Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3935 | 1 | 0.5 |
Brugia malayi | thymidylate synthase | 0.3091 | 0.7757 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3935 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.3091 | 0.7757 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.3091 | 0.7757 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.3091 | 0.7757 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.2208 | 0.541 | 0.6959 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3935 | 1 | 0.5 |
Onchocerca volvulus | 0.0186 | 0.0038 | 0.0049 | |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2208 | 0.541 | 0.6959 |
Mycobacterium ulcerans | thymidylate synthase | 0.3091 | 0.7757 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.3091 | 0.7757 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.147 | 0.3451 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.2208 | 0.541 | 0.6959 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3935 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3091 | 0.7757 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3935 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2208 | 0.541 | 0.4549 |
Echinococcus granulosus | thymidylate synthase | 0.3091 | 0.7757 | 1 |
Brugia malayi | hypothetical protein | 0.147 | 0.3451 | 0.4422 |
Brugia malayi | Dihydrofolate reductase | 0.2208 | 0.541 | 0.6959 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2208 | 0.541 | 0.5 |
Onchocerca volvulus | 0.3091 | 0.7757 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log K (ADMET) | = 6.9 | Association constant required to reduce the S-peptide / S-protein association by nonlinear curve fitting analysis | ChEMBL. | 10340601 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.