Detailed information for compound 377069

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2937.39 | Formula: C126H214N44O35S
  • H donors: 39 H acceptors: 36 LogP: -13.34 Rotable bonds: 122
    Rule of 5 violations (Lipinski): 4
  • SMILES: CSCC[C@@H](C(=O)O)NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H]([C@H](CC)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)N)CC(C)C)CCC(=O)N)CCCN=C(N)N)CC(C)C)CCC(=O)N)CCCN=C(N)N)CC(C)C)CC(C)C)CCC(=O)N)C)CC(=O)N)Cc1nc[nH]c1)C)C)CC(C)C
  • InChi: 1S/C126H214N44O35S/c1-18-65(12)99(119(200)165-82(49-64(10)11)116(197)167-100(69(16)171)120(201)159-77(123(204)205)37-44-206-17)166-97(180)57-143-101(182)66(13)149-102(183)67(14)151-110(191)83(50-70-53-139-59-148-70)164-115(196)85(52-93(132)176)154-95(178)55-145-105(186)84(51-92(131)175)160-103(184)68(15)150-106(187)75(32-35-90(129)173)157-113(194)80(47-62(6)7)163-114(195)81(48-63(8)9)162-108(189)73(27-21-40-142-126(137)138)155-109(190)76(33-36-91(130)174)158-112(193)79(46-61(4)5)161-107(188)72(26-20-39-141-125(135)136)152-94(177)54-144-104(185)74(31-34-89(128)172)156-111(192)78(45-60(2)3)153-96(179)56-146-117(198)87-29-23-43-170(87)122(203)88-30-24-41-168(88)98(181)58-147-118(199)86-28-22-42-169(86)121(202)71(127)25-19-38-140-124(133)134/h53,59-69,71-88,99-100,171H,18-52,54-58,127H2,1-17H3,(H2,128,172)(H2,129,173)(H2,130,174)(H2,131,175)(H2,132,176)(H,139,148)(H,143,182)(H,144,185)(H,145,186)(H,146,198)(H,147,199)(H,149,183)(H,150,187)(H,151,191)(H,152,177)(H,153,179)(H,154,178)(H,155,190)(H,156,192)(H,157,194)(H,158,193)(H,159,201)(H,160,184)(H,161,188)(H,162,189)(H,163,195)(H,164,196)(H,165,200)(H,166,180)(H,167,197)(H,204,205)(H4,133,134,140)(H4,135,136,141)(H4,137,138,142)/t65-,66-,67-,68-,69+,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,99-,100-/m0/s1
  • InChiKey: WGMOJBHHMACBCG-GWQFQBPDSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hypocretin (orexin) receptor 1 Starlite/ChEMBL References
Homo sapiens hypocretin (orexin) receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Get druggable targets OG5_127863 All targets in OG5_127863
Echinococcus multilocularis neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
Echinococcus granulosus neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
Echinococcus multilocularis G protein coupled receptor 139 Get druggable targets OG5_127863 All targets in OG5_127863
Schistosoma mansoni neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus sex peptide receptor hypocretin (orexin) receptor 1 425 aa 350 aa 23.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor 0.0131 0.1394 0.1386
Echinococcus granulosus NADP dependent malic enzyme 0.0025 0.0139 0.0139
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0708 0.069
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0029 0.001
Trypanosoma brucei cysteine peptidase, putative 0.0035 0.0253 0.1272
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0147 0.158 0.1572
Echinococcus granulosus tachykinin peptides receptor 99D 0.0127 0.1344 0.1405
Loa Loa (eye worm) hypothetical protein 0.0073 0.0708 0.0708
Brugia malayi nuclear hormone receptor family member odr-7 0.0131 0.1394 0.1382
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.04 0.4572 0.4567
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0127 0.1344 0.1344
Echinococcus multilocularis neuronal calcium sensor 0.003 0.0194 0.0197
Entamoeba histolytica grainin, putative 0.003 0.0199 0.1804
Schistosoma mansoni importin beta-1 0.003 0.0192 0.0183
Trichomonas vaginalis calcium binding proteins, putative 0.003 0.0194 0.0176
Brugia malayi Cathepsin L-like precursor 0.0016 0.0029 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0016 0.0029 0.001
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0127 0.1344 0.1405
Schistosoma mansoni cathepsin S (C01 family) 0.0016 0.0029 0.002
Echinococcus granulosus neurocalcin 0.003 0.0194 0.0197
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.052 0.052
Onchocerca volvulus 0.0016 0.0029 0.005
Onchocerca volvulus 0.0127 0.1344 0.4264
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0035 0.0253 0.0234
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0009 0.0003
Brugia malayi RE15519p 0.0127 0.1344 0.1332
Loa Loa (eye worm) EF hand family protein 0.003 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0131 0.1394 0.1386
Brugia malayi cathepsin Z-like cysteine proteinase 0.0016 0.0029 0.0016
Schistosoma mansoni hypothetical protein 0.0127 0.1344 0.1336
Mycobacterium ulcerans lipase LipD 0.0073 0.0708 0.0649
Mycobacterium ulcerans glutaminase 0.0859 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0286 0.0293
Schistosoma mansoni hypothetical protein 0.0317 0.3591 0.3585
Trypanosoma brucei Calpain-like protein 1.1 0.0035 0.0253 0.1272
Echinococcus granulosus tm gpcr rhodopsin 0.0127 0.1344 0.1405
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0278 0.3134 0.3125
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0016 0.0029 0.001
Echinococcus multilocularis programmed cell death protein 0.0045 0.0373 0.0385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0029 0.01
Brugia malayi Tachykinin-like peptides receptor 99D 0.0127 0.1344 0.1332
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0708 0.069
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0035 0.0253 0.0382
Toxoplasma gondii kringle domain-containing protein 0.0071 0.0679 0.3498
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0184 0.0171
Schistosoma mansoni amine GPCR 0.0127 0.1344 0.1336
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.027 0.0277
Loa Loa (eye worm) hypothetical protein 0.0131 0.1394 0.1394
Echinococcus multilocularis EF HAND 1, calcium binding site 0.003 0.0194 0.0197
Toxoplasma gondii EF hand domain-containing protein 0.0015 0.0019 0.0028
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0099 0.0086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0029 0.01
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Brugia malayi Cathepsin L-like precursor 0.0016 0.0029 0.0016
Echinococcus multilocularis geminin 0.0183 0.2002 0.2096
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Loa Loa (eye worm) NADP-malic enzyme 0.0019 0.0061 0.0061
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0029 0.0024
Plasmodium vivax unspecified product 0.0016 0.0029 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0194 0.0176
Schistosoma mansoni mitochondrial solute carrier 0.003 0.0194 0.0185
Echinococcus granulosus glutamate NMDA receptor subunit 0.0062 0.0572 0.0594
Loa Loa (eye worm) myosin Light Chain family member 0.0016 0.0024 0.0024
Onchocerca volvulus 0.0016 0.0029 0.005
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0127 0.1344 0.1332
Echinococcus granulosus calcyphosin protein 0.0015 0.0019 0.0013
Leishmania major centrin, putative,caltractin, putative 0.003 0.0194 0.0874
Brugia malayi cathepsin L-like cysteine proteinase 0.0016 0.0029 0.0016
Plasmodium vivax hypothetical protein, conserved 0.003 0.0199 0.1278
Toxoplasma gondii centrin 0.003 0.0194 0.0949
Brugia malayi Neuronal calcium sensor family protein 1 0.0015 0.0019 0.0005
Loa Loa (eye worm) hypothetical protein 0.0131 0.1394 0.1394
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0016 0.0029 0.001
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Trypanosoma cruzi centrin, putative 0.0045 0.0373 0.0579
Loa Loa (eye worm) hypothetical protein 0.0131 0.1394 0.1394
Loa Loa (eye worm) TK/ROR protein kinase 0.0071 0.0679 0.0679
Entamoeba histolytica calcium binding family protein 0.003 0.0194 0.175
Trypanosoma cruzi malic enzyme, putative 0.0025 0.0139 0.0196
Trichomonas vaginalis myosin light chain 1, putative 0.003 0.0194 0.0176
Giardia lamblia Cathepsin B precursor 0.0016 0.0029 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0131 0.1394 0.1457
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0278 0.3134 0.3125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0029 0.0024
Loa Loa (eye worm) myosin regulatory light chain 1 0.0015 0.0019 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0086 0.0401
Echinococcus granulosus somatostatin receptor 0.0127 0.1344 0.1405
Echinococcus multilocularis rhodopsin orphan GPCR 0.0127 0.1344 0.1405
Schistosoma mansoni alpha-1 adrenergic receptor 0.0127 0.1344 0.1336
Echinococcus multilocularis importin subunit beta 1 0.003 0.0192 0.0195
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.003 0.0194 0.0287
Loa Loa (eye worm) hypothetical protein 0.0131 0.1394 0.1394
Plasmodium vivax unspecified product 0.0016 0.0029 0.0073
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0051 0.0051
Trichomonas vaginalis calcium binding protein, putative 0.003 0.0194 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0086 0.0401
Echinococcus granulosus calpain 5 0.0135 0.1433 0.1498
Onchocerca volvulus 0.0127 0.1344 0.4264
Brugia malayi nuclear hormone receptor 0.0131 0.1394 0.1382
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0086 0.0401
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0194
Schistosoma mansoni calmodulin related calcium binding protein 0.003 0.0194 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Schistosoma mansoni adenoreceptor 0.0127 0.1344 0.1336
Loa Loa (eye worm) nuclear hormone receptor 0.0131 0.1394 0.1394
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0127 0.1344 0.1336
Trypanosoma cruzi I/6 autoantigen, putative 0.003 0.0194 0.0287
Brugia malayi CXXC zinc finger family protein 0.0057 0.052 0.0508
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0127 0.1344 0.1336
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0035 0.0253 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0029 0.005
Echinococcus multilocularis g protein coupled receptor 0.0127 0.1344 0.1405
Plasmodium falciparum cysteine proteinase falcipain 1 0.0016 0.0029 0.0156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0029 0.01
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0176 0.1918 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0029 0.0016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0278 0.3134 0.3285
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0016 0.0029 0.0073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0127 0.1344 0.1405
