Detailed information for compound 377555

Basic information

Technical information
  • TDR Targets ID: 377555
  • Name: hexasodium 8-[[4-methyl-3-[[3-[[3-[[2-methyl- 5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamo yl]phenyl]carbamoyl]phenyl]carbamoylamino]ben zoyl]amino]benzoyl]amino]naphthalene-1,3,5-tr isulfonate
  • MW: 1429.17 | Formula: C51H34N6Na6O23S6
  • H donors: 6 H acceptors: 23 LogP: 1.05 Rotable bonds: 22
    Rule of 5 violations (Lipinski): 4
  • SMILES: O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
  • InChi: 1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6
  • InChiKey: VAPNKLKDKUDFHK-UHFFFAOYSA-H  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • hexasodium 8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonato-1-naphthyl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonate
  • hexasodium 8-[[[4-methyl-3-[[[3-[[[3-[[2-methyl-5-[oxo-[(4,6,8-trisulfonato-1-naphthyl)amino]methyl]anilino]-oxomethyl]anilino]-oxomethyl]amino]phenyl]-oxomethyl]amino]phenyl]-oxomethyl]amino]naphthalene-1,3,5-trisulfonate
  • hexasodium 8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]phenyl]carbonylamino]phenyl]carbonylamino]naphthalene-1,3,5-trisulfonate
  • Suramin
  • hexasodium 8-[[[4-methyl-3-[[[3-[[[[3-[[[2-methyl-5-[oxo-[(4,6,8-trisulfonato-1-naphthyl)amino]methyl]phenyl]amino]-oxomethyl]phenyl]amino]-oxomethyl]amino]phenyl]-oxomethyl]amino]phenyl]-oxomethyl]amino]naphthalene-1,3,5-trisulfonate
  • 129-46-4
  • EU-0101182
  • Bayer 205 (TN)
  • D00808
  • Suramin hexasodium
  • Suramin hexasodium (USAN)
  • SPECTRUM1502032
  • CI-1003
  • Metaret
  • NF-060
  • NSC-34936
  • S2671_SIGMA
  • Suramin sodium salt
  • Suramine sodium salt
  • NCGC00094436-01
  • 1,3,5-Naphthalenetrisulfonic acid, 8,8'-(carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-, hexasodium salt (9CI)
  • 1,3,5-Naphthylenetrisulfonic acid, 8,8'-(ureylenebis(m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino))di-, hexasodium salt
  • 1-(3-Benzamido-4-methylbenzamido)naphthalene-4,6,8-trisulfonic acid sym-3''-urea sodium salt
  • 309 F
  • Antrypol
  • BAY 205
  • Bayer 205
  • EINECS 204-949-3
  • Fourneau 309
  • Germanin
  • Moranyl
  • NF060
  • NSC 34936
  • Naganin
  • Naganine
  • Naganinum
  • Naganol
  • Naphuride sodium
  • SK 24728
  • SURAMIN SODIUM
  • Sodium suramin
  • Suramin Hexasodium [USAN]
  • Suramina sodica [INN-Spanish]
  • Suramine sodique [INN-French]
  • Suramine sodium
  • Suraminum natricum [INN-Latin]
  • Lopac-S-149
  • NCGC00016201-01
  • NCGC00094436-02

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma brucei glycerol-3-phosphate dehydrogenase [NAD+], glycosomal Curated by TDR Targets References
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Escherichia coli endonuclease IV with intrinsic 3'-5' exonuclease activity Starlite/ChEMBL No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Leishmania mexicana pyruvate kinase, putative Starlite/ChEMBL No references
Homo sapiens thrombopoietin Starlite/ChEMBL No references
Schistosoma mansoni P2X receptor subunit Curated by TDR Targets No references
Homo sapiens sirtuin 2 Starlite/ChEMBL References
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens M-phase phosphoprotein 8 Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens galactokinase 1 Starlite/ChEMBL No references
Homo sapiens sirtuin 1 Starlite/ChEMBL References
Homo sapiens lamin A/C Starlite/ChEMBL No references
Leishmania major fructose-1,6-bisphosphate aldolase Curated by TDR Targets References
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Rattus norvegicus Muscarinic acetylcholine receptor M1 Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Starlite/ChEMBL No references
Homo sapiens core-binding factor, beta subunit No references
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Trypanosoma cruzi nucleoside phosphatase, putative Curated by TDR Targets No references
Trypanosoma cruzi nucleoside phosphatase, putative Curated by TDR Targets No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) Get druggable targets OG5_129467 All targets in OG5_129467
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni glycerol-3-phosphate dehydrogenase Get druggable targets OG5_126704 All targets in OG5_126704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis apurinic/apyrimidinic endonuclease Apn1 Get druggable targets OG5_129467 All targets in OG5_129467
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis chromatin regulatory protein sir2, putative Get druggable targets OG5_127826 All targets in OG5_127826
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 Get druggable targets OG5_127826 All targets in OG5_127826
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi hypothetical protein Get druggable targets OG5_136365 All targets in OG5_136365
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 Get druggable targets OG5_129944 All targets in OG5_129944
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Schistosoma mansoni multiple ankyrin repeats single kh domain protein Get druggable targets OG5_136365 All targets in OG5_136365
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni glycerol-3-phosphate dehydrogenase Get druggable targets OG5_126704 All targets in OG5_126704
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K01623 fructose-bisphosphate aldolase, class I [EC4.1.2.13A], putative Get druggable targets OG5_127143 All targets in OG5_127143
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(P)+] GPDA (NAD(P)H- DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE) Get druggable targets OG5_126704 All targets in OG5_126704
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129944 All targets in OG5_129944
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma congolense fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative Get druggable targets OG5_127143 All targets in OG5_127143
Trypanosoma cruzi galactokinase, putative Get druggable targets OG5_129789 All targets in OG5_129789
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana nucleoside phosphatase, putative,guanosine diphosphatase, putative Get druggable targets OG5_127709 All targets in OG5_127709
Trichomonas vaginalis glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi transcriptional regulator, Sir2 family protein Get druggable targets OG5_127826 All targets in OG5_127826
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Plasmodium yoelii glycerol-3-phosphate dehydrogenase Get druggable targets OG5_126704 All targets in OG5_126704
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii fructose-bisphosphate aldolase, putative Get druggable targets OG5_127143 All targets in OG5_127143
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium parvum glycerol-3-phosphate dehydrogenase Get druggable targets OG5_126704 All targets in OG5_126704
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase (NAD+) Get druggable targets OG5_126704 All targets in OG5_126704
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana silent information regulator 2, putative,NAD-dependent SIR2, putative Get druggable targets OG5_127826 All targets in OG5_127826
