Detailed information for compound 376254

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 994.308 | Formula: C58H83N5O9
  • H donors: 5 H acceptors: 6 LogP: 9.21 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCOC(=O)[C@H](NC(=O)[C@@]1(O)[C@@H](O)[C@@]2(CC)C=CCN3[C@H]2[C@@]2([C@@]1(C)N(C)c1c2cc(c(c1)OC)[C@@]1(CC2CN(CCc4c1[nH]c1c4cccc1)C[C@@](C2)(O)CC)C(=O)OC)CC3)CC(C)C
  • InChi: 1S/C58H83N5O9/c1-10-13-14-15-16-19-29-72-48(64)44(30-37(4)5)60-51(66)58(69)50(65)55(12-3)24-20-26-63-28-25-57(49(55)63)41-31-42(46(70-8)32-45(41)61(7)53(57,58)6)56(52(67)71-9)34-38-33-54(68,11-2)36-62(35-38)27-23-40-39-21-17-18-22-43(39)59-47(40)56/h17-18,20-22,24,31-32,37-38,44,49-50,59,65,68-69H,10-16,19,23,25-30,33-36H2,1-9H3,(H,60,66)/t38?,44-,49-,50+,53+,54-,55+,56-,57+,58-/m0/s1
  • InChiKey: CBHDRKVSAZCMQU-YBPSWOKVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0121 0.026 0.0863
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0008
Echinococcus granulosus transcription factor btf3 0.0035 0.0045 0.0137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0041 0.0133
Brugia malayi PHD-finger family protein 0.008 0.0159 0.141
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0305 0.0724 0.646
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0023 0.1932
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0084 0.0168 0.0556
Toxoplasma gondii heat shock protein 75, putative 0.0026 0.0023 0.0037
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0084 0.0168 0.0164
Echinococcus multilocularis muscleblind protein 0.0155 0.0347 0.0343
Schistosoma mansoni hypothetical protein 0.0841 0.2071 0.6885
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0041 0.0066
Echinococcus granulosus survival motor neuron protein 1 0.0463 0.112 0.3715
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0137 0.0228
Loa Loa (eye worm) hypothetical protein 0.0155 0.0347 0.3095
Schistosoma mansoni hypothetical protein 0.1213 0.3008 1
Brugia malayi beta-lactamase family protein 0.0072 0.0137 0.1217
Loa Loa (eye worm) hypothetical protein 0.021 0.0484 0.4321
Loa Loa (eye worm) beta-lactamase 0.0072 0.0137 0.1224
Loa Loa (eye worm) PHD-finger family protein 0.0061 0.011 0.0985
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0015 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0058 0.0514
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0058 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0272 0.436
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0137 0.0133
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0022 0.0285
Trypanosoma cruzi heat shock protein, putative 0.0026 0.0023 0.0986
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0058 0.0189
Loa Loa (eye worm) hypothetical protein 0.0072 0.0137 0.1224
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.2412 0.6025 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.001 0.0006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0136 0.0132
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Loa Loa (eye worm) hypothetical protein 0.0096 0.0199 0.1778
Schistosoma mansoni alpha-glucosidase 0.0143 0.0315 0.1046
Trypanosoma cruzi Heat shock protein 83, putative 0.0065 0.0119 0.6111
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.039 0.6291
Echinococcus multilocularis protein dispatched 1 0.0143 0.0316 0.0312
Onchocerca volvulus 0.0115 0.0246 0.4215
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0004 0.0011
Brugia malayi beta-NAC-like protein 0.0035 0.0045 0.0395
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0194 0.1723
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0058 0.0178
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0058 0.0189
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0373 0.3326
Schistosoma mansoni endoplasmin 0.0065 0.0119 0.0393
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0137 0.0228
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0031 0.0027
Toxoplasma gondii Hsp90 domain-containing protein 0.0026 0.0023 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0058 0.0178
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Loa Loa (eye worm) hypothetical protein 0.0292 0.0691 0.6168
Brugia malayi Bromodomain containing protein 0.0114 0.0242 0.2155
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.001 0.008
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0034 0.2491
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0617 1
Onchocerca volvulus 0.0072 0.0137 0.2346
Loa Loa (eye worm) hypothetical protein 0.005 0.0082 0.0731
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0137 0.0228
Loa Loa (eye worm) bromodomain containing protein 0.0052 0.0088 0.0787
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0192 0.2726
Giardia lamblia Heat shock protein HSP 90-alpha 0.0051 0.0086 0.4343
Schistosoma mansoni zinc finger protein 0.0065 0.0119 0.0393
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0058 0.0506
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.0119 0.1666
Brugia malayi nuclear receptor RXR 0.0021 0.001 0.008
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0107 0.0225 0.0734
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.2412 0.6025 1
Mycobacterium ulcerans lipase LipD 0.0072 0.0137 0.0228
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0049 0.2372
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Trypanosoma cruzi ISWI complex protein 0.0045 0.0071 0.3529
Trichomonas vaginalis heat shock protein, putative 0.0065 0.0119 0.1867
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.0199 0.1771
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.025 0.2233
