TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 1069.11 | Formula: C60H60O18
H donors: 0 H acceptors: 4 LogP: 8.26 Rotable bonds: 14
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc(cc(c1OC)OC)[C@H]1[C@H]2C(=O)OC[C@@H]2[C@@H](c2c1cc1OCOc1c2)OC(=O)C1CC2CC1C=C2.COc1cc(cc(c1OC)OC)[C@H]1[C@H]2C(=O)OC[C@@H]2[C@@H](c2c1cc1OCOc1c2)OC(=O)C1CC2CC1C=C2
InChi: 1S/2C30H30O9/c2*1-33-23-8-16(9-24(34-2)28(23)35-3)25-18-10-21-22(38-13-37-21)11-19(18)27(20-12-36-30(32)26(20)25)39-29(31)17-7-14-4-5-15(17)6-14/h2*4-5,8-11,14-15,17,20,25-27H,6-7,12-13H2,1-3H3/t2*14?,15?,17?,20-,25+,26-,27+/m00/s1
InChiKey: NYIGLVQSOLZRLA-BAYDZMHGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0024	0.0408	0.0408
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0264	1	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0408	0.0408
Loa Loa (eye worm)	DR-78	0.0125	0.4426	0.4426
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0264	1	1
Entamoeba histolytica	hypothetical protein	0.0028	0.0569	0.5
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0125	0.4426	0.4426
Schistosoma mansoni	neurotransmitter gated ion channel	0.0028	0.0569	0.0569
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0264	1	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0264	1	1
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0028	0.0569	0.0569
Brugia malayi	hypothetical protein	0.0139	0.5023	0.5023
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0052	0.1529	0.1529
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0264	1	1
Schistosoma mansoni	nAChR subunit	0.0052	0.1529	0.1529
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0139	0.5023	0.5023
Schistosoma mansoni	nAChR subunit	0.0024	0.0408	0.0408
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0125	0.4426	0.4426
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0408	0.0408
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0264	1	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0052	0.1529	0.1529
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0264	1	1
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0042	0.1129	0.1129
Brugia malayi	nuclear receptor RXR	0.0125	0.4426	0.4426
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0052	0.1529	0.1529
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0041	0.1102	0.1102
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0139	0.5023	0.5023
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0125	0.4426	0.4426
Brugia malayi	Nuclear hormone receptor E75	0.0125	0.4426	0.4426
Brugia malayi	Nuclear hormone receptor-like 1	0.0139	0.5023	0.5023
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0052	0.1529	0.1529
Onchocerca volvulus	Protein ultraspiracle homolog	0.0264	1	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Schistosoma mansoni	acetylcholine receptor-related	0.0024	0.0408	0.0408
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0036	0.0898	0.5
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0125	0.4426	0.4189
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0264	1	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0052	0.1529	0.1529
Brugia malayi	conserved hypotetical protein	0.0125	0.4426	0.4426
Brugia malayi	hypothetical protein	0.0125	0.4426	0.4426
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0139	0.5023	0.5023
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0028	0.0569	0.0569
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0052	0.1529	0.1529
Loa Loa (eye worm)	LGC-31 protein	0.0052	0.1529	0.1529
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0264	1	1
Loa Loa (eye worm)	hypothetical protein	0.0264	1	1
Loa Loa (eye worm)	GABA receptor subunit	0.0028	0.0569	0.0569
Echinococcus multilocularis	FTZ F1 alpha	0.0264	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0264	1	1
Schistosoma mansoni	hypothetical protein	0.0054	0.1624	0.1624
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0024	0.0408	0.0408
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0139	0.5023	0.5023
Echinococcus multilocularis	sodium channel protein	0.0042	0.1129	0.1129
Onchocerca volvulus		0.0052	0.1529	0.1168
Echinococcus granulosus	serine:threonine protein kinase TAO1	0.0186	0.6868	0.6868
Loa Loa (eye worm)	hypothetical protein	0.0264	1	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0264	1	1
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0052	0.1529	0.1529
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0264	1	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Onchocerca volvulus		0.0028	0.0569	0.0168
Brugia malayi	nuclear hormone receptor	0.0264	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0125	0.4426	0.4426
Schistosoma mansoni	nAChR subunit	0.0052	0.1529	0.1529
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0264	1	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0052	0.1529	0.1529
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0408	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0125	0.4426	0.4426
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0041	0.1102	0.1102
