Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.006 | 0.006 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0508 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0013 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0073 | 0.1244 | 0.1244 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0025 | 0.0278 | 0.0278 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0508 | 1 | 1 |
Echinococcus multilocularis | neuroglian | 0.0015 | 0.006 | 0.006 |
Toxoplasma gondii | thioredoxin reductase | 0.0073 | 0.1244 | 0.0994 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0085 | 0.0085 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0085 | 0.0085 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0085 | 0.0085 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0774 | 0.0774 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0025 | 0.0278 | 0.0278 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0508 | 1 | 1 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.01 | 0.1776 | 0.1776 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0013 | 0.0021 | 0.0021 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0774 | 0.0774 |
Trypanosoma brucei | trypanothione reductase | 0.0073 | 0.1244 | 0.0994 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0085 | 0.0085 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0073 | 0.1244 | 0.1244 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0508 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0508 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0508 | 1 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0025 | 0.0278 | 0.0278 |
Brugia malayi | Thioredoxin reductase | 0.0073 | 0.1244 | 0.1244 |
Plasmodium falciparum | thioredoxin reductase | 0.0073 | 0.1244 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0085 | 0.0085 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.01 | 0.1776 | 0.1776 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0073 | 0.1244 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0508 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0508 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0774 | 0.0774 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0025 | 0.0278 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0455 | 0.0455 |
Echinococcus multilocularis | roundabout 2 | 0.0015 | 0.006 | 0.006 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0025 | 0.0278 | 0.0278 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0085 | 0.0085 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0508 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0085 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0085 | 0.0085 |
Echinococcus granulosus | roundabout 2 | 0.0015 | 0.006 | 0.006 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0025 | 0.0278 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0508 | 1 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0019 | 0.0142 | 0.0142 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0025 | 0.0278 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0508 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0025 | 0.0278 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0085 | 0.0085 |
Plasmodium vivax | glutathione reductase, putative | 0.0073 | 0.1244 | 1 |
Echinococcus granulosus | neuroglian | 0.0015 | 0.006 | 0.006 |
Loa Loa (eye worm) | TK protein kinase | 0.0103 | 0.1836 | 0.1836 |
Echinococcus granulosus | twitchin | 0.0019 | 0.0153 | 0.0153 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0025 | 0.0278 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0073 | 0.1244 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0073 | 0.1244 | 0.1244 |
Brugia malayi | glutathione reductase | 0.0073 | 0.1244 | 0.1244 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0508 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0085 | 0.0085 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0073 | 0.1244 | 0.0994 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0455 | 0.0455 |
Trypanosoma brucei | protein kinase, putative | 0.0508 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0025 | 0.0278 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0073 | 0.1244 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0508 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0085 | 0.0085 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0774 | 0.0774 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0508 | 1 | 1 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.01 | 0.1776 | 0.1776 |
Schistosoma mansoni | tyrosine kinase | 0.01 | 0.1776 | 0.1776 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0508 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0508 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0455 | 0.0455 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0019 | 0.0142 | 0.0142 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0508 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0073 | 0.1244 | 0.0994 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0085 | 0.0085 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0085 | 0.0085 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0025 | 0.0278 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0508 | 1 | 1 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.01 | 0.1776 | 0.1776 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0025 | 0.0278 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0508 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.006 | 0.006 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0085 | 0.0085 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0103 | 0.1836 | 0.1836 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0073 | 0.1244 | 0.1244 |
Schistosoma mansoni | nephrin | 0.0015 | 0.006 | 0.006 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 65 % | Cell Cycle inhibition against mouse lymphocytic leukemia cells (L1210) at 10 microM | ChEMBL. | 10780917 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.