Echinococcus multilocularis expressed conserved protein 0.0274 0.0646 0.0643
Entamoeba histolytica hypothetical protein 0.0035 0.0045 0.0592
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.0031 0.0101
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0051 0.0086 0.4343
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Trypanosoma brucei heat shock protein, putative 0.0065 0.0119 0.6111
Brugia malayi steroid hormone receptor 0.004 0.0058 0.0506
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0058 0.0189
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0022 0.0285
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0034 0.003
Schistosoma mansoni hypothetical protein 0.0121 0.026 0.0863
Brugia malayi hypothetical protein 0.0463 0.112 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0192 0.1711
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0137 0.0204
Echinococcus multilocularis protein patched 0.0125 0.0272 0.0268
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0049 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0045 0.0663
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0119 0.6111
Toxoplasma gondii heat shock protein 90, putative 0.0065 0.0119 0.0196
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0008
Echinococcus multilocularis dnaJ subfamily B 0.1213 0.3008 0.3006
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0045 0.0663
Loa Loa (eye worm) hypothetical protein 0.0072 0.0137 0.1224
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.0507 0.4521
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0192 0.3284
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0073 0.0141 0.0467
Echinococcus granulosus dnaJ subfamily C 6 0.0062 0.0113 0.0363
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0133 0.0291 0.2598
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0058 0.0975
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0192 0.3054
Onchocerca volvulus 0.0019 0.0004 0.0055
Schistosoma mansoni nuclear hormone receptor 0.004 0.0058 0.0189
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0137 0.0228
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.001 0.003
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0137 0.0228
Loa Loa (eye worm) hypothetical protein 0.0155 0.0347 0.3095
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0015 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0058 0.0506
Echinococcus granulosus Niemann Pick C1 protein 0.0292 0.0691 0.2286
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0004 0.0037
Entamoeba histolytica hypothetical protein 0.0071 0.0136 0.1919
Toxoplasma gondii heat shock protein HSP90 0.0065 0.0119 0.0196
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0107 0.0225 0.022
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0236 0.0549 0.0545
Mycobacterium ulcerans hypothetical protein 0.0072 0.0137 0.0228
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0034 0.0111
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0058 0.0178
Brugia malayi nuclear receptor NHR-88 0.004 0.0058 0.0506
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0004 0.0028
Schistosoma mansoni hypothetical protein 0.0096 0.0199 0.066
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0049 0.0149
Trypanosoma brucei ISWI complex protein 0.0045 0.0071 0.3529
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0015 0.0024
Schistosoma mansoni transcription factor btf3 0.0035 0.0045 0.0148
Brugia malayi heat shock protein 90 0.0065 0.0119 0.1054
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0043
Trypanosoma brucei Heat shock protein 83, putative 0.0065 0.0119 0.6111
Echinococcus multilocularis cpg binding protein 0.0127 0.0276 0.0272
Loa Loa (eye worm) hypothetical protein 0.0125 0.0272 0.2425
Plasmodium vivax heat shock protein 86, putative 0.0065 0.0119 0.8666
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0058 0.0506
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0245 0.0573 0.1903
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.039 0.6291
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0049 0.0724
Trypanosoma brucei glucosidase, putative 0.0037 0.0049 0.2372
Entamoeba histolytica hypothetical protein 0.0071 0.0136 0.1919
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Trypanosoma brucei heat shock protein, putative 0.0065 0.0119 0.6111
Schistosoma mansoni patched 1 0.0125 0.0272 0.0901
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.0084 0.0276
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Echinococcus granulosus Protein patched homolog 1 0.0125 0.0272 0.089
Echinococcus multilocularis endoplasmin 0.0051 0.0086 0.0082
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0026 0.0023 0.0063
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0023 0.1932
Schistosoma mansoni hypothetical protein 0.0071 0.0136 0.0451
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0049 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0192 0.3054
Schistosoma mansoni cpg binding protein 0.0127 0.0276 0.0917
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0137 0.709
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0058 0.0975
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0088
Brugia malayi Muscleblind-like protein 0.0155 0.0347 0.3089
Echinococcus multilocularis dnaJ subfamily C 6 0.0062 0.0113 0.0109
Trypanosoma cruzi ISWI complex protein 0.0045 0.0071 0.3529
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.039 0.6291
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0022 0.0285
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.0119 0.6111
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0005 0.004
