0.0177
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0044 0.0218 0.059
Brugia malayi hypothetical protein 0.0241 0.2039 0.2114
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0241 0.2039 0.2039
Brugia malayi hypothetical protein 0.0241 0.2039 0.2114
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0079 0.011
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0039 0.0171 0.0463
Schistosoma mansoni thyroid hormone receptor 0.0263 0.2242 0.2242
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.2039 0.2039
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0241 0.2039 0.2039
Onchocerca volvulus Neuropeptide F receptor homolog 0.0241 0.2039 0.9059
Echinococcus granulosus serotonin receptor 0.0241 0.2039 0.2039
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0178 0.1455 0.1509
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0044 0.0218 0.059
Echinococcus multilocularis neuropeptides capa receptor 0.0241 0.2039 0.2039
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0039 0.0171 0.0171
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0044 0.0218 0.059
Schistosoma mansoni neuropeptide receptor 0.0241 0.2039 0.2039
Onchocerca volvulus 0.0124 0.096 0.4072
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0241 0.2039 0.2039
Schistosoma mansoni amine GPCR 0.0241 0.2039 0.2039
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0044 0.0218 0.0218
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0079 0.011
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0093 0.0093
Echinococcus multilocularis neuropeptide receptor 0.0241 0.2039 0.2039
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0019 0.002
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0044 0.0218 0.059
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0044 0.0218 0.059
Brugia malayi Tachykinin-like peptides receptor 99D 0.0241 0.2039 0.2114
Schistosoma mansoni hypothetical protein 0.0064 0.0402 0.0402
Leishmania major cytochrome p450-like protein 0.0044 0.0218 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0263 0.2242 0.2325
Echinococcus granulosus neuropeptide Y receptor 0.0241 0.2039 0.2039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0263 0.2242 0.2325
Brugia malayi hypothetical protein 0.0139 0.1097 0.1138
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0241 0.2039 0.2039
Echinococcus granulosus dro:myosuppressin receptor 0.0241 0.2039 0.2039
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.042 0.3694 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0124 0.096 0.096
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.2039 0.2039
Schistosoma mansoni hypothetical protein 0.0064 0.0402 0.0402
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0263 0.2242 0.2242
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0039 0.0171 0.0171
Schistosoma mansoni amine GPCR 0.0241 0.2039 0.2039
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Schistosoma mansoni hypothetical protein 0.0064 0.0402 0.0402
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0039 0.0171 0.0171
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0263 0.2242 0.2242
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0241 0.2039 0.2039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.2039 0.2039
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Loa Loa (eye worm) hypothetical protein 0.0124 0.096 0.0995
Schistosoma mansoni biogenic amine (5HT) receptor 0.0241 0.2039 0.2039
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0044 0.0218 0.059
Toxoplasma gondii pyruvate carboxylase 0.042 0.3694 0.3694
Leishmania major cytochrome p450-like protein 0.0044 0.0218 0.0218
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0794 0.5118
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.1103 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0241 0.2039 0.2114
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.2792 0.2895
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0044 0.0218 0.059
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0241 0.2039 0.2039
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.015 0.1194 0.3233
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0241 0.2039 0.2114
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0376 0.0376
Schistosoma mansoni cpg binding protein 0.0029 0.0079 0.0079
Brugia malayi ecdysteroid receptor 0.0263 0.2242 0.2325
Echinococcus multilocularis serotonin receptor 0.0241 0.2039 0.2039
Echinococcus granulosus neuropeptide receptor 0.0241 0.2039 0.2039
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0794 0.0794
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0044 0.0218 0.059
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0039 0.0171 0.0171
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0235 0.0244
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0376 0.1017
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0044 0.0218 0.0356
