Detailed information for compound 376375

Basic information

Technical information
  • TDR Targets ID: 376375
  • Name: (E)-N-(4-amino-2-tert-butylquinolin-6-yl)-3-[ 4-(trifluoromethyl)phenyl]prop-2-enamide
  • MW: 413.435 | Formula: C23H22F3N3O
  • H donors: 2 H acceptors: 2 LogP: 5.36 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc2c(c1)c(N)cc(n2)C(C)(C)C)/C=C/c1ccc(cc1)C(F)(F)F
  • InChi: 1S/C23H22F3N3O/c1-22(2,3)20-13-18(27)17-12-16(9-10-19(17)29-20)28-21(30)11-6-14-4-7-15(8-5-14)23(24,25)26/h4-13H,1-3H3,(H2,27,29)(H,28,30)/b11-6+
  • InChiKey: FOZHABDRGZDSMZ-IZZDOVSWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-N-(4-amino-2-tert-butyl-6-quinolyl)-3-[4-(trifluoromethyl)phenyl]prop-2-enamide
  • (E)-N-(4-amino-2-tert-butyl-6-quinolyl)-3-[4-(trifluoromethyl)phenyl]-2-propenamide
  • (E)-N-(4-azanyl-2-tert-butyl-quinolin-6-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-enamide
  • (E)-N-(4-amino-2-tert-butyl-6-quinolyl)-3-[4-(trifluoromethyl)phenyl]acrylamide
  • (E)-N-(4-amino-2-tert-butyl-quinolin-6-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-enamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanin-concentrating hormone receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica casein kinase 1, putative 0.0121 0.1486 0.1693
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0026 0.0083 0.0083
Brugia malayi Protein kinase domain containing protein 0.0184 0.2421 0.3419
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0216 0.084
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0078 0.0856 0.0856
Trichomonas vaginalis CMGC family protein kinase 0.0141 0.179 0.2056
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0248 0.0215
Trichomonas vaginalis AGC family protein kinase 0.0127 0.1582 0.1807
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0216 0.0176
Echinococcus multilocularis serine:threonine protein kinase N2 0.0025 0.0068 0.0068
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0127 0.1582 0.883
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0139 0.1754 0.1754
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0025 0.0068 0.0068
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0983 0.2052
Loa Loa (eye worm) glutathione reductase 0.0038 0.0259 0.0366
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0103 0.1225 0.6709
Leishmania major protein kinase A catalytic subunit isoform 2 0.0127 0.1582 0.883
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0031 0.0151 0.0095
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0127 0.1582 0.8788
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0123 0.0173
Plasmodium falciparum glycogen synthase kinase 3 0.0103 0.1225 0.6709
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0214
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0068 0.0706 0.3704
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0025 0.0068 0.0097
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0248 0.0215
Echinococcus granulosus Protein kinase C brain isozyme 0.0118 0.1446 0.1446
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0983 0.2052
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0088 0.0088
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0248 0.1026
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.1225 0.1381
Loa Loa (eye worm) hypothetical protein 0.004 0.0288 0.0407
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.059 0.8444 1
Schistosoma mansoni roundabout 0.0031 0.0151 0.0151
Echinococcus granulosus casein kinase ii subunit alpha 0.0141 0.179 0.179
Echinococcus granulosus twitchin 0.0055 0.0503 0.0503
Echinococcus multilocularis hemicentin 1 0.0031 0.0151 0.0151
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.031 0.1387
Plasmodium falciparum casein kinase 2, alpha subunit 0.0141 0.179 1
Echinococcus multilocularis GPCR, family 2 0.004 0.0288 0.0288
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.0706 0.0706
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0167 0.0881
Echinococcus multilocularis serine:threonine protein kinase N2 0.0025 0.0068 0.0068
Brugia malayi Immunoglobulin I-set domain containing protein 0.0498 0.7081 1
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0068 0.0068
Toxoplasma gondii AGC kinase 0.0127 0.1582 0.8791
Giardia lamblia Kinase, CMGC GSK 0.0103 0.1225 0.144
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0167 0.0554
Schistosoma mansoni hypothetical protein 0.004 0.0288 0.0288
Echinococcus granulosus serine:threonine protein kinase N2 0.0025 0.0068 0.0068
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.004 0.0288 0.0407
Plasmodium falciparum protein kinase 5 0.0094 0.1095 0.5953
Plasmodium falciparum calcium-dependent protein kinase 3 0.0068 0.0706 0.3692
Loa Loa (eye worm) hypothetical protein 0.0031 0.016 0.0226
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0031 0.0151 0.0151
Echinococcus multilocularis cpg binding protein 0.0031 0.0147 0.0147
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0041 0.03 0.03
Entamoeba histolytica hypothetical protein 0.0035 0.0216 0.0176
Entamoeba histolytica hypothetical protein, conserved 0.0058 0.0561 0.0588
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0507 0.7215 0.7215
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0418 0.059
Entamoeba histolytica DNA repair and recombination protein, putative 0.0058 0.0561 0.0588
Loa Loa (eye worm) TK/ROR protein kinase 0.0026 0.0083 0.0117
Trichomonas vaginalis CMGC family protein kinase 0.0141 0.179 0.2056
Brugia malayi Furin-like cysteine rich region family protein 0.0214 0.2865 0.4046
Brugia malayi Casein kinase II, alpha chain 0.0141 0.179 0.2528
Echinococcus multilocularis dna polymerase kappa 0.0042 0.031 0.031
Echinococcus multilocularis tyrosine protein kinase otk 0.0031 0.0151 0.0151
Brugia malayi hypothetical protein 0.0026 0.0072 0.0102
