Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thymidylate synthase | 0.3091 | 0.7757 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3935 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3935 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.2208 | 0.541 | 0.6959 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2208 | 0.541 | 0.4549 |
Echinococcus multilocularis | thymidylate synthase | 0.3091 | 0.7757 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3935 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.2208 | 0.541 | 0.6959 |
Onchocerca volvulus | 0.0186 | 0.0038 | 0.0049 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3935 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.3091 | 0.7757 | 1 |
Onchocerca volvulus | 0.3091 | 0.7757 | 1 | |
Loa Loa (eye worm) | thymidylate synthase | 0.3091 | 0.7757 | 1 |
Brugia malayi | hypothetical protein | 0.147 | 0.3451 | 0.4422 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3091 | 0.7757 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2208 | 0.541 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.3091 | 0.7757 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3935 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2208 | 0.541 | 0.6959 |
Schistosoma mansoni | dihydrofolate reductase | 0.2208 | 0.541 | 0.6959 |
Brugia malayi | thymidylate synthase | 0.3091 | 0.7757 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.3091 | 0.7757 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.147 | 0.3451 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log K (ADMET) | = 7.6 | Association constant required to reduce the S-peptide / S-protein association by nonlinear curve fitting analysis | ChEMBL. | 10340601 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.