Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidasin homolog | 0.25 | 0.8464 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.25 | 0.8464 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.25 | 0.8464 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.25 | 0.8464 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.25 | 0.8464 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.25 | 0.8464 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.25 | 0.8464 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0993 | 0.2384 | 0.2817 |
Onchocerca volvulus | Peroxidasin homolog | 0.25 | 0.8464 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0993 | 0.2384 | 0.2817 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 0.0322 | 0.038 |
Echinococcus granulosus | peroxidasin | 0.25 | 0.8464 | 0.8413 |
Loa Loa (eye worm) | serotonin transporter b | 0.0993 | 0.2384 | 0.2817 |
Loa Loa (eye worm) | hypothetical protein | 0.25 | 0.8464 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.25 | 0.8464 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0402 | 0 | 0.5 |
Loa Loa (eye worm) | doublecortin family protein | 0.0482 | 0.0322 | 0.038 |
Loa Loa (eye worm) | hypothetical protein | 0.25 | 0.8464 | 1 |
Schistosoma mansoni | lipoxygenase | 0.2881 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.25 | 0.8464 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.25 | 0.8464 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.25 | 0.8464 | 1 |
Onchocerca volvulus | 0.0993 | 0.2384 | 0.2533 | |
Schistosoma mansoni | peroxidasin | 0.25 | 0.8464 | 0.8413 |
Onchocerca volvulus | 0.25 | 0.8464 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.25 | 0.8464 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0402 | 0 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.25 | 0.8464 | 0.8413 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0993 | 0.2384 | 0.2817 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0993 | 0.2384 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.25 | 0.8464 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0482 | 0.0322 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0993 | 0.2384 | 0.2817 |
Loa Loa (eye worm) | hypothetical protein | 0.0993 | 0.2384 | 0.2817 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.2881 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.25 | 0.8464 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0402 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.25 | 0.8464 | 1 |
Onchocerca volvulus | 0.25 | 0.8464 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.25 | 0.8464 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.25 | 0.8464 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.25 | 0.8464 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.25 | 0.8464 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.25 | 0.8464 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0993 | 0.2384 | 0.2131 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0482 | 0.0322 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.2014 | 0.6503 | 0.6387 |
Loa Loa (eye worm) | hypothetical protein | 0.25 | 0.8464 | 1 |
Brugia malayi | hypothetical protein | 0.0482 | 0.0322 | 0.038 |
Loa Loa (eye worm) | hypothetical protein | 0.0993 | 0.2384 | 0.2817 |
Brugia malayi | Animal haem peroxidase family protein | 0.25 | 0.8464 | 1 |
Brugia malayi | Doublecortin family protein | 0.0482 | 0.0322 | 0.038 |
Onchocerca volvulus | 0.25 | 0.8464 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.25 | 0.8464 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0993 | 0.2384 | 0.2131 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 0.0322 | 0.038 |
Loa Loa (eye worm) | animal heme peroxidase | 0.25 | 0.8464 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.25 | 0.8464 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.25 | 0.8464 | 1 |
Brugia malayi | hypothetical protein | 0.0482 | 0.0322 | 0.038 |
Schistosoma mansoni | peroxidasin | 0.25 | 0.8464 | 0.8413 |
Echinococcus granulosus | serotonin transporter | 0.0993 | 0.2384 | 0.2131 |
Brugia malayi | Animal haem peroxidase family protein | 0.25 | 0.8464 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.25 | 0.8464 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.25 | 0.8464 | 1 |
Brugia malayi | hypothetical protein | 0.25 | 0.8464 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0993 | 0.2384 | 0.2131 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.08 mM | Compound was tested for the inhibition of E-selectin-mediated cellular adhesion | ChEMBL. | 8691465 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.