Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0115 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0043 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1056 | 0.149 |
Schistosoma mansoni | notch | 0.0311 | 0.1171 | 0.1653 |
Onchocerca volvulus | 0.0282 | 0.1056 | 0.135 | |
Echinococcus multilocularis | calcium transporting ATPase type 2C member | 0.0018 | 0.0012 | 0.0016 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0669 | 0.2586 | 0.2577 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1807 | 0.7086 | 1 |
Echinococcus multilocularis | fibropellin Ia | 0.0311 | 0.1171 | 0.1653 |
Schistosoma mansoni | Na+/K+ transporting ATPase subunit alpha | 0.0044 | 0.0115 | 0.0162 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0669 | 0.2586 | 0.3648 |
Brugia malayi | EGF-like domain containing protein | 0.0311 | 0.1171 | 0.1653 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0311 | 0.1171 | 0.1653 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0311 | 0.1171 | 0.1161 |
Echinococcus multilocularis | protein jagged 2 | 0.0311 | 0.1171 | 0.1653 |
Schistosoma mansoni | slit | 0.0311 | 0.1171 | 0.1653 |
Schistosoma mansoni | na+/k+ atpase alpha subunit | 0.0041 | 0.0101 | 0.0142 |
Toxoplasma gondii | PAN domain-containing protein | 0.0233 | 0.0861 | 0.085 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0311 | 0.1171 | 0.1653 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.0861 | 0.1214 |
Toxoplasma gondii | hypothetical protein | 0.0233 | 0.0861 | 0.085 |
Echinococcus granulosus | Na:K ATPase alpha subunit | 0.0041 | 0.0101 | 0.0142 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0669 | 0.2586 | 0.3649 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.007 | 0.0216 | 0.0616 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.107 | 0.4174 | 0.589 |
Loa Loa (eye worm) | PAN domain-containing protein | 0.0233 | 0.0861 | 0.1214 |
Loa Loa (eye worm) | hypothetical protein | 0.107 | 0.4174 | 0.589 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0078 | 0.0249 | 0.0351 |
Brugia malayi | EGF-like domain containing protein | 0.0311 | 0.1171 | 0.1653 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0082 | 0.0263 | 0.0371 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.1171 | 0.1653 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0311 | 0.1171 | 0.1515 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0311 | 0.1171 | 0.1653 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0022 | 0.0025 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Echinococcus granulosus | delta-like protein 1 | 0.0311 | 0.1171 | 0.1653 |
Onchocerca volvulus | Putative cubilin | 0.0311 | 0.1171 | 0.1515 |
Mycobacterium ulcerans | metal cation transporter p-type ATPase a | 0.0044 | 0.0115 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0025 | 0.0035 |
Echinococcus multilocularis | Na+:K+ ATPase alpha subunit | 0.0041 | 0.0101 | 0.0142 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.063 | 0.2433 | 0.3433 |
Onchocerca volvulus | 0.0311 | 0.1171 | 0.1515 | |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0311 | 0.1171 | 0.1653 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0282 | 0.1056 | 0.1491 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0311 | 0.1171 | 0.1653 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0311 | 0.1171 | 0.1653 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1056 | 0.149 |
Echinococcus granulosus | Tolloid protein 1 | 0.0669 | 0.2586 | 0.3649 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0282 | 0.1056 | 0.1491 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2543 | 1 | 1 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0282 | 0.1056 | 0.1491 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0311 | 0.1172 | 0.1516 |
Toxoplasma gondii | kringle domain-containing protein | 0.063 | 0.2433 | 0.2424 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0012 | 0.0016 |
Echinococcus granulosus | fibropellin Ia | 0.0311 | 0.1171 | 0.1653 |
Loa Loa (eye worm) | hypothetical protein | 0.0669 | 0.2586 | 0.3648 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0075 | 0.0236 | 0.0333 |
Brugia malayi | dihydrofolate reductase family protein | 0.0737 | 0.2854 | 0.4027 |
Echinococcus multilocularis | protein jagged 1 | 0.0311 | 0.1171 | 0.1653 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.0861 | 0.1214 |
Brugia malayi | Delta serrate ligand family protein | 0.0311 | 0.1171 | 0.1653 |