Brugia malayi Protein kinase domain containing protein 0.0071 0.0679 0.0667
Trichomonas vaginalis calcium binding protein, putative 0.0045 0.0373 0.0355
Trichomonas vaginalis calcium binding protein, putative 0.003 0.0194 0.0176
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0029 0.01
Echinococcus multilocularis snurportin 1 0.0317 0.3591 0.3765
Echinococcus multilocularis neurocalcin 0.003 0.0194 0.0197
Brugia malayi larval opioid receptor 0.0127 0.1344 0.1332
Plasmodium falciparum serine repeat antigen 3 0.0016 0.0029 0.0156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0029 0.01
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0184 0.0184
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Echinococcus granulosus NADP dependent malic enzyme 0.0025 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0131 0.1394 0.1394
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.3591 0.3591
Entamoeba histolytica hypothetical protein, conserved 0.003 0.0199 0.1804
Schistosoma mansoni thyroid hormone receptor 0.0278 0.3134 0.3127
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0086 0.0111
Echinococcus multilocularis calcyphosin protein 0.0015 0.0019 0.0013
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0016 0.0029 0.002
Schistosoma mansoni biogenic amine receptor 0.0127 0.1344 0.1336
Schistosoma mansoni calpain C (C02 family) 0.0135 0.1433 0.1425
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0127 0.1344 0.1336
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0127 0.1344 0.1405
Loa Loa (eye worm) hypothetical protein 0.0147 0.158 0.158
Plasmodium falciparum serine repeat antigen 8 0.0016 0.0029 0.0156
Trypanosoma brucei Calpain-like protein 1.2 0.0035 0.0253 0.1272
Echinococcus multilocularis dnaJ subfamily B 0.0819 0.9528 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0708 0.0699
Loa Loa (eye worm) hypothetical protein 0.0029 0.0184 0.0184
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0029 0.0016
Echinococcus granulosus lamin 0.0029 0.0184 0.0187
Toxoplasma gondii centrin family protein 0.0015 0.0019 0.0028
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0029 0.01
Leishmania major DNA polymerase kappa, putative 0.0021 0.0086 0.0304
Plasmodium vivax serine-repeat antigen (SERA) 0.0016 0.0029 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0278 0.3134 0.3134
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.1918 0.191
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0099 0.0099
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0086 0.0073
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0099 0.1211
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0016 0.0029 0.0073
Entamoeba histolytica calpain large subunit domain III containing protein 0.01 0.102 1
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0029 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0029 0.01
Brugia malayi conserved hypotetical protein 0.0131 0.1394 0.1382
Trichomonas vaginalis calmodulin, putative 0.003 0.0199 0.0181
Giardia lamblia Cathepsin B precursor 0.0176 0.1918 1
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0127 0.1344 0.1336
Schistosoma mansoni lamin 0.0029 0.0184 0.0175
Echinococcus multilocularis calpain A 0.04 0.4577 0.4801
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0286 0.1888
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0016 0.0029 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0029 0.01
Leishmania major importin beta-1 subunit, putative 0.0024 0.0125 0.0509
Trichomonas vaginalis malic enzyme, putative 0.0025 0.0139 0.012
Echinococcus granulosus NADP dependent malic enzyme 0.0025 0.0139 0.0139
Schistosoma mansoni reticulocalbin 0.003 0.0199 0.019
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0029 0.0016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0147 0.158 0.1572
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0016 0.0029 0.0054
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0016 0.0029 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0029
Brugia malayi Melatonin receptor type 1A 0.0127 0.1344 0.1332
Brugia malayi EF hand family protein 0.003 0.0194 0.0181
Schistosoma mansoni amine GPCR 0.0127 0.1344 0.1336
Onchocerca volvulus 0.0016 0.0029 0.005
Loa Loa (eye worm) hypothetical protein 0.0278 0.3134 0.3134
Echinococcus multilocularis FTZ F1 alpha 0.0278 0.3134 0.3285
Echinococcus granulosus neuropeptide receptor 0.0251 0.2804 0.2939
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0127 0.1344 0.1336
Brugia malayi Cathepsin L-like cysteine proteinase 0.0016 0.0029 0.0016
Echinococcus granulosus neuropeptide s receptor 0.0127 0.1344 0.1405
Schistosoma mansoni opsin-like receptor 0.0127 0.1344 0.1336
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0278 0.3134 0.3285
Brugia malayi calpain family protein 1 0.037 0.4218 0.421
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0016 0.0029 0.0073
Trypanosoma brucei I/6 autoantigen 0.003 0.0194 0.0965
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0029 0.001
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0099 0.0421
Brugia malayi calpain D 0.0035 0.0253 0.024
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0086 0.0073
Plasmodium vivax calpain, putative 0.0135 0.1433 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1433 0.7432
Trypanosoma brucei calpain-like protein, putative 0.0135 0.1433 0.7458
Echinococcus multilocularis Calcium binding protein 0.0015 0.0019 0.0013
Brugia malayi calcium-binding protein 0.003 0.0194 0.0181
Echinococcus granulosus calpain 0.0135 0.1433 0.1498
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0029 0.01
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0029 0.01
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0009 0.0003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0051 0.0047
Trypanosoma cruzi calmodulin, putative 0.003 0.0194 0.0287
Trypanosoma cruzi conserved protein 0.0035 0.0253 0.0382
Schistosoma mansoni neuropeptide F-like receptor 0.0127 0.1344 0.1336
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.1129 0.5858
Toxoplasma gondii ABC1 family protein 0.0073 0.0708 0.3647
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1433 0.2312
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0127 0.1344 0.1405
Schistosoma mansoni neuronal calcium sensor 0.003 0.0194 0.0185
Entamoeba histolytica cysteine proteinase 2 0.0016 0.0029 0.0103
Echinococcus multilocularis cathepsin L 0.0016 0.0029 0.0024
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0016 0.0029 0.002
Brugia malayi G-protein coupled receptor 0.0127 0.1344 0.1332
Echinococcus multilocularis cysteine protease 0.0016 0.0029 0.0024
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0086 0.0068
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0016 0.0029 0.0073
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0013 0.0013
Trypanosoma brucei mitochondrial calcium uptake 1 0.003 0.0194 0.0965
Schistosoma mansoni nuclear receptor 0.0131 0.1394 0.1386
Echinococcus multilocularis musashi 0.0029 0.0184 0.0187
Echinococcus multilocularis calpain 7 (C02 family) 0.0135 0.1433 0.1498
Echinococcus multilocularis rhodopsin orphan GPCR 0.0127 0.1344 0.1405
Schistosoma mansoni hypothetical protein 0.0047 0.0395 0.0387
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0127 0.1344 0.1344
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0029 0.002
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0127 0.1344 0.1405
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0708 0.069
Trypanosoma cruzi major cysteine proteinase, putative 0.0016 0.0029 0.0017
Onchocerca volvulus 0.0127 0.1344 0.4264
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0286 0.2665
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.0382
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0051 0.0047
Echinococcus granulosus tm gpcr rhodopsin 0.0127 0.1344 0.1405
Mycobacterium tuberculosis Conserved protein 0.0073 0.0708 0.1213
Brugia malayi EF hand family protein 0.003 0.0199 0.0186
Onchocerca volvulus 0.0131 0.1394 0.4424
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.003 0.0194 0.0176
Giardia lamblia Encystation-specific protease 0.0016 0.0029 0.0054
Echinococcus granulosus geminin 0.0183 0.2002 0.2096
Echinococcus multilocularis g protein coupled receptor 0.0127 0.1344 0.1405
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0278 0.3134 0.3285
Schistosoma mansoni ran 0.0022 0.0099 0.009
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0086 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Onchocerca volvulus 0.003 0.0199 0.0596
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0708 0.1213
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0278 0.3134 0.3125
Trypanosoma brucei kinesin, putative 0.01 0.102 0.5295
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0708 0.0737
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Mycobacterium ulcerans malate dehydrogenase 0.0025 0.0139 0.0077
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0009 0.0003
Trichomonas vaginalis ran, putative 0.0022 0.0099 0.008
Brugia malayi cathepsin L-like precursor 0.0016 0.0029 0.0016
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.003 0.0194 0.0287
Trichomonas vaginalis calmodulin, putative 0.0045 0.0373 0.0355
Schistosoma mansoni calpain-7 (C02 family) 0.0135 0.1433 0.1425
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.003 0.0194 0.175
Loa Loa (eye worm) hypothetical protein 0.0131 0.1394 0.1394
Echinococcus granulosus g protein coupled receptor 0.0127 0.1344 0.1405
Trypanosoma cruzi malic enzyme 0.0025 0.0139 0.0196
Echinococcus granulosus 7tm_1 domain containing protein 0.0127 0.1344 0.1405
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0053 0.0466 0.0483
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0029 0.01
Leishmania major DNA polymerase eta, putative 0.0021 0.0086 0.0304
Brugia malayi hypothetical protein 0.0127 0.1344 0.1332
Mycobacterium tuberculosis Conserved protein 0.0073 0.0708 0.1213
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1433 0.7432
Trypanosoma cruzi malic enzyme 0.0025 0.0139 0.0196
