Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0186 | 0.0038 | 0.0049 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3935 | 1 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.2208 | 0.541 | 0.6959 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.3091 | 0.7757 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2208 | 0.541 | 0.6959 |
Mycobacterium ulcerans | thymidylate synthase | 0.3091 | 0.7757 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.147 | 0.3451 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.3091 | 0.7757 | 1 |
Brugia malayi | thymidylate synthase | 0.3091 | 0.7757 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3935 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.3091 | 0.7757 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.3091 | 0.7757 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3935 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.147 | 0.3451 | 0.4422 |
Echinococcus granulosus | thymidylate synthase | 0.3091 | 0.7757 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.2208 | 0.541 | 0.6959 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2208 | 0.541 | 0.5 |
Onchocerca volvulus | 0.3091 | 0.7757 | 1 | |
Schistosoma mansoni | dihydrofolate reductase | 0.2208 | 0.541 | 0.6959 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3935 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3091 | 0.7757 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3935 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2208 | 0.541 | 0.4549 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log K (ADMET) | = 7.1 | Association constant required to reduce the S-peptide / S-protein association by nonlinear curve fitting analysis | ChEMBL. | 10340601 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.