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase Get druggable targets OG5_129467 All targets in OG5_129467
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii endonuclease IV APN Get druggable targets OG5_129467 All targets in OG5_129467
Trypanosoma cruzi nucleoside phosphatase, putative Get druggable targets OG5_127709 All targets in OG5_127709
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi M-phase phosphoprotein, mpp8 Get druggable targets OG5_136365 All targets in OG5_136365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense galactokinase, putative Get druggable targets OG5_129789 All targets in OG5_129789
Entamoeba histolytica Sir2 family transcriptional regulator, putative Get druggable targets OG5_127826 All targets in OG5_127826
Schistosoma japonicum M-phase phosphoprotein 8, putative Get druggable targets OG5_136365 All targets in OG5_136365
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus glycerol 3 phosphate dehydrogenase NAD Get druggable targets OG5_126704 All targets in OG5_126704
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi galactokinase, putative Get druggable targets OG5_129789 All targets in OG5_129789
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis galactokinase-like protein Get druggable targets OG5_129789 All targets in OG5_129789
Trichomonas vaginalis glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei galactokinase-like protein, putative Get druggable targets OG5_129789 All targets in OG5_129789
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis chromatin regulatory protein sir2, putative Get druggable targets OG5_129944 All targets in OG5_129944
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major glycerol-3-phosphate dehydrogenase [NAD ], glycosomal Get druggable targets OG5_126704 All targets in OG5_126704
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Fructose-bisphosphate aldolase (EC 4.1.2.13), related Get druggable targets OG5_127143 All targets in OG5_127143
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium yoelii NAD-dependent glycerol-3-phosphate dehydrogenase Get druggable targets OG5_126704 All targets in OG5_126704
Schistosoma mansoni fructose 16-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) transcriptional regulator Get druggable targets OG5_127826 All targets in OG5_127826
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans likely SIR2 family histone deacetylase similar to S. cerevisiae HST2 (YPL015C) involved in telomeric chromatin silencing Get druggable targets OG5_127826 All targets in OG5_127826
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei nucleoside phosphatase, putative Get druggable targets OG5_127709 All targets in OG5_127709
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana nucleoside diphosphatase, putative Get druggable targets OG5_127709 All targets in OG5_127709
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Giardia lamblia NAD-dependent histone deacetylase Sir2 Get druggable targets OG5_129944 All targets in OG5_129944
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_129467 All targets in OG5_129467
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis chromatin regulatory protein sir2, putative Get druggable targets OG5_127826 All targets in OG5_127826
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans guanosine diphosphatase Get druggable targets OG5_127709 All targets in OG5_127709
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium hominis fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA1 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-depe Get druggable targets OG5_126704 All targets in OG5_126704
Leishmania donovani galactokinase-like protein Get druggable targets OG5_129789 All targets in OG5_129789
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana glycerol-3-phosphate dehydrogenase [NAD ], glycosomal/mitochondrial Get druggable targets OG5_126704 All targets in OG5_126704
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium yoelii Fructose-bisphosphate aldolase class-I Get druggable targets OG5_127143 All targets in OG5_127143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Toxoplasma gondii glycerol-3-phosphate dehydrogenase (gpdh), putative Get druggable targets OG5_126704 All targets in OG5_126704
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum ATP diphosphohydrolase Get druggable targets OG5_127709 All targets in OG5_127709
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani glycerol-3-phosphate dehydrogenase [NAD+], glycosomal Get druggable targets OG5_126704 All targets in OG5_126704
Schistosoma japonicum ko:K00006 glycerol-3-phosphate dehydrogenase (NAD+) [EC1.1.1.8], putative Get druggable targets OG5_126704 All targets in OG5_126704
Trypanosoma brucei glycerol-3-phosphate dehydrogenase [NAD+], glycosomal Get druggable targets OG5_126704 All targets in OG5_126704
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi galactokinase-like protein, putative Get druggable targets OG5_129789 All targets in OG5_129789
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium falciparum glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Chlamydia trachomatis glycerol-3-phosphate dehydrogenase Get druggable targets OG5_126704 All targets in OG5_126704
Theileria parva fructose-bisphosphate aldolase, putative Get druggable targets OG5_127143 All targets in OG5_127143
Plasmodium vivax glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Plasmodium berghei fructose-bisphosphate aldolase 2 Get druggable targets OG5_127143 All targets in OG5_127143
Treponema pallidum galactokinase Get druggable targets OG5_129789 All targets in OG5_129789
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium ulcerans endonuclease IV Get druggable targets OG5_129467 All targets in OG5_129467
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 Get druggable targets OG5_127143 All targets in OG5_127143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01463 sirtuin 1 (silent mating type information regulation 2, homolog) 1 [EC:3.5.1.-], putative Get druggable targets OG5_129944 All targets in OG5_129944
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii AP endonuclease 1 Get druggable targets OG5_129467 All targets in OG5_129467
Leishmania donovani nucleoside phosphatase, putative Get druggable targets OG5_127709 All targets in OG5_127709
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva NAD-dependent glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 Get druggable targets OG5_127826 All targets in OG5_127826
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei Silent information regulator 2 related protein 1 Get druggable targets OG5_127826 All targets in OG5_127826
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Trichomonas vaginalis chromatin regulatory protein sir2, putative Get druggable targets OG5_129944 All targets in OG5_129944