Schistosoma mansoni	neurotransmitter gated ion channel	0.0024	0.0408	0.0408
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0264	1	1
Echinococcus multilocularis	serine:threonine protein kinase TAO1	0.0186	0.6868	0.6868
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0125	0.4426	0.4426
Onchocerca volvulus		0.0052	0.1529	0.1168
Echinococcus granulosus	FTZ F1 alpha	0.0264	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0897	0.0897
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0052	0.1529	0.1529
Brugia malayi	hypothetical protein	0.0024	0.0408	0.0408
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0052	0.1529	0.1529
Echinococcus granulosus	nAChR subunit	0.0028	0.0569	0.0569
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0264	1	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0125	0.4426	0.4426
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0125	0.4426	0.4426
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0408	0.0408
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.1245	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0125	0.4426	0.4426
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0024	0.0408	0.0408
Onchocerca volvulus		0.0052	0.1529	0.1168
Brugia malayi	hypothetical protein	0.0024	0.0408	0.0408
Schistosoma mansoni	nuclear receptor nhr-48	0.0125	0.4426	0.4426
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0264	1	1
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0024	0.0408	0.0408
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0052	0.1529	0.1529
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0052	0.1529	0.1529
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0125	0.4426	0.4426
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0041	0.1102	0.1102
Loa Loa (eye worm)	hypothetical protein	0.0264	1	1
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0024	0.0408	0.0408
Brugia malayi	Nuclear hormone receptor-like 1	0.0264	1	1
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0052	0.1529	0.1529
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0125	0.4426	0.4426
Loa Loa (eye worm)	hypothetical protein	0.0125	0.4426	0.4426
Brugia malayi	nuclear hormone receptor family member odr-7	0.0125	0.4426	0.4426
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0264	1	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0408	0.0408
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0052	0.1529	0.1529
Echinococcus granulosus	nAChR subunit	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0408	0.0408
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0125	0.4426	0.4189
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0125	0.4426	0.4426
Echinococcus granulosus	thyroid hormone receptor alpha	0.0125	0.4426	0.4426
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0052	0.1529	0.1529
Onchocerca volvulus		0.0028	0.0569	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0052	0.1529	0.1529
Loa Loa (eye worm)	STE/STE20/TAO protein kinase	0.0186	0.6868	0.6868
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0264	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0264	1	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0264	1	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Schistosoma mansoni	nAChR subunit	0.0052	0.1529	0.1529
Schistosoma mansoni	serine/threonine protein kinase	0.0186	0.6868	0.6868
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Schistosoma mansoni	nuclear hormone receptor	0.0264	1	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0052	0.1529	0.1529
Schistosoma mansoni	zinc finger protein	0.0125	0.4426	0.4426
Echinococcus multilocularis	ecdysone induced protein 78C	0.0264	1	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0052	0.1529	0.1529
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0264	1	1
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0024	0.0408	0.0408
Onchocerca volvulus		0.0052	0.1529	0.1168
Schistosoma mansoni	neurotransmitter gated ion channel	0.0024	0.0408	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0408	0.0408
Brugia malayi	Cation transporter family protein	0.0052	0.1529	0.1529
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0052	0.1529	0.1529
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0052	0.1529	0.1529
Brugia malayi	excitatory GABA receptor EXP-1A	0.0052	0.1529	0.1529
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0264	1	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0264	1	1
Brugia malayi	nuclear receptor NHR-67	0.0125	0.4426	0.4426
Onchocerca volvulus		0.0125	0.4426	0.4189
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0139	0.5023	0.5023
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0028	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0264	1	1
Brugia malayi	tailless protein	0.0125	0.4426	0.4426
Echinococcus granulosus	ecdysone induced protein 78C	0.0264	1	1
Schistosoma mansoni	nAChR subunit	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0125	0.4426	0.4426
Schistosoma mansoni	nAChR subunit	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0408	0.0408