Echinococcus granulosus | Ankyrin | 0.0015 | 0.0001 | 0.0001 |
Schistosoma mansoni | notch | 0.0311 | 0.1171 | 0.1653 |
Echinococcus multilocularis | Ankyrin | 0.0015 | 0.0001 | 0.0001 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0022 | 0.0025 | 0.0036 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0018 | 0.0012 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0282 | 0.1056 | 0.1491 |
Echinococcus granulosus | dihydrofolate reductase | 0.0737 | 0.2854 | 0.4027 |
Schistosoma mansoni | notch | 0.0311 | 0.1171 | 0.1653 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.1171 | 0.1653 |
Schistosoma mansoni | hypothetical protein | 0.063 | 0.2433 | 0.3434 |
Onchocerca volvulus | 0.0233 | 0.0861 | 0.107 | |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Onchocerca volvulus | 0.107 | 0.4174 | 0.5822 | |
Loa Loa (eye worm) | Notch2 | 0.0311 | 0.1171 | 0.1652 |
Mycobacterium ulcerans | hypothetical protein | 0.0282 | 0.1056 | 0.1477 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1807 | 0.7086 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.1807 | 0.7086 | 1 |
Loa Loa (eye worm) | PAN domain-containing protein | 0.0233 | 0.0861 | 0.1214 |
Brugia malayi | Trypsin family protein | 0.0282 | 0.1056 | 0.1491 |
Brugia malayi | Trypsin family protein | 0.0282 | 0.1056 | 0.1491 |
Toxoplasma gondii | microneme protein, putative | 0.0233 | 0.0861 | 0.085 |
Echinococcus granulosus | notch | 0.0311 | 0.1171 | 0.1653 |
Onchocerca volvulus | 0.0311 | 0.1171 | 0.1515 | |
Toxoplasma gondii | microneme protein MIC17C | 0.0233 | 0.0861 | 0.085 |
Echinococcus granulosus | tissue type plasminogen activator | 0.063 | 0.2433 | 0.3434 |
Onchocerca volvulus | 0.0311 | 0.1171 | 0.1515 | |
Schistosoma mansoni | septate junction protein | 0.0311 | 0.1171 | 0.1653 |
Echinococcus granulosus | plasma membrane calcium transporting ATPase 2 | 0.0018 | 0.0012 | 0.0016 |
Toxoplasma gondii | PAN domain-containing protein | 0.0233 | 0.0861 | 0.085 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0282 | 0.1056 | 0.1491 |
Loa Loa (eye worm) | thymidylate synthase | 0.1807 | 0.7086 | 1 |
Brugia malayi | PAN domain containing protein | 0.0233 | 0.0861 | 0.1215 |
Toxoplasma gondii | 1,3(4)-beta-glucanase | 0.0233 | 0.0861 | 0.085 |
Loa Loa (eye worm) | hypothetical protein | 0.0669 | 0.2586 | 0.3648 |
Brugia malayi | Trypsin family protein | 0.107 | 0.4174 | 0.589 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0075 | 0.0236 | 0.0332 |
Brugia malayi | Kringle domain containing protein | 0.063 | 0.2433 | 0.3434 |
Brugia malayi | PAN domain containing protein | 0.0233 | 0.0861 | 0.1215 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.1171 | 0.1653 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0859 | 0.3339 | 1 |
Echinococcus granulosus | slit 2 protein | 0.0311 | 0.1171 | 0.1653 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0737 | 0.2854 | 0.4027 |
Onchocerca volvulus | 0.0282 | 0.1056 | 0.135 | |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Schistosoma mansoni | notch | 0.0311 | 0.1172 | 0.1653 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.0861 | 0.1214 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2543 | 1 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.0669 | 0.2586 | 0.3649 |
Brugia malayi | Fibulin-1 precursor | 0.0669 | 0.2586 | 0.3649 |
Echinococcus multilocularis | notch | 0.0311 | 0.1171 | 0.1653 |
Brugia malayi | PAN domain containing protein | 0.0233 | 0.0861 | 0.1215 |
Toxoplasma gondii | PAN domain-containing protein | 0.1339 | 0.5235 | 0.523 |
Loa Loa (eye worm) | hypothetical protein | 0.063 | 0.2433 | 0.3433 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0311 | 0.1171 | 0.1653 |
Echinococcus multilocularis | thymidylate synthase | 0.1807 | 0.7086 | 1 |
Loa Loa (eye worm) | sodium/potassium-transporting ATPase subunit alpha | 0.0039 | 0.0092 | 0.0129 |
Brugia malayi | thymidylate synthase | 0.1807 | 0.7086 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0022 | 0.0025 | 0.0036 |
Schistosoma mansoni | dihydrofolate reductase | 0.0737 | 0.2854 | 0.4027 |
Echinococcus granulosus | protein jagged 2 | 0.0311 | 0.1171 | 0.1653 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2543 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1807 | 0.7086 | 1 |
Loa Loa (eye worm) | PAN domain-containing protein | 0.0233 | 0.0861 | 0.1214 |
Echinococcus granulosus | neural cadherin | 0.0311 | 0.1171 | 0.1653 |