Brugia malayi nuclear receptor RXR 0.0019 0.0004 0.0028
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.0514
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0015 0.0149
Trypanosoma brucei heat shock protein, putative 0.0065 0.0119 0.6111
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0058 0.0053
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0058 0.0053
Echinococcus granulosus methyl CpG binding domain protein 2 0.0051 0.0084 0.0265
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Echinococcus granulosus cpg binding protein 0.0127 0.0276 0.0907
Schistosoma mansoni heat shock protein 0.0065 0.0119 0.0393
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0049 0.0724
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Brugia malayi tailless protein 0.0019 0.0004 0.0028
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0052 0.2554
Trichomonas vaginalis set domain proteins, putative 0.0249 0.0582 0.942
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0459 0.1111 0.1845
Loa Loa (eye worm) hypothetical protein 0.0072 0.0137 0.1224
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Loa Loa (eye worm) hypothetical protein 0.012 0.0258 0.2302
Schistosoma mansoni myst-related protein 0.0019 0.0005 0.0013
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0049 0.0724
Echinococcus granulosus histone lysine methyltransferase setb 0.0084 0.0168 0.0545
Plasmodium vivax patched family protein, putative 0.0018 0.0001 0.0069
Echinococcus granulosus heat shock protein 0.0065 0.0119 0.0382
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0373 0.0369
Echinococcus multilocularis Niemann Pick C1 protein 0.0417 0.1006 0.1003
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.001 0.003
Loa Loa (eye worm) hypothetical protein 0.0463 0.112 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0137 0.1224
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.0514
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0045 0.2171
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0041 0.0037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Trypanosoma brucei polo-like protein kinase 0.0093 0.0192 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0015 0.0024
Mycobacterium leprae Probable lipase LipE 0.0072 0.0137 0.0204
Loa Loa (eye worm) hypothetical protein 0.0114 0.0243 0.2166
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0192 1
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0058 0.0189
Trypanosoma brucei heat shock protein, putative 0.0065 0.0119 0.6111
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0034 0.0057
Brugia malayi nuclear hormone receptor 0.0019 0.0004 0.0028
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0137 0.2165
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.039 0.6291
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0058 0.0506
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0373 0.3332
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0015 0.0547
Echinococcus granulosus sterol regulatory element binding protein 0.0125 0.0272 0.089
Trypanosoma brucei heat shock protein 84, putative 0.0026 0.0023 0.0986
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0051 0.0084 0.008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0058 0.0506
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Schistosoma mansoni hypothetical protein 0.0096 0.0199 0.066
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0058 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0058 0.0514
Echinococcus granulosus endoplasmin 0.0051 0.0086 0.0272
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0023 0.0301
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0058 0.0506
Plasmodium falciparum endoplasmin, putative 0.004 0.0056 0.4716
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0263 0.0617 0.5509
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.0119 0.1666
Schistosoma mansoni zinc finger protein 0.0019 0.0004 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0617 1
Mycobacterium tuberculosis Conserved protein 0.0072 0.0137 0.0228
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0074 0.1137
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0022 0.0285
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0004 0.0055
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0031 0.009
Brugia malayi Bromodomain containing protein 0.0229 0.0533 0.4749
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.039 0.6291
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0058 0.0178
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0008
Trichomonas vaginalis endoplasmin, putative 0.004 0.0056 0.0841
Echinococcus granulosus Niemann Pick C1 protein 0.0417 0.1006 0.3336
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0008
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0058 0.0178
Loa Loa (eye worm) hypothetical protein 0.0153 0.0343 0.3058
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0058 0.0506
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0034 0.0297
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0058 0.0506
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0049 0.0647
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0045 0.2171
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.2412 0.6025 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0137 0.2165
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0125 0.0272 0.2425
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Brugia malayi Calcitonin receptor-like protein seb-1 0.0305 0.0724 0.6457
Schistosoma mansoni hypothetical protein 0.0096 0.0199 0.066
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0015 0.0547
