Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0276 | 1 | 1 | |
Echinococcus multilocularis | FTZ F1 alpha | 0.0276 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0276 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0276 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0224 | 0.6397 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0276 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0276 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0276 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0276 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0146 | 0.1071 | 0.1071 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0224 | 0.6397 | 0.6397 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0276 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0276 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0276 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0146 | 0.1071 | 0.1071 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0276 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0276 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1071 | 0.1071 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0155 | 0.1669 | 0.1027 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0276 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0276 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0276 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0155 | 0.1669 | 0.1027 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0276 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0276 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0276 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0276 | 1 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0147 | 0.1127 | 0.1127 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0146 | 0.1071 | 0.1071 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0276 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0276 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0276 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0146 | 0.1071 | 0.1071 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0276 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0276 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0276 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0276 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0146 | 0.1071 | 0.1071 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0276 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0276 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0276 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0276 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0224 | 0.6397 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0276 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0224 | 0.6397 | 1 |
Brugia malayi | hypothetical protein | 0.0146 | 0.1071 | 0.1071 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0224 | 0.6397 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0276 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1071 | 0.1071 |
Brugia malayi | steroid hormone receptor | 0.0276 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0276 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0276 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0146 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0276 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0276 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0276 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0224 | 0.6397 | 0.6397 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0276 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0276 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0224 | 0.6397 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0276 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0276 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0146 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0276 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0276 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0224 | 0.6397 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0146 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0276 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0276 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0146 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0276 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0 % | Viability in ATP-lite assay relative to control | ChEMBL. | 17004713 |
Activity (functional) | = 11 % | Viability of MM6 cells at 100 uM by Roche-XTT assay relative to control | ChEMBL. | 17004713 |
Activity (functional) | = 11 % | Viability of MM6 cells at 100 uM by Roche-XTT assay relative to control | ChEMBL. | 17004713 |
Activity (functional) | = 46 % | Viability of BAEC by Roche-XTT assay relative to control | ChEMBL. | 17004713 |
Inhibition (functional) | 0 | Inhibition of MM6 cell adhesion to recombinant E-selectin at 100 uM relative to control by flow chamber assay | ChEMBL. | 17004713 |
Inhibition (binding) | = 43 % | Inhibition of sLex binding to E-selectin at 100 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 |
Inhibition (binding) | = 43 % | Inhibition of sLex binding to E-selectin at 100 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 |
Inhibition (functional) | = 82 % | Inhibition of MM6 cell adhesion to BAEC at 100 uM relative to control by static assay | ChEMBL. | 17004713 |
Inhibition (binding) | = 92 % | Inhibition of sLex binding to L-selectin at 500 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 |
Inhibition (binding) | = 92 % | Inhibition of sLex binding to L-selectin at 500 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 |
Inhibition (binding) | = 95 % | Inhibition of sLex binding to P-selectin at 500 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 |
Inhibition (binding) | = 95 % | Inhibition of sLex binding to P-selectin at 500 uM relative to control by glyco-ELISA assay | ChEMBL. | 17004713 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.