Schistosoma mansoni microtubule-associated protein tau 0.0695 1 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0139 0.1754 0.1754
Giardia lamblia Kinase, CMGC GSK 0.0103 0.1225 0.144
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0234 0.0198
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.004 0.0288 0.0288
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0167 0.0881
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0151 0.0214
Schistosoma mansoni hypothetical protein 0.0052 0.047 0.047
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0234 0.0198
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0167 0.0572
Toxoplasma gondii thioredoxin reductase 0.0038 0.0259 0.1106
Plasmodium falciparum glutathione reductase 0.0038 0.0259 0.1089
Plasmodium vivax calcium-dependent protein kinase, putative 0.0068 0.0706 0.3692
Mycobacterium tuberculosis Possible L-lactate dehydrogenase (cytochrome) LldD2 0.0341 0.475 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0566 0.0799
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0234 0.0198
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0058 0.0561 0.3095
Leishmania major protein kinase A catalytic subunit 0.0127 0.1582 0.883
Echinococcus granulosus hemicentin 1 0.0031 0.0151 0.0151
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.031 0.1387
Echinococcus granulosus roundabout 2 0.0059 0.0566 0.0566
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0706 0.0706
Schistosoma mansoni casein kinase II beta subunit 0.0036 0.0234 0.0234
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0234 0.0198
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0151 0.0214
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0288 0.3968 0.8264
Trichomonas vaginalis CK1 family protein kinase 0.0121 0.1486 0.1693
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.1126 0.2355
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0151 0.0214
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0234 0.0198
Trypanosoma cruzi cdc2-related kinase 3 0.0094 0.1095 0.5953
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.031 0.1685
Echinococcus multilocularis epidermal growth factor receptor 0.0145 0.1848 0.1848
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0167 0.0167
Echinococcus granulosus neuroglian 0.0031 0.0151 0.0151
Trypanosoma brucei protein kinase, putative 0.0103 0.1225 0.6823
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0025 0.0068 0.0068
Trypanosoma brucei unspecified product 0.0035 0.0211 0.1129
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0127 0.1571 0.2219
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0121 0.1486 0.2099
Echinococcus multilocularis serine threonine protein kinase 0.0106 0.1268 0.1268
Giardia lamblia Rrm3p helicase 0.0058 0.0561 0.0653
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0072 0.0004
Plasmodium falciparum casein kinase II beta chain 0.0036 0.0234 0.0943
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0068 0.0706 0.3692
Entamoeba histolytica protein kinase domain containing protein 0.0141 0.179 0.2056
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0216 0.0176
Schistosoma mansoni tyrosine kinase 0.0139 0.1754 0.1754
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0566 0.0566
Leishmania major basic transcription factor 3a, putative 0.0035 0.0216 0.1157
Giardia lamblia Kinase, AGC PKA 0.0127 0.1582 0.1864
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0151 0.0214
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0259 0.1089
Loa Loa (eye worm) DEAH box polypeptide 35 0.0035 0.021 0.0296
Loa Loa (eye worm) AGC/PKN protein kinase 0.0025 0.0068 0.0097
Echinococcus multilocularis casein kinase ii subunit alpha 0.0141 0.179 0.179
Onchocerca volvulus 0.0121 0.1486 0.2101
Trypanosoma cruzi cdc2-related kinase 1 0.0094 0.1095 0.5953
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0153
Brugia malayi hypothetical protein 0.0239 0.3242 0.4578
Echinococcus granulosus cpg binding protein 0.0031 0.0147 0.0147
Schistosoma mansoni hypothetical protein 0.004 0.0288 0.0288
Treponema pallidum fructose-bisphosphate aldolase 0.059 0.8444 1
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.1486 0.1486
Brugia malayi protein unc-22 0.0027 0.0088 0.0125
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0088 0.0088
Mycobacterium ulcerans L-lactate dehydrogenase (cytochrome) LldD1 0.0122 0.1506 0.2794
Echinococcus granulosus protein kinase c iota type 0.0037 0.0247 0.0247
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0103 0.1225 0.1225
Schistosoma mansoni protein kinase 0.0507 0.7215 0.7215
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0167 0.0554
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.059 0.8444 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0248 0.0215
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0566 0.0594
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0167 0.0167
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0031 0.0151 0.0151
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0058 0.0561 0.2847
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0025 0.0068 0.0097
Entamoeba histolytica cell division protein kinase 2, putative 0.0094 0.1095 0.1225
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1063 0.1063
Schistosoma mansoni titin 0.0031 0.0151 0.0151
Plasmodium falciparum calcium-dependent protein kinase 1 0.0068 0.0706 0.3692
Echinococcus multilocularis serine:threonine protein kinase 38 0.0025 0.0068 0.0068
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0058 0.0561 0.0561
Giardia lamblia Kinase, CMGC CK2 0.0141 0.179 0.2111
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.1095 0.1225
Echinococcus multilocularis protein kinase c epsilon type 0.004 0.0284 0.0284
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0072 0.0002