Echinococcus multilocularis | slit 2 protein | 0.0311 | 0.1171 | 0.1653 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0737 | 0.2854 | 0.4017 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.063 | 0.2433 | 0.3434 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0669 | 0.2586 | 0.3649 |
Brugia malayi | PAN domain containing protein | 0.0233 | 0.0861 | 0.1215 |
Schistosoma mansoni | ATPase | 0.0018 | 0.0012 | 0.0016 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0015 | 0.0001 | 0.0001 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0663 | 0.2562 | 0.3615 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0066 | 0.0092 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0282 | 0.1056 | 0.1491 |
Loa Loa (eye worm) | hypothetical protein | 0.0669 | 0.2586 | 0.3648 |
Onchocerca volvulus | 0.0233 | 0.0861 | 0.107 | |
Brugia malayi | EGF-like domain containing protein | 0.0311 | 0.1171 | 0.1653 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0311 | 0.1171 | 0.1653 |
Loa Loa (eye worm) | hypothetical protein | 0.0669 | 0.2586 | 0.3648 |
Brugia malayi | Protein kinase domain containing protein | 0.063 | 0.2433 | 0.3434 |
Mycobacterium ulcerans | thymidylate synthase | 0.1807 | 0.7086 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0282 | 0.1056 | 0.1491 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0282 | 0.1056 | 0.1491 |
Toxoplasma gondii | microneme protein MIC17B | 0.0233 | 0.0861 | 0.085 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0018 | 0.0012 | 0.5 |
Echinococcus granulosus | voltage gated potassium channel | 0.0022 | 0.0025 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1056 | 0.149 |
Brugia malayi | hypothetical protein | 0.0282 | 0.1056 | 0.1491 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0022 | 0.0025 | 0.0036 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0282 | 0.1056 | 0.1491 |
Echinococcus granulosus | protein jagged 2 | 0.0311 | 0.1171 | 0.1653 |
Onchocerca volvulus | 0.0282 | 0.1056 | 0.135 | |
Brugia malayi | Cadherin domain containing protein | 0.0311 | 0.1171 | 0.1653 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0311 | 0.1171 | 0.1653 |
Brugia malayi | PAN domain containing protein | 0.0233 | 0.0861 | 0.1215 |
Echinococcus multilocularis | protein jagged 1 | 0.0311 | 0.1171 | 0.1653 |
Onchocerca volvulus | 0.0311 | 0.1171 | 0.1515 | |
Echinococcus granulosus | sarco:endoplasmic reticulum calcium ATPase | 0.0018 | 0.0012 | 0.0016 |
Brugia malayi | Dihydrofolate reductase | 0.0737 | 0.2854 | 0.4027 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0282 | 0.1056 | 0.1491 |
Echinococcus granulosus | calcium transporting ATPase type 2C member | 0.0018 | 0.0012 | 0.0016 |
Echinococcus multilocularis | Tetracycline resistance leader peptide, TetL | 0.0018 | 0.0012 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0282 | 0.1056 | 0.1491 |
Toxoplasma gondii | microneme protein MIC17A | 0.0233 | 0.0861 | 0.085 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0669 | 0.2586 | 0.3648 |
Schistosoma mansoni | ATPase | 0.0018 | 0.0012 | 0.0016 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.063 | 0.2433 | 0.2424 |
Loa Loa (eye worm) | trypsin family protein | 0.0282 | 0.1056 | 0.149 |
Onchocerca volvulus | 0.063 | 0.2433 | 0.3325 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2543 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1056 | 0.149 |
Leishmania major | hypothetical protein, conserved | 0.063 | 0.2433 | 0.2424 |
Echinococcus multilocularis | neural cadherin | 0.0311 | 0.1171 | 0.1653 |
Brugia malayi | Muscle positioning protein 4 | 0.0311 | 0.1171 | 0.1653 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0737 | 0.2854 | 0.4027 |
Echinococcus granulosus | laminin | 0.0669 | 0.2586 | 0.3649 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.0861 | 0.1214 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Brugia malayi | PAN domain containing protein | 0.0233 | 0.0861 | 0.1215 |
Schistosoma mansoni | notch | 0.0311 | 0.1171 | 0.1653 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0282 | 0.1056 | 0.1491 |
Brugia malayi | PAN domain containing protein | 0.0233 | 0.0861 | 0.1215 |
Echinococcus granulosus | protein jagged 1 | 0.0311 | 0.1171 | 0.1653 |
Loa Loa (eye worm) | PAN domain-containing protein | 0.0233 | 0.0861 | 0.1214 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Schistosoma mansoni | hypothetical protein | 0.0282 | 0.1056 | 0.1491 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0282 | 0.1056 | 0.1491 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0197 | 0.0277 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0282 | 0.1056 | 0.1491 |