Onchocerca volvulus 0.0127 0.1344 0.4264
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Trichomonas vaginalis calpain, putative 0.0035 0.0253 0.0234
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0708 0.0695
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0127 0.1344 0.1405
Loa Loa (eye worm) glutaminase 0.0859 1 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0016 0.0029 0.0103
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0035 0.0253 0.0234
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0086 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0029 0.001
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0016 0.0029 0.0017
Giardia lamblia Hypothetical protein 0.0016 0.0029 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Trypanosoma brucei NADP-dependent malic enzyme, cytosolic 0.0025 0.0139 0.0674
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0708 0.3659
Trypanosoma cruzi cruzipain precursor, putative 0.0016 0.0029 0.0017
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1184
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0086 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0278 0.3134 0.3125
Leishmania major protein kinase, putative 0.003 0.0194 0.0874
Echinococcus multilocularis g protein coupled receptor 0.0127 0.1344 0.1405
Leishmania major hypothetical protein, unknown function 0.0035 0.0253 0.1184
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1184
Echinococcus granulosus rhodopsin orphan GPCR 0.0127 0.1344 0.1405
Onchocerca volvulus 0.0127 0.1344 0.4264
Brugia malayi hypothetical protein 0.0147 0.158 0.1569
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0135 0.1433 0.2312
Loa Loa (eye worm) G-protein coupled receptor 0.0127 0.1344 0.1344
Loa Loa (eye worm) calmodulin-like protein 0.003 0.0194 0.0194
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1184
Onchocerca volvulus Neuropeptide F receptor homolog 0.0127 0.1344 0.4264
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Loa Loa (eye worm) neuropeptide F receptor 0.0127 0.1344 0.1344
Entamoeba histolytica hypothetical protein 0.0024 0.0125 0.1062
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0009 0.0003
Giardia lamblia Cathepsin B precursor 0.0176 0.1918 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0131 0.1394 0.4424
Loa Loa (eye worm) hypothetical protein 0.037 0.4218 0.4218
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0278 0.3134 0.3285
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.0382
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0029 0.0017
Leishmania major programmed cell death 6 protein-like protein 0.003 0.0194 0.0874
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1184
Schistosoma mansoni neuropeptide receptor 0.0127 0.1344 0.1336
Trypanosoma cruzi cysteine proteinase, putative 0.0016 0.0029 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0708 0.1127
Onchocerca volvulus 0.0073 0.0708 0.2226
Echinococcus granulosus serotonin receptor 0.0127 0.1344 0.1405
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0125 0.0174
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0127 0.1344 0.1332
Plasmodium falciparum calpain 0.0035 0.0253 0.3541
Trypanosoma brucei unspecified product 0.0021 0.0086 0.0401
Plasmodium falciparum serine repeat antigen 7 0.0016 0.0029 0.0156
Onchocerca volvulus 0.0016 0.0029 0.005
Echinococcus granulosus 7TM GPCR rhodopsin 0.0127 0.1344 0.1405
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0708 0.069
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0532 0.6135 1
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0278 0.3134 0.3127
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0286 0.0273
Echinococcus multilocularis NADP dependent malic enzyme 0.0025 0.0139 0.0139
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0099 0.0465
Echinococcus multilocularis nuclear receptor nhr 48 0.0131 0.1394 0.1457
Trypanosoma cruzi centrin-3 0.0045 0.0373 0.0579
Plasmodium falciparum serine repeat antigen 1 0.0016 0.0029 0.0156
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0532 0.6135 0.6132
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0086 0.0401
Trichomonas vaginalis malic enzyme, putative 0.0025 0.0139 0.012
Echinococcus multilocularis Myosin regulatory light chain 0.0015 0.0019 0.0013
Brugia malayi Kringle domain containing protein 0.0071 0.0679 0.0667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0029 0.01
Schistosoma mansoni calpain-2 (C02 family) 0.0035 0.0253 0.0244
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0127 0.1344 0.1405
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0127 0.1344 0.1405
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0048 0.0035
Trypanosoma cruzi kinesin, putative 0.01 0.102 0.1637
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0278 0.3134 0.3134
Brugia malayi Nuclear hormone receptor-like 1 0.0278 0.3134 0.3125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Trichomonas vaginalis malic enzyme, putative 0.0025 0.0139 0.012
Toxoplasma gondii troponin c, isotype gamma, putative 0.003 0.0194 0.0949
Echinococcus multilocularis rhodopsin orphan GPCR 0.0127 0.1344 0.1405
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0131 0.1394 0.1457
Echinococcus granulosus neuropeptide receptor A26 0.0127 0.1344 0.1405
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0029 0.0103
Onchocerca volvulus Protein ultraspiracle homolog 0.0278 0.3134 1
Brugia malayi nuclear receptor RXR 0.0147 0.158 0.1569
Brugia malayi Nuclear hormone receptor E75 0.0131 0.1394 0.1382
Echinococcus granulosus Calcium binding protein 0.0015 0.0019 0.0013
Brugia malayi RNA, U transporter 1 0.0084 0.0839 0.0827
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0286 0.1445
Onchocerca volvulus 0.0127 0.1344 0.4264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.001
Echinococcus granulosus cathepsin l1 0.0016 0.0029 0.0024
Schistosoma mansoni neuropeptide receptor 0.0127 0.1344 0.1336
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0029 0.005
Schistosoma mansoni reticulocalbin 0.003 0.0194 0.0185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.001
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.0149 0.015
Schistosoma mansoni calpain (C02 family) 0.0135 0.1433 0.1425
Trypanosoma cruzi malic enzyme, putative 0.0025 0.0139 0.0196
Echinococcus multilocularis cpg binding protein 0.0061 0.0559 0.0581
Brugia malayi calpain family protein 1 0.037 0.4218 0.421
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0029
Echinococcus granulosus orexin receptor type 2 0.0127 0.1344 0.1405
Echinococcus granulosus rhodopsin orphan GPCR 0.0127 0.1344 0.1405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.1344 0.1336
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0127 0.1344 0.1344
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0035 0.0253 0.0234
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0131 0.1394 0.1382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0278 0.3134 0.3134
Echinococcus multilocularis neuropeptide FF receptor 2 0.0127 0.1344 0.1405
Onchocerca volvulus Malic enzyme homolog 0.0025 0.0139 0.0401
Brugia malayi cathepsin Z-like cysteine proteinase 0.0016 0.0029 0.0016
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0016 0.0029 0.0073
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Mycobacterium leprae Probable lipase LipE 0.0073 0.0708 0.5
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Echinococcus multilocularis rhodopsin orphan GPCR 0.0127 0.1344 0.1405
Echinococcus granulosus allatostatin A receptor 0.0127 0.1344 0.1405
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Echinococcus granulosus rhodopsin orphan GPCR 0.0127 0.1344 0.1405
Trypanosoma brucei Calpain-like protein 2 0.0035 0.0253 0.1272
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0029
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0532 0.6135 0.6132
Trichomonas vaginalis calmodulin, putative 0.003 0.0194 0.0176
Trypanosoma brucei Calpain-like protein CALP1.3 0.0035 0.0253 0.1272
Trichomonas vaginalis calmodulin, putative 0.003 0.0194 0.0176
Giardia lamblia Cathepsin B precursor 0.0016 0.0029 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0278 0.3134 0.3125
Echinococcus granulosus hypothetical protein 0.0127 0.1344 0.1405
Schistosoma mansoni nuclear hormone receptor 0.0278 0.3134 0.3127
Echinococcus multilocularis cysteine protease 0.0016 0.0029 0.0024
Echinococcus granulosus neuronal calcium sensor 0.003 0.0194 0.0197
Trichomonas vaginalis centrin, putative 0.003 0.0194 0.0176
Echinococcus granulosus nuclear factor of activated T cells 5 0.0053 0.0466 0.0483
Brugia malayi beta-lactamase family protein 0.0073 0.0708 0.0695
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0035 0.0253 0.0234
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1184
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Giardia lamblia Cathepsin L-like protease 0.0016 0.0029 0.0054
Schistosoma mansoni hypothetical protein 0.003 0.0194 0.0185
Entamoeba histolytica calcium-binding protein, putative 0.003 0.0194 0.175
Leishmania major centrin, putative 0.003 0.0194 0.0874
Onchocerca volvulus 0.0073 0.0708 0.2226
Onchocerca volvulus 0.003 0.0194 0.0579
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0194
Onchocerca volvulus 0.0015 0.0019 0.0017
Schistosoma mansoni cathepsin B (C01 family) 0.0016 0.0029 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.001
Schistosoma mansoni ef hand domain family member A2 0.003 0.0194 0.0185
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0035 0.0253 0.0382
Echinococcus multilocularis cathepsin b 0.0532 0.6135 0.6437
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0086 0.0084
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0029
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0029 0.002
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Giardia lamblia Cathepsin L precursor 0.0016 0.0029 0.0054
Schistosoma mansoni steroid hormone receptor ad4bp 0.0278 0.3134 0.3127
Echinococcus granulosus neuropeptide Y receptor 0.0127 0.1344 0.1405
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0086 0.0077