Loa Loa (eye worm) hypothetical protein 0.0072 0.0137 0.1224
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0373 0.1229
Trypanosoma cruzi heat shock protein 90, putative 0.0051 0.0086 0.4343
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0049 0.0724
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.001 0.0088
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0058 0.0053
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0004 0.0028
Echinococcus granulosus FTZ F1 alpha 0.004 0.0058 0.0178
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0015 0.0547
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0049 0.2372
Loa Loa (eye worm) endoplasmin 0.0065 0.0119 0.1061
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0015 0.0024
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0049 0.0724
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0004 0.0011
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0051 0.0086 0.0272
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0137 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0034 0.0305
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0045 0.3291
Trypanosoma cruzi heat shock protein 85, putative 0.0051 0.0086 0.4343
Trichomonas vaginalis protein kinase inhibitor, putative 0.0062 0.0113 0.1773
Loa Loa (eye worm) hypothetical protein 0.0072 0.0137 0.1224
Brugia malayi conserved hypotetical protein 0.0019 0.0004 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.039 0.6291
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0058 0.0506
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0058 0.0178
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0049 0.0724
Brugia malayi hypothetical protein 0.0021 0.001 0.008
Echinococcus granulosus geminin 0.0841 0.2071 0.6881
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0015 0.0024
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.0199 0.0195
Schistosoma mansoni hypothetical protein 0.0061 0.011 0.0364
Echinococcus multilocularis muscleblind protein 1 0.0155 0.0347 0.0343
Leishmania major heat shock protein, putative 0.0026 0.0023 0.0986
Leishmania major basic transcription factor 3a, putative 0.0035 0.0045 0.2171
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0208 0.0481 0.4293
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0137 0.0228
Echinococcus granulosus GPCR family 2 0.0096 0.0199 0.0649
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0005 0.038
Brugia malayi beta-lactamase family protein 0.0072 0.0137 0.1217
Brugia malayi hypothetical protein 0.012 0.0258 0.2295
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0004 0.0028
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Entamoeba histolytica hypothetical protein 0.0071 0.0136 0.1919
Brugia malayi CXXC zinc finger family protein 0.0115 0.0246 0.2187
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0045 0.0403
Schistosoma mansoni cpg binding protein 0.0127 0.0276 0.0917
Echinococcus multilocularis sterol regulatory element binding protein 0.0125 0.0272 0.0268
Loa Loa (eye worm) CXXC zinc finger family protein 0.0115 0.0246 0.2193
Leishmania major hypothetical protein, conserved 0.0045 0.0071 0.3529
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0034 0.1585
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0004 0.0011
Schistosoma mansoni hypothetical protein 0.0062 0.0113 0.0374
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0045 0.0592
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0192 0.3054
Plasmodium vivax endoplasmin, putative 0.0065 0.0119 0.8666
Trypanosoma brucei heat shock protein, putative 0.0065 0.0119 0.6111
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0049 0.0724
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.0514
Brugia malayi beta-lactamase 0.0072 0.0137 0.1217
Echinococcus multilocularis Niemann Pick C1 protein 0.0292 0.0691 0.0687
Plasmodium falciparum lipid/sterol:H+ symporter 0.0018 0.0001 0.0079
Plasmodium falciparum zinc finger protein, putative 0.0019 0.0005 0.0402
Schistosoma mansoni kinase 0.0048 0.0077 0.0254
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0004 0.0011
Onchocerca volvulus 0.005 0.0082 0.1395
Trichomonas vaginalis heat shock protein, putative 0.004 0.0056 0.0841
Plasmodium falciparum heat shock protein 90 0.0065 0.0119 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0192 0.3054
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0137 0.0228
Trichomonas vaginalis esterase, putative 0.0072 0.0137 0.2165
Echinococcus granulosus fetal alzheimer antigen falz 0.0073 0.0141 0.0456
Onchocerca volvulus 0.0072 0.0137 0.2346
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0034 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0045 0.0663
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0137 0.0454
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0373 0.0369
Schistosoma mansoni coup transcription factor 0.004 0.0058 0.0189
Brugia malayi Latrophilin receptor protein 2 0.0096 0.0199 0.1771
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0617 1
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0617 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.0199 0.0195
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.025 0.2233
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.0119 0.6111
Schistosoma mansoni alpha-glucosidase 0.0143 0.0315 0.1046
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0058 0.0506
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.0514
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0058 0.0514
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0086 0.1326