Onchocerca volvulus | 0.0233 | 0.0861 | 0.107 | |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0663 | 0.2562 | 0.3615 |
Onchocerca volvulus | Slit protein homolog | 0.0311 | 0.1171 | 0.1515 |
Onchocerca volvulus | 0.0233 | 0.0861 | 0.107 | |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0859 | 0.3339 | 0.1148 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0069 | 0.0097 |
Toxoplasma gondii | PAN domain-containing protein | 0.0233 | 0.0861 | 0.085 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0669 | 0.2586 | 0.2577 |
Echinococcus granulosus | protein jagged 1 | 0.0311 | 0.1171 | 0.1653 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0022 | 0.0025 | 0.0036 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0669 | 0.2586 | 0.3649 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0663 | 0.2562 | 0.3615 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0859 | 0.3339 | 0.3332 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0282 | 0.1056 | 0.1491 |
Onchocerca volvulus | 0.0311 | 0.1171 | 0.1515 | |
Onchocerca volvulus | 0.0233 | 0.0861 | 0.107 | |
Brugia malayi | Sodium/potassium-transporting ATPase alpha chain, putative | 0.0039 | 0.0092 | 0.013 |
Onchocerca volvulus | 0.0282 | 0.1056 | 0.135 | |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.0861 | 0.1214 |
Toxoplasma gondii | PAN domain-containing protein | 0.1339 | 0.5235 | 0.523 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0282 | 0.1056 | 0.1491 |
Echinococcus granulosus | enteropeptidase | 0.0663 | 0.2562 | 0.3615 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0311 | 0.1171 | 0.1653 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0282 | 0.1056 | 0.1491 |
Loa Loa (eye worm) | notch protein | 0.0311 | 0.1171 | 0.1652 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Toxoplasma gondii | PAN domain-containing protein | 0.0233 | 0.0861 | 0.085 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0669 | 0.2586 | 0.3648 |
Brugia malayi | EGF-like domain containing protein | 0.0311 | 0.1171 | 0.1653 |
Brugia malayi | EGF-like domain containing protein | 0.0311 | 0.1171 | 0.1653 |
Brugia malayi | PAN domain containing protein | 0.0233 | 0.0861 | 0.1215 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0737 | 0.2854 | 0.5 |
Toxoplasma gondii | PAN/Apple domain-containing protein | 0.0233 | 0.0861 | 0.085 |
Onchocerca volvulus | 0.0233 | 0.0861 | 0.107 | |
Entamoeba histolytica | calcium-transporting P-type ATPase, putative | 0.0018 | 0.0012 | 0.5 |
Brugia malayi | hypothetical protein | 0.0859 | 0.3339 | 0.4713 |
Echinococcus multilocularis | sarco:endoplasmic reticulum calcium ATPase | 0.0018 | 0.0012 | 0.0016 |
Brugia malayi | EGF-like domain containing protein | 0.0311 | 0.1171 | 0.1653 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0075 | 0.0236 | 0.0333 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0082 | 0.0263 | 0.0371 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0311 | 0.1171 | 0.1653 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0282 | 0.1056 | 0.1491 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Onchocerca volvulus | 0.1807 | 0.7086 | 1 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2543 | 1 | 1 |
Brugia malayi | PAN domain containing protein | 0.0233 | 0.0861 | 0.1215 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0282 | 0.1056 | 0.1491 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0311 | 0.1171 | 0.1653 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0022 | 0.0025 | 0.0036 |
Onchocerca volvulus | 0.0233 | 0.0861 | 0.107 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.063 | 0.2433 | 0.2424 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0078 | 0.0249 | 0.0351 |
Echinococcus multilocularis | Mastin | 0.0663 | 0.2562 | 0.3615 |
Loa Loa (eye worm) | PAN domain-containing protein | 0.0233 | 0.0861 | 0.1214 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0282 | 0.1056 | 0.1491 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0075 | 0.0236 | 0.0333 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.107 | 0.4174 | 0.589 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Echinococcus multilocularis | enteropeptidase | 0.0663 | 0.2562 | 0.3615 |
Brugia malayi | EGF-like domain containing protein | 0.0311 | 0.1171 | 0.1653 |