Echinococcus multilocularis Immunoglobulin 0.0028 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0097
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0094 0.1095 0.6093
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0566 0.2876
Schistosoma mansoni protein kinase 0.0141 0.179 0.179
Toxoplasma gondii casein kinase I 0.0121 0.1486 0.8233
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.1225 0.1381
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0028 0.0109 0.0109
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0216 0.084
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.004 0.0288 0.0288
Onchocerca volvulus 0.0099 0.1166 0.162
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0127 0.1582 0.2234
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0706 0.0706
Brugia malayi Csnk2b protein 0.0036 0.0234 0.033
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0983 0.2052
Brugia malayi beta-NAC-like protein 0.0035 0.0216 0.0305
Brugia malayi MAP kinase sur-1 0.0059 0.0566 0.0799
Schistosoma mansoni tyrosine kinase 0.0145 0.1848 0.1848
Plasmodium vivax unspecified product 0.0141 0.179 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0031 0.0151 0.0151
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.031 0.0138
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0068 0.0068
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0248 0.5
Echinococcus granulosus tyrosine protein kinase otk 0.0031 0.0151 0.0151
Trypanosoma brucei cdc2-related kinase 1 0.0094 0.1095 0.6093
Schistosoma mansoni transcription factor btf3 0.0035 0.0216 0.0216
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0151 0.0214
Echinococcus granulosus Immunoglobulin 0.0028 0.0109 0.0109
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0127 0.1582 0.8788
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0566 0.0566
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0507 0.2544
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0604 0.0604
Brugia malayi protein kinase C II. 0.004 0.0284 0.04
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.004 0.0288 0.0288
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0266 0.0266
Brugia malayi cell division control protein 2 homolog 0.0094 0.1095 0.1546
Echinococcus granulosus defective proboscis extension response 0.0028 0.0109 0.0109
Echinococcus granulosus fibroblast growth factor receptor 4 0.0139 0.1754 0.1754
Loa Loa (eye worm) hypothetical protein 0.0068 0.0706 0.0997
Echinococcus granulosus protein kinase shaggy 0.0103 0.1225 0.1225
Loa Loa (eye worm) AGC/NDR protein kinase 0.0025 0.0068 0.0097
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0094 0.1095 0.1546
Trichomonas vaginalis CMGC family protein kinase 0.0141 0.179 0.2056
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.3242 0.3242
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.031 0.1685
Leishmania major casein kinase II, putative 0.0141 0.179 1
Leishmania major protein kinase A catalytic subunit isoform 1 0.0127 0.1582 0.883
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1063 0.1063
Echinococcus multilocularis protein kinase shaggy 0.0103 0.1225 0.1225
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0151 0.0214
Echinococcus granulosus dna polymerase kappa 0.0042 0.031 0.031
Trichomonas vaginalis CMGC family protein kinase 0.0141 0.179 0.2056
Brugia malayi isocitrate dehydrogenase 0.0032 0.0167 0.0236
Echinococcus multilocularis casein kinase I delta 0.0121 0.1486 0.1486
Schistosoma mansoni septate junction protein 0.0031 0.0151 0.0151
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0566 0.0659
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0141 0.179 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0109 0.0153
Echinococcus multilocularis peroxidasin 0.0031 0.0151 0.0151
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0121 0.1486 0.2099
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0031 0.0151 0.0151
Onchocerca volvulus 0.0103 0.1225 0.1708
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0103 0.1225 0.1729
Echinococcus granulosus casein kinase ii subunit beta 0.0036 0.0234 0.0234
Echinococcus granulosus cyclin dependent kinase 1 0.0094 0.1095 0.1095
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0127 0.1582 0.883
Loa Loa (eye worm) TK/EGFR protein kinase 0.0214 0.2865 0.4046
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0072 0.0072
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0566 0.3123
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0072 0.002
Brugia malayi p70 ribosomal S6 kinase beta 0.0025 0.0068 0.0097
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0439 0.6203 0.876
Brugia malayi intracellular kinase 0.0103 0.1225 0.1729
Echinococcus granulosus GPCR family 2 0.004 0.0288 0.0288
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0139 0.1754 0.1754
Echinococcus multilocularis protein kinase c iota type 0.0037 0.0247 0.0247
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0983 0.2052
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0234 0.0198
Echinococcus granulosus neuroglian 0.0046 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0153
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0088 0.0125
Loa Loa (eye worm) hypothetical protein 0.0124 0.1532 0.2164
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.059 0.8444 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0234 0.0198
Loa Loa (eye worm) AGC/PKA protein kinase 0.0127 0.1582 0.2234
Entamoeba histolytica protein kinase, putative 0.0103 0.1225 0.1381
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0027 0.0088 0.0125
Giardia lamblia Kinase, CK1 Casein kinase 0.0121 0.1486 0.175
Echinococcus granulosus RNA directed DNA polymerase 0.0078 0.0856 0.0856
Echinococcus multilocularis epidermal growth factor receptor 0.0214 0.2865 0.2865
Brugia malayi casein kinase I 0.0121 0.1486 0.2099
