Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0165 | 0.417 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.417 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0165 | 0.417 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0165 | 0.417 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0165 | 0.417 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0165 | 0.417 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0165 | 0.417 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0165 | 0.417 | 1 |
Trypanosoma brucei | squalene synthase, putative | 0.0273 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.417 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0165 | 0.417 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0165 | 0.417 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0165 | 0.417 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0165 | 0.417 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.417 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0165 | 0.417 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0165 | 0.417 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0165 | 0.417 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0165 | 0.417 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0165 | 0.417 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0165 | 0.417 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0165 | 0.417 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0165 | 0.417 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0165 | 0.417 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0165 | 0.417 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0165 | 0.417 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0165 | 0.417 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0165 | 0.417 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0165 | 0.417 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0165 | 0.417 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0165 | 0.417 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0165 | 0.417 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0165 | 0.417 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0165 | 0.417 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0165 | 0.417 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0165 | 0.417 | 1 |
Brugia malayi | steroid hormone receptor | 0.0165 | 0.417 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0165 | 0.417 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0165 | 0.417 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.417 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.417 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0165 | 0.417 | 1 |
Trypanosoma cruzi | squalene synthase, putative | 0.0273 | 1 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0165 | 0.417 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0165 | 0.417 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0165 | 0.417 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0165 | 0.417 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0165 | 0.417 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0165 | 0.417 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0165 | 0.417 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0165 | 0.417 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.417 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0165 | 0.417 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0165 | 0.417 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0165 | 0.417 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0165 | 0.417 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0165 | 0.417 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0165 | 0.417 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0165 | 0.417 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0165 | 0.417 | 1 |
Trypanosoma cruzi | squalene synthase, putative | 0.0273 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0165 | 0.417 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.417 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0165 | 0.417 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0165 | 0.417 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.417 | 1 |
Onchocerca volvulus | 0.0165 | 0.417 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0165 | 0.417 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0165 | 0.417 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0165 | 0.417 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0165 | 0.417 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0165 | 0.417 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0165 | 0.417 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0165 | 0.417 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 31 nM | Dissociation constant of compound with Rev-responsive element (RRE) IIB RNA was determined by the competition assay | ChEMBL. | 11354369 |
Ratio (binding) | = 2.8 | Ratio of the dissociation constant between Rev37-50 and the PNA-peptide | ChEMBL. | 11354369 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.