Brugia malayi sulfakinin receptor protein 0.0241 0.2039 0.2114
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0044 0.0218 0.059
Loa Loa (eye worm) hypothetical protein 0.0064 0.0402 0.0417
Brugia malayi G protein-coupled receptor F59B2.13 0.0241 0.2039 0.2114
Onchocerca volvulus Bile acid receptor homolog 0.0263 0.2242 1
Echinococcus multilocularis g protein coupled receptor 0.0241 0.2039 0.2039
Schistosoma mansoni cpg binding protein 0.003 0.0094 0.0094
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0079 0.0079
Chlamydia trachomatis acetyl-CoA carboxylase biotin carboxyl carrier protein 0.0039 0.0171 0.0283
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0019 0.0019
Brugia malayi Dopamine receptor protein 1 0.0241 0.2039 0.2114
Mycobacterium ulcerans hypothetical protein 0.0039 0.0171 0.0463
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.2039 0.2039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0263 0.2242 0.2325
Echinococcus multilocularis snurportin 1 0.0323 0.2792 0.2792
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.1671 0.1733
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0263 0.2242 0.2242
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0263 0.2242 0.2242
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.2039 0.2039
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0139 0.1097 0.1097
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0139 0.1097 0.1097
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0241 0.2039 0.2039
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0044 0.0218 0.059
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.2039 0.2039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0263 0.2242 0.2325
Loa Loa (eye worm) TYRA-2 protein 0.0241 0.2039 0.2114
Echinococcus granulosus 7tm_1 domain containing protein 0.0241 0.2039 0.2039
Schistosoma mansoni cytochrome P450 0.0044 0.0218 0.0218
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0044 0.0218 0.059
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0241 0.2039 0.2114
Brugia malayi Melatonin receptor type 1A 0.0241 0.2039 0.2114
Onchocerca volvulus 0.0241 0.2039 0.9059
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.015 0.1194 0.3233
Loa Loa (eye worm) hypothetical protein 0.0124 0.096 0.0995
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0044 0.0218 0.059
Echinococcus granulosus neuropeptide Y receptor 0.0241 0.2039 0.2039
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0095 0.0691 0.0962
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0263 0.2242 0.2325
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0402 0.0417
Loa Loa (eye worm) hypothetical protein 0.0178 0.1455 0.1509
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0039 0.0171 0.0171
Onchocerca volvulus 0.0241 0.2039 0.9059
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.0794 0.0794
Onchocerca volvulus 0.0241 0.2039 0.9059
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0263 0.2242 0.2242
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0044 0.0218 0.059
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0794 0.5118
Loa Loa (eye worm) hypothetical protein 0.0139 0.1097 0.1138
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.2039 0.2039
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0019 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0263 0.2242 0.2325
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0794 0.5631
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0241 0.2039 0.9059
Schistosoma mansoni nuclear hormone receptor 0.0263 0.2242 0.2242
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0241 0.2039 0.2039
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0044 0.0218 0.059
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0044 0.0218 0.059
Brugia malayi hypothetical protein 0.0241 0.2039 0.2114
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.1065 0.9643 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.096 0.0995
Echinococcus multilocularis g protein coupled receptor 0.0241 0.2039 0.2039
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0039 0.0171 0.0171
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0241 0.2039 0.2039
Onchocerca volvulus 0.0241 0.2039 0.9059
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0263 0.2242 0.2325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.2039 0.2039
Echinococcus granulosus Nuclear hormone receptor HR96 0.0124 0.096 0.096
Onchocerca volvulus 0.0241 0.2039 0.9059
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.0039 0.0171 0.0463
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0044 0.0218 0.059
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0241 0.2039 0.2039
Schistosoma mansoni hypothetical protein 0.0516 0.4573 0.4573
Schistosoma mansoni steroid hormone receptor ad4bp 0.0263 0.2242 0.2242
Brugia malayi nuclear receptor NHR-67 0.0124 0.096 0.0995
