Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | fmrfamide receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.0094 | 0.0646 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0226 | 0.4337 | 0.581 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0337 | 0.7465 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0337 | 0.7465 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0337 | 0.7465 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.024 | 0.473 | 0.6337 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0094 | 0.0646 | 0.5 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.024 | 0.473 | 0.6337 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.0094 | 0.0646 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0226 | 0.4337 | 0.581 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0226 | 0.4337 | 0.581 |
Mycobacterium ulcerans | thioesterase | 0.0188 | 0.3283 | 0.4398 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | neuropeptide receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0219 | 0.4144 | 0.5551 |
Echinococcus granulosus | orexin receptor type 2 | 0.0094 | 0.0646 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0226 | 0.4337 | 0.581 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | g-protein coupled receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0094 | 0.0646 | 0.5 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0337 | 0.7465 | 1 |
Loa Loa (eye worm) | acyl carrier protein | 0.0104 | 0.0922 | 0.0344 |
Schistosoma mansoni | biogenic amine receptor | 0.0094 | 0.0646 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0182 | 0.3102 | 0.4155 |
Mycobacterium ulcerans | thioesterase TesA | 0.0188 | 0.3283 | 0.4398 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | fmrfamide receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0094 | 0.0646 | 0.5 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.024 | 0.473 | 0.6337 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.024 | 0.473 | 0.6337 |
Schistosoma mansoni | amine GPCR | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0094 | 0.0646 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.024 | 0.473 | 0.6337 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.024 | 0.473 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0226 | 0.4337 | 0.581 |
Echinococcus multilocularis | orexin receptor type 2 | 0.0094 | 0.0646 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0379 | 0.8637 | 1 |
Schistosoma mansoni | amine GPCR | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0211 | 0.3922 | 0.5254 |
Loa Loa (eye worm) | fatty acid synthase | 0.0223 | 0.4253 | 0.4514 |
Schistosoma mansoni | neuropeptide receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.0094 | 0.0646 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0226 | 0.4337 | 0.581 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0149 | 0.2195 | 0.2941 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0094 | 0.0646 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0078 | 0.0188 | 0.0251 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0094 | 0.0646 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0185 | 0.3185 | 0.4267 |
Mycobacterium ulcerans | polyketide synthase | 0.0226 | 0.4337 | 0.581 |
Schistosoma mansoni | amine GPCR | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | g protein coupled receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | dro:myosuppressin receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0094 | 0.0646 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0182 | 0.3102 | 0.4155 |
Echinococcus granulosus | serotonin receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.024 | 0.473 | 0.6337 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.0094 | 0.0646 | 0.5 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0146 | 0.2116 | 0.2574 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0188 | 0.3283 | 0.4398 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0094 | 0.0646 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0091 | 0.0571 | 0.0765 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.024 | 0.473 | 0.6337 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | allatostatin A receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | allatostatin A receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0211 | 0.3922 | 0.4099 |
Echinococcus multilocularis | somatostatin receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0094 | 0.0646 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0149 | 0.2195 | 0.2941 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0226 | 0.4337 | 0.581 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0094 | 0.0646 | 0.5 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.024 | 0.473 | 0.6337 |
Schistosoma mansoni | histamine h1 receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | neuropeptide receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0407 | 0.9413 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0149 | 0.2195 | 0.2941 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | myosin xvIII | 0.0094 | 0.0646 | 0.5 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0188 | 0.3283 | 0.4398 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | g-protein coupled receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | sex peptide receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | g protein coupled receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | fmrfamide receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | adenoreceptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0094 | 0.0646 | 0.5 |
Onchocerca volvulus | 0.0393 | 0.9021 | 0.9552 | |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0094 | 0.0646 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0161 | 0.2515 | 0.3708 |
Echinococcus granulosus | g protein coupled receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0094 | 0.0646 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0226 | 0.4337 | 0.581 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.0094 | 0.0646 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0182 | 0.3102 | 0.4155 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0162 | 0.2556 | 0.3424 |
Echinococcus multilocularis | g protein coupled receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.0094 | 0.0646 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0211 | 0.3922 | 0.3502 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1557 | 0.1139 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0226 | 0.4337 | 0.3946 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0094 | 0.0646 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.024 | 0.473 | 0.6337 |
Echinococcus granulosus | neuropeptide s receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | sex peptide receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | somatostatin receptor | 0.0094 | 0.0646 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0128 | 0.1609 | 0.2155 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0219 | 0.4144 | 0.5551 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.0094 | 0.0646 | 0.5 |
Onchocerca volvulus | 0.0211 | 0.3922 | 0.3736 | |
Echinococcus granulosus | g protein coupled receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.0094 | 0.0646 | 0.5 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.0094 | 0.0646 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0094 | 0.0646 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0226 | 0.4337 | 0.581 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 20 % | Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assay at 1uM | ChEMBL. | 17010606 |
Inhibition (functional) | = 20 % | Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assay at 1uM | ChEMBL. | 17010606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.