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Trypanosoma congolense glycerol-3-phosphate dehydrogenase [NAD+], glycosomal, putative Get druggable targets OG5_126704 All targets in OG5_126704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Hypothetical protein Get druggable targets OG5_127826 All targets in OG5_127826
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_136365 All targets in OG5_136365
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major nucleoside phosphatase, putative,guanosine diphosphatase, putative Get druggable targets OG5_127709 All targets in OG5_127709
Trichomonas vaginalis glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_136365 All targets in OG5_136365
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense silent information regulator 2 Get druggable targets OG5_127826 All targets in OG5_127826
Echinococcus granulosus fructose bisphosphate aldolase class I Get druggable targets OG5_127143 All targets in OG5_127143
Neospora caninum Glycerol-3-phosphate dehydrogenase, related Get druggable targets OG5_126704 All targets in OG5_126704
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana galactokinase-like protein Get druggable targets OG5_129789 All targets in OG5_129789
Treponema pallidum NAD(P)H-dependent glycerol-3-phosphate dehydrogenase Get druggable targets OG5_126704 All targets in OG5_126704
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) Get druggable targets OG5_129467 All targets in OG5_129467
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Mycobacterium tuberculosis Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H- dependent glycerol-3-phosphate dehydrogenase) Get druggable targets OG5_126704 All targets in OG5_126704
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126704 All targets in OG5_126704
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Loa Loa (eye worm) glycerol 3 phosphate dehydrogenase Get druggable targets OG5_126704 All targets in OG5_126704
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense fructose-bisphosphate aldolase, glycosomal putative Get druggable targets OG5_127143 All targets in OG5_127143
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis glycerol-3-phosphate dehydrogenase [NAD ], glycosomal Get druggable targets OG5_126704 All targets in OG5_126704
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum endonuclease V, putative Get druggable targets OG5_129467 All targets in OG5_129467
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium knowlesi apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Echinococcus granulosus fructose 16 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Leishmania braziliensis fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis fructose bisphosphate aldolase class I Get druggable targets OG5_127143 All targets in OG5_127143
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of two genes similar to S. cerevisiae GPD1 (YDL022W) and GPD2 (YOL059W) glycerol-3-phosphate dehydrogenase Get druggable targets OG5_126704 All targets in OG5_126704
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans one of two genes similar to S. cerevisiae GPD1 (YDL022W) and GPD2 (YOL059W) glycerol-3-phosphate dehydrogenase Get druggable targets OG5_126704 All targets in OG5_126704
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Loa Loa (eye worm) glycerol-3-Phosphate DeHydrogenase family member Get druggable targets OG5_126704 All targets in OG5_126704
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi fructose-bisphosphate aldolase 2 Get druggable targets OG5_127143 All targets in OG5_127143
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 Get druggable targets OG5_129944 All targets in OG5_129944
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major galactokinase-like protein Get druggable targets OG5_129789 All targets in OG5_129789
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense nucleoside diphosphatase, putative Get druggable targets OG5_127709 All targets in OG5_127709
Candida albicans likely SIR2 family histone deacetylase similar to S. cerevisiae HST2 (YPL015C) involved in telomeric chromatin silencing Get druggable targets OG5_127826 All targets in OG5_127826
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum silent information regulator 2, putative Get druggable targets OG5_127826 All targets in OG5_127826
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi fructose-bisphosphate aldolase, putative Get druggable targets OG5_127143 All targets in OG5_127143
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania donovani Silent information regulator 2 related protein 1 Get druggable targets OG5_127826 All targets in OG5_127826
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Schistosoma japonicum ko:K01511 nucleoside-diphosphatase [EC3.6.1.6], putative Get druggable targets OG5_127709 All targets in OG5_127709
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_136365 All targets in OG5_136365
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum glycerol-3-phosphate dehydrogenase [NAD ], glycosomal Get druggable targets OG5_126704 All targets in OG5_126704
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni chromatin regulatory protein sir2 Get druggable targets OG5_129944 All targets in OG5_129944
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum galactokinase-like protein Get druggable targets OG5_129789 All targets in OG5_129789
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense silent information regulator 2,NAD-dependent SIR2 Get druggable targets OG5_127826 All targets in OG5_127826
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium hominis glycerol-3-phosphate dehydrogenase Get druggable targets OG5_126704 All targets in OG5_126704
Candida albicans one of two genes similar to S. cerevisiae GPD1 (YDL022W) and GPD2 (YOL059W) glycerol-3-phosphate dehydrogenase Get druggable targets OG5_126704 All targets in OG5_126704
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans one of two genes similar to S. cerevisiae SIR2 (YDL042C) NAD+-dependent histone deacetylase Get druggable targets OG5_129944 All targets in OG5_129944
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni chromatin regulatory protein sir2 Get druggable targets OG5_127826 All targets in OG5_127826
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum Glycerol-3-phosphate dehydrogenase [NAD+], putative Get druggable targets OG5_126704 All targets in OG5_126704
Trypanosoma brucei nucleoside diphosphatase, putative Get druggable targets OG5_127709 All targets in OG5_127709
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei gambiense glycerol-3-phosphate dehydrogenase [NAD ], glycosomal, putative Get druggable targets OG5_126704 All targets in OG5_126704
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus galactokinase Get druggable targets OG5_129789 All targets in OG5_129789
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Chlamydia trachomatis endonuclease IV Get druggable targets OG5_129467 All targets in OG5_129467
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica galactokinase, putative Get druggable targets OG5_129789 All targets in OG5_129789