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0139 0.1097 0.1097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0263 0.2242 0.2325
Loa Loa (eye worm) nuclear receptor NHR-67 0.0124 0.096 0.0995
Brugia malayi hypothetical protein 0.0241 0.2039 0.2114
Chlamydia trachomatis dihydrolipoamide acetyltransferase 0.0039 0.0171 0.0283
Schistosoma mansoni hypothetical protein 0.0241 0.2039 0.2039
Echinococcus granulosus importin subunit beta 1 0.003 0.0093 0.0093
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0039 0.0171 0.0463
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.042 0.3694 0.3694
Loa Loa (eye worm) neuropeptide F receptor 0.0241 0.2039 0.2114
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0044 0.0218 0.059
Loa Loa (eye worm) neuropeptide F receptor 0.0241 0.2039 0.2114
Brugia malayi conserved hypotetical protein 0.0124 0.096 0.0995
Echinococcus granulosus alpha 1A adrenergic receptor 0.0241 0.2039 0.2039
Echinococcus granulosus g-protein coupled receptor 0.0241 0.2039 0.2039
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0263 0.2242 0.2325
Schistosoma mansoni growth hormone secretagogue receptor 0.0241 0.2039 0.2039
Loa Loa (eye worm) hypothetical protein 0.0263 0.2242 0.2325
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0044 0.0218 0.059
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0315 0.0315
Schistosoma mansoni histamine h1 receptor 0.0241 0.2039 0.2039
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.015 0.1194 0.3233
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0044 0.0218 0.059
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0263 0.2242 0.2242
Loa Loa (eye worm) cytochrome P450 family protein 0.0071 0.047 0.0487
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Echinococcus granulosus somatostatin receptor 0.0241 0.2039 0.2039
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0241 0.2039 0.2039
Brugia malayi nuclear receptor NHR-88 0.0124 0.096 0.0995
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0124 0.096 0.0995
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.042 0.3694 0.6036
Echinococcus granulosus neuropeptide receptor A26 0.0241 0.2039 0.2039
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.015 0.1194 0.3233
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0019 0.0032
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0402 0.0402
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0039 0.0171 0.0279
Onchocerca volvulus Protein ultraspiracle homolog 0.0263 0.2242 1
Brugia malayi Nuclear hormone receptor E75 0.0124 0.096 0.0995
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.042 0.3694 0.3694
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0044 0.0218 0.059
Echinococcus granulosus ecdysone induced protein 78C 0.0263 0.2242 0.2242
Schistosoma mansoni nuclear receptor 0.0124 0.096 0.096
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0241 0.2039 0.2039
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0039 0.0171 0.0171
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.015 0.1194 0.3233
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0263 0.2242 0.2242
Schistosoma mansoni myosin xvIII 0.0241 0.2039 0.2039
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.042 0.3694 0.3694
Loa Loa (eye worm) hypothetical protein 0.0124 0.096 0.0995
Loa Loa (eye worm) nuclear hormone receptor 0.0124 0.096 0.0995
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0241 0.2039 0.2039
Echinococcus granulosus FTZ F1 alpha 0.0263 0.2242 0.2242
Loa Loa (eye worm) cytochrome P450 0.0044 0.0218 0.0226
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0039 0.0171 0.0177
Onchocerca volvulus 0.0241 0.2039 0.9059
Echinococcus granulosus orexin receptor type 2 0.0241 0.2039 0.2039
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0039 0.0171 0.0171
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.2039 0.2039
Brugia malayi CXXC zinc finger family protein 0.0029 0.0079 0.0081
Brugia malayi Serotonin receptor 0.0241 0.2039 0.2114
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0241 0.2039 0.2039
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Schistosoma mansoni ran 0.0022 0.0019 0.0019
Brugia malayi hypothetical protein 0.0241 0.2039 0.2114
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0079 0.0081
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Echinococcus multilocularis neuropeptides capa receptor 0.0241 0.2039 0.2039
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.015 0.1194 0.1194
Onchocerca volvulus 0.0241 0.2039 0.9059
Echinococcus granulosus biogenic amine 5HT receptor 0.0241 0.2039 0.2039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0376 0.1017
Echinococcus granulosus g protein coupled receptor 0.0241 0.2039 0.2039
Trypanosoma brucei acetyl-CoA carboxylase 0.1103 1 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.2039 0.2039
Brugia malayi putative neuropeptide receptor 0.0241 0.2039 0.2114