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0153
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0153
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1063 0.1063
Giardia lamblia Fructose-bisphosphate aldolase 0.059 0.8444 1
Plasmodium falciparum thioredoxin reductase 0.0038 0.0259 0.1089
Schistosoma mansoni hypothetical protein 0.004 0.0288 0.0288
Echinococcus multilocularis cyclin dependent kinase 5 0.0094 0.1095 0.1095
Schistosoma mansoni cell adhesion molecule 0.0031 0.0151 0.0151
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0566 0.3123
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0103 0.1225 0.1225
Echinococcus multilocularis microtubule associated protein 2 0.0695 1 1
Echinococcus granulosus casein kinase I gamma 0.0127 0.1583 0.1583
Plasmodium vivax protein kinase Crk2 0.0094 0.1095 0.5953
Echinococcus multilocularis 0.0063 0.0626 0.0626
Schistosoma mansoni nephrin 0.0031 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0071 0.0746 0.1054
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0068 0.0706 0.3704
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0119 0.1454 0.1454
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0068 0.0706 0.391
Giardia lamblia Kinase, CMGC CDK 0.0094 0.1095 0.1286
Brugia malayi hypothetical protein 0.0124 0.1532 0.2164
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1095 0.1095
Echinococcus multilocularis Immunoglobulin 0.0028 0.0109 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0566 0.0566
Schistosoma mansoni hypothetical protein 0.0342 0.4767 0.4767
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0248 0.1337
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0036 0.0234 0.1257
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0127 0.1582 0.1582
Loa Loa (eye worm) protein kinase domain-containing protein 0.0127 0.1583 0.2236
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0028 0.0109 0.0109
Echinococcus granulosus titin 0.0027 0.0088 0.0088
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0068 0.0706 0.0997
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0127 0.1582 0.8788
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0072 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.031 0.1685
Entamoeba histolytica casein kinase, putative 0.0141 0.179 0.2056
Onchocerca volvulus 0.0049 0.0418 0.0495
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0151 0.0214
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.1582 0.1582
Brugia malayi Inositol-1 0.0037 0.0248 0.035
Leishmania major hypothetical protein, conserved 0.0026 0.0072 0.0348
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0167 0.0236
Echinococcus multilocularis casein kinase I gamma 0.0127 0.1583 0.1583
Echinococcus granulosus geminin 0.0342 0.4767 0.4767
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0234 0.0234
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0121 0.1486 0.823
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.1166 0.1166
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.1063 0.1502
Entamoeba histolytica hypothetical protein 0.0036 0.0234 0.0197
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0234 0.0234
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0439 0.6203 0.876
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.1095 0.1225
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.031 0.1685
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0121 0.1486 0.2099
Schistosoma mansoni tyrosine kinase 0.0137 0.1725 0.1725
Brugia malayi Prion-like- 0.0031 0.0151 0.0214
Loa Loa (eye worm) latrophilin receptor protein 2 0.004 0.0288 0.0407
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0234 0.0198
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0566 0.2876
Echinococcus multilocularis tumor protein p63 0.0678 0.9752 0.9752
Trypanosoma cruzi casein kinase, putative 0.0121 0.1486 0.823
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0234 0.0198
Trypanosoma cruzi casein kinase, putative 0.0121 0.1486 0.823
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0234 0.0198
Schistosoma mansoni cell adhesion molecule 0.0041 0.03 0.03
Trypanosoma brucei casein kinase I, isoform 2 0.0121 0.1486 0.8291
Loa Loa (eye worm) hypothetical protein 0.0078 0.0856 0.1209
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0167 0.0167
Trypanosoma brucei Casein kinase II 0.0141 0.179 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0145 0.1848 0.1848
Loa Loa (eye worm) hypothetical protein 0.009 0.1034 0.1461
Trichomonas vaginalis CMGC family protein kinase 0.0141 0.179 0.2056
Toxoplasma gondii AGC kinase 0.0127 0.1582 0.8791
Loa Loa (eye worm) AGC/AKT protein kinase 0.0025 0.0068 0.0097
Brugia malayi Protein kinase c protein 2 0.0102 0.1199 0.1694
Schistosoma mansoni hypothetical protein 0.004 0.0288 0.0288
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0031 0.0151 0.0151
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0151 0.0214
Echinococcus multilocularis twitchin 0.0027 0.0088 0.0088
Entamoeba histolytica casein kinase, putative 0.0121 0.1486 0.1693
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0248 0.0248
Schistosoma mansoni titin 0.0027 0.0088 0.0088
Loa Loa (eye worm) AGC/PKA protein kinase 0.0127 0.1582 0.2234
Leishmania major trypanothione reductase 0.0038 0.0259 0.1398
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0118 0.1446 0.1446
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.059 0.8444 1
Schistosoma mansoni tyrosine kinase 0.0184 0.2421 0.2421
Toxoplasma gondii CMGC kinase, CK2 family 0.0141 0.179 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.059 0.8444 1
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0112 0.1358 0.7486
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0234 0.0198
Echinococcus granulosus casein kinase I delta 0.0121 0.1486 0.1486
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0498 0.7081 1