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Onchocerca volvulus Get druggable targets OG5_126704 All targets in OG5_126704
Schistosoma mansoni adenosine diphosphatase Get druggable targets OG5_127709 All targets in OG5_127709
Mycobacterium tuberculosis Probable galactokinase GalK (galactose kinase) Get druggable targets OG5_129789 All targets in OG5_129789
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus fructose 16 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni fructose 16-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii GDA1/CD39 (nucleoside phosphatase) family protein Get druggable targets OG5_127709 All targets in OG5_127709
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum expressed protein Get druggable targets OG5_129944 All targets in OG5_129944
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis chromatin regulatory protein sir2 Get druggable targets OG5_127826 All targets in OG5_127826
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum nucleoside phosphatase, putative,guanosine diphosphatase, putative Get druggable targets OG5_127709 All targets in OG5_127709
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis nucleoside phosphatase, putative,guanosine diphosphatase, putative Get druggable targets OG5_127709 All targets in OG5_127709
Trichomonas vaginalis chromatin regulatory protein sir2, putative Get druggable targets OG5_129944 All targets in OG5_129944
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Ectonucleoside triphosphate diphosphohydrolase 2, related Get druggable targets OG5_127709 All targets in OG5_127709
Plasmodium falciparum fructose-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Mycobacterium ulcerans galactokinase Get druggable targets OG5_129789 All targets in OG5_129789
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129944 All targets in OG5_129944
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii NAD-dependent glycerol-3-phosphate dehydrogenase Get druggable targets OG5_126704 All targets in OG5_126704
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K01463 sirtuin (silent mating type information regulation 2 homolog) 2 [EC:3.5.1.-], putative Get druggable targets OG5_127826 All targets in OG5_127826
Brugia malayi NAD-dependent deacetylase SIRT1 Get druggable targets OG5_129944 All targets in OG5_129944
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_126704 All targets in OG5_126704
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense nucleoside diphosphatase, putative Get druggable targets OG5_127709 All targets in OG5_127709
Babesia bovis apurinic endonuclease (APN1) family protein Get druggable targets OG5_129467 All targets in OG5_129467
Trypanosoma brucei gambiense nucleoside phosphatase, putative,guanosine diphosphatase, putative Get druggable targets OG5_127709 All targets in OG5_127709
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans NAD(P)H-dependent glycerol-3-phosphate dehydrogenase Get druggable targets OG5_126704 All targets in OG5_126704
Candida albicans apurinic/apyrimidinic endonuclease/3'-repair diesterase Get druggable targets OG5_129467 All targets in OG5_129467
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus fructose 16 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Babesia bovis glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Echinococcus multilocularis Ankyrin repeat domain containing protein Get druggable targets OG5_136365 All targets in OG5_136365
Entamoeba histolytica Sir2 family transcriptional regulator, putative Get druggable targets OG5_127826 All targets in OG5_127826
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma congolense nucleoside phosphatase, putative Get druggable targets OG5_127709 All targets in OG5_127709
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii Unknown-related Get druggable targets OG5_126704 All targets in OG5_126704
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129467 All targets in OG5_129467
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum AP endonuclease of the TIM barrel fold, possible bacterial horizontal transfer Get druggable targets OG5_129467 All targets in OG5_129467
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Ankyrin repeat domain containing protein Get druggable targets OG5_136365 All targets in OG5_136365
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 Get druggable targets OG5_127143 All targets in OG5_127143
Schistosoma mansoni multiple ankyrin repeats single kh domain protein Get druggable targets OG5_136365 All targets in OG5_136365
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum CBR-GPDH-1 protein, related Get druggable targets OG5_126704 All targets in OG5_126704
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania donovani ATP diphosphohydrolase Get druggable targets OG5_127709 All targets in OG5_127709
Candida albicans one of two genes similar to S. cerevisiae SIR2 (YDL042C) NAD+-dependent histone deacetylase Get druggable targets OG5_129944 All targets in OG5_129944
Plasmodium berghei apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Trypanosoma cruzi Silent information regulator 2 related protein 1 Get druggable targets OG5_127826 All targets in OG5_127826
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Probable glycerol-3-phosphate dehydrogenase, cytoplasmic Get druggable targets OG5_126704 All targets in OG5_126704
Candida albicans one of two genes similar to S. cerevisiae GPD1 (YDL022W) and GPD2 (YOL059W) glycerol-3-phosphate dehydrogenase Get druggable targets OG5_126704 All targets in OG5_126704
Leishmania braziliensis ATP diphosphohydrolase Get druggable targets OG5_127709 All targets in OG5_127709
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Leishmania mexicana fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Mycobacterium ulcerans NAD(P)H-dependent glycerol-3-phosphate dehydrogenase Get druggable targets OG5_126704 All targets in OG5_126704
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Leishmania major ATP diphosphohydrolase Get druggable targets OG5_127709 All targets in OG5_127709
Brugia malayi fructose-bisphosphate aldolase 1 Get druggable targets OG5_127143 All targets in OG5_127143
Plasmodium knowlesi glycerol-3-phosphate dehydrogenase, putative Get druggable targets OG5_126704 All targets in OG5_126704
Echinococcus multilocularis galactokinase Get druggable targets OG5_129789 All targets in OG5_129789
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni chromatin regulatory protein sir2 Get druggable targets OG5_127826 All targets in OG5_127826
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Wolbachia endosymbiont of Brugia malayi NAD(P)H-dependent glycerol-3-phosphate dehydrogenase Get druggable targets OG5_126704 All targets in OG5_126704
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi Silent information regulator 2 related protein 1 Get druggable targets OG5_127826 All targets in OG5_127826
Schistosoma mansoni chromatin regulatory protein sir2 Get druggable targets OG5_127826 All targets in OG5_127826
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis chromatin regulatory protein sir2, putative Get druggable targets OG5_129944 All targets in OG5_129944