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0044 0.0218 0.059
Schistosoma mansoni nuclear receptor 0.0124 0.096 0.096
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0794 0.0794
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.042 0.3694 1
Schistosoma mansoni opsin-like receptor 0.0241 0.2039 0.2039
Trypanosoma cruzi acetyl-CoA carboxylase 0.0683 0.612 1
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0039 0.0171 0.0238
Onchocerca volvulus 0.0124 0.096 0.4072
Schistosoma mansoni hypothetical protein 0.0241 0.2039 0.2039
Loa Loa (eye worm) hypothetical protein 0.0027 0.0066 0.0068
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0263 0.2242 0.2242
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Echinococcus granulosus geminin 0.0516 0.4573 0.4573
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0079 0.0508
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0263 0.2242 0.2242
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0263 0.2242 0.2242
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.1103 1 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0039 0.0171 0.0238
Brugia malayi steroid hormone receptor 0.0263 0.2242 0.2325
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0079 0.0559
Schistosoma mansoni nuclear receptor nhr-48 0.0124 0.096 0.096
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0039 0.0171 0.0171
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.2039 0.2039
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0124 0.096 0.096
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0019 0.0019
Echinococcus granulosus biogenic amine 5HT receptor 0.0241 0.2039 0.2039
Brugia malayi nuclear receptor RXR 0.0139 0.1097 0.1138
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0402 0.0417
Echinococcus granulosus cytochrome P450 2K1 0.0044 0.0218 0.0218
Brugia malayi Dopamine receptor protein 2 0.0241 0.2039 0.2114
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0263 0.2242 0.2325
Brugia malayi photoreceptor-specific nuclear receptor 0.0263 0.2242 0.2325
Loa Loa (eye worm) hypothetical protein 0.0263 0.2242 0.2325
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0093 0.0093
Echinococcus granulosus g protein coupled receptor 0.0241 0.2039 0.2039
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.015 0.1194 0.3424
Loa Loa (eye worm) G-protein coupled receptor 0.0241 0.2039 0.2114
Brugia malayi Serotonin receptor 0.0241 0.2039 0.2114
Loa Loa (eye worm) cytochrome P450 family protein 0.0071 0.047 0.0487
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0263 0.2242 0.2325
Toxoplasma gondii cytochrome p450 superfamily protein 0.0044 0.0218 0.0218
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.015 0.1194 0.2905
Loa Loa (eye worm) phosphofructokinase 0.0106 0.0794 0.0823
Brugia malayi hypothetical protein 0.0241 0.2039 0.2114
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.1103 1 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0919 0.0952
Echinococcus granulosus tachykinin peptides receptor 99D 0.0241 0.2039 0.2039
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.0794 0.0794
Brugia malayi nuclear receptor NHR-88 0.0263 0.2242 0.2325
Onchocerca volvulus 0.0241 0.2039 0.9059
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0235 0.0235
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.015 0.1194 0.1194
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0139 0.1097 0.1138
Echinococcus granulosus GPCR family 2 0.0064 0.0402 0.0402
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0799 0.7185 1
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0039 0.0171 0.0171
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0124 0.096 0.4072
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0241 0.2039 0.2039
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0079 0.0079
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0039 0.0171 0.0463
Loa Loa (eye worm) hypothetical protein 0.0124 0.096 0.0995
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.004 0.0066
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Brugia malayi follicle stimulating hormone receptor 0.0241 0.2039 0.2114
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Loa Loa (eye worm) steroid hormone receptor 0.0263 0.2242 0.2325
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0235 0.0235
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.2039 0.2039
Brugia malayi cytochrome P450 0.0044 0.0218 0.0226
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0241 0.2039 0.2039
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0044 0.0218 0.059
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0263 0.2242 0.2242
Plasmodium vivax importin-beta 2, putative 0.003 0.0093 0.013
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0263 0.2242 0.2325
Schistosoma mansoni ran 0.0022 0.0019 0.0019
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0241 0.2039 0.2114
Loa Loa (eye worm) hypothetical protein 0.0039 0.0171 0.0177