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0292 0.0691 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.0199 0.1778
Brugia malayi hypothetical protein 0.0019 0.0004 0.0028
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.0199 0.0649
Brugia malayi Pre-SET motif family protein 0.0034 0.0041 0.0355
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Plasmodium vivax SET domain protein, putative 0.0034 0.0041 0.2968
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0137 0.2165
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0015 0.0024
Echinococcus multilocularis heat shock protein 90 0.0051 0.0086 0.0082
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0026 0.0023 0.0379
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0132
Giardia lamblia Grp94/Hsp90 0.0051 0.0086 0.4343
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.039 0.6699
Loa Loa (eye worm) heat shock protein 75 0.0026 0.0023 0.0205
Echinococcus granulosus heat shock protein 90 0.0051 0.0086 0.0272
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0034 0.2875
Mycobacterium tuberculosis Conserved protein 0.0072 0.0137 0.0228
Brugia malayi MH2 domain containing protein 0.0117 0.025 0.2226
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0034 0.0055
Schistosoma mansoni hypothetical protein 0.0096 0.0199 0.066
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0022 0.0285
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0034 0.003
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0004 0.0011
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0058 0.0514
Echinococcus granulosus tumor protein p63 0.0341 0.0814 0.2696
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.001 0.008
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0026 0.0023 0.0019
Onchocerca volvulus 0.0096 0.0198 0.3385
Entamoeba histolytica hypothetical protein 0.0019 0.0005 0.0004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0058 0.0506
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0034 0.0055
Onchocerca volvulus 0.0034 0.0041 0.0685
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0049 0.2372
Schistosoma mansoni bromodomain containing protein 0.0019 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0137 0.1224
Echinococcus multilocularis tumor protein p63 0.0341 0.0814 0.081
Brugia malayi hypothetical protein 0.0071 0.0136 0.1209
Loa Loa (eye worm) DnaJ domain-containing protein 0.0062 0.0113 0.101
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0192 0.0635
Loa Loa (eye worm) heat shock protein 90 0.0065 0.0119 0.1061
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0058 0.0506
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0137 0.0228
Schistosoma mansoni myst-related protein 0.0019 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Schistosoma mansoni ap endonuclease 0.0019 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Schistosoma mansoni thyroid hormone receptor 0.004 0.0058 0.0189
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0137 0.0454
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0015 0.0123
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0132
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0022 0.0285
Schistosoma mansoni bromodomain containing protein 0.0194 0.0445 0.1477
Schistosoma mansoni heat shock protein 0.0026 0.0023 0.0074
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0032 0.0091
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0305 0.0724 0.6457
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0015 0.0149
Schistosoma mansoni thyroid hormone receptor 0.004 0.0058 0.0189
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0058 0.0189
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0058 0.0975
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0022 0.0285
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.039 0.6291
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0049 0.0647
Schistosoma mansoni hypothetical protein 0.0841 0.2071 0.6885
Onchocerca volvulus 0.0023 0.0015 0.0238
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0015 0.0123
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0137 0.709
Brugia malayi Endoplasmin precursor 0.0065 0.0119 0.1054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0058 0.0514
Schistosoma mansoni hypothetical protein 0.0208 0.0481 0.1596
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0058 0.0189
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0058 0.0178
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0004 0.0028
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0058 0.0506
Brugia malayi Niemann-Pick C1 protein precursor 0.0292 0.0691 0.6165
Brugia malayi DnaJ domain containing protein 0.0062 0.0113 0.1002
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0034 0.1585
Brugia malayi Pre-SET motif family protein 0.0219 0.0507 0.4517
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0015 0.0123
Plasmodium vivax heat shock protein 90, putative 0.0026 0.0023 0.1675
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0004 0.0037
Loa Loa (eye worm) DR-78 0.0019 0.0004 0.0037
Toxoplasma gondii pantoate-beta-alanine ligase 0.2412 0.6025 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0015 0.0024
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0058 0.0189
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0263 0.0617 0.5505
Giardia lamblia Kinase, PLK 0.0093 0.0192 1
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Brugia malayi ecdysteroid receptor 0.004 0.0058 0.0506
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0617 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0049 0.0436