Giardia lamblia Cathepsin L precursor 0.0016 0.0029 0.0054
Trypanosoma brucei calmodulin, putative 0.003 0.0199 0.0993
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0029 0.0103
Echinococcus multilocularis EF hand domain containing family member A2 0.003 0.0194 0.0197
Onchocerca volvulus 0.0016 0.0029 0.005
Trichomonas vaginalis malic enzyme, putative 0.0025 0.0139 0.012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0253 0.0253
Loa Loa (eye worm) neuropeptide F receptor 0.0127 0.1344 0.1344
Echinococcus multilocularis dro:myosuppressin receptor 0.0127 0.1344 0.1405
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.0382
Schistosoma mansoni hypothetical protein 0.0035 0.0253 0.0244
Onchocerca volvulus 0.0278 0.3134 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.001
Echinococcus multilocularis neuropeptide receptor 0.0251 0.2804 0.2939
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1272
Brugia malayi nuclear receptor NHR-88 0.0278 0.3134 0.3125
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0016 0.0029 0.0073
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0086 0.0045
Brugia malayi cathepsin F-like cysteine proteinase 0.0016 0.0029 0.0016
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.003 0.0194 0.0185
Schistosoma mansoni DNA polymerase eta 0.0021 0.0086 0.0077
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0708 0.1213
Onchocerca volvulus 0.0016 0.0029 0.005
Brugia malayi programmed cell death protein 6 0.003 0.0194 0.0181
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0029 0.0029
Giardia lamblia Cathepsin B precursor 0.0016 0.0029 0.0054
Schistosoma mansoni centrin-related 0.003 0.0194 0.0185
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.0382
Brugia malayi RasGEF domain containing protein 0.0015 0.0019 0.0005
Onchocerca volvulus 0.0127 0.1344 0.4264
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0469 0.5384 1
Leishmania major calcineurin B subunit, putative 0.003 0.0194 0.0874
Brugia malayi Cathepsin L-like precursor 0.0016 0.0029 0.0016
Trypanosoma brucei hypothetical protein 0.0035 0.0253 0.1272
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0127 0.1344 0.1405
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0035 0.0253 0.0234
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0016 0.0029 0.0017
Entamoeba histolytica hypothetical protein 0.0036 0.027 0.251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Toxoplasma gondii calmodulin CAM1 0.003 0.0199 0.0977
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0192 0.0936
Onchocerca volvulus 0.0016 0.0029 0.005
Trichomonas vaginalis calmodulin, putative 0.003 0.0194 0.0176
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0278 0.3134 0.3285
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0127 0.1344 0.1332
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0099 0.0448
Echinococcus granulosus FTZ F1 alpha 0.0278 0.3134 0.3285
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.003 0.0194 0.0197
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0099 0.0097
Schistosoma mansoni lamin 0.0029 0.0184 0.0175
Loa Loa (eye worm) hypothetical protein 0.0073 0.0708 0.0708
Schistosoma mansoni amine GPCR 0.0127 0.1344 0.1336
Trichomonas vaginalis glutaminase, putative 0.0859 1 1
Plasmodium vivax importin-beta 2, putative 0.003 0.0192 0.1222
Onchocerca volvulus 0.0127 0.1344 0.4264
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0086 0.0111
Loa Loa (eye worm) steroid hormone receptor 0.0278 0.3134 0.3134
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0286 0.0419
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Trichomonas vaginalis malic enzyme, putative 0.0019 0.0061 0.0043
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0708 0.5
Brugia malayi Cathepsin L-like precursor 0.0016 0.0029 0.0016
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1433 0.2312
Leishmania major calmodulin-like protein 0.003 0.0194 0.0874
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0278 0.3134 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0127 0.1344 0.1332
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Giardia lamblia Malic enzyme 0.0025 0.0139 0.0631
Echinococcus granulosus thyroid hormone receptor alpha 0.0131 0.1394 0.1457
Brugia malayi hypothetical protein 0.0127 0.1344 0.1332
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0029 0.0024
Echinococcus granulosus neuropeptide receptor 0.0127 0.1344 0.1405
Giardia lamblia Cathepsin L precursor 0.0016 0.0029 0.0054
Schistosoma mansoni cpg binding protein 0.0057 0.052 0.0512
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0278 0.3134 0.3285
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0131 0.1394 0.1394
Echinococcus granulosus EF hand domain containing family member A2 0.003 0.0194 0.0197
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.027 0.0261
Echinococcus granulosus biogenic amine 5HT receptor 0.0372 0.4241 0.4448
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0016 0.0029 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0127 0.1344 0.1405
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Echinococcus granulosus calmodulin 0.003 0.0194 0.0197
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0013
Toxoplasma gondii centrin, putative 0.003 0.0194 0.0949
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0127 0.1344 0.1336
Onchocerca volvulus Bile acid receptor homolog 0.0278 0.3134 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0131 0.1394 0.1457
Brugia malayi Serotonin receptor 0.0127 0.1344 0.1332
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.001
Trypanosoma cruzi I/6 autoantigen, putative 0.003 0.0194 0.0287
Echinococcus granulosus calpain 7 C02 family 0.0135 0.1433 0.1498
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1433 0.7458
Giardia lamblia Cysteine protease 0.0016 0.0029 0.0054
Brugia malayi Nuclear hormone receptor-like 1 0.0147 0.158 0.1569
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0035 0.0253 0.1272
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0013
Trypanosoma cruzi cysteine proteinase, putative 0.0016 0.0029 0.0017
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Echinococcus granulosus dnaJ subfamily B 0.0819 0.9528 1
Schistosoma mansoni neuronal calcium sensor 0.003 0.0194 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0016 0.0029 0.001
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Loa Loa (eye worm) hypothetical protein 0.0278 0.3134 0.3134
Leishmania major GTP-binding protein, putative 0.0022 0.0099 0.0369
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0127 0.1344 0.1405
Brugia malayi hypothetical protein 0.0131 0.1394 0.1382
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0086 0.0084
Trichomonas vaginalis calcineurin B subunit, putative 0.003 0.0194 0.0176
Loa Loa (eye worm) hypothetical protein 0.0278 0.3134 0.3134
Giardia lamblia Cathepsin L precursor 0.0016 0.0029 0.0054
Onchocerca volvulus 0.0127 0.1344 0.4264
Brugia malayi hypothetical protein 0.0131 0.1394 0.1382
Brugia malayi hypothetical protein 0.0127 0.1344 0.1332
Brugia malayi ecdysteroid receptor 0.0278 0.3134 0.3125
Schistosoma mansoni neuronal calcium sensor 0.003 0.0194 0.0185
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0099 0.0566
Loa Loa (eye worm) hypothetical protein 0.0071 0.0679 0.0679
Schistosoma mansoni zinc finger protein 0.0131 0.1394 0.1386
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0016 0.0029 0.0073
Echinococcus granulosus calumenin 0.003 0.0199 0.0203
Trichomonas vaginalis malic enzyme, putative 0.0025 0.0139 0.012
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1184
Echinococcus granulosus calpain A 0.04 0.4577 0.4801
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0086 0.0077
Schistosoma mansoni retinoic acid receptor RXR 0.0278 0.3134 0.3127
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0016 0.0029 0.001
Loa Loa (eye worm) hypothetical protein 0.0147 0.158 0.158
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0086 0.0401
Schistosoma mansoni amine GPCR 0.0127 0.1344 0.1336
Giardia lamblia Cysteine protease 0.0016 0.0029 0.0054
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0278 0.3134 0.3285
Giardia lamblia Cysteine protease 0.0016 0.0029 0.0054
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0099 0.0097
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0029 0.0024
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Echinococcus granulosus rhodopsin orphan GPCR 0.0127 0.1344 0.1405
Toxoplasma gondii calmodulin, putative 0.0015 0.0019 0.0028
Entamoeba histolytica cysteine proteinase 1, putative 0.0016 0.0029 0.0103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0278 0.3134 0.3134
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0184 0.0184
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0035 0.0253 0.0382
Echinococcus granulosus calbindin 32 0.003 0.0199 0.0203
Giardia lamblia Cathepsin L precursor 0.0016 0.0029 0.0054
Echinococcus multilocularis fmrfamide receptor 0.0127 0.1344 0.1405
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0029 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.001
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Echinococcus multilocularis programmed cell death protein 0.0045 0.0373 0.0385
Loa Loa (eye worm) hypothetical protein 0.0235 0.2626 0.2626
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0016 0.0029 0.001
Mycobacterium tuberculosis Probable [NAD] dependent malate oxidoreductase Mez (malic enzyme) (NAD-malic enzyme) (malate dehydrogenase (oxaloacetate decarbo 0.0025 0.0139 0.0143
Toxoplasma gondii cathepsin CPC2 0.0016 0.0029 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0278 0.3134 0.3125
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0086 0.0401
Plasmodium falciparum serine repeat antigen 5 0.0016 0.0029 0.0156
Leishmania major malic enzyme, putative 0.0025 0.0139 0.058
Loa Loa (eye worm) hypothetical protein 0.0073 0.0708 0.0708
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0029 0.002
Brugia malayi nuclear receptor NHR-67 0.0131 0.1394 0.1382
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0278 0.3134 0.3285