Brugia malayi tailless protein 0.0124 0.096 0.0995
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0263 0.2242 0.2325
Echinococcus multilocularis G-protein coupled receptor, putative 0.0241 0.2039 0.2039
Brugia malayi phosphofructokinase 0.0106 0.0794 0.0823
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0124 0.096 0.096
Echinococcus granulosus sex peptide receptor 0.0241 0.2039 0.2039
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0095 0.0691 0.0691
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0039 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0263 0.2242 0.2325
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0044 0.0218 0.0218
Brugia malayi Cytochrome P450 family protein 0.0071 0.047 0.0487
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.015 0.1194 0.1194
Echinococcus granulosus nuclear receptor nhr 48 0.0124 0.096 0.096
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.2039 0.2039
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0071 0.047 0.1272
Loa Loa (eye worm) hypothetical protein 0.0138 0.1084 0.1124
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0079 0.0079
Schistosoma mansoni nuclear hormone receptor 0.0124 0.096 0.096
Leishmania major acetyl-CoA carboxylase, putative 0.1103 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0263 0.2242 0.2242
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0124 0.096 0.096
Schistosoma mansoni retinoic acid receptor RXR 0.0263 0.2242 0.2242
Brugia malayi nuclear hormone receptor 0.0263 0.2242 0.2325
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.1671 0.1733
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0044 0.0218 0.059
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0039 0.0171 0.0171
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.2039 0.2039
Leishmania major carboxylase, putative 0.042 0.3694 0.3694
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0039 0.0171 0.0171
Onchocerca volvulus 0.0241 0.2039 0.9059
Schistosoma mansoni thyroid hormone receptor 0.0263 0.2242 0.2242
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0376 0.0376
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.015 0.1194 0.3233
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0235 0.0235
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0019 0.0019
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0095 0.0691 0.1129
Onchocerca volvulus 0.0241 0.2039 0.9059
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0079 0.0508
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0079 0.0559
Brugia malayi Cytochrome P450 family protein 0.0071 0.047 0.0487
Loa Loa (eye worm) hypothetical protein 0.0039 0.0171 0.0177
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.015 0.1194 0.3233
Brugia malayi Cytochrome P450 family protein 0.0142 0.1122 0.1164
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0241 0.2039 0.2039
Echinococcus multilocularis neuropeptide receptor A26 0.0241 0.2039 0.2039
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0044 0.0218 0.059
Brugia malayi RNA, U transporter 1 0.0086 0.0607 0.063
Echinococcus granulosus Biotin lipoyl attachment 0.0039 0.0171 0.0171
Schistosoma mansoni pyruvate carboxylase 0.042 0.3694 0.3694
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0241 0.2039 0.2039
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0039 0.0171 0.0463
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0241 0.2039 0.2114
Schistosoma mansoni coup transcription factor 0.0263 0.2242 0.2242
Brugia malayi Nuclear hormone receptor-like 1 0.0139 0.1097 0.1138
Onchocerca volvulus 0.0241 0.2039 0.9059
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0095 0.0691 0.1871
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0263 0.2242 0.2242
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0263 0.2242 0.2325
Onchocerca volvulus 0.0241 0.2039 0.9059
Brugia malayi 6-phosphofructokinase 0.0106 0.0794 0.0823
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.2039 0.2039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0124 0.096 0.096
Plasmodium falciparum importin beta, putative 0.003 0.0093 0.013
Onchocerca volvulus 0.0241 0.2039 0.9059
Toxoplasma gondii carbamoylphosphate synthetase 0.0095 0.0691 0.0691
Schistosoma mansoni RAR-like nuclear receptor 0.0263 0.2242 0.2242
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0241 0.2039 0.2114
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0019 0.0032
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Brugia malayi ecdysone receptor 0.0124 0.096 0.0995
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0188 0.1551 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.2039 0.2039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0263 0.2242 0.2325
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0044 0.0218 0.059
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0039 0.0171 0.0279
