Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0211 | 0.068 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0443 | 0.5922 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0443 | 0.5922 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0443 | 0.5922 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0624 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0443 | 0.5922 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0624 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0624 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0624 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0181 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0211 | 0.068 | 0.1148 |
Echinococcus granulosus | thymidylate synthase | 0.0443 | 0.5922 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0624 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0443 | 0.5922 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0211 | 0.068 | 0.1148 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0443 | 0.5922 | 1 |
Brugia malayi | thymidylate synthase | 0.0443 | 0.5922 | 1 |
Onchocerca volvulus | 0.0443 | 0.5922 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | 0 | Inhibition of Mycobacterium tuberculosis InhA at 20 uM | ChEMBL. | 17034137 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.