Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0078 | 0.1309 | 0.1309 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.0851 | 0.1141 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0258 | 0.7423 | 0.5 |
Plasmodium falciparum | AMP deaminase, putative | 0.0333 | 1 | 1 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.3336 | 0.3336 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0197 | 0.5367 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0258 | 0.7423 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0333 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0258 | 0.7423 | 1 |
Brugia malayi | Adenosylhomocysteinase | 0.0126 | 0.2939 | 0.2939 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0078 | 0.1309 | 0.1309 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0333 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0137 | 0.3336 | 0.0562 |
Trypanosoma brucei | AMP deaminase, putative | 0.0333 | 1 | 1 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Leishmania major | adenine aminohydrolase | 0.0197 | 0.5367 | 0.3438 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.5327 | 0.5327 |
Trypanosoma brucei | AMP deaminase, putative | 0.0333 | 1 | 1 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.0333 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0197 | 0.5367 | 0.5367 |
Entamoeba histolytica | AMP deaminase, putative | 0.0333 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.0197 | 0.5367 | 0.3438 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0197 | 0.5367 | 0.5367 |
Trichomonas vaginalis | FMN-dependent NADH-azoreductase, putative | 0.0064 | 0.0851 | 0.1141 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0126 | 0.2939 | 0.2939 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0126 | 0.2939 | 0.2939 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.0851 | 0.1141 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0126 | 0.2939 | 0.2939 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.0851 | 0.1141 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.0851 | 0.1141 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0258 | 0.7423 | 1 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0197 | 0.5367 | 0.4936 |
Plasmodium vivax | adenosine/AMP deaminase, putative | 0.0333 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.0851 | 0.1141 |
Schistosoma mansoni | AMP deaminase | 0.0333 | 1 | 1 |
Toxoplasma gondii | AMP deaminase | 0.0333 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0333 | 1 | 1 |
Echinococcus granulosus | AMP deaminase 2 | 0.0333 | 1 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.0333 | 1 | 1 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0258 | 0.7423 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0064 | 0.0851 | 0.1141 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0126 | 0.2939 | 0.2939 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.5367 | 0.5367 |
Leishmania major | AMP deaminase, putative | 0.0333 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0258 | 0.7423 | 1 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.0333 | 1 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0258 | 0.7423 | 0.5 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0126 | 0.2939 | 0.2939 |
Treponema pallidum | adenosine deaminase | 0.0197 | 0.5367 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.0851 | 0.1141 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0258 | 0.7423 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.0851 | 0.1141 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0693 | 0.0693 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0197 | 0.5367 | 0.5367 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0258 | 0.7423 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0258 | 0.7423 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0333 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.0197 | 0.5367 | 0.5367 |
Mycobacterium ulcerans | adenosine deaminase | 0.0197 | 0.5367 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0126 | 0.2939 | 0.2939 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0693 | 0.0693 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0126 | 0.2939 | 0.3955 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.0333 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.0851 | 0.1141 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0078 | 0.1309 | 0.1309 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0258 | 0.7423 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0197 | 0.5367 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0333 | 1 | 1 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0258 | 0.7423 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0126 | 0.2939 | 0.2282 |
Plasmodium vivax | adenosine deaminase, putative | 0.0197 | 0.5367 | 0.5367 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0197 | 0.5367 | 0.7228 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0258 | 0.7423 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0197 | 0.5367 | 0.5367 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0258 | 0.7423 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0258 | 0.7423 | 0.5 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Entamoeba histolytica | AMP deaminase, putative | 0.0333 | 1 | 1 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0258 | 0.7423 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0064 | 0.0851 | 0.1141 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0333 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.0333 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0693 | 0.0693 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0126 | 0.2939 | 0.3955 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0258 | 0.7423 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0333 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0137 | 0.3336 | 0.0562 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0126 | 0.2939 | 0.2939 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0333 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0333 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.0851 | 0.1141 |
Plasmodium falciparum | adenosine deaminase | 0.0197 | 0.5367 | 0.5367 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0197 | 0.5367 | 0.5367 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0197 | 0.5367 | 0.3047 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0258 | 0.7423 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0197 | 0.5367 | 0.4936 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0197 | 0.5367 | 0.7228 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0693 | 0.0693 |
Trichomonas vaginalis | modulator of drug activity B, putative | 0.0064 | 0.0851 | 0.1141 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0258 | 0.7423 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0078 | 0.1309 | 0.1309 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0193 | 0.5234 | 0.7049 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0333 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 5.8 dose ratio | In vitro inhibition of substance P induced contractions of the guinea pig ileum at 5 uM. | ChEMBL. | 2433443 |
Activity (binding) | = 5.8 dose ratio | In vitro inhibition of substance P induced contractions of the guinea pig ileum at 5 uM. | ChEMBL. | 2433443 |
Activity (binding) | = 18.2 dose ratio | In vitro inhibition of substance P induced contractions of the guinea pig ileum at 10 uM. | ChEMBL. | 2433443 |
Activity (binding) | = 18.2 dose ratio | In vitro inhibition of substance P induced contractions of the guinea pig ileum at 10 uM. | ChEMBL. | 2433443 |
Activity (binding) | = 69 dose ratio | In vitro inhibition of substance P (6-11) hexapeptide induced contractions of the guinea pig ileum at 5 uM. | ChEMBL. | 2433443 |
Activity (binding) | = 69 dose ratio | In vitro inhibition of substance P (6-11) hexapeptide induced contractions of the guinea pig ileum at 5 uM. | ChEMBL. | 2433443 |
Activity (binding) | = 225 dose ratio | In vitro inhibition of substance P (6-11) hexapeptide induced contractions of the guinea pig ileum at 10 uM. | ChEMBL. | 2433443 |
Activity (binding) | = 225 dose ratio | In vitro inhibition of substance P (6-11) hexapeptide induced contractions of the guinea pig ileum at 10 uM. | ChEMBL. | 2433443 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.