Chlamydia trachomatis biotin carboxylase 0.0382 0.3337 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Echinococcus granulosus tm gpcr rhodopsin 0.0241 0.2039 0.2039
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0044 0.0218 0.059
Brugia malayi G-protein coupled receptor 0.0241 0.2039 0.2114
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0794 0.5631
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0124 0.096 0.096
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0044 0.0218 0.0356
Echinococcus granulosus neuropeptide s receptor 0.0241 0.2039 0.2039
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0079 0.0559
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0376 0.0376
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.015 0.1194 0.3233
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.2039 0.2039
Echinococcus multilocularis g-protein coupled receptor 0.0241 0.2039 0.2039
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.3581 0.3581
Echinococcus multilocularis neuropeptide s receptor 0.0241 0.2039 0.2039
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0794 0.0794
Schistosoma mansoni amine GPCR 0.0241 0.2039 0.2039
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0039 0.0171 0.0171
Echinococcus granulosus peptide allatostatin:somatostatin 0.0241 0.2039 0.2039
Brugia malayi hypothetical protein 0.0241 0.2039 0.2114
Brugia malayi hypothetical protein 0.0241 0.2039 0.2114
Trichomonas vaginalis ran, putative 0.0022 0.0019 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.2039 0.2039
Schistosoma mansoni cpg binding protein 0.003 0.0094 0.0094
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0019 0.002
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0039 0.0171 0.0171
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.015 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0263 0.2242 0.2325
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0039 0.0171 0.0177
Schistosoma mansoni importin beta-1 0.003 0.0093 0.0093
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0241 0.2039 0.2039
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0241 0.2039 0.2039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0376 0.1017
Trypanosoma cruzi cytochrome P450, putative 0.0071 0.047 0.0768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0235 0.0235
Schistosoma mansoni neuropeptide F-like receptor 0.0241 0.2039 0.2039
Loa Loa (eye worm) hypothetical protein 0.0241 0.2039 0.2114
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.042 0.3694 0.3694
Schistosoma mansoni hypothetical protein 0.0064 0.0402 0.0402
Schistosoma mansoni hypothetical protein 0.0516 0.4573 0.4573
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0124 0.096 0.4072
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0241 0.2039 0.2039
Trichomonas vaginalis importin beta-1, putative 0.0025 0.004 0.0286
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0039 0.0171 0.0171
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0241 0.2039 0.2039
Loa Loa (eye worm) hypothetical protein 0.0124 0.096 0.0995
Echinococcus granulosus snurportin 1 0.0323 0.2792 0.2792
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0235 0.0244
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.015 0.1194 0.2905
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.042 0.3694 1
Leishmania major importin beta-1 subunit, putative 0.0025 0.004 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.2039 0.2039
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0039 0.0171 0.0177
Loa Loa (eye worm) hypothetical protein 0.0263 0.2242 0.2325
Mycobacterium leprae putative cytochrome p450 0.0044 0.0218 0.0134
Brugia malayi hypothetical protein 0.0139 0.1097 0.1138
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0794 0.5118
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0039 0.0171 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0263 0.2242 0.2325
Schistosoma mansoni biogenic amine receptor 0.0241 0.2039 0.2039
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0044 0.0218 0.059
Echinococcus granulosus hypothetical protein 0.0241 0.2039 0.2039

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 355 nM Binding affinity towards cloned human somatostatin 2 (hsst) receptor ChEMBL. 9544214
IC50 (binding) = 903 nM Binding affinity towards cloned human somatostatin 3 (hsst) receptor ChEMBL. 9544214
IC50 (binding) = 1000 nM Binding affinity towards cloned human somatostatin 1 (hsst) receptor ChEMBL. 9544214
IC50 (binding) = 1000 nM Binding affinity towards cloned human somatostatin 4 (hsst) receptor ChEMBL. 9544214
IC50 (binding) = 1000 nM Binding affinity towards cloned human somatostatin 5 (hsst) receptor ChEMBL. 9544214
IC50 (functional) = 0.056 uM Compound was tested for in vitro SRIF inhibition of GH release in rats ChEMBL. 9544214

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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