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0264	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0125	0.4426	0.4426
Loa Loa (eye worm)	hypothetical protein	0.0125	0.4426	0.4426
Brugia malayi	Nuclear hormone receptor E75	0.0125	0.4426	0.4426
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0139	0.5023	0.5023
Onchocerca volvulus	Bile acid receptor homolog	0.0264	1	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0028	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0139	0.5023	0.5023
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0408	0.0408
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0125	0.4426	0.4426
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0264	1	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0052	0.1529	0.1529
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0052	0.1529	0.1529
Schistosoma mansoni	nuclear receptor	0.0125	0.4426	0.4426
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0408	0.0408
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0052	0.1529	0.1529
Onchocerca volvulus		0.0052	0.1529	0.1168
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0024	0.0408	0.0408
Loa Loa (eye worm)	acetylcholine receptor protein	0.0024	0.0408	0.0408
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.1245	0.1245
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0052	0.1529	0.1529
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0125	0.4426	0.4426
Brugia malayi	hypothetical protein	0.0186	0.6868	0.6868
Schistosoma mansoni	nAChR subunit	0.0052	0.1529	0.1529
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0264	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0264	1	1
Loa Loa (eye worm)	hypothetical protein	0.0264	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0264	1	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0569	0.0569
Brugia malayi	orphan nuclear receptor NR2E1	0.0125	0.4426	0.4426
Brugia malayi	hypothetical protein	0.0139	0.5023	0.5023
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0408	0.0408
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0264	1	1
Brugia malayi	nuclear receptor NHR-88	0.0264	1	1
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0052	0.1529	0.1529
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0125	0.4426	0.4426
Onchocerca volvulus		0.0125	0.4426	0.4189
Loa Loa (eye worm)	ACC-1 protein	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0125	0.4426	0.4426
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0052	0.1529	0.1529
Loa Loa (eye worm)	nuclear hormone receptor	0.0125	0.4426	0.4426
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0569	0.0569
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0139	0.5023	0.5023
Echinococcus multilocularis	nuclear receptor nhr 48	0.0125	0.4426	0.4426
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0042	0.1129	0.5
Onchocerca volvulus		0.0264	1	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0264	1	1
Onchocerca volvulus		0.0052	0.1529	0.1168
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0052	0.1529	0.1529
Schistosoma mansoni	nuclear receptor	0.0125	0.4426	0.4426
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0024	0.0408	0.0408
Brugia malayi	nuclear receptor RXR	0.0139	0.5023	0.5023
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0052	0.1529	0.1529
Brugia malayi	steroid hormone receptor	0.0264	1	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.5023	0.5023
Echinococcus multilocularis	nAChR subunit	0.0052	0.1529	0.1529
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0264	1	1
Schistosoma mansoni	nAChR subunit	0.0052	0.1529	0.1529
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0264	1	1
Brugia malayi	Steroid receptor seven-up type 2	0.0264	1	1
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0052	0.1529	0.1529
Schistosoma mansoni	nuclear hormone receptor	0.0125	0.4426	0.4426
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0264	1	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0125	0.4426	0.4426
Schistosoma mansoni	nAChR subunit	0.0024	0.0408	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0125	0.4426	0.4426
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0024	0.0408	0.0408
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0024	0.0408	0.0408
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0264	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0264	1	1
Echinococcus granulosus	glycine receptor subunit beta	0.0052	0.1529	0.1529
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0264	1	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0408	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0569	0.0569
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0036	0.0898	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0052	0.1529	0.1529
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0125	0.4426	0.4426
Brugia malayi	ecdysone receptor	0.0125	0.4426	0.4426
Brugia malayi	hypothetical protein	0.0024	0.0408	0.0408
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0052	0.1529	0.1529