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0058 0.0506
Onchocerca volvulus Huntingtin homolog 0.012 0.0258 0.4424
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0022 0.0285
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0045 0.2171
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Onchocerca volvulus 0.0072 0.0137 0.2346
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0192 0.0624
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0073 0.0141 0.0137
Echinococcus multilocularis mixed lineage leukemia protein mll 0.003 0.0031 0.0027
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0058 0.0189
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0034 0.1585
Brugia malayi isocitrate dehydrogenase 0.0031 0.0034 0.0297
Leishmania major hypothetical protein, conserved 0.0072 0.0137 0.709
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0058 0.0514
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0137 0.0443
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0034 0.01
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Toxoplasma gondii ABC1 family protein 0.0072 0.0137 0.0226
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0137 0.1217
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Echinococcus granulosus expressed conserved protein 0.0274 0.0646 0.2138
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0137 0.709
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0296 0.0702 0.2333
Echinococcus multilocularis transcription factor btf3 0.0035 0.0045 0.0041
Onchocerca volvulus Huntingtin homolog 0.012 0.0258 0.4424
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0058 0.0514
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0088
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0192 0.1704
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0058 0.0053
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0005 0.0329
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.001 0.0019
Entamoeba histolytica hypothetical protein 0.0071 0.0136 0.1919
Brugia malayi latrophilin 2 splice variant baaae 0.0208 0.0481 0.4288
Brugia malayi ecdysone receptor 0.0019 0.0004 0.0028
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0005 0.0032
Schistosoma mansoni heat shock protein 0.0065 0.0119 0.0393
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0088
Brugia malayi hypothetical protein 0.0021 0.001 0.008
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0004 0.0028
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0184 0.0418 0.1379
Brugia malayi nuclear hormone receptor 0.004 0.0058 0.0506
Mycobacterium ulcerans heat shock protein 90 0.0051 0.0086 0.0142
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0008
Echinococcus granulosus dnaJ subfamily B 0.1213 0.3008 1
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0137 0.2165
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Onchocerca volvulus 0.0249 0.0582 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0168 0.1499
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0026 0.0023 0.0269
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0086 0.1326
Schistosoma mansoni ap endonuclease 0.0019 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.0514
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0136 0.0451
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0413 0.6672
Schistosoma mansoni nuclear receptor 0.0019 0.0004 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Echinococcus multilocularis GPCR, family 2 0.0096 0.0199 0.0195
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0004 0.0055
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0074 0.1137
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0058 0.0514
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.0514
Trypanosoma brucei heat shock protein, putative 0.0065 0.0119 0.6111
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Onchocerca volvulus 0.0094 0.0194 0.3321
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0045 0.0073
Schistosoma mansoni survival motor neuron protein 0.0094 0.0194 0.0642
Schistosoma mansoni nuclear receptor 0.0019 0.0004 0.0011
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.0084 0.0276
Loa Loa (eye worm) hypothetical protein 0.0121 0.026 0.2324
Echinococcus granulosus zinc finger protein 0.0065 0.0119 0.0382
Treponema pallidum heat shock protein 90 0.0051 0.0086 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0058 0.0506
Toxoplasma gondii histone lysine methyltransferase SET1 0.0226 0.0525 0.087
Echinococcus multilocularis heat shock protein 0.0065 0.0119 0.0115
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0005 0.0001
Schistosoma mansoni alpha glucosidase 0.0037 0.0049 0.016
Schistosoma mansoni cpg binding protein 0.0115 0.0246 0.0814
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.0199 0.0649
Echinococcus granulosus heat shock protein 90 0.0065 0.0119 0.0382
Schistosoma mansoni zinc finger protein 0.0045 0.0071 0.0232
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0004 0.0037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0084 0.0168 0.0556
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0005 0.0007
Toxoplasma gondii exonuclease III APE 0.0019 0.0005 0.0006
Schistosoma mansoni endoplasmin 0.0065 0.0119 0.0393
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0088
Loa Loa (eye worm) histone methyltransferase 0.0037 0.0049 0.0435
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0005 0.0007
Mycobacterium tuberculosis Conserved protein 0.0072 0.0137 0.0228
Brugia malayi Hsp90 protein 0.0026 0.0023 0.0197
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0192 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0137 0.2165