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0025 0.0025
Loa Loa (eye worm) fibroinase 0.0016 0.0029 0.0029
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1267 0.1267
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0131 0.1394 0.1457
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.003 0.0194 0.0287
Loa Loa (eye worm) G-protein coupled receptor 0.0127 0.1344 0.1344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0278 0.3134 0.3134
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.1344 0.1336
Onchocerca volvulus 0.0127 0.1344 0.4264
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0708 0.0737
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0278 0.3134 0.3125
Echinococcus granulosus tm gpcr rhodopsin 0.0127 0.1344 0.1405
Toxoplasma gondii preprocathepsin c precursor, putative 0.0016 0.0029 0.0082
Echinococcus multilocularis ecdysone induced protein 78C 0.0278 0.3134 0.3285
Plasmodium vivax vivapain-3 0.0016 0.0029 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0029 0.01
Loa Loa (eye worm) hypothetical protein 0.0372 0.4241 0.4241
Echinococcus granulosus cathepsin L 0.0016 0.0029 0.0024
Entamoeba histolytica grainin 2 0.0045 0.0373 0.3534
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0194 0.0176
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0029
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0099 0.0131
Echinococcus multilocularis calpain 5 0.0135 0.1433 0.1498
Echinococcus multilocularis hypothetical protein 0.0135 0.1433 0.1498
Brugia malayi hypothetical protein 0.0036 0.027 0.0257
Brugia malayi follicle stimulating hormone receptor 0.0127 0.1344 0.1332
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1433 0.2312
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0127 0.1344 0.1405
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.0149 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0016 0.0029 0.001
Loa Loa (eye worm) hypothetical protein 0.023 0.2562 0.2562
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0029 0.002
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Onchocerca volvulus 0.0029 0.0184 0.0548
Giardia lamblia Cathepsin B precursor 0.0016 0.0029 0.0054
Giardia lamblia DINP protein human, muc B family 0.0021 0.0086 0.0356
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0278 0.3134 0.3125
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0013 0.0013
Leishmania major kinesin, putative 0.01 0.102 0.5248
Trypanosoma brucei calpain-like protein, putative 0.0135 0.1433 0.7458
Brugia malayi nuclear receptor NHR-88 0.0131 0.1394 0.1382
Toxoplasma gondii calmodulin CAM2 0.0015 0.0019 0.0028
Leishmania major centrin, putative 0.003 0.0194 0.0874
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0127 0.1344 0.1336
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0035 0.0253 0.1257
Trypanosoma brucei calpain, putative 0.0035 0.0253 0.1272
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.001
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0708 0.0649
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.001
Onchocerca volvulus 0.0071 0.0679 0.2134
Brugia malayi GnHR receptor homolog 0.0127 0.1344 0.1332
Echinococcus multilocularis dna polymerase eta 0.0021 0.0086 0.0084
Echinococcus multilocularis calmodulin 0.003 0.0194 0.0197
Schistosoma mansoni histamine h1 receptor 0.0127 0.1344 0.1336
Trichomonas vaginalis calpain, putative 0.0035 0.0253 0.0234
Brugia malayi Probable myosin regulatory light chain 0.0016 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0278 0.3134 0.3134
Schistosoma mansoni biogenic amine receptor 0.0127 0.1344 0.1336
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0286 0.0436
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.001
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0176 0.1918 0.3104
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1184
Echinococcus granulosus intermediate filament protein 0.0029 0.0184 0.0187
Echinococcus granulosus rhodopsin orphan GPCR 0.0127 0.1344 0.1405
Echinococcus granulosus rhodopsin orphan GPCR 0.0127 0.1344 0.1405
Loa Loa (eye worm) hypothetical protein 0.0131 0.1394 0.1394
Schistosoma mansoni biogenic amine receptor 0.0127 0.1344 0.1336
Trichomonas vaginalis calcineurin B subunit, putative 0.003 0.0199 0.0181
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0708 0.069
Schistosoma mansoni cpg binding protein 0.0061 0.0559 0.0551
Schistosoma mansoni cpg binding protein 0.0061 0.0559 0.0551
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0029 0.0017
Echinococcus granulosus programmed cell death protein 0.0045 0.0373 0.0385
Loa Loa (eye worm) hypothetical protein 0.0147 0.158 0.158
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0035 0.0253 0.0234
Trichomonas vaginalis calpain, putative 0.0035 0.0253 0.0234
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0127 0.1344 0.1336
Echinococcus granulosus cathepsin l1 0.0016 0.0029 0.0024
Trichomonas vaginalis calmodulin, putative 0.003 0.0194 0.0176
Echinococcus multilocularis G protein coupled receptor 139 0.0251 0.2804 0.2939
Entamoeba histolytica calmodulin, putative 0.003 0.0194 0.175
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0278 0.3134 0.3285
Echinococcus multilocularis NADP dependent malic enzyme 0.0025 0.0139 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0278 0.3134 0.3125
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0029 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0025 0.0011
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0029 0.0156
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Schistosoma mansoni myosin light chain 0.0015 0.0019 0.001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0029
Trypanosoma cruzi cysteine protease, putative 0.0016 0.0029 0.0017
Trypanosoma cruzi calmodulin, putative 0.003 0.0194 0.0287
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Echinococcus multilocularis calcium uptake protein 1 0.003 0.0199 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0708 0.0649
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.001
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0176 0.1918 0.1902
Loa Loa (eye worm) cysteine protease 0.0016 0.0029 0.0029
Schistosoma mansoni nuclear receptor nhr-48 0.0131 0.1394 0.1386
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0147 0.158 0.158
Brugia malayi hypothetical protein 0.0127 0.1344 0.1332
Brugia malayi G-protein coupled receptor 0.0127 0.1344 0.1332
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.04 0.4572 0.4567
Onchocerca volvulus 0.0127 0.1344 0.4264
Echinococcus granulosus G protein coupled receptor 139 0.0127 0.1344 0.1405
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0013 0.0013
Onchocerca volvulus 0.003 0.0194 0.0579
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1184
Schistosoma mansoni hypothetical protein 0.0127 0.1344 0.1336
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.037 0.4218 0.4213
Echinococcus granulosus programmed cell death protein 6 0.0016 0.0024 0.0019
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0016 0.0029 0.002
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1184
Brugia malayi cathepsin B-like cysteine proteinase 0.0532 0.6135 0.613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Echinococcus multilocularis neuropeptide Y receptor 0.0127 0.1344 0.1405
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.1344 0.1336
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1184
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0086 0.0401
Plasmodium vivax serine-repeat antigen (SERA) 0.0016 0.0029 0.0073
Brugia malayi G protein-coupled receptor F59B2.13 0.0127 0.1344 0.1332
Loa Loa (eye worm) hypothetical protein 0.0131 0.1394 0.1394
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0016 0.0029 0.0073
Giardia lamblia Hypothetical protein 0.0016 0.0029 0.0054
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0131 0.1394 0.1457
Echinococcus granulosus biogenic amine 5HT receptor 0.0127 0.1344 0.1405
Plasmodium falciparum serine repeat antigen 6 0.0016 0.0029 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0278 0.3134 0.3134
Plasmodium falciparum serine repeat antigen 4 0.0016 0.0029 0.0156
Loa Loa (eye worm) cathepsin B 0.0176 0.1918 0.1918
Schistosoma mansoni calcium binding atopy-related autoantigen 0.003 0.0199 0.019
Brugia malayi Importin beta-1 subunit 0.003 0.0192 0.0178
Schistosoma mansoni centrin 0.003 0.0194 0.0185
Entamoeba histolytica protein kinase, putative 0.01 0.102 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.158 0.158
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0127 0.1344 0.1336
Loa Loa (eye worm) hypothetical protein 0.0278 0.3134 0.3134
Echinococcus granulosus g protein coupled receptor 0.0127 0.1344 0.1405
Trypanosoma brucei centrin-3 0.0045 0.0373 0.1901
Echinococcus granulosus peptide allatostatin:somatostatin 0.0127 0.1344 0.1405
Onchocerca volvulus 0.0131 0.1394 0.4424
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.1344 0.1336
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0029 0.0024
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.027 0.0277
Echinococcus granulosus calcium uptake protein 1 0.003 0.0199 0.0203
Leishmania major hypothetical protein, conserved 0.0071 0.0679 0.3444
Schistosoma mansoni calmodulin 0.003 0.0194 0.0185
Echinococcus granulosus neuropeptide Y receptor 0.0127 0.1344 0.1405
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0278 0.3134 0.3125
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Echinococcus granulosus dna polymerase eta 0.0021 0.0086 0.0084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0013
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.003 0.0194 0.175
Echinococcus multilocularis orexin receptor type 2 0.0127 0.1344 0.1405
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0708 0.4874
Loa Loa (eye worm) hypothetical protein 0.0029 0.0178 0.0178
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0035 0.0253 0.0382
Echinococcus multilocularis NADP dependent malic enzyme 0.0025 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Trypanosoma cruzi calmodulin, putative 0.003 0.0194 0.0287
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0086 0.0111