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major silent information regulator 2, putative Get druggable targets OG5_127826 All targets in OG5_127826
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis NAD-dependent SIR2, putative Get druggable targets OG5_127826 All targets in OG5_127826
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Get druggable targets OG5_136365 All targets in OG5_136365
Trypanosoma cruzi galactokinase, putative Get druggable targets OG5_129789 All targets in OG5_129789
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus chromatin regulatory protein sir2 Get druggable targets OG5_127826 All targets in OG5_127826
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi galactokinase family protein galactokinase 1 392 aa 405 aa 30.1 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Echinococcus multilocularis serotonin receptor Muscarinic acetylcholine receptor M1   460 aa 432 aa 26.6 %
Loa Loa (eye worm) hypothetical protein Muscarinic acetylcholine receptor M1   460 aa 425 aa 22.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Muscarinic acetylcholine receptor M1   460 aa 462 aa 23.4 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, putative 498 aa 515 aa 27.6 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Schistosoma mansoni amine GPCR Muscarinic acetylcholine receptor M1   460 aa 463 aa 27.0 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Echinococcus granulosus biogenic amine 5HT receptor Muscarinic acetylcholine receptor M1   460 aa 432 aa 26.6 %
Plasmodium falciparum transcriptional regulatory protein sir2a sirtuin 2 234 aa 207 aa 26.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei nucleoside phosphatase, putative nucleoside phosphatase, putative 246 aa 241 aa 56.4 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.0120412 0.0452663 0.616134
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0159066 0.0625249 0.664479
Giardia lamblia Hypothetical protein 0.0183576 0.0734682 0.735097
Echinococcus granulosus lysine specific histone demethylase 1A 0.0159066 0.0625249 0.664479
Brugia malayi amine oxidase, flavin-containing family protein 0.0159066 0.0625249 0.664479
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.00553706 0.0162263 0.172444
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.00386259 0.00875 0.09299
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0183576 0.0734682 1
Mycobacterium ulcerans monoamine oxidase 0.0159066 0.0625249 0.0625249
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.00553706 0.0162263 0.172444
Plasmodium vivax hypothetical protein, conserved 0.0159066 0.0625249 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.00386259 0.00875 0.09299
Echinococcus granulosus fructose bisphosphate aldolase class I 0.0120412 0.0452663 0.481064
Leishmania major silent information regulator 2, putative 0.0183576 0.0734682 1
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0120412 0.0452663 0.723972
Brugia malayi transcriptional regulator, Sir2 family protein 0.00553706 0.0162263 0.172444
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0183576 0.0734682 1
Plasmodium falciparum fructose-bisphosphate aldolase 0.0120412 0.0452663 0.723972
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.0120412 0.0452663 0.723972
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0159066 0.0625249 1
Loa Loa (eye worm) transcriptional regulator 0.00553706 0.0162263 0.172444
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0120412 0.0452663 0.601564
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0183576 0.0734682 0.780778
Trypanosoma brucei SIR2-like protein 4, putative 0.00553706 0.0162263 0.220861
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.00386259 0.00875 0.09299
Loa Loa (eye worm) sirtuin 4 0.00553706 0.0162263 0.172444
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.0120412 0.0452663 0.481064
Schistosoma mansoni chromatin regulatory protein sir2 0.00553706 0.0162263 0.172444
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0120412 0.0452663 0.481064
Mycobacterium ulcerans Sir2-like regulatory protein 0.00553706 0.0162263 0.0162263
Schistosoma mansoni chromatin regulatory protein sir2 0.0229776 0.0940961 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.00553706 0.0162263 0.172444
Wolbachia endosymbiont of Brugia malayi NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 0.00190285 0 0.5
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.00386259 0.00875 0.119099
Echinococcus multilocularis 0.0159066 0.0625249 0.664479
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0120412 0.0452663 0.601564
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.00386259 0.00875 0.119099
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0159066 0.0625249 1
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0120412 0.0452663 0.481064
Brugia malayi Peptidase family M1 containing protein 0.00386259 0.00875 0.09299
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0120412 0.0452663 0.481064
Loa Loa (eye worm) hypothetical protein 0.0159066 0.0625249 0.664479
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.00553706 0.0162263 0.115521
Leishmania major sir2-family protein-like protein 0.00553706 0.0162263 0.220861
Entamoeba histolytica hypothetical protein, conserved 0.00553706 0.0162263 0.115521
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.00386259 0.00875 0.09299
Plasmodium vivax hypothetical protein, conserved 0.00553706 0.0162263 0.259517
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.00553706 0.0162263 0.172444
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159066 0.0625249 0.0673049
Echinococcus granulosus chromatin regulatory protein sir2 0.0183576 0.0734682 0.780778
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0159066 0.0625249 1
Echinococcus multilocularis protoporphyrinogen oxidase 0.0159066 0.0625249 0.664479
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.0120412 0.0452663 0.481064
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0229776 0.0940961 1
Brugia malayi Peptidase family M1 containing protein 0.0130393 0.0497229 0.528426
Plasmodium vivax NAD-dependent deacetylase, putative 0.00553706 0.0162263 0.259517
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0120412 0.0452663 0.481064
Loa Loa (eye worm) hypothetical protein 0.00917673 0.0324769 0.345146
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0229776 0.0940961 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.00553706 0.0162263 0.172444
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0183576 0.0734682 0.780778
Echinococcus granulosus lysine specific histone demethylase 1A 0.0159066 0.0625249 0.664479
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.00386259 0.00875 0.09299
Echinococcus granulosus puromycin sensitive aminopeptidase 0.00386259 0.00875 0.09299
Echinococcus multilocularis chromatin regulatory protein sir2 0.0183576 0.0734682 0.780778
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0159066 0.0625249 1
