Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0529 | 1 | 1 |
Leishmania major | glucose transporter, lmgt2 | 0.0164 | 0.1693 | 0.5 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0529 | 1 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0164 | 0.1693 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0164 | 0.1693 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0529 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0164 | 0.1693 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0529 | 1 | 1 |
Trypanosoma cruzi | hexose transporter | 0.0164 | 0.1693 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0164 | 0.1693 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 0.3048 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0529 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 0.3048 | 0.5 |
Plasmodium vivax | hexose transporter | 0.0529 | 1 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0529 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0529 | 1 | 0.5 |
Plasmodium falciparum | hexose transporter | 0.0529 | 1 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0164 | 0.1693 | 1 |
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0164 | 0.1693 | 0.5 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0529 | 1 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0223 | 0.3048 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0164 | 0.1693 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0529 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0164 | 0.1693 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 0.3048 | 0.5 |
Leishmania major | glucose transporter, lmgt1 | 0.0164 | 0.1693 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0164 | 0.1693 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0529 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0164 | 0.1693 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0529 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0164 | 0.1693 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 0.3048 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 0.3048 | 0.1631 |
Trypanosoma brucei | glucose transporter 1E | 0.0164 | 0.1693 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0529 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0164 | 0.1693 | 0.5 |
Loa Loa (eye worm) | sugar transporter | 0.0529 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0164 | 0.1693 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0529 | 1 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0164 | 0.1693 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0529 | 1 | 1 |
Leishmania major | glucose transporter, lmgt3 | 0.0164 | 0.1693 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0164 | 0.1693 | 0.5 |
Trypanosoma brucei | glucose transporter 2A | 0.0164 | 0.1693 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.46 uM | Inhibition of Mycobacterium tuberculosis InhA | ChEMBL. | 17034137 |
IC50 (binding) | = 0.46 uM | Inhibition of Mycobacterium tuberculosis InhA | ChEMBL. | 17034137 |
Inhibition (binding) | = 75 % | Inhibition of Mycobacterium tuberculosis InhA at 1.5 uM | ChEMBL. | 17034137 |
Inhibition (binding) | = 75 % | Inhibition of Mycobacterium tuberculosis InhA at 1.5 uM | ChEMBL. | 17034137 |
Inhibition (binding) | > 90 % | Inhibition of Mycobacterium tuberculosis InhA at 15 uM | ChEMBL. | 17034137 |
Inhibition (binding) | > 90 % | Inhibition of Mycobacterium tuberculosis InhA at 15 uM | ChEMBL. | 17034137 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.