Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Ovis aries | Cyclooxygenase-1 | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Mus musculus | prostaglandin-endoperoxide synthase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | peroxidasin | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0143 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0143 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0143 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0143 | 0.5 | 0.5 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0143 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0143 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0143 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0143 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0143 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0143 | 0.5 | 0.5 | |
Echinococcus multilocularis | peroxidasin | 0.0143 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0143 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.92 | Inhibitory activity against prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 12383007 |
IC50 (binding) | = 7.68 | Inhibition of human Prostaglandin G/H synthase 2 | ChEMBL. | 11563921 |
IC50 (binding) | = 7.68 | Inhibitory activity against prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 12383007 |
IC50 (binding) | = 0.021 uM | In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 9135032 |
IC50 (binding) | = 0.021 uM | In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 9135032 |
IC50 (binding) | = 1.21 uM | In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 9135032 |
IC50 (binding) | = 1.21 uM | In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 9135032 |
Ki (binding) | = 1.14 | Inhibitory constant against prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 12383007 |
Ki (binding) | = 2.03 | Inhibitory constant against prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 12383007 |
Ki (binding) | = 1.14 | Inhibitory constant against prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 12383007 |
Ki (binding) | = 2.03 | Inhibitory constant against prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 12383007 |
Log IC50 (binding) | = 5.92 | Inhibitory activity against prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 12383007 |
Log IC50 (binding) | = 7.68 | Inhibition of human Prostaglandin G/H synthase 2 | ChEMBL. | 11563921 |
Log IC50 (binding) | = 7.68 | Inhibitory activity against prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 12383007 |
Selectivity (binding) | = 1.76 | Selectivity as log (IC50[COX-1]/IC50[COX-2]). | ChEMBL. | 12383007 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.