Toxoplasma gondii | subtilisin SUB12 | 0.0233 | 0.0861 | 0.085 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.1171 | 0.1653 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.0861 | 0.1214 |
Schistosoma mansoni | hypothetical protein | 0.0282 | 0.1056 | 0.1491 |
Loa Loa (eye worm) | Na,K-ATPase alpha subunit | 0.0044 | 0.0115 | 0.0162 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0311 | 0.1171 | 0.1653 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Brugia malayi | Trypsin family protein | 0.0282 | 0.1056 | 0.1491 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.1171 | 0.1653 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0282 | 0.1056 | 0.1491 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0018 | 0.0012 | 0.5 |
Onchocerca volvulus | 0.0233 | 0.0861 | 0.107 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0282 | 0.1056 | 0.1491 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0282 | 0.1056 | 0.1491 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.007 | 0.0216 | 0.0616 |
Echinococcus multilocularis | laminin | 0.0669 | 0.2586 | 0.3649 |
Toxoplasma gondii | hypothetical protein | 0.0233 | 0.0861 | 0.085 |
Brugia malayi | Na,K-ATPase alpha subunit | 0.0044 | 0.0115 | 0.0162 |
Schistosoma mansoni | egf-like domain protein | 0.0669 | 0.2586 | 0.3649 |
Giardia lamblia | Potassium-transporting ATPase alpha chain 1 | 0.0041 | 0.0101 | 0.0769 |
Loa Loa (eye worm) | hypothetical protein | 0.0669 | 0.2586 | 0.3648 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0311 | 0.1171 | 0.1653 |
Toxoplasma gondii | microneme protein MIC4 | 0.0233 | 0.0861 | 0.085 |
Brugia malayi | Cadherin domain containing protein | 0.0311 | 0.1171 | 0.1653 |
Onchocerca volvulus | 0.0233 | 0.0861 | 0.107 | |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0311 | 0.1171 | 0.1653 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0311 | 0.1171 | 0.1653 |
Echinococcus granulosus | Mastin | 0.0663 | 0.2562 | 0.3615 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0737 | 0.2854 | 0.3949 |
Loa Loa (eye worm) | hypothetical protein | 0.107 | 0.4174 | 0.589 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0282 | 0.1056 | 0.1491 |
Giardia lamblia | High cysteine protein | 0.0311 | 0.1171 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0669 | 0.2586 | 0.3649 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1056 | 0.149 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.063 | 0.2433 | 0.2424 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.1171 | 0.1653 |
Schistosoma mansoni | cell polarity protein | 0.0311 | 0.1171 | 0.1653 |
Onchocerca volvulus | 0.0233 | 0.0861 | 0.107 | |
Onchocerca volvulus | 0.0788 | 0.3057 | 0.422 | |
Echinococcus granulosus | neurogenic locus notch protein | 0.0311 | 0.1171 | 0.1653 |
Brugia malayi | notch-like transmembrane receptor | 0.0311 | 0.1171 | 0.1653 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.1171 | 0.1652 |
Onchocerca volvulus | 0.0233 | 0.0861 | 0.107 | |
Schistosoma mansoni | notch | 0.0311 | 0.1171 | 0.1653 |
Brugia malayi | PAN domain containing protein | 0.0233 | 0.0861 | 0.1215 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.0861 | 0.1214 |
Onchocerca volvulus | Arrow homolog | 0.0669 | 0.2586 | 0.3544 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.1171 | 0.1653 |
Onchocerca volvulus | 0.0282 | 0.1056 | 0.135 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 10 mg kg-1 | In vivo effective dose against experimental infections in rodent caused by S. pyogenes C203 when administered sc | ChEMBL. | 3398001 |
ED50 (functional) | = 91 mg kg-1 | In vivo effective dose against experimental infections in rodent caused by S. pyogenes C203 when administered orally | ChEMBL. | 3398001 |
MIC (functional) | = 2 ug ml-1 | In vitro antimicrobial activity against Staphylococcus aureus X1 | ChEMBL. | 3398001 |
MIC (functional) | = 2 ug ml-1 | In vitro antimicrobial activity against Streptococcus epidermidis EPI1 | ChEMBL. | 3398001 |
MIC (functional) | = 4 ug ml-1 | In vitro antimicrobial activity against Staphylococcus pyogenes C203 | ChEMBL. | 3398001 |
MIC (functional) | = 32 ug ml-1 | In vitro antimicrobial activity against Streptococcus pneumoniae | ChEMBL. | 3398001 |
MIC (functional) | > 128 ug ml-1 | In vitro antimicrobial activity against Streptococcus faecium X66 | ChEMBL. | 3398001 |
MIC (functional) | > 128 ug ml-1 | In vitro antimicrobial activity against Haemophilus influenzae. | ChEMBL. | 3398001 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.