Plasmodium vivax vivapain-1 0.0016 0.0029 0.0073
Echinococcus granulosus Nuclear hormone receptor HR96 0.0131 0.1394 0.1457
Brugia malayi fibroinase precursor 0.0016 0.0029 0.0016
Loa Loa (eye worm) melatonin receptor type 1A 0.0127 0.1344 0.1344
Onchocerca volvulus 0.0057 0.052 0.1625
Schistosoma mansoni neuropeptide receptor 0.0127 0.1344 0.1336
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0395 0.0383
Trypanosoma brucei calpain-like protein, putative 0.0135 0.1433 0.7458
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0029 0.0103
Trypanosoma brucei centrin, putative 0.003 0.0194 0.0965
Onchocerca volvulus Malic enzyme homolog 0.0025 0.0139 0.0401
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0016 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0131 0.1394 0.1394
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Toxoplasma gondii EF hand domain-containing protein 0.003 0.0194 0.0949
Leishmania major hypothetical protein, conserved 0.003 0.0194 0.0874
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0029 0.0016
Brugia malayi hypothetical protein 0.0127 0.1344 0.1332
Onchocerca volvulus 0.0016 0.0029 0.005
Brugia malayi cathepsin L precursor 0.0016 0.0029 0.0016
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Entamoeba histolytica Ran family GTPase 0.0022 0.0099 0.0799
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0286 0.404
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0127 0.1344 0.1405
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.2562 0.2685
Leishmania major calpain protease-like protein 0.0035 0.0253 0.1184
Plasmodium falciparum cysteine repeat modular protein 1 0.0071 0.0679 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0029 0.0029
Echinococcus granulosus sex peptide receptor 0.0127 0.1344 0.1405
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0016 0.0029 0.0156
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.04 0.4572 0.4795
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.003 0.0194 0.0287
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0029
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0125 0.0107
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0029 0.0029
Brugia malayi hypothetical protein 0.0127 0.1344 0.1332
Brugia malayi Dopamine receptor protein 2 0.0127 0.1344 0.1332
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0016 0.0029 0.001
Echinococcus multilocularis thyroid hormone receptor alpha 0.0278 0.3134 0.3285
Loa Loa (eye worm) hypothetical protein 0.0131 0.1394 0.1394
Loa Loa (eye worm) hypothetical protein 0.0372 0.4241 0.4241
Onchocerca volvulus 0.0235 0.2626 0.8372
Schistosoma mansoni hypothetical protein 0.0183 0.2002 0.1995
Brugia malayi calpain 7 0.0135 0.1433 0.1421
Echinococcus multilocularis programmed cell death protein 6 0.0016 0.0024 0.0019
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0278 0.3134 0.3127
Echinococcus granulosus neuropeptide FF receptor 2 0.0127 0.1344 0.1405
Echinococcus multilocularis allatostatin A receptor 0.0127 0.1344 0.1405
Echinococcus multilocularis rhodopsin orphan GPCR 0.0127 0.1344 0.1405
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0016 0.0029 0.0103
Onchocerca volvulus Malic enzyme homolog 0.0025 0.0139 0.0401
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0029 0.0103
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0127 0.1344 0.1405
Brugia malayi MH2 domain containing protein 0.0121 0.1267 0.1255
Schistosoma mansoni neuropeptide F-like receptor 0.0127 0.1344 0.1336
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0086 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0278 0.3134 0.3125
Echinococcus multilocularis calmodulin 0.003 0.0194 0.0197
Toxoplasma gondii hypothetical protein 0.0035 0.0253 0.1257
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0708 0.1213
Schistosoma mansoni amine GPCR 0.0127 0.1344 0.1336
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0127 0.1344 0.1405
Trichomonas vaginalis centrin, putative 0.003 0.0194 0.0176
Leishmania major calmodulin, putative 0.003 0.0194 0.0874
Brugia malayi hypothetical protein 0.0127 0.1344 0.1332
Schistosoma mansoni hypothetical protein 0.003 0.0194 0.0185
Toxoplasma gondii calcium binding protein precursor, putative 0.0015 0.0019 0.0028
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0086 0.0086
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0286 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1184
Loa Loa (eye worm) hypothetical protein 0.0532 0.6135 0.6135
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Schistosoma mansoni hypothetical protein 0.0183 0.2002 0.1995
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0708 0.1213
Leishmania major phospholipase c-like protein 0.003 0.0194 0.0874
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0029 0.002
Trichomonas vaginalis hypothetical protein 0.0035 0.0253 0.0234
Plasmodium vivax vivapain-2 0.0016 0.0029 0.0073
Echinococcus granulosus cathepsin b 0.0532 0.6135 0.6437
Schistosoma mansoni calmodulin 0.003 0.0194 0.0185
Echinococcus multilocularis neuropeptides capa receptor 0.0127 0.1344 0.1405
Onchocerca volvulus 0.0127 0.1344 0.4264
Loa Loa (eye worm) hypothetical protein 0.003 0.0192 0.0192
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0016 0.0029 0.0156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.1344 0.1336
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0708 0.0699
Echinococcus multilocularis cathepsin b 0.0532 0.6135 0.6437
Echinococcus multilocularis neuropeptide receptor 0.0127 0.1344 0.1405
Onchocerca volvulus 0.0127 0.1344 0.4264
Echinococcus multilocularis sex peptide receptor 0.0127 0.1344 0.1405
Loa Loa (eye worm) calpain 5 0.01 0.102 0.102
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1433 0.2312
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0071 0.0679 0.4672
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.0382
Leishmania major hypothetical protein, conserved 0.0035 0.0253 0.1184
Echinococcus granulosus EF hand domain containing family member A2 0.003 0.0199 0.0203
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0286 0.0436
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0013
Echinococcus granulosus lamin dm0 0.0029 0.0184 0.0187
Brugia malayi hypothetical protein 0.0147 0.158 0.1569
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0253 0.0234
Schistosoma mansoni glutamate receptor NMDA 0.0062 0.0572 0.0563
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.0149 0.015
Brugia malayi intermediate filament protein 0.0029 0.0184 0.0171
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0127 0.1344 0.1405
Trypanosoma brucei centrin, putative 0.003 0.0194 0.0965
Brugia malayi nuclear hormone receptor 0.0278 0.3134 0.3125
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.0382
Echinococcus granulosus fmrfamide receptor 0.0127 0.1344 0.1405
Leishmania major hypothetical protein, conserved 0.0073 0.0708 0.3595
Schistosoma mansoni microtubule-associated protein tau 0.0697 0.8087 0.8085
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0016 0.0029 0.002
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0035 0.0253 0.0382
Echinococcus granulosus cathepsin L 0.0016 0.0029 0.0024
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Brugia malayi steroid hormone receptor 0.0278 0.3134 0.3125
Leishmania major hypothetical protein, conserved 0.003 0.0199 0.0902
Echinococcus granulosus cathepsin L cysteine protease 0.0016 0.0029 0.0024
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0131 0.1394 0.1457
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0286 0.5
Onchocerca volvulus 0.0047 0.0395 0.1224
Trypanosoma cruzi kinesin, putative 0.01 0.102 0.1637
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0286 0.0286
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0016 0.0029 0.0054
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0029 0.0017
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0013 0.0013
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0127 0.1344 0.1405
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0035 0.0253 0.0382
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0086 0.0045
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0035 0.0253 0.1272
Brugia malayi AKH receptor 0.0127 0.1344 0.1332
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Schistosoma mansoni biogenic amine (5HT) receptor 0.0372 0.4241 0.4236
Giardia lamblia Cathepsin L-like protease 0.0016 0.0029 0.0054
Echinococcus multilocularis g-protein coupled receptor 0.0127 0.1344 0.1405
Plasmodium falciparum importin beta, putative 0.003 0.0192 0.2615
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1433 0.2312
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0029
Trichomonas vaginalis calcium binding protein, putative 0.003 0.0194 0.0176
Brugia malayi ORL1-like opioid receptor 0.0127 0.1344 0.1332
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1433 0.7432
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0127 0.1344 0.1405
Brugia malayi NAD-dependent malic enzyme, mitochondrial precursor, putative 0.0025 0.0139 0.0125
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.003 0.0194 0.0965
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1272
Onchocerca volvulus 0.0015 0.0019 0.0017
Onchocerca volvulus 0.0127 0.1344 0.4264
Trypanosoma cruzi caltractin, putative 0.003 0.0194 0.0287
Brugia malayi hypothetical protein 0.0127 0.1344 0.1332
Schistosoma mansoni biogenic amine (5HT) receptor 0.0127 0.1344 0.1336
Loa Loa (eye worm) hypothetical protein 0.0278 0.3134 0.3134
Echinococcus multilocularis serotonin receptor 0.0372 0.4241 0.4448
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Echinococcus granulosus neuropeptides capa receptor 0.0127 0.1344 0.1405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0035 0.0253 0.1272
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0131 0.1394 0.4424
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Onchocerca volvulus 0.0016 0.0029 0.005
Schistosoma mansoni hypothetical protein 0.0036 0.027 0.0261
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0192 0.0952