Onchocerca volvulus 0.0159066 0.0625249 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.00553706 0.0162263 0.172444
Schistosoma mansoni chromatin regulatory protein sir2 0.0183576 0.0734682 0.780778
Leishmania major UDP-galactopyranose mutase 0.0159066 0.0625249 0.851047
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.00553706 0.0162263 0.115521
Mycobacterium tuberculosis Possible oxidoreductase 0.0159066 0.0625249 0.0673049
Trypanosoma brucei Silent information regulator 2 related protein 3 0.00553706 0.0162263 0.220861
Plasmodium vivax hypothetical protein, conserved 0.0159066 0.0625249 1
Trypanosoma cruzi aminopeptidase, putative 0.00386259 0.00875 0.0856638
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.00250456 0.00268657 0.0285514
Brugia malayi SWIRM domain containing protein 0.0159066 0.0625249 0.664479
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0183576 0.0734682 0.780778
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0120412 0.0452663 0.723972
Brugia malayi transcriptional regulator, Sir2 family protein 0.00553706 0.0162263 0.172444
Chlamydia trachomatis protoporphyrinogen oxidase 0.0159066 0.0625249 1
Brugia malayi hypothetical protein 0.00386259 0.00875 0.09299
Toxoplasma gondii histone deacetylase SIR2 0.00553706 0.0162263 0.259517
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0159066 0.0625249 0.664479
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0229776 0.0940961 1
Brugia malayi fructose-bisphosphate aldolase 1 0.0120412 0.0452663 0.481064
Loa Loa (eye worm) aminopeptidase N 0.00386259 0.00875 0.09299
Toxoplasma gondii histone deacetylase SIR2-like 0.00553706 0.0162263 0.259517
Loa Loa (eye worm) transcriptional regulator 0.00553706 0.0162263 0.172444
Loa Loa (eye worm) hypothetical protein 0.0159066 0.0625249 0.664479
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.0120412 0.0452663 0.481064
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.225874 1 1
Onchocerca volvulus 0.0130393 0.0497229 0.79525
Plasmodium falciparum protoporphyrinogen oxidase 0.0159066 0.0625249 1
Toxoplasma gondii histone lysine-specific demethylase 0.0159066 0.0625249 1
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0159066 0.0625249 1
Loa Loa (eye worm) hypothetical protein 0.0159066 0.0625249 0.664479
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.00386259 0.00875 0.0856638
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0183576 0.0734682 0.780778
Mycobacterium tuberculosis Transcriptional regulatory protein 0.00553706 0.0162263 0.0174668
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0183576 0.0734682 1
Loa Loa (eye worm) hypothetical protein 0.0159066 0.0625249 0.664479
Brugia malayi fructose-bisphosphate aldolase 2 0.0120412 0.0452663 0.481064
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0120412 0.0452663 0.601564
Mycobacterium ulcerans aminopeptidase N PepN 0.00386259 0.00875 0.00875
Trypanosoma brucei Aminopeptidase M1, putative 0.00386259 0.00875 0.119099
Leishmania major fructose-1,6-bisphosphate aldolase 0.0120412 0.0452663 0.616134
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.00553706 0.0162263 0.191289
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.0120412 0.0452663 0.723972
Schistosoma mansoni chromatin regulatory protein sir2 0.0183576 0.0734682 0.780778
Schistosoma mansoni chromatin regulatory protein sir2 0.00553706 0.0162263 0.172444
Schistosoma mansoni chromatin regulatory protein sir2 0.00553706 0.0162263 0.172444
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.00386259 0.00875 0.09299
Brugia malayi hypothetical protein 0.0159066 0.0625249 0.664479
Loa Loa (eye worm) hypothetical protein 0.0159066 0.0625249 0.664479
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0229776 0.0940961 1
Mycobacterium ulcerans NAD-dependent deacetylase 0.00553706 0.0162263 0.0162263
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0183576 0.0734682 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.00553706 0.0162263 0.172444
Treponema pallidum NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 0.00190285 0 0.5
Trypanosoma brucei Aminopeptidase M1, putative 0.00386259 0.00875 0.119099
Schistosoma mansoni chromatin regulatory protein sir2 0.0183576 0.0734682 0.780778
Brugia malayi NAD-dependent deacetylase SIRT1 0.0229776 0.0940961 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0159066 0.0625249 0.0625249
Loa Loa (eye worm) hypothetical protein 0.0116813 0.0436594 0.463988
Schistosoma mansoni amine oxidase 0.0159066 0.0625249 0.664479
Loa Loa (eye worm) hypothetical protein 0.0159066 0.0625249 0.664479
Echinococcus granulosus puromycin sensitive aminopeptidase 0.00386259 0.00875 0.09299
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.00386259 0.00875 0.119099
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0120412 0.0452663 0.601564
Loa Loa (eye worm) transcriptional regulator 0.0183576 0.0734682 0.780778
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0120412 0.0452663 0.481064
Mycobacterium ulcerans dehydrogenase 0.0159066 0.0625249 0.0625249
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0229776 0.0940961 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0183576 0.0734682 1
Onchocerca volvulus 0.00386259 0.00875 0.139944
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0229776 0.0940961 1
Loa Loa (eye worm) hypothetical protein 0.00250456 0.00268657 0.0285514
Loa Loa (eye worm) hypothetical protein 0.0174406 0.0693739 0.737266
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.00386259 0.00875 0.09299
Echinococcus granulosus puromycin sensitive aminopeptidase 0.00386259 0.00875 0.09299
Loa Loa (eye worm) hypothetical protein 0.00250456 0.00268657 0.0285514
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.00553706 0.0162263 0.220861
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.00250456 0.00268657 0.0285514
Loa Loa (eye worm) peptidase family M1 containing protein 0.0105348 0.0385403 0.409585
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.00386259 0.00875 0.09299
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.225874 1 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0159066 0.0625249 1
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0120412 0.0452663 0.481064
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0120412 0.0452663 0.481064
Echinococcus multilocularis aminopeptidase N 0.0130393 0.0497229 0.528426
Echinococcus granulosus aminopeptidase N 0.0130393 0.0497229 0.528426
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.00553706 0.0162263 0.172444
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0159066 0.0625249 0.664479
Schistosoma mansoni amine oxidase 0.0159066 0.0625249 0.664479
Loa Loa (eye worm) hypothetical protein 0.0229776 0.0940961 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0159066 0.0625249 0.845393
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0229776 0.0940961 1
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.209967 0.928979 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.00386259 0.00875 0.09299
Echinococcus granulosus puromycin sensitive aminopeptidase 0.00386259 0.00875 0.09299