Entamoeba histolytica hypothetical protein 0.0036 0.0234 0.0197
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0025 0.0068 0.0068
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0248 0.0215
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.059 0.8444 1
Trypanosoma cruzi casein kinase, putative 0.0121 0.1486 0.823
Trichomonas vaginalis CMGC family protein kinase 0.0141 0.179 0.2056
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0216 0.0858
Plasmodium falciparum casein kinase II beta chain 0.0036 0.0234 0.0943
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0167 0.0167
Loa Loa (eye worm) TK/INSR protein kinase 0.0184 0.2421 0.3419
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0259 0.0366
Plasmodium vivax glutathione reductase, putative 0.0038 0.0259 0.1089
Brugia malayi Protein kinase domain containing protein 0.0025 0.0068 0.0097
Trypanosoma brucei cdc2-related kinase 3 0.0094 0.1095 0.6093
Brugia malayi glutathione reductase 0.0038 0.0259 0.0366
Brugia malayi Peroxidasin 0.0031 0.0151 0.0214
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0058 0.0561 0.2847
Echinococcus multilocularis hemicentin 1 0.0031 0.0151 0.0151
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.031 0.0289
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0578 0.0578
Entamoeba histolytica PH domain containing protein kinase, putative 0.0127 0.1582 0.1807
Loa Loa (eye worm) CAMK protein kinase 0.0027 0.0088 0.0125
Loa Loa (eye worm) hypothetical protein 0.0124 0.1532 0.2164
Echinococcus granulosus casein kinase I alpha 0.0121 0.1486 0.1486
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0068 0.0706 0.3692
Schistosoma mansoni tyrosine kinase 0.0039 0.0274 0.0274
Trypanosoma brucei isopentenyl-diphosphate delta-isomerase (type II) 0.0122 0.1506 0.8402
Echinococcus granulosus casein kinase I alpha 0.0121 0.1486 0.1486
Trichomonas vaginalis CK1 family protein kinase 0.0121 0.1486 0.1693
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0566 0.2876
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0072 0.0002
Schistosoma mansoni tyrosine kinase 0.0137 0.1725 0.1725
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0566 0.0594
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0167 0.0331
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.059 0.8444 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0706 0.0706
Giardia lamblia Casein kinase II beta chain 0.0036 0.0234 0.0265
Echinococcus granulosus transcription factor btf3 0.0035 0.0216 0.0216
Schistosoma mansoni hypothetical protein 0.0087 0.0977 0.0977
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1063 0.1063
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0072 0.0022
Schistosoma mansoni tyrosine kinase 0.0214 0.2865 0.2865
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.1126 0.2355
Loa Loa (eye worm) hypothetical protein 0.0239 0.3242 0.4578
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0058 0.0561 0.3095
Loa Loa (eye worm) hypothetical protein 0.0127 0.1582 0.2234
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0141 0.179 0.2528
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0094 0.1095 0.6093
Trypanosoma cruzi cdc2-related kinase 3 0.0094 0.1095 0.5953
Schistosoma mansoni serine/threonine kinase 0.0025 0.0068 0.0068
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0566 0.3123
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0234 0.0234
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0072 0.0101
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0288 0.3968 0.8286
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0151 0.0214
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0068 0.0706 0.0997
Brugia malayi Protein kinase domain containing protein 0.0127 0.1583 0.2236
Schistosoma mansoni inositol monophosphatase 0.0037 0.0248 0.0248
Echinococcus multilocularis casein kinase ii subunit beta 0.0036 0.0234 0.0234
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0068 0.0706 0.0997
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0214
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0031 0.0151 0.0151
Echinococcus granulosus flap endonuclease 1 0.0025 0.0072 0.0072
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.059 0.8444 1
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0039 0.0279 0.0394
Loa Loa (eye worm) hypothetical protein 0.0127 0.1571 0.2219
Echinococcus multilocularis casein kinase i 0.0121 0.1486 0.1486
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0094 0.1095 0.1546
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.009 0.1021 0.1442
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0566 0.289
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0103 0.1225 0.1225
Loa Loa (eye worm) hypothetical protein 0.0059 0.0566 0.0799
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.031 0.0138
Onchocerca volvulus Tyrosine kinase homolog 0.0475 0.6742 1
Entamoeba histolytica hypothetical protein 0.0036 0.0234 0.0197
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0094 0.1095 0.1546
Trypanosoma cruzi cdc2-related kinase 1 0.0094 0.1095 0.5953
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.0706 0.0706
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0119 0.1454 0.1454
Trypanosoma brucei rac serine-threonine kinase, putative 0.0025 0.0068 0.0328
Schistosoma mansoni cpg binding protein 0.0031 0.0147 0.0147
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.0234 0.0943
Entamoeba histolytica protein kinase domain containing protein 0.0103 0.1225 0.1381
Entamoeba histolytica isopentenyl-diphosphate delta-isomerase, putative 0.0122 0.1506 0.1716
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.004 0.0284 0.04
Loa Loa (eye worm) TK protein kinase 0.0157 0.202 0.2853
Loa Loa (eye worm) hypothetical protein 0.0099 0.1166 0.1647
Schistosoma mansoni septate junction protein 0.0031 0.0151 0.0151
