Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dipeptidyl peptidase IV | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Dipeptidyl peptidase IV | 767 aa | 637 aa | 27.0 % | |
Onchocerca volvulus | Dipeptidyl peptidase IV | 767 aa | 789 aa | 30.2 % | |
Candida albicans | dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor | Dipeptidyl peptidase IV | 767 aa | 814 aa | 25.6 % |
Candida albicans | dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor | Dipeptidyl peptidase IV | 767 aa | 814 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydrofolate reductase | 0.0328 | 0.1286 | 0.1995 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0804 | 0.6447 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1132 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0804 | 0.6447 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0804 | 0.6447 | 1 |
Brugia malayi | thymidylate synthase | 0.0804 | 0.6447 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0328 | 0.1286 | 0.1995 |
Onchocerca volvulus | 0.0804 | 0.6447 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0383 | 0.1878 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1132 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0328 | 0.1286 | 0.1995 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1132 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0804 | 0.6447 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0804 | 0.6447 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0804 | 0.6447 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0804 | 0.6447 | 1 |
Brugia malayi | hypothetical protein | 0.0383 | 0.1878 | 0.2913 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1132 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0383 | 0.1878 | 0.1148 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0328 | 0.1286 | 0.1995 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0328 | 0.1286 | 0.1995 |
Brugia malayi | dihydrofolate reductase family protein | 0.0328 | 0.1286 | 0.1995 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0328 | 0.1286 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1132 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.