Mycobacterium ulcerans oxidoreductase 0.0159066 0.0625249 0.0625249
Plasmodium falciparum transcriptional regulatory protein sir2a 0.00553706 0.0162263 0.259517
Trypanosoma cruzi UDP-galactopyranose mutase 0.0159066 0.0625249 0.845393
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.00386259 0.00875 0.09299
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0120412 0.0452663 0.481064
Plasmodium falciparum transcriptional regulatory protein sir2b 0.00553706 0.0162263 0.259517
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.00553706 0.0162263 0.172444
Brugia malayi transcriptional regulator, Sir2 family protein 0.0183576 0.0734682 0.780778
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.00553706 0.0162263 0.191289
Trypanosoma cruzi Aminopeptidase M1, putative 0.00386259 0.00875 0.0856638

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Antifilarial activity against M. dessetae in vivo against male adult worms at a dose of 40 mg/kg subcutaneously once a day for 5 days; Active ChEMBL. 3681893
Activity (functional) 0 Antifilarial activity against M. dessetae in vivo against female adult worms at a dose of 40 mg/kg subcutaneously once a day for 5 days; Active ChEMBL. 3681893
Activity (functional) = 2 Antifilarial activity against M. dessetae in vivo in P. oris the natural host at a dose of 40 mg/kg subcutaneously once a day for 5 days. Value is expressed as number of infected P. oris. ChEMBL. 3681893
CC50 (ADMET) = 250 uM Evaluated for 50% cytotoxic concentration based on reduction of viability of mock-infected cells ChEMBL. 1282569
EC50 (functional) = 1000 nM The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 1 (P2X1) at 1 microM,expressed in Xenopus oocytes ChEMBL. 12213051
EC50 (functional) = 3000 nM The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X2) at 10 microM,expressed in Xenopus oocytes ChEMBL. 12213051
EC50 (functional) = 4000 nM Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12) ChEMBL. 12213051
EC50 (functional) = 4000 nM Antagonist activity against recombinant rat P2X purinoceptor 5 (P2X5) ChEMBL. 12213051
EC50 (functional) > 10000 nM Evaluated for antagonistactivity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytes ChEMBL. 12213051
EC50 (functional) = 10400 nM The compound was evaluated for antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 30 microM,expressed in Xenopus oocytes ChEMBL. 12213051
EC50 (functional) = 14900 nM Antagonist activity against recombinant human P2X purinoceptor 3 (P2X3 ) ChEMBL. 12213051
EC50 (functional) = 16000 nM The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) ChEMBL. 12213051
EC50 (functional) = 48000 nM Evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 2 (P2Y2) ChEMBL. 12213051
EC50 (functional) = 92000 nM Antagonist activity against recombinant human P2X purinoceptor 7 (P2X7) ChEMBL. 12213051
EC50 (functional) > 100000 nM The compound was evaluated for antagonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 4 (P2Y4) ChEMBL. 12213051
EC50 (functional) > 100000 nM Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 3 microM,expressed in Xenopus oocytes ChEMBL. 12213051
EC50 (functional) > 100000 nM Antagonist activity against recombinant rat P2X purinoceptor 6 (P2X6 ) ChEMBL. 12213051
EC50 (functional) = 8.2 uM Evaluated for 50% antiviral effective concentration based on inhibition of HIV-1(HTLV-IIIB) induced cytopathogenicity in MT-4 cells ChEMBL. 1282569
EC50 (functional) = 500 uM Effective concentration of compound necessary to kill 50% of infective larvae of M. dessetae after 7 days was determined in vitro; Value ranges from 100-500 ChEMBL. 3681893
EC90 (functional) = 500 uM Effective concentration of compound necessary to kill 90% of infective larvae of M. dessetae after 7 days was determined in vitro; Value ranges from 100-500 ChEMBL. 3681893
ED50 (binding) = 21 ug ml-1 Ability to destroy fluid-phase human complement 1 in the presence of complement 4 with appropriate serial twofold dilutions of the test compound using C1 assay ChEMBL. 7365741
ED50 (binding) = 50 ug ml-1 The ability of the compound to inhibit late component of human complement (C3-C9) using C-late assay ChEMBL. 7365741
ED50 (binding) = 167 ug ml-1 Inhibition of the complement alternative pathway by Mercaptan-treated human erythrocytes lyse in autologous serum via the alternative pathway activated by cobra venom factor in the presence of appropriate serial twofold dilutions of the test compound ChEMBL. 7365741
ED50 (functional) = 603 ug ml-1 Evaluated in vitro for complement activity using guinea pig serum was determined by cap 50 assay ChEMBL. 7365741
IC50 (functional) = -5 Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -4.9 Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -4.9 Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -4.9 Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -4.9 Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) 0 uM In vitro anti protozoal activity of the compound against Trypanosoma cruzi strain Tulahuen CL2 was determined; ND = Not determined ChEMBL. 15203133
IC50 (functional) 0 uM In vitro anti protozoal activity of the compound against Leishmania infantum strain MHOM-ET-67/L82 was determined; ND = Not determined ChEMBL. 15203133
IC50 (functional) 0 uM In vitro anti protozoal activity of the compound against Leishmania amazonensis strain MHOM/ET/L82/LV9 was determined; ND = Not determined ChEMBL. 15203133
IC50 (functional) 0 uM Cytotoxicity of the compound was determined in macrophages; ND = Not determined ChEMBL. 15203133
IC50 (functional) 0 uM In vitro anti protozoal activity of the compound against Plasmodium falciparum sensitive strain W2; ND = Not determined ChEMBL. 15203133
IC50 (functional) 0 uM In vitro anti protozoal activity of the compound against Plasmodium falciparum resistant strain Ghana ;ND = Not determined ChEMBL. 15203133
IC50 (functional) 0 uM Cytotoxicity of the compound was determined in MRC-5 cells; ND = Not determined ChEMBL. 15203133
IC50 (functional) = 0.043 uM In vitro anti-protozoal parasite activity of the compound against T. brucei TB-1 ChEMBL. 12781185
IC50 (functional) = 0.043 uM In vitro anti-protozoal parasite activity of the compound against T. brucei TB-1 ChEMBL. 12781185
IC50 (binding) = 0.3 uM Inhibition of SIRT1 ChEMBL. 21080630
IC50 (functional) = 0.3 uM Antitrypanosomal activity against Trypanosoma brucei brucei after 48 hrs ChEMBL. 17239596
IC50 (functional) = 0.31 uM Trypanocidal activity against Trypanosoma brucei brucei after 48 hrs ChEMBL. 16516467
IC50 (functional) = 0.31 uM Antitrypanosomal activity against Trypanosoma brucei brucei TC221 infected in mouse J774.1 cells after 48 hrs by alamar blue assay ChEMBL. 22376072
IC50 (functional) = 0.31 uM Trypanocidal activity against Trypanosoma brucei brucei after 48 hrs ChEMBL. 16516467
IC50 (functional) = 0.9 uM In vitro anti protozoal activity against Trypanosoma brucei strain S427 was determined ChEMBL. 15203133
IC50 (binding) = 1.2 uM Inhibition of SIRT2 ChEMBL. 21080630
IC50 (binding) = 1.2 uM Inhibition of human recombinant SIRT2 ChEMBL. 25515955