Schistosoma mansoni hypothetical protein 0.0049 0.0418 0.0418
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.0234 0.0219
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.1582 0.1582
Entamoeba histolytica cell division protein kinase 2, putative 0.0094 0.1095 0.1225
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0214
Echinococcus granulosus epidermal growth factor receptor 0.0214 0.2865 0.2865
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0094 0.1095 0.5961
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0127 0.1582 0.1582
Echinococcus granulosus protein kinase c epsilon type 0.004 0.0284 0.0284
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0167 0.0167
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1063 0.1063
Echinococcus granulosus casein kinase i 0.0121 0.1486 0.1486
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0214
Leishmania major protein kinase, putative 0.0068 0.0706 0.391
Echinococcus granulosus peroxidasin 0.0031 0.0151 0.0151
Echinococcus granulosus contactin 0.0031 0.0151 0.0151
Brugia malayi CXXC zinc finger family protein 0.0029 0.0123 0.0173
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0127 0.1582 0.8788
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0127 0.1582 0.1582
Schistosoma mansoni inositol monophosphatase 0.0037 0.0248 0.0248
Schistosoma mansoni hypothetical protein 0.0058 0.0561 0.0561
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0094 0.1095 0.1095
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.031 0.1685
Echinococcus multilocularis lachesin 0.0031 0.0151 0.0151
Entamoeba histolytica protein kinase, putative 0.0068 0.0706 0.0762
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0072 0.0002
Trypanosoma brucei protein kinase, putative 0.0059 0.0566 0.3123
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0068 0.0706 0.3692
Entamoeba histolytica protein kinase, putative 0.0071 0.0743 0.0806
Echinococcus multilocularis titin 0.0027 0.0088 0.0088
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0127 0.1582 0.1582
Giardia lamblia Kinase, CMGC CDK 0.0094 0.1095 0.1286
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0058 0.0561 0.3095
Echinococcus multilocularis insulin receptor 0.0184 0.2421 0.2421
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0072 0.0073
Echinococcus granulosus titin 0.0027 0.0088 0.0088
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0706 0.0706
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0072 0.0347
Echinococcus granulosus roundabout 2 0.0031 0.0151 0.0151
Schistosoma mansoni cpg binding protein 0.0031 0.0147 0.0147
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0983 0.2052
Brugia malayi polk-prov protein 0.0031 0.016 0.0226
Schistosoma mansoni neuroglian 0.0031 0.0151 0.0151
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0167 0.0572
Brugia malayi latrophilin 2 splice variant baaae 0.0087 0.0977 0.138
Brugia malayi Immunoglobulin I-set domain containing protein 0.0157 0.202 0.2853
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1063 0.1063
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0127 0.1582 0.8788
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0151 0.0214
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0234 0.0198
Loa Loa (eye worm) hypothetical protein 0.0035 0.021 0.0296
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.059 0.8444 1
Plasmodium vivax glycogen synthase kinase 3, putative 0.0103 0.1225 0.6709
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0028 0.0109 0.0109
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.3242 0.3242
Trichomonas vaginalis CK1 family protein kinase 0.0121 0.1486 0.1693
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.031 0.1387
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0103 0.1225 0.6823
Plasmodium falciparum calcium-dependent protein kinase 5 0.0068 0.0706 0.3692
Schistosoma mansoni cell adhesion molecule 0.0031 0.0151 0.0151
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.1446 0.1446
Onchocerca volvulus 0.0112 0.1358 0.1909
Schistosoma mansoni vesicular amine transporter 0.0028 0.0109 0.0109
Echinococcus multilocularis geminin 0.0342 0.4767 0.4767
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0214
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0566 0.0566
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1063 0.1063
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.0234 0.0943
Trypanosoma cruzi casein kinase, putative 0.0121 0.1486 0.823
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0072 0.0002
Echinococcus granulosus casein kinase I alpha 0.0121 0.1486 0.1486
Echinococcus multilocularis roundabout 2 0.0031 0.0151 0.0151
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0167 0.0236
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0103 0.1225 0.6715
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0184 0.2421 0.2421
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0072 0.0004
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0058 0.0561 0.3095
Onchocerca volvulus 0.0449 0.6353 0.9415
Echinococcus granulosus protein kinase C gamma type 0.0106 0.1268 0.1268
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0259 0.0525
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0058 0.0561 0.0561
Schistosoma mansoni cell adhesion molecule 0.0031 0.0151 0.0151
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0127 0.1582 0.883
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0566 0.2876
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0216 0.1157
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0127 0.1582 0.1582
Brugia malayi Hr1 repeat family protein 0.0025 0.0068 0.0097
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.004 0.0288 0.0288
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0234 0.0198