Schistosoma mansoni neuropeptide f receptor 76f 0.0127 0.1344 0.1336
Leishmania major calmodulin, putative 0.003 0.0194 0.0874
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0127 0.1344 0.1405
Entamoeba histolytica calmodulin, putative 0.003 0.0194 0.175
Loa Loa (eye worm) hypothetical protein 0.0131 0.1394 0.1394
Echinococcus multilocularis calbindin 32 0.003 0.0199 0.0203
Plasmodium vivax vivapain-2 0.0016 0.0029 0.0073
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0029 0.0103
Brugia malayi neuropeptide F receptor 0.0127 0.1344 0.1332
Mycobacterium ulcerans beta-lactamase 0.0073 0.0708 0.0649
Entamoeba histolytica calpain family cysteine protease, putative 0.0035 0.0253 0.2336
Brugia malayi Nuclear hormone receptor-like 1 0.0147 0.158 0.1569
Schistosoma mansoni myosin regulatory light chain 0.0015 0.0019 0.001
Echinococcus multilocularis fmrfamide receptor 0.0127 0.1344 0.1405
Schistosoma mansoni ran 0.0022 0.0099 0.009
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0192 0.0952
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0029 0.0156
Echinococcus multilocularis EF hand domain containing family member A2 0.003 0.0199 0.0203
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0127 0.1344 0.1344
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0029
Brugia malayi Nuclear hormone receptor E75 0.0131 0.1394 0.1382
Echinococcus granulosus cathepsin b 0.0532 0.6135 0.6437
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0029 0.0016
Loa Loa (eye worm) hypothetical protein 0.0147 0.158 0.158
Brugia malayi NAD-dependent malic enzyme, mitochondrial precursor, putative 0.0025 0.0139 0.0125
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0278 0.3134 0.3285
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0029 0.0016
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Giardia lamblia Hypothetical protein 0.003 0.0199 0.0952
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1267 0.1267
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1184
Plasmodium falciparum serine repeat antigen 9 0.0016 0.0029 0.0156
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1433 0.2312
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0194 0.0965
Entamoeba histolytica hypothetical protein 0.0036 0.027 0.251
Schistosoma mansoni myosin regulatory light chain 0.0015 0.0019 0.001
Loa Loa (eye worm) hypothetical protein 0.0335 0.3806 0.3806
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0086 0.0401
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0127 0.1344 0.1336
Brugia malayi Cathepsin L-like precursor 0.0016 0.0029 0.0016
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0278 0.3134 0.3127
Mycobacterium tuberculosis Conserved protein 0.0073 0.0708 0.1213
Schistosoma mansoni hypothetical protein 0.0127 0.1344 0.1336
Trichomonas vaginalis esterase, putative 0.0073 0.0708 0.069
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0086 0.0401
Schistosoma mansoni hypothetical protein 0.0071 0.0679 0.0671
Brugia malayi tailless protein 0.0131 0.1394 0.1382
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1184
Trichomonas vaginalis calmodulin, putative 0.003 0.0194 0.0176
Leishmania major calmodulin-like protein 0.003 0.0194 0.0874
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0127 0.1344 0.1405
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0029 0.002
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.003 0.0194 0.124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0016 0.0029 0.0073
Loa Loa (eye worm) calpain family protein 1 0.037 0.4218 0.4218
Loa Loa (eye worm) nuclear receptor NHR-67 0.0131 0.1394 0.1394
Onchocerca volvulus 0.0127 0.1344 0.4264
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0016 0.0029 0.0073
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0016 0.0029 0.0054
Toxoplasma gondii calcium-dependent protein kinase 0.003 0.0199 0.0977
Echinococcus granulosus dna polymerase kappa 0.0021 0.0086 0.0084
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0127 0.1344 0.1336
Loa Loa (eye worm) hypothetical protein 0.027 0.3038 0.3038
Schistosoma mansoni intermediate filament proteins 0.0029 0.0184 0.0175
Mycobacterium ulcerans hypothetical protein 0.0073 0.0708 0.0649
Brugia malayi Myosin regulatory light chain 1 0.0015 0.0019 0.0005
Schistosoma mansoni glutaminase 0.0859 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0127 0.1344 0.1344
Plasmodium falciparum centrin-1 0.003 0.0194 0.2653
Trypanosoma cruzi centrin, putative 0.0045 0.0373 0.0579
Giardia lamblia Cysteine protease 0.0016 0.0029 0.0054
Brugia malayi beta-lactamase 0.0073 0.0708 0.0695
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0013
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0278 0.3134 0.3285
Schistosoma mansoni cathepsin C 0.0016 0.0029 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.0127 0.1344 0.1405
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0086 0.0401
Echinococcus granulosus tissue type plasminogen activator 0.0071 0.0679 0.0707
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.001
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.003 0.0194 0.0176
Schistosoma mansoni myosin xvIII 0.0127 0.1344 0.1336
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0015 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.0131 0.1394 0.1394
Echinococcus granulosus cysteine protease 0.0016 0.0029 0.0024
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0029 0.0156
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0708 0.1213
Echinococcus granulosus g protein coupled receptor 0.0127 0.1344 0.1405
Trypanosoma brucei calmodulin, putative 0.003 0.0194 0.0965
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.003 0.0194 0.0287
Loa Loa (eye worm) hypothetical protein 0.0073 0.0708 0.0708
Schistosoma mansoni calmodulin-related 0.0015 0.0019 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.1344 0.1336
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Schistosoma mansoni RAR-like nuclear receptor 0.0278 0.3134 0.3127
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0086 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Brugia malayi ecdysone receptor 0.0131 0.1394 0.1382
Echinococcus granulosus centrin 2 0.003 0.0194 0.0197
Loa Loa (eye worm) hypothetical protein 0.0021 0.0086 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0708 0.1127
Schistosoma mansoni neuropeptide receptor 0.0251 0.2804 0.2798
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0035 0.0253 0.0382
Echinococcus granulosus microtubule associated protein 2 0.0697 0.8087 0.8487
Loa Loa (eye worm) hypothetical protein 0.0073 0.0708 0.0708
Toxoplasma gondii EFHC1, putative 0.003 0.0194 0.0949
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Trichomonas vaginalis malic enzyme, putative 0.0025 0.0139 0.012
Schistosoma mansoni neuronal calcium sensor 0.003 0.0194 0.0185
Brugia malayi Calmodulin-like protein 0.003 0.0194 0.0181
Onchocerca volvulus 0.0073 0.0708 0.2226
Trichomonas vaginalis calmodulin-2, putative 0.003 0.0194 0.0176
Loa Loa (eye worm) calpain 0.0135 0.1433 0.1433
Brugia malayi G protein-coupled receptor 0.0127 0.1344 0.1332
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0029 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.1344 0.1336
Leishmania major calpain family cysteine protease-like protein 0.0035 0.0253 0.1184
Brugia malayi nuclear hormone receptor family member nhr-6 0.0131 0.1394 0.1382
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1272
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0013 0.0013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0278 0.3134 0.3285
Leishmania major i/6 autoantigen-like protein 0.003 0.0194 0.0874
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Brugia malayi Dopamine receptor 0.0127 0.1344 0.1332
Schistosoma mansoni malic enzyme 0.0025 0.0139 0.013
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0125 0.0107
Echinococcus granulosus Nuclear hormone receptor HR96 0.0131 0.1394 0.1457
Trypanosoma brucei malic enzyme 0.0025 0.0139 0.0674
Echinococcus granulosus cpg binding protein 0.0061 0.0559 0.0581
Schistosoma mansoni nuclear receptor 0.0131 0.1394 0.1386
Loa Loa (eye worm) hypothetical protein 0.0278 0.3134 0.3134
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0679 0.108
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0286 0.1359
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1433 0.2312
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0013
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0015 0.0019 0.0017
Brugia malayi calpain 5 0.01 0.102 0.1008
Schistosoma mansoni coup transcription factor 0.0278 0.3134 0.3127
Brugia malayi putative neuropeptide receptor NPR1 0.0127 0.1344 0.1332
Echinococcus multilocularis rhodopsin orphan GPCR 0.0127 0.1344 0.1405
Brugia malayi hypothetical protein 0.023 0.2562 0.2552
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Brugia malayi photoreceptor-specific nuclear receptor 0.0278 0.3134 0.3125
Schistosoma mansoni hypothetical protein 0.0819 0.9528 0.9528
Schistosoma mansoni rab 0.003 0.0194 0.0185
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0278 0.3134 0.3127
Echinococcus granulosus Myosin regulatory light chain 0.0015 0.0019 0.0013
Echinococcus multilocularis calpain 0.0135 0.1433 0.1498
Trypanosoma brucei antigen, putative 0.0135 0.1433 0.7458
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0532 0.6135 0.6132
Trypanosoma brucei protein I/6 0.003 0.0194 0.0965
Trichomonas vaginalis calmodulin, putative 0.003 0.0194 0.0176
Echinococcus granulosus importin subunit beta 1 0.003 0.0192 0.0195
Echinococcus multilocularis somatostatin receptor 0.0127 0.1344 0.1405
Echinococcus multilocularis microtubule associated protein 2 0.0697 0.8087 0.8487
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0099 0.0131
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1433 0.7458
Trypanosoma brucei Component of motile flagella 41 0.003 0.0194 0.0965
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0278 0.3134 0.3127
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0029 0.0103
Echinococcus multilocularis neuropeptide receptor A26 0.0127 0.1344 0.1405