Trypanosoma brucei heat shock protein, putative 0.0065 0.0119 0.6111
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0051 0.0086 0.0142
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.0514
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0413 0.6672
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0136 0.044
Brugia malayi nuclear receptor NHR-67 0.0019 0.0004 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0041 0.0133
Plasmodium vivax heat shock protein, putative 0.0026 0.0023 0.1675
Brugia malayi nuclear receptor NHR-88 0.0019 0.0004 0.0028
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0051 0.0086 0.0118
Brugia malayi hypothetical protein 0.0019 0.0004 0.0028
Loa Loa (eye worm) hypothetical protein 0.012 0.0258 0.2302
Echinococcus multilocularis survival motor neuron protein 1 0.0463 0.112 0.1117
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0049 0.0045
Schistosoma mansoni hypothetical protein 0.0094 0.0194 0.0642
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0617 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0034 0.1585
Brugia malayi F/Y-rich N-terminus family protein 0.0042 0.0062 0.0544
Onchocerca volvulus 0.0019 0.0004 0.0055
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0086 0.1326
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0058 0.0053
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.0514
Echinococcus multilocularis heat shock protein 90 0.0065 0.0119 0.0115
Loa Loa (eye worm) hypothetical protein 0.0305 0.0724 0.646
Trichomonas vaginalis helicase, putative 0.0026 0.0022 0.0285
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0119 0.6111
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0192 0.3054
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0058 0.0053
Mycobacterium ulcerans beta-lactamase 0.0072 0.0137 0.0228
Brugia malayi CHE-14 protein 0.0125 0.0272 0.2418
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Mycobacterium ulcerans hypothetical protein 0.0023 0.0015 0.0024
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0058 0.0053
Echinococcus multilocularis geminin 0.0841 0.2071 0.2068
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0192 0.3054
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0192 0.3054
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0058 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0082 0.027
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0034 0.1585
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0137 0.0228
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0051 0.0086 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0049 0.0724
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0192 0.0188
Schistosoma mansoni hypothetical protein 0.0121 0.026 0.0863
Echinococcus granulosus muscleblind protein 0.0155 0.0347 0.114
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0236 0.0549 0.1814
Giardia lamblia Heat shock protein HSP 90-alpha 0.0065 0.0119 0.6111
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0058 0.0506
Trypanosoma brucei heat shock protein, putative 0.0065 0.0119 0.6111
Echinococcus multilocularis zinc finger protein 0.0065 0.0119 0.0115
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0119 0.6111
Trypanosoma cruzi heat shock protein 90, putative 0.0065 0.0119 0.6111
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0236 0.0549 0.1823
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0049 0.0428
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0015 0.0149
Echinococcus granulosus mixed lineage leukemia protein mll 0.003 0.0031 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0184 0.0418 0.0414
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0049 0.0724
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0004 0.0028
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0058 0.0178
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0192 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Schistosoma mansoni hypothetical protein 0.0045 0.0071 0.0232
Schistosoma mansoni hypothetical protein 0.0121 0.026 0.0863
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0045 0.3798
Onchocerca volvulus 0.004 0.0058 0.0975
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037

Activities

Activity type Activity value Assay description Source Reference
ILS (functional) = -0.9 % Percent increase in life span at dose 40 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 7.8 % Percent increase in life span at dose 60 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 9.5 % Percent increase in life span at dose 80 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
Survivors (functional) = 0 Number of survivors on 30th day at dose 40 mg/kg/day in 10 mice implanted with P388 leukemia cell line; 0/10 ChEMBL. 4020828
Survivors (functional) = 0 Number of survivors on 30th day at dose 60 mg/kg/day in 10 mice implanted with P388 leukemia cell line; 0/10 ChEMBL. 4020828
Survivors (functional) = 0 Number of survivors on 30th day at dose 80 mg/kg/day in 8 mice implanted with P388 leukemia cell line; 0/8 ChEMBL. 4020828
Survivors (functional) = 0 Number of survivors on 60th day at dose 40 mg/kg/day in 10 mice implanted with P388 leukemia cell line; 0/10 ChEMBL. 4020828
Survivors (functional) = 0 Number of survivors on 60th day at dose 60 mg/kg/day in 10 mice implanted with P388 leukemia cell line; 0/10 ChEMBL. 4020828
Survivors (functional) = 0 Number of survivors on 60th day at dose 80 mg/kg/day in 8 mice implanted with P388 leukemia cell line; 0/8 ChEMBL. 4020828

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.