Trypanosoma brucei trypanothione reductase 0.0038 0.0259 0.1398
Echinococcus granulosus cyclin dependent kinase 0.0094 0.1095 0.1095
Schistosoma mansoni nephrin 0.0046 0.0375 0.0375
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0288 0.3968 0.8351
Echinococcus multilocularis cyclin dependent kinase 1 0.0094 0.1095 0.1095
Onchocerca volvulus Huntingtin homolog 0.0124 0.1532 0.217
Mycobacterium ulcerans L-lactate dehydrogenase (cytochrome) LldD2 0.0341 0.475 1
Echinococcus granulosus cyclin dependent kinase 5 0.0094 0.1095 0.1095
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.031 0.1387
Leishmania major casein kinase, putative 0.0121 0.1486 0.8291
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0025 0.0068 0.0068
Loa Loa (eye worm) Csnk2b protein 0.0036 0.0234 0.033
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0072 0.0347
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.0234 0.0219
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0248 0.1026
Echinococcus multilocularis casein kinase I alpha 0.0121 0.1486 0.1486
Schistosoma mansoni protein kinase 0.0121 0.1486 0.1486
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0036 0.0234 0.1257
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0072 0.0348
Leishmania major isopentenyl-diphosphate delta-isomerase, putative,isomerase, putative 0.0122 0.1506 0.8402
Brugia malayi hypothetical protein 0.0028 0.0109 0.0153
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0025 0.0068 0.0068
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0216 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.031 0.1685
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.5803 0.5803
Echinococcus granulosus NDR protein kinase 0.0025 0.0068 0.0068
Brugia malayi hypothetical protein 0.0036 0.0234 0.033
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0184 0.2421 0.2421
Brugia malayi Protein kinase domain containing protein 0.0079 0.0869 0.1227
Onchocerca volvulus 0.0029 0.0123 0.0052
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0167 0.0167
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.031 0.1685
Echinococcus granulosus tumor protein p63 0.0678 0.9752 0.9752
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.016 0.0844
Echinococcus multilocularis transcription factor btf3 0.0035 0.0216 0.0216
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0266 0.0266
Schistosoma mansoni tyrosine kinase 0.0145 0.1848 0.1848
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.059 0.8444 1
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0068 0.0068
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1095 0.1095
Schistosoma mansoni flap endonuclease-1 0.0023 0.0035 0.0035
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0234 0.0198
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0214
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0058 0.0561 0.2847
Schistosoma mansoni tyrosine kinase 0.0184 0.2421 0.2421
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0566 0.0566
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0031 0.0151 0.0151
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.019 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0216 0.0176
Echinococcus multilocularis casein kinase I alpha 0.0121 0.1486 0.1486
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0025 0.0068 0.0068
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0983 0.1738
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0561 0.0588
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.031 0.0289
Echinococcus multilocularis casein kinase I delta 0.0121 0.1486 0.1486
Echinococcus granulosus roundabout 2 0.0031 0.0151 0.0151
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0167 0.0554
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0216 0.084
Echinococcus multilocularis cyclin dependent kinase 1 0.0094 0.1095 0.1095
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.031 0.1685
Mycobacterium ulcerans isopentenyl pyrophosphate isomerase 0.0122 0.1506 0.2794
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0025 0.0068 0.0097
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.0102
Schistosoma mansoni cpg binding protein 0.0029 0.0123 0.0123
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0151 0.0214
Plasmodium falciparum casein kinase 1 0.0121 0.1486 0.823
Echinococcus multilocularis roundabout 2 0.0059 0.0566 0.0566
Echinococcus granulosus insulin receptor 0.0184 0.2421 0.2421
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.0234 0.0943
Echinococcus multilocularis neuroglian 0.0031 0.0151 0.0151
Brugia malayi Probable ATP-dependent helicase DHX35 0.0035 0.021 0.0296
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0036 0.0234 0.0961
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0167 0.0554
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.031 0.1685
Schistosoma mansoni protein kinase 0.0507 0.7215 0.7215
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0234 0.0198
Echinococcus multilocularis neuroglian 0.0046 0.0375 0.0375
Brugia malayi Protein kinase domain containing protein 0.0094 0.1095 0.1546
Echinococcus granulosus lachesin 0.0031 0.0151 0.0151
Brugia malayi Fibronectin type III domain containing protein 0.0028 0.0109 0.0153
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0507 0.7215 0.7215
Brugia malayi Protein kinase domain containing protein 0.0025 0.0068 0.0097
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.1583 0.1583
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0234 0.0198
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0127 0.1582 0.8788
Schistosoma mansoni atypical protein kinase C 0.0037 0.0247 0.0247
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0234 0.0198
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0103 0.1225 0.1729
Loa Loa (eye worm) hypothetical protein 0.0086 0.0967 0.1366