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0052	0.1529	0.1529
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0264	1	1
Brugia malayi	nuclear receptor NHR-88	0.0125	0.4426	0.4426
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0052	0.1529	0.1529
Brugia malayi	nuclear hormone receptor	0.0125	0.4426	0.4426
Echinococcus granulosus	nuclear receptor nhr 48	0.0125	0.4426	0.4426
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0052	0.1529	0.1529
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0024	0.0408	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0408	0.0408
Brugia malayi	Serine/threonine-protein kinase SULU	0.0186	0.6868	0.6868
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0139	0.5023	0.5023
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0024	0.0408	0.0408
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0125	0.4426	0.4426
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0264	1	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0125	0.4426	0.4426
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Schistosoma mansoni	RAR-like nuclear receptor	0.0264	1	1
Loa Loa (eye worm)	hypothetical protein	0.0125	0.4426	0.4426
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0408	0.0408
Echinococcus granulosus	glycine receptor subunit beta	0.0052	0.1529	0.1529
Brugia malayi	hypothetical protein	0.0024	0.0408	0.0408
Loa Loa (eye worm)	ACC-1 protein	0.0052	0.1529	0.1529
Schistosoma mansoni	thyroid hormone receptor	0.0264	1	1
Onchocerca volvulus	Putative nachr subunit	0.0052	0.1529	0.1168
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0024	0.0408	0.0408
Echinococcus multilocularis	nAChR subunit	0.0028	0.0569	0.0569
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0052	0.1529	0.1529
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0028	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0569	0.0569
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0041	0.1102	0.1102
Schistosoma mansoni	coup transcription factor	0.0264	1	1
Brugia malayi	Cation transporter family protein	0.0052	0.1529	0.1529
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0125	0.4426	0.4426
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0052	0.1529	0.1529
Brugia malayi	Cation transporter family protein	0.0052	0.1529	0.1529
Schistosoma mansoni	retinoic acid receptor RXR	0.0264	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0139	0.5023	0.5023
Echinococcus granulosus	sodium channel protein	0.0042	0.1129	0.1129
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Brugia malayi	photoreceptor-specific nuclear receptor	0.0264	1	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0024	0.0408	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0264	1	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0264	1	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0408	0.0408
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0264	1	1
Loa Loa (eye worm)	hypothetical protein	0.0125	0.4426	0.4426
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0264	1	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0024	0.0408	0.0408
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0264	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.0264	1	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0264	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0264	1	1
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0052	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1529	0.1529
Echinococcus multilocularis	glycine receptor subunit beta	0.0052	0.1529	0.1529
Brugia malayi	hypothetical protein	0.0125	0.4426	0.4426
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0125	0.4426	0.4426
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0264	1	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0028	0.0569	0.0569

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 1122 nM	In vitro cytotoxicity against the P-388 (from DBA/2 mouse) neoplastic cell line	ChEMBL.	14980682
IC50 (functional)	= 1122 nM	In vitro cytotoxicity against the A-549 (human lung carcinoma) neoplastic cell line	ChEMBL.	14980682
IC50 (functional)	= 1122 nM	In vitro cytotoxicity against the HT-29 (human colon carcinoma) neoplastic cell line	ChEMBL.	14980682
IC50 (functional)	= 1122 nM	In vitro cytotoxicity against MEL-28 (human malign melanoma) neoplastic cell line	ChEMBL.	14980682
IC50 (functional)	= 1122 nM	In vitro cytotoxicity against the P-388 (from DBA/2 mouse) neoplastic cell line	ChEMBL.	14980682
IC50 (functional)	= 1122 nM	In vitro cytotoxicity against the A-549 (human lung carcinoma) neoplastic cell line	ChEMBL.	14980682
IC50 (functional)	= 1122 nM	In vitro cytotoxicity against the HT-29 (human colon carcinoma) neoplastic cell line	ChEMBL.	14980682
IC50 (functional)	= 1122 nM	In vitro cytotoxicity against MEL-28 (human malign melanoma) neoplastic cell line	ChEMBL.	14980682

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mus musculus	ChEMBL23	14980682
Homo sapiens	ChEMBL23	14980682

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 376946