IC50 (binding) = 9.4 uM Inhibition of purified HIV-1 reverse transcriptase ChEMBL. 1282569
IC50 (binding) = 15 uM Inhibition of purified HIV-2 reverse transcriptase ChEMBL. 1282569
IC50 (functional) = 500 uM Antiproliferative activity against human umbilical vein endothelial cells (HUVECs) using MTT assay ChEMBL. 11591505
IC50 (functional) > 1000 uM Cytotoxicity against J774.1 cell line after 48 hrs ChEMBL. 16516467
IC50 (functional) > 1000 uM Cytotoxicity against J774.1 cell line after 48 hrs ChEMBL. 16516467
Inhibition (functional) 0 % Inhibitory activity of the compound against proliferationof HTLV-1 transformed cell lines (HUT-102) at 10 microM; ND = Not determined ChEMBL. 15203133
Inhibition (functional) = 27 % The compound was evaluated for antagonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 6 (P2Y6) ChEMBL. 12213051
Inhibition (binding) = 31.5 % Inhibition of Trypanosoma brucei rhodesiense rhodesain at 200 uM ChEMBL. 16516467
Inhibition (binding) = 31.5 % Inhibition of Trypanosoma brucei rhodesiense rhodesain at 200 uM ChEMBL. 16516467
Inhibition (functional) = 44 % Evaluated in vivo after intraperitoneal administration by guinea pig assay ChEMBL. 7365741
Inhibition (functional) = 50.5 % Percent inhibition of agonist-induced calcium mobilization at P2Y purinoceptor 2 recombinantly expressed in human HEK293 cells at 100 uM dose ChEMBL. 16250663
Inhibition (functional) = 54.5 % Percent inhibition of agonist-induced calcium mobilization at P2Y purinoceptor 1 recombinantly expressed in human HEK293 cells at 100 uM dose ChEMBL. 16250663
Inhibition (functional) = 93.7000000000001 % Percent inhibition of agonist-induced calcium mobilization at P2Y purinoceptor 11 recombinantly expressed in human HEK293 cells at 100 uM dose ChEMBL. 16250663
Ki (binding) = 12.7 uM Inhibition of rat recombinant NTPDase3 expressed in CHO cells ChEMBL. 16997558
Ki (binding) = 65.4 uM Inhibition of rat recombinant NTPDase2 expressed in CHO cells ChEMBL. 16997558
Ki (binding) = 300 uM Inhibition of rat recombinant NTPDase1 expressed in CHO cells ChEMBL. 16997558
Log Ki (binding) = 6.52 Inhibitiory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6 ChEMBL. 16250663
MIC (functional) = 0.13 uM Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei s247 after 48 hrs by alamar blue assay ChEMBL. 21306904
MIC (functional) = 1 uM Trypanocidal activity against Trypanosoma brucei brucei after 48 hrs ChEMBL. 16516467
MIC (functional) = 1 uM Trypanocidal activity against Trypanosoma brucei brucei after 48 hrs ChEMBL. 16516467
MIC (functional) = 35 uM Minimum inhibitory concentration of the compound, achieving a complete protection of ATH8 cells against the cytopathic effect of HTLV-III / LAV reverse transcriptase ChEMBL. 2427720
potency (functional) = 15 Relative potency was measured against P2Y purinoceptor 11 ChEMBL. 16250663
Potency (functional) 0.1 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 0.2239 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 0.3548 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for NFkB Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 895 ] ChEMBL. No reference
Potency (functional) = 0.3548 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Validation Assay for Activators of Leishmania Mexicana Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 594 (Rhodamine region spectral profiling screen)] ChEMBL. No reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485290, AID485312, AID504464, AID504474] ChEMBL. No reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 1.4125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: Validation of Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for Thrombopoietin (TPO) Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 918 ] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for Thrombopoietin (TPO) Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 917 ] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV. (Class of assay: confirmatory) [Related pubchem assays: 1705, 1707 ] ChEMBL. No reference
Potency (binding) 4.4668 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485290, AID485312, AID504464, AID504474] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) [Related pubchem assays: 1705 (qHTS Validation Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) ), 2324 (Probe Development Summary of Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1707 (Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Validation Assay), 2517 (qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1708 (Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV)] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) [Related pubchem assays: 1707, 1708 ] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.4662 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 915 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 914 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 594 (Rhodamine region spectral profiling screen)] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of Human Galactosidase (GALK). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1868, AID2114] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Ratio IC50 (functional) > 3225 Selectivity index, IC50 for J774.1/IC50 for Trypanosoma brucei brucei ChEMBL. 16516467
SI (functional) = 5 Selectivity index expressed as ratio of compound concentration required to reduce the growth of normal uninfected ATH8 cells by 50% to the compound concentration (MIC) ChEMBL. 2427720
Stabilty 0 Stability at pH 7.6 at 10 uM ChEMBL. 16997558

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense 12781185
Plasmodium falciparum ChEMBL23 19734910
Trypanosoma brucei ChEMBL23 12781185

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania mexicana 21366  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with ALD inhibitors leads to reduced enzyme activity in vitro; References: 10551371
extracellular ligand-gated ion channel activity (GO:0005230) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Schistosoma mansoni 293597  
Annotator: crowther@u.washington.edu Comment: 2009/05/29 References: 15292267
catalytic activity (GO:0003824) decreased (PATO:0000468) trypomastigote (BTO:0001398) inferred from animal model system (ECO:0000179) Trypanosoma cruzi 34434  
Annotator: millerja@u.washington.edu Comment: Note: GeneBank ID is AY540630.1; included 3 hits (98% or better homology in BLAST search) to Tc genes in column A. Note: drugs also appear to reduce infectivity. Note: unable to find ARL 67156 in TDR Targets. References: 19255624
catalytic activity (GO:0003824) decreased (PATO:0000468) trypomastigote (BTO:0001398) inferred from animal model system (ECO:0000179) Trypanosoma cruzi 46102  
Annotator: millerja@u.washington.edu Comment: Note: GeneBank ID is AY540630.1; included 3 hits (98% or better homology in BLAST search) to Tc genes in column A. Note: drugs also appear to reduce infectivity. Note: unable to find ARL 67156 in TDR Targets. References: 19255624

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

240 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.