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0147 0.158 0.1653
Trypanosoma brucei calpain-like protein, putative 0.0135 0.1433 0.7458
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0125 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0278 0.3134 0.3134
Echinococcus multilocularis centrin 2 0.003 0.0194 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0278 0.3134 0.3125
Echinococcus granulosus survival motor neuron protein 1 0.023 0.2562 0.2685
Brugia malayi calpain 5 0.0035 0.0253 0.024
Trypanosoma brucei caltractin, putative 0.0045 0.0373 0.1901
Echinococcus granulosus nuclear receptor nhr 48 0.0131 0.1394 0.1457
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0127 0.1344 0.4264
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1433 0.2312
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1433 0.2312
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0029 0.0029
Onchocerca volvulus 0.0127 0.1344 0.4264
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0029 0.0016
Brugia malayi Serotonin receptor 0.0127 0.1344 0.1332
Schistosoma mansoni Mername-AA248 (C02 family) 0.0135 0.1433 0.1425
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0086 0.0401
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0016 0.0029 0.0156
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0029 0.005
Echinococcus multilocularis neuropeptides capa receptor 0.0127 0.1344 0.1405
Echinococcus multilocularis serotonin receptor 0.0372 0.4241 0.4448
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0029 0.0017
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0016 0.0029 0.002
Loa Loa (eye worm) beta-lactamase 0.0073 0.0708 0.0708
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1184
Echinococcus multilocularis neuropeptide Y receptor 0.0127 0.1344 0.1405
Onchocerca volvulus 0.0127 0.1344 0.4264
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.04 0.4572 0.4795
Schistosoma mansoni calpain-7 (C02 family) 0.0135 0.1433 0.1425
Giardia lamblia Cathepsin B precursor 0.0016 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Schistosoma mansoni thyroid hormone receptor 0.0278 0.3134 0.3127
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1184
Trypanosoma brucei cysteine peptidase C (CPC) 0.0176 0.1918 1
Echinococcus multilocularis cathepsin L 0.0016 0.0029 0.0024
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0019 0.0063 0.5
Plasmodium falciparum serine repeat antigen 2 0.0016 0.0029 0.0156
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0127 0.1344 0.1405
Echinococcus granulosus neuropeptides capa receptor 0.0127 0.1344 0.1405
Trichomonas vaginalis calmodulin, putative 0.003 0.0194 0.0176
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0086 0.0304
Onchocerca volvulus 0.0029 0.0184 0.0548
Entamoeba histolytica hypothetical protein 0.0036 0.027 0.251
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0029
Schistosoma mansoni growth hormone secretagogue receptor 0.0127 0.1344 0.1336
Echinococcus multilocularis calpain family protein 1, d 0.027 0.3038 0.3184
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0286 0.0293
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0278 0.3134 0.3285
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0086 0.0111
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0127 0.1344 0.1336
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0131 0.1394 0.1457
Trypanosoma cruzi major cysteine proteinase, putative 0.0016 0.0029 0.0017
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.003 0.0194 0.0965
Echinococcus multilocularis tissue type plasminogen activator 0.0071 0.0679 0.0707
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0708 0.0708
Loa Loa (eye worm) DR-78 0.0131 0.1394 0.1394
Brugia malayi glutaminase DH11.1 0.0859 1 1
Brugia malayi nuclear receptor RXR 0.0131 0.1394 0.1382
Schistosoma mansoni opsin-like receptor 0.0127 0.1344 0.1336
Trypanosoma brucei calpain, putative 0.0035 0.0253 0.1272
Giardia lamblia Cathepsin B precursor 0.0176 0.1918 1
Loa Loa (eye worm) calpain D 0.0035 0.0253 0.0253
Schistosoma mansoni hypothetical protein 0.0127 0.1344 0.1336
Brugia malayi hypothetical protein 0.0127 0.1344 0.1332
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0278 0.3134 0.3125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Brugia malayi orphan nuclear receptor NR2E1 0.0131 0.1394 0.1382
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0029 0.001
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0286 0.1405
Brugia malayi Cathepsin L-like precursor 0.0016 0.0029 0.0016
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0029 0.0024
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0286 0.0267
Brugia malayi sulfakinin receptor protein 0.0127 0.1344 0.1332
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0086 0.0024
Brugia malayi neuropeptide F receptor 0.0127 0.1344 0.1332
Giardia lamblia Cathepsin L precursor 0.0016 0.0029 0.0054
Entamoeba histolytica hypothetical protein 0.0036 0.027 0.251
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0286 0.0267
Toxoplasma gondii cathepsin B 0.0176 0.1918 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0532 0.6135 0.6132
Echinococcus multilocularis neuropeptide s receptor 0.0127 0.1344 0.1405
Toxoplasma gondii cathepsin CPC1 0.0016 0.0029 0.0082
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0127 0.1344 0.1405
Echinococcus multilocularis G-protein coupled receptor, putative 0.0127 0.1344 0.1405
Brugia malayi Cathepsin L-like precursor 0.0016 0.0029 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0086 0.0401
Loa Loa (eye worm) calpain family protein 1 0.027 0.3038 0.3038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0086 0.0676
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0035 0.0253 0.0382
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0035 0.0253 0.0382
Echinococcus granulosus g-protein coupled receptor 0.0127 0.1344 0.1405
Brugia malayi beta-lactamase family protein 0.0073 0.0708 0.0695
Loa Loa (eye worm) hypothetical protein 0.0073 0.0708 0.0708
Echinococcus granulosus calpain A 0.0135 0.1433 0.1498
Loa Loa (eye worm) ctsf protein 0.0016 0.0029 0.0029
Schistosoma mansoni nuclear hormone receptor 0.0131 0.1394 0.1386
Schistosoma mansoni survival motor neuron protein 0.0047 0.0395 0.0387
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0127 0.1344 0.1344
Echinococcus granulosus sarcoplasmic calcium binding protein 0.003 0.0194 0.0197
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0708 0.1213
Echinococcus multilocularis lamin dm0 0.0029 0.0184 0.0187
Echinococcus multilocularis calumenin 0.003 0.0199 0.0203
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0286 0.0225
Toxoplasma gondii exonuclease III APE 0.0038 0.0286 0.143
Loa Loa (eye worm) hypothetical protein 0.0131 0.1394 0.1394
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0127 0.1344 0.1336
Loa Loa (eye worm) hypothetical protein 0.0278 0.3134 0.3134
Plasmodium vivax centrin-1, putative 0.003 0.0194 0.124
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0131 0.1394 0.1386
Loa Loa (eye worm) hypothetical protein 0.0127 0.1344 0.1344
Echinococcus granulosus EF HAND 1 calcium binding site 0.003 0.0194 0.0197
Echinococcus granulosus snurportin 1 0.0317 0.3591 0.3765
Brugia malayi Steroid receptor seven-up type 2 0.0278 0.3134 0.3125
Brugia malayi putative neuropeptide receptor 0.0127 0.1344 0.1332
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Onchocerca volvulus Malic enzyme homolog 0.0025 0.0139 0.0401
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0127 0.1344 0.1332
Loa Loa (eye worm) programmed cell death protein 6 0.003 0.0199 0.0199
Echinococcus granulosus ecdysone induced protein 78C 0.0278 0.3134 0.3285
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.003 0.0199 0.0295
Brugia malayi hypothetical protein 0.0127 0.1344 0.1332
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0062 0.0572 0.0594
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0708 0.1213
Chlamydia trachomatis glutamine binding protein 0.0019 0.0063 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.1344 0.1336
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0029 0.0103
Entamoeba histolytica hypothetical protein 0.0016 0.0029 0.0103
Schistosoma mansoni ap endonuclease 0.0038 0.0286 0.0277
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0016 0.0029 0.0016
Schistosoma mansoni opsin-like receptor 0.0127 0.1344 0.1336
Echinococcus granulosus dro:myosuppressin receptor 0.0127 0.1344 0.1405
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.1283 0.1275
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.1344 0.1336
Brugia malayi Dopamine receptor protein 1 0.0127 0.1344 0.1332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0278 0.3134 0.3127
Echinococcus granulosus alpha 1A adrenergic receptor 0.0127 0.1344 0.1405
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0035 0.0253 0.1184
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.001
Toxoplasma gondii cathepsin CPL 0.0016 0.0029 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.001
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0147 0.158 0.1653
Echinococcus multilocularis lamin 0.0029 0.0184 0.0187
Schistosoma mansoni ap endonuclease 0.0038 0.0286 0.0277
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.0103
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0086 0.0401

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.13 uM Effective agonist concentration to the human Orexin receptor type 2 was determined using the Xlfit program ChEMBL. 14971895
EC50 (functional) = 0.13 uM Effective agonist concentration to the human Orexin receptor type 2 was determined using the Xlfit program ChEMBL. 14971895
EC50 (functional) = 0.93 uM Effective agonist concentration to human orexin receptor type 1 determined using the Xlfit program ChEMBL. 14971895
EC50 (functional) = 0.93 uM Effective agonist concentration to human orexin receptor type 1 determined using the Xlfit program ChEMBL. 14971895
Ratio (binding) = 7.2 Ratio of orexin-1 receptor to orexin-2 receptor in human ChEMBL. 14971895

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.