Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0222 | 0.2096 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0127 | 0.011 | 0.011 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0596 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0596 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Onchocerca volvulus | Cathepsin F homolog | 0.0222 | 0.2096 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0222 | 0.2106 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0222 | 0.2106 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0596 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0222 | 0.2096 | 0.2021 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0222 | 0.2096 | 0.9956 |
Onchocerca volvulus | 0.0222 | 0.2096 | 1 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0154 | 0.0667 | 0.0667 |
Echinococcus granulosus | cathepsin l1 | 0.0222 | 0.2096 | 0.2096 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0222 | 0.2096 | 0.2096 |
Onchocerca volvulus | Cathepsin L homolog | 0.0222 | 0.2096 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0222 | 0.2096 | 0.2096 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Onchocerca volvulus | 0.0222 | 0.2096 | 1 | |
Brugia malayi | Probable ATP-dependent helicase DHX35 | 0.0127 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0667 | 0.0578 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0222 | 0.2096 | 0.9956 |
Plasmodium vivax | vivapain-2 | 0.0222 | 0.2096 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0222 | 0.2096 | 0.9956 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Echinococcus multilocularis | cathepsin b | 0.0596 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0154 | 0.0667 | 0.0667 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0222 | 0.2096 | 0.2096 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Loa Loa (eye worm) | hypothetical protein | 0.0596 | 1 | 1 |
Onchocerca volvulus | 0.0222 | 0.2096 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0222 | 0.2096 | 0.9956 |
Brugia malayi | Trypsin family protein | 0.0127 | 0.011 | 0.011 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0222 | 0.2096 | 0.2021 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0222 | 0.2096 | 0.2096 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Loa Loa (eye worm) | cathepsin B | 0.0222 | 0.2106 | 0.2031 |
Brugia malayi | cathepsin L-like precursor | 0.0154 | 0.0667 | 0.0667 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0667 | 0.0578 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0154 | 0.0667 | 0.3182 |
Loa Loa (eye worm) | cysteine protease | 0.0222 | 0.2096 | 0.2021 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0222 | 0.2096 | 0.9956 |
Brugia malayi | Cathepsin L-like precursor | 0.0222 | 0.2096 | 0.2096 |
Brugia malayi | Cathepsin L-like precursor | 0.0222 | 0.2096 | 0.2096 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0222 | 0.2096 | 0.2096 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0222 | 0.2096 | 0.2021 |
Echinococcus granulosus | cathepsin b | 0.0596 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0596 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Brugia malayi | Cathepsin L-like precursor | 0.0222 | 0.2096 | 0.2096 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Onchocerca volvulus | 0.0222 | 0.2096 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0154 | 0.0667 | 0.0667 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0222 | 0.2106 | 0.2106 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0222 | 0.2106 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0154 | 0.0667 | 0.0667 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0222 | 0.2096 | 0.9956 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0154 | 0.0667 | 0.3168 |
Onchocerca volvulus | 0.0154 | 0.0667 | 0.2803 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0222 | 0.2096 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0222 | 0.2096 | 0.9956 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Brugia malayi | Cathepsin L-like precursor | 0.0222 | 0.2096 | 0.2096 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.011 | 0.0017 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0222 | 0.2096 | 0.2096 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0222 | 0.2096 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0222 | 0.2096 | 0.9956 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0222 | 0.2096 | 1 |
Onchocerca volvulus | 0.0222 | 0.2096 | 1 | |
Onchocerca volvulus | 0.0222 | 0.2096 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0667 | 0.0578 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0596 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0222 | 0.2096 | 0.2096 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0222 | 0.2096 | 0.2096 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Echinococcus multilocularis | cysteine protease | 0.0222 | 0.2096 | 0.2096 |
Brugia malayi | Cathepsin L-like precursor | 0.0222 | 0.2096 | 0.2096 |
Echinococcus granulosus | cathepsin b | 0.0596 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0596 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0222 | 0.2096 | 0.2096 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0222 | 0.2096 | 0.9956 |
Echinococcus granulosus | cathepsin l1 | 0.0154 | 0.0667 | 0.0667 |
Entamoeba histolytica | cysteine protease, putative | 0.0222 | 0.2096 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0222 | 0.2096 | 0.2096 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.2096 | 0.2021 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0222 | 0.2106 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0222 | 0.2096 | 0.2021 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0222 | 0.2096 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0127 | 0.011 | 0.011 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0222 | 0.2096 | 0.9956 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0222 | 0.2096 | 0.2096 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0222 | 0.2096 | 0.9956 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0154 | 0.0667 | 0.3168 |
Giardia lamblia | Cathepsin B precursor | 0.0222 | 0.2106 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0154 | 0.0667 | 0.0667 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0222 | 0.2096 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0222 | 0.2096 | 0.2096 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.011 | 0.0017 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0222 | 0.2106 | 0.2106 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0222 | 0.2096 | 0.9956 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0222 | 0.2096 | 0.2096 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0222 | 0.2106 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0222 | 0.2096 | 0.2096 |
Plasmodium vivax | vivapain-2 | 0.0222 | 0.2096 | 1 |
Onchocerca volvulus | 0.0222 | 0.2096 | 1 | |
Toxoplasma gondii | cathepsin B | 0.0222 | 0.2106 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0222 | 0.2096 | 0.2096 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0222 | 0.2096 | 0.2096 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Viability of MM6 cells at 100 uM by Roche-XTT assay relative to control | ChEMBL. | 17004713 |
Activity (functional) | 0 | Viability in ATP-lite assay relative to control | ChEMBL. | 17004713 |
Activity (functional) | = 36 % | Viability of BAEC by Roche-XTT assay relative to control | ChEMBL. | 17004713 |
Inhibition (binding) | Inhibition of sLex binding to E-selectin at 100 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 | |
Inhibition (functional) | Inhibition of MM6 cell adhesion to recombinant E-selectin at 100 uM relative to control by flow chamber assay | ChEMBL. | 17004713 | |
Inhibition (functional) | 0 | Inhibition of MM6 cell adhesion to recombinant E-selectin at 100 uM relative to control by flow chamber assay | ChEMBL. | 17004713 |
Inhibition (binding) | 0 | Inhibition of sLex binding to E-selectin at 100 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 |
Inhibition (binding) | = 49 % | Inhibition of sLex binding to P-selectin at 500 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 |
Inhibition (binding) | = 49 % | Inhibition of sLex binding to P-selectin at 500 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 |
Inhibition (binding) | = 50 % | Inhibition of sLex binding to L-selectin at 500 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 |
Inhibition (binding) | = 50 % | Inhibition of sLex binding to L-selectin at 500 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 |
Inhibition (functional) | = 56 % | Inhibition of MM6 cell adhesion to BAEC at 100 uM relative to control by static assay | ChEMBL. | 17004713 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.