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0127 0.1582 0.1582
Echinococcus multilocularis roundabout 2 0.0031 0.0151 0.0151
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0167 0.0167
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.0234 0.0943
Brugia malayi Flap endonuclease-1 0.0025 0.0072 0.0101
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0153
Schistosoma mansoni protein kinase 0.0507 0.7215 0.7215
Schistosoma mansoni hypothetical protein 0.0109 0.1307 0.1307
Schistosoma mansoni hypothetical protein 0.0036 0.0234 0.0234
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0248 0.1337
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.031 0.1685
Brugia malayi Latrophilin receptor protein 2 0.004 0.0288 0.0407
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0214
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0216 0.0305
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0167 0.0881
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0025 0.0068 0.0097
Brugia malayi Protein kinase domain containing protein 0.0025 0.0068 0.0097
Brugia malayi Cam kinase protein 1 0.0068 0.0706 0.0997
Echinococcus granulosus epidermal growth factor receptor 0.0145 0.1848 0.1848
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0248 0.0248
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.1095 0.1225
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0211 0.1129
Trypanosoma cruzi casein kinase, putative 0.0121 0.1486 0.823
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0068 0.0706 0.0706
Loa Loa (eye worm) inositol-1 0.0037 0.0248 0.035
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0068 0.0706 0.3704
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0216 0.084
Loa Loa (eye worm) casein kinase 0.0119 0.1455 0.2055
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0234 0.0198
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0248 0.1044
Toxoplasma gondii ck2 beta subunit 0.0036 0.0234 0.0961
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0068 0.0068
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0127 0.1571 0.2219
Echinococcus granulosus casein kinase I delta 0.0121 0.1486 0.1486
Trypanosoma cruzi casein kinase II, putative 0.0141 0.179 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.0418 0.0418
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.1446 0.1446
Brugia malayi casein kinase 1, delta 0.0121 0.1486 0.2099
Echinococcus multilocularis casein kinase I alpha 0.0121 0.1486 0.1486
Mycobacterium tuberculosis Probable reductase 0.0087 0.0983 0.2052
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.1582 0.1582
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0031 0.0151 0.0151
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0026 0.0083 0.0083
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0127 0.1582 0.8791
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0566 0.0594
Schistosoma mansoni hypothetical protein 0.0412 0.5803 0.5803
Plasmodium falciparum calcium-dependent protein kinase 4 0.0068 0.0706 0.3692
Brugia malayi Calcitonin receptor-like protein seb-1 0.0127 0.1571 0.2219
Echinococcus multilocularis cyclin dependent kinase 0.0094 0.1095 0.1095
Mycobacterium leprae POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD2 0.0341 0.475 1
Schistosoma mansoni hypothetical protein 0.0342 0.4767 0.4767
Entamoeba histolytica PH domain containing protein kinase, putative 0.0127 0.1582 0.1807
Loa Loa (eye worm) hypothetical protein 0.0087 0.0977 0.138
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0566 0.0799
Trichomonas vaginalis CMGC family protein kinase 0.0141 0.179 0.2056
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0566 0.0594
Plasmodium vivax casein kinase 1, putative 0.0121 0.1486 0.823
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.1063 0.1502
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0578 0.0578
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0127 0.1582 0.1582
Schistosoma mansoni tyrosine kinase 0.0137 0.1725 0.1725
Echinococcus multilocularis RNA directed DNA polymerase 0.0078 0.0856 0.0856
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0259 0.1089
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0214
Entamoeba histolytica hypothetical protein 0.0036 0.0234 0.0197
Plasmodium falciparum calcium-dependent protein kinase 2 0.0068 0.0706 0.3692
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.031 0.1685
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0706 0.0762
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0151 0.0214
Entamoeba histolytica protein kinase domain containing protein 0.0103 0.1225 0.1381
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.1126 0.2054
Onchocerca volvulus Huntingtin homolog 0.0124 0.1532 0.217
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0423
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.1126 0.2355
Brugia malayi Thioredoxin reductase 0.0038 0.0259 0.0366
Echinococcus granulosus dnaJ subfamily B 0.0412 0.5803 0.5803
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.016 0.0844
Trypanosoma brucei RNA helicase, putative 0.0109 0.1307 0.7285

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 29 nM Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1 ChEMBL. 16919453
EC50 (functional) = 29 nM Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1 ChEMBL. 16919453
IC50 (binding) = 0.3 nM Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1 ChEMBL. 16919453
IC50 (binding) = 0.3 nM Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1 ChEMBL. 16919453
Inhibition (binding) < 50 % Inhibition of 125I-[Phe13,Tyr19]-MCH binding to human MCH-R2 at 2uM ChEMBL. 16919453
Inhibition (binding) < 50 % Inhibition of 125I-[Phe13,Tyr19]-MCH binding to human MCH-R2 at 2uM